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See detailA quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics?
Penoy, Noémie ULiege; Avohou, Tonakpon Hermane ULiege; Lebrun, Pierre ULiege et al

Scientific conference (2019, December 11)

Liposomes are nanoparticles made of phospholipids, able to encapsulate many active molecules, protecting and transporting them in a targeted way. Liposomes are thus widely studied as vectors of numerous ... [more ▼]

Liposomes are nanoparticles made of phospholipids, able to encapsulate many active molecules, protecting and transporting them in a targeted way. Liposomes are thus widely studied as vectors of numerous active molecules, improving their therapeutic window. However, the usual production methods at the laboratory scale have many disadvantages and are generally difficult to transfer to the industrial scale under GMP conditions [1], [2]. Supercritical fluids are increasingly used in the pharmaceutical industry. One of the pharmaceutical applications of supercritical fluids is the production of particles. For the liposomes production, the use of supercritical CO2 as a dispersing agent has been preferred because of the total absence of organic solvent. Since this process involves many parameters such as pressure, temperature, stirring speed, lipid concentration, volume and contact time, a quality by design approach was used in order to determine the influence of each parameters on the physicochemical properties of liposomes such as the size and the polydispersity. These experimental analyses helped us to find two production areas. These conditions were validated with five different liposome formulations regarding the size and polydispersity expectations. We will now focus on the impact of each parameter on the physicochemical properties of liposomes but also their impact on the integrity of the phospholipids used. [less ▲]

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See detailA quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics?
Penoy, Noémie ULiege; Avohou, Tonakpon Hermane ULiege; Lebrun, Pierre ULiege et al

Scientific conference (2019, December 11)

Liposomes are nanoparticles made of phospholipids, able to encapsulate many active molecules, protecting and transporting them in a targeted way. Liposomes are thus widely studied as vectors of numerous ... [more ▼]

Liposomes are nanoparticles made of phospholipids, able to encapsulate many active molecules, protecting and transporting them in a targeted way. Liposomes are thus widely studied as vectors of numerous active molecules, improving their therapeutic window. However, the usual production methods at the laboratory scale have many disadvantages and are generally difficult to transfer to the industrial scale under GMP conditions [1], [2]. Supercritical fluids are increasingly used in the pharmaceutical industry. One of the pharmaceutical applications of supercritical fluids is the production of particles. For the liposomes production, the use of supercritical CO2 as a dispersing agent has been preferred because of the total absence of organic solvent. Since this process involves many parameters such as pressure, temperature, stirring speed, lipid concentration, volume and contact time, a quality by design approach was used in order to determine the influence of each parameters on the physicochemical properties of liposomes such as the size and the polydispersity. These experimental analyses helped us to find two production areas. These conditions were validated with five different liposome formulations regarding the size and polydispersity expectations. We will now focus on the impact of each parameter on the physicochemical properties of liposomes but also their impact on the integrity of the phospholipids used. References [1] C. Tikshdeep, A. Sonia, P. Bharat, and C. Abhishek, “Liposome Drug Delivery,” Int. J. Pharm. Chem. Sci., vol. 1, no. 3, pp. 1103–1113, 2012. [2] L. A. Meure, N. R. Foster, and F. Dehghani, “Conventional and Dense Gas Techniques for the Production of Liposomes: A Review,” AAPS PharmSciTech, vol. 9, no. 3, pp. 798–809, 2008. [3] B. S. Sekhon, “Supercritical fluid technology: An overview of pharmaceutical applications,” Int. J. PharmTech Res., vol. 2, no. 1, pp. 810–826, 2010 [less ▲]

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See detailUpdate of the progresses and development prospects of the FEDER project Phare
Emonts, Paul ULiege; Penoy, Noémie ULiege; Rocks, Natacha ULiege et al

Scientific conference (2019, January 19)

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See detailSupercritical fluid methods: an alternative to conventional methods to prepare liposomes
Bigazzi, William ULiege; Penoy, Noémie ULiege; Evrard, Brigitte ULiege et al

in Chemical Engineering Journal (2019)

Liposomes are used as nanovectors to encapsulate several active molecules with a prolongation of the drug effect, to target specific tissues or to reduce certain side effects. Innovative therapies using ... [more ▼]

Liposomes are used as nanovectors to encapsulate several active molecules with a prolongation of the drug effect, to target specific tissues or to reduce certain side effects. Innovative therapies using nanovectors have been developed and accepted for clinical trials, however their conventional methods of production suffer from drawbacks such as the use of large amounts of organic solvents, the small quantities produced and the many steps involved in the production that prevent the production at industrial scale. For several years, supercritical fluid-based preparation processes have been considered as a good alternative to conventional liposome preparation methods. A number of supercritical fluid processes allowing the liposome preparation are described depending on the role of the supercritical fluid with respect to the liposome raw materials. The supercritical fluid can act as a solvent or a cosolvent for the lipids material which are next put in contact with an aqueous solution before or during the depressurization. The supercritical fluid can also be used as an antisolvent to induce the formation of proliposomes which can be easily converted into liposomes by hydration. Finally the supercritical fluid can be used as a dispersing agent in order to finely disperse the lipid molecules into an aqueous medium. Several of these methods using supercritical fluids to produce liposomes are described in the literature. The aim of this review article is to summarize and classify the current supercritical fluid-based liposome preparation methods according to the function of the supercritical fluid within the process and compare them in terms of liposome’s physicochemical properties, hydration methods, molecules that can be encapsulated, encapsulation efficiencies and the use or not of organic solvents. [less ▲]

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See detailLiposome production by innovative method using supercritical fluids
Penoy, Noémie ULiege; Bigazzi, William ULiege; Piel, Géraldine ULiege et al

Scientific conference (2018, December 19)

Detailed reference viewed: 59 (25 ULiège)