References of "Piette, Caroline"
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See detailProspective, real-time monitoring of pegylated Escherichia coli and Erwinia asparaginase therapy in childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma in Belgium.
Mondelaers, Veerle; Ferster, Alina; Uyttebroeck, Anne et al

in British journal of haematology (2020)

Asparaginase (ASNase) is an important anti-leukaemic drug in the treatment of childhood acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma (NHL). A substantial proportion of patients develop ... [more ▼]

Asparaginase (ASNase) is an important anti-leukaemic drug in the treatment of childhood acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma (NHL). A substantial proportion of patients develop hypersensitivity reactions with anti-ASNase neutralising antibodies, resulting in allergic reactions or silent inactivation (SI), and characterised by inactivation and rapid clearance of ASNase. We report results of a prospective, real-time therapeutic drug monitoring of pegylated Escherichia coli (PEG-)ASNase and Erwinia ASNase in children treated for ALL and NHL in Belgium. Erwinia ASNase was given as second-line after hypersensitivity to PEG-ASNase. In total, 286 children were enrolled in the PEG-ASNase cohort. Allergy was seen in 11 2% and SI in 5.2% of patients. Of the 42 patients treated with Erwinia ASNase, 7.1% experienced allergy and 2.4% SI. The median trough PEG-ASNase activity was high in all patients without hypersensitivity. After Erwinia administration significantly more day 3 samples had activities <100 IU/l (62.5% vs. 10% at day 2 (D2)). The median D2 activity was significantly higher for intramuscular (IM; 347 IU/l) than for intravenous Erwinia administrations (159 IU/l). This prospective, multicentre study shows that monitoring of ASNase activity during treatment of children with ALL and NHL is feasible and informative. Treatment with Erwinia ASNase warrants close monitoring and optimally adherence to a 2-day interval of IM administrations. [less ▲]

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See detailLong-term outcome evaluation of medium/high risk acute lymphoblastic leukaemia children treated with or without cranial radiotherapy in the EORTC 58832 randomized study.
Piette, Caroline ULiege; Suciu, Stefan; Bertrand, Yves et al

in British journal of haematology (2019)

We investigated the long-term outcome, the incidence of second neoplasms (SN) and the rate of late adverse effects (LAE) in children with central nervous system (CNS) negative medium/high-risk de novo ... [more ▼]

We investigated the long-term outcome, the incidence of second neoplasms (SN) and the rate of late adverse effects (LAE) in children with central nervous system (CNS) negative medium/high-risk de novo acute lymphoblastic leukaemia (ALL), in first complete remission (CR1) at end of late intensification, randomized to receive no cranial radiotherapy (No CRT, n = 92) versus CRT (standard arm, n = 84) in the non-inferiority EORTC 58832 study (1983-1989). Median follow-up was 20 years (range 4-32 years). The 25-year disease-free survival rate (+/-SE) was 67.4 +/- 4.9% without CRT and 70.2 +/- 5.0% with CRT. The 25-year incidence of isolated (6.5 +/- 2.6% vs. 4.8 +/- 2.3%) and any CNS relapse {8.7 +/- 2.9% vs. 11.9 +/- 3.5%; hazard ratio (HR) 0.71 [95% confidence interval (CI) 0.28-1.79]; test of non-inferiority: P = 0.01} was not increased without CRT. The 25-year SN incidence in CR1 was 7.9 +/- 4.6% vs. 11.0 +/- 4.2%. The 25-year event-free and overall survival rates were quite similar in both arms [59.5 +/- 6.3% vs. 60.5 +/- 5.9%, HR 0.94 (95% CI 0.57-1.52), and 78.1 +/- 4.3% vs. 78.5 +/- 4.5%, HR 1.00 (95% CI 0.53-1.88)]. Omission of CRT was associated with dramatic decrease in CNS and endocrine LAE rates. In conclusion, our data suggest that, with proper systemic and intrathecal CNS prophylaxis, CRT could totally be omitted in CR1 without jeopardizing survival, while decreasing LAE in childhood ALL. [less ▲]

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See detailA simple case of torticollis leads to the diagnosis of an infantile desmoplasticf astrocytoma
Gillis, Nathalie; Bex, Alix; Bex, Vincent et al

Conference (2019, May 24)

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See detailA simple case of torticollis leads to the diagnosis of an infantile desmoplastic astrocytoma.
Gilis, N.; BEX, Alix ULiege; Bex, V. et al

Poster (2019, March 16)

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See detailL'image du mois. Cardiopathie congenitale : fistule entre l'artere circonflexe et le sinus coronaire.
Piette, Caroline ULiege; BERNARD, Anne-Catherine ULiege; GACH, Olivier ULiege et al

in Revue medicale de Liege (2019), 74(12), 625-626

Congenital coronary artery fistulas are infrequent but sometimes hemodynamically important anomalies depending on their magnitude and the cardiac chamber or vascular site involved. Fistula from left ... [more ▼]

Congenital coronary artery fistulas are infrequent but sometimes hemodynamically important anomalies depending on their magnitude and the cardiac chamber or vascular site involved. Fistula from left circumflex artery to coronary sinus are potentially curable causes of ischemic heart disease. [less ▲]

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See detailResults of successive EORTC-CLG 58 881 and 58 951 trials in paediatric T-cell acute lymphoblastic leukaemia (ALL)
Hofmans, Mattias; Suciu, Stefan; Ferster, Alina et al

in British Journal of Haematology (2019)

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See detailThe strategic plan for paediatric cancer treatment and clinical research development in Belgium
van Damme, An; De Moerloose, Barbara; Brichard, Bénédicte et al

in Belgian Journal of Medical Oncology (2019), 13(1), 21-26

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See detailEpidémiologie des cancers de l'enfant, une étude monocentrique (1985-2016)
Jankowski, M.; Dresse, Marie-Françoise ULiege; FORGET, Patricia ULiege et al

in Revue Medicale de Liege (2019), 74(3), 146-151

Cancer is the second leading cause of death among children aged 5 to 14, after accidents. We conducted a study on the epidemiology of childhood cancer in the university pediatric oncology department of ... [more ▼]

Cancer is the second leading cause of death among children aged 5 to 14, after accidents. We conducted a study on the epidemiology of childhood cancer in the university pediatric oncology department of the CHU-CHR in Liège, Belgium. We studied a cohort of 662 patients between the ages of 0 and 17 whose malignancy diagnosis was made between 1985 and 2016. The analyzes were performed retrospectively using medical files. The number of new cases, the proportion of different cancers, sex ratio, age at diagnosis and survival at 5 and 10 years were the epidemiological factors studied.We have been able to show an increase in the number of new diagnoses per year. More than 40 % of childhood cancers occur before the age of five. The most common neoplasias are leukemias, tumors of the central nervous system and lymphomas. This distribution is influenced by age. All malignant tumours combined, we observed a slightly larger proportion of affected boys than girls. Overall survival at 5 years reaches 80.2 %. However, it varies according to the type of tumour from 59.3 % for malignant soft tissue tumors up to 100 % for hepatoblastomas. © 2019 Revue Medicale de Liege. All Rights Reserved. [less ▲]

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See detailDifferential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia: results of the EORTC CLG 58881 and 58951 trials
Piette, Caroline ULiege; Suciu, S; Clappier, E et al

in Leukemia (2018), 32

In childhood B-cell precursor acute lymphoblastic leukaemias (BCP-ALL), the presence of an ETV6-RUNX1 fusion transcript defines one of the most prevalent genetic subgroups, together with the high ... [more ▼]

In childhood B-cell precursor acute lymphoblastic leukaemias (BCP-ALL), the presence of an ETV6-RUNX1 fusion transcript defines one of the most prevalent genetic subgroups, together with the high hyperdiploidy (HeH) ALL. Although ETV6-RUNX1pos ALLs are associated with favourable outcome, their proper treatment strategies remain debatable, some groups suggesting crucial impact of upfront intensive treatment while others favour low-intensity antimetabolite-based therapy. [less ▲]

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See detailVignette diagnostique de l'étudiant: Analyse critique des plaintes douloureuses du patient atteint de schizophrénie
CAUBO, Isabelle ULiege; Piette, Caroline ULiege; FONTAINE, Robert ULiege et al

in Revue Médicale de Liège (2017), 72(6), 318-322

Schizophrenia is a complex pathology. Its prevalence reaches almost 1 %. Its semiology can be diversified. Sensorial perception can be altered included pain perception. Most of the studies conclude that ... [more ▼]

Schizophrenia is a complex pathology. Its prevalence reaches almost 1 %. Its semiology can be diversified. Sensorial perception can be altered included pain perception. Most of the studies conclude that psychotic patients have a hypoalgesia. It's important to consider this fact to avoid missing potentially grave somatic disease. [less ▲]

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See detailLong Term Socioeconomic Outcomes of Childhood Acute Lymphoblastic Leukemia (ALL) Survivors Enrolled in EORTC Children Leukemia Group Trials 58741, 58831/2 and 58881
Barbati, Mélissa; Kicinski, Michal; Suciu, Stefan et al

in Blood (2017)

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See detailSchéma d’administration des glucocorticoïdes et risque d’ostéonécrose chez les enfants traités pour leucémie lymphoblastique aiguë – où en sommes-nous ?
Geurten, Claire ULiege; Piette, Caroline ULiege; Hoyoux, Claire ULiege

in Revue d'Oncologie Hematologie Pédiatrique (2016), 4(3), 182-187

En tant que tumeur pédiatrique la plus fréquente, de surcroît grevée d’un excellent pronostic global, la leucémie lymphoblastique aiguë (LAL) représente la plus grande pourvoyeuse de survivants exposés à ... [more ▼]

En tant que tumeur pédiatrique la plus fréquente, de surcroît grevée d’un excellent pronostic global, la leucémie lymphoblastique aiguë (LAL) représente la plus grande pourvoyeuse de survivants exposés à la toxicité des traitements chimiothérapeutiques. L’ostéonécrose est une complication bien décrite du traitement de la leucémie touchant jusqu’à un enfant sur dix, avec un tropisme particulier pour les adolescents atteints de leucémie à haut risque. Cette complication est liée à l’emploi des corticoïdes, dont la toxicité osseuse est potentialisée par l’emploi d’autres molécules, telles l’asparaginase et le méthotrexate. L’incidence de cette complication est plus élevée chez les patients recevant la dexaméthasone à titre de corticoïde principal. De récents protocoles thérapeutiques ont adopté, dans le but de réduire l’incidence de l’ostéonécrose, l’usage du schéma thérapeutique baptisé « split dexamethasone », une initiative du Children's Oncology Group (COG) consistant à marquer une pause de quelques jours dans l’administration de la dexaméthasone lors de la phase de réintensification. À ce jour, seuls un modèle animal et deux essais randomisés contrôlés du COG ont évalué l’intérêt de cette pratique. Ces derniers mettent en évidence un bénéfice de la méthode, avec une réduction de l’incidence d’ostéonécrose à 5 ans de l’ordre de 50 % pour le CCG 1961 et de 33 % chez les patients entre 10 et 12 ans pour le AALL0232, sans modification de la survie sans événement à 5 ans (EFS-5), qui reste de l’ordre de 75 % chez ces patients à haut risque. En conclusion, la prévention de l’apparition des lésions d’ostéonécrose via des amendements thérapeutiques, tel le « split dexamethasone » est non seulement réalisable et efficace, mais semble également sans danger sur le plan pronostic. [less ▲]

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See detailProlapsus rectal révélant une tumeur : intérêt de l’échographie abdominale, à propos de 3 cas
Bequet, Emeline ULiege; Stiennon, Laurie ULiege; Lhomme, Angélique et al

in Archives de Pédiatrie (2016), 23

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See detailPurpura thrombocytopénique idiopathique...idiopathique, vraiment?
LONGTON, Julie ULiege; DRESSE, Marie-Françoise ULiege; Florkin, Benoît et al

in Tijdschrift van de Belgische Kinderarts (2016), 18(1), 112

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See detailProlapsus rectal revelant une tumeur : interet de l'echographie abdominale, a propos de 3 cas.
Bequet, E.; Stiennon, L.; Lhomme, A. et al

in Archives de Pédiatrie (2016), 23(7), 723-6

Rectal prolapse is rare in children and usually benign. However, there are various diseases that can be associated with it, such as cystic fibrosis or other causes of increased abdominal pressure. Here ... [more ▼]

Rectal prolapse is rare in children and usually benign. However, there are various diseases that can be associated with it, such as cystic fibrosis or other causes of increased abdominal pressure. Here, we review the various underlying conditions that pediatricians or pediatric gastroenterologists should consider in the case of rectal prolapse. We report on three cases of children with a rectal prolapse and intra-abdominal tumors. Current recommendations and practice do not include a systematic check via abdominal imaging in cases of rectal prolapse. However, in some situations, imaging is indicated to detect a possible expansive process. Thus, in the presence of recurrent prolapse or of associated urinary or neurological signs, imaging is justified so as to allow for an early diagnosis and treatment of these neoplasms. Given its lack of radiation exposure and good sensitivity in children, ultrasound imaging is the first choice. [less ▲]

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