References of "Moonen, Marie"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLa myocardite.
MOONEN, Marie ULiege; Lancellotti, Patrizio ULiege

in Revue Medicale de Liege (2018), 73(5-6), 269-276

Myocarditis is an illness characterized by myocardial infiltration with inflammatory cells and non-ischemic myocytic necrosis. The clinical presentation of myocarditis varies widely and diagnosis is ... [more ▼]

Myocarditis is an illness characterized by myocardial infiltration with inflammatory cells and non-ischemic myocytic necrosis. The clinical presentation of myocarditis varies widely and diagnosis is sometimes difficult to establish. The current incidence of myocarditis is also difficult to determine as endomyocardial biopsy, the diagnostic gold standard, is unfrequently used, or even not justified. The leading causes are infections, immune-mediated injury and toxins. Prognosis is most often good but, in some patients, the disease can be fulminant with progression to cardiogenic shock, or occurrence of sudden cardiac death. Prognosis in myocarditis patients varies according to the underlying aetiology. Treatment is generally symptomatic, but in some cases, a specific therapy is appropriated as a function of the corresponding aetiology. This paper aims to review current knowledge concerning myocarditis, with particular emphasis on <<urgent>> situations. [less ▲]

Detailed reference viewed: 27 (2 ULiège)
Full Text
Peer Reviewed
See detailEchocardiographic reference ranges for normal left atrial function parameters: results from the EACVI NORRE study.
Sugimoto, Tadafumi; ROBINET, Sébastien ULiege; DULGHERU, Raluca Elena ULiege et al

in European Heart Journal - Cardiovascular Imaging (2018), 19(6), 630-638

Aims: To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender. Methods and results: A total of ... [more ▼]

Aims: To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender. Methods and results: A total of 371 (median age 45 years) healthy subjects were enrolled at 22 collaborating institutions collaborating in the Normal Reference Ranges for Echocardiography (NORRE) study of the European Association of Cardiovascular Imaging (EACVI). Left atrial data sets were analysed with a vendor-independent software (VIS) package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire data sets. The lowest expected values of LA function were 26.1%, 48.7%, and 41.4% for left atrial strain (LAS), 2D left atrial emptying fraction (LAEF), and 3D LAEF (reservoir function); 7.7%, 24.2%, and -0.53/s for LAS-active, LAEF-active, and LA strain rate during LA contraction (SRa) (pump function) and 12.0% and 21.6% for LAS-passive and LAEF-passive (conduit function). Left atrial reservoir and conduit function were decreased with age while pump function was increased. All indices of reservoir function and all LA strains had no difference in both gender and vendor. However, inter-vendor differences were observed in LA SRa despite the use of VIS. Conclusion: The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function. Our data highlight the importance of age-specific reference values for LA functions. [less ▲]

Detailed reference viewed: 113 (3 ULiège)
Full Text
Peer Reviewed
See detailTreating cardiovascular complications of radiotherapy: a role for new pharmacotherapies
Donis, Nathalie ULiege; Oury, Cécile ULiege; MOONEN, Marie ULiege et al

in Expert Opinion on Pharmacotherapy (2018), 19(5), 431-442

Introduction: Available data indicate that survivors of breast cancer and Hodgkin lymphoma who received mediastinal radiotherapy are at increased risk of developing radiation-induced cardiovascular ... [more ▼]

Introduction: Available data indicate that survivors of breast cancer and Hodgkin lymphoma who received mediastinal radiotherapy are at increased risk of developing radiation-induced cardiovascular diseases (RICVD) one or two decades after treatment. Although the risk with modern radiation treatment is likely to be lower in these patient groups, cardiotoxicity is still observed in a subset of patients. In addition, radiation-associated cardiovascular complications can, in the future, extend to other groups of cancer patients who are treated for tumors that are localized near the heart. Areas covered: The authors briefly describe the most commonly observed types of RICVD. They then present an overview of preclinical animal and cellular models that have been used to investigate the mechanisms underlying RICVD pathophysiology. The beneficial effects of available drugs, and potential targets for new molecules are also reported. Expert opinion: There is a need to develop cardio-oncological programs and pharmacotherapies specifically targeting RICVD. Beyond statins, ACE inhibitors, anti-inflammatory and antioxidant agents, preclinical studies indicate that TGFβ receptor I inhibitors, Sestrin2 inducers, recombinant neuregulin-1 and miR-21 inhibitors might represent novel promising strategies. In order to properly determine the optimal therapeutic index for these molecules, in vivo models combining cancer and RICVD should be envisioned. © 2018 Informa UK Limited, trading as Taylor & Francis Group. [less ▲]

Detailed reference viewed: 47 (4 ULiège)
Full Text
Peer Reviewed
See detailProtocol update and preliminary results of EACVI/HFA Cardiac Oncology Toxicity (COT) Registry of the European Society of Cardiology.
Lancellotti, Patrizio ULiege; Galderisi, Maurizio; Donal, Erwan et al

in ESC Heart Failure (2017), 4(3), 312-318

AIMS: European Association of Cardiovascular Imaging/Heart Failure Association Cardiac Oncology Toxicity Registry was launched in October 2014 as a European Society of Cardiology multicentre registry of ... [more ▼]

AIMS: European Association of Cardiovascular Imaging/Heart Failure Association Cardiac Oncology Toxicity Registry was launched in October 2014 as a European Society of Cardiology multicentre registry of breast cancer patients referred to imaging laboratories for routine surveillance, suspected, or confirmed anticancer drug-related cardiotoxicity (ADRC). After a pilot phase (1 year recruitment and 1 year follow-up), some changes have been made to the protocol (version 1.0) and electronic case report form. METHODS AND RESULTS: Main changes of the version 2.0 concerned exclusion criteria, registry duration, and clarification of the population characteristics. Breast cancer radiotherapy has been removed as an exclusion criterion, which involves now only history of a pre-chemotherapy left ventricular dysfunction. The period for long-term registry recruitment has been reduced (December 2017), but the target study population was extended to 3000 patients. The characteristics of the population are now better defined: patients seen in an imaging lab, which will include patients undergoing chemotherapy with associated targeted therapy or no targeted therapy, at increased risk of ADRC. In total, 1294 breast cancer patients have been enrolled, and 783 case report forms locked from October 2014 to November 2016. Of these, 481 (61.4%) were seen at first evaluation and 302 (38.6%) while on oncologic treatment with anticancer drugs. Fifty-two patients (17.2%) were not in targeted therapies, 191 (63.3%) were ongoing targeted therapy, and 59 (19.5%) had completed it. Twenty-three (2.9%) patients had a suspected diagnosis and 35 (4.5%) a confirmed diagnosis of ADRC. Arterial hypertension was the most prevalent cardiovascular risk factor (29.2%) followed by diabetes (6.1%). Previous history of heart failure accounted for 0.5%, whereas previous cardiac disease was identified in 6.3% of population. CONCLUSION: The changes of the original protocol of the COT Registry and first update allow a first glance to the panorama of cardiovascular characteristics of breast cancer patients enrolled. [less ▲]

Detailed reference viewed: 46 (4 ULiège)
Full Text
Peer Reviewed
See detailCardiac Imaging: Multimodality Advances and Surveillance Strategies in Detection of Cardiotoxicity.
MOONEN, Marie ULiege; Oury, Cécile ULiege; Lancellotti, Patrizio ULiege

in Current Oncology Reports (2017), 19(10), 63

Contemporary cancer management has increased the overall number of cancer survivors, but cardiotoxicity remains a subject of concern, which is a major cause of noncancer mortality among survivors. Among ... [more ▼]

Contemporary cancer management has increased the overall number of cancer survivors, but cardiotoxicity remains a subject of concern, which is a major cause of noncancer mortality among survivors. Among the potential cardiovascular complications, left ventricular (LV) systolic dysfunction is a poor prognostic factor. The importance of its early detection is based on the principle that the likelihood of response to heart failure (HF) treatment is temporally related to the initiation of HF treatment. For these reasons, cardiac monitoring is commonly applied in general practice, based on serial measurements of LV ejection fraction (LVEF); transthoracic echocardiography (TTE) is generally used. However, the LVEF, as a diagnostic and predictive parameter, has significant limitations, which calls for more effective multimodality imaging strategies. This approach requires further study, but there is increasing available data in the literature, encouraging the combination of multimodality imaging parameters and techniques for early cancer therapeutic-related cardiac dysfunction (CTRCD) detection. [less ▲]

Detailed reference viewed: 100 (2 ULiège)
Full Text
Peer Reviewed
See detailEchocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study
Sugimoto, T; DULGHERU, Raluca Elena ULiege; BERNARD, Anne-Catherine ULiege et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A ... [more ▼]

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean were −16.7% in men and −17.8% in women for longitudinal strain, −22.3% and −23.6% for circumferential strain, 20.6% and 21.5% for radial strain, and 2.2 degrees and 1.9 degrees for twist, respectively. In multivariable analysis, longitudinal strain decreased with age whereas the opposite occurred with circumferential and radial strain. Male gender was associated with lower strain for longitudinal, circumferential, and radial strain. Inter-vendor differences were observed for circumferential and radial strain despite the use of vendor-independent software. Importantly, no intervendor differences were noted in longitudinal strain. Conclusion The NORRE study provides contemporary, applicable 2D echocardiographic reference ranges for LV longitudinal, radial, and circumferential strain. Our data highlight the importance of age- and gender-specific reference values for LV strain. [less ▲]

Detailed reference viewed: 40 (4 ULiège)
Peer Reviewed
See detailCardiac Monitoring During Clinical Trials
MOONEN, Marie ULiege; Frere, Pol ULiege; Lancellotti, Patrizio ULiege et al

in Anticancer Treatments and Cardiotoxicity 1st Edition Mechanisms, Diagnostic and Therapeutic Interventions (2016)

The prognosis of breast cancer has greatly improved over time, particularly through the development of targeted therapy. Close cardiac monitoring during clinical trials investigating anticancer ... [more ▼]

The prognosis of breast cancer has greatly improved over time, particularly through the development of targeted therapy. Close cardiac monitoring during clinical trials investigating anticancer therapeutics is a field in cardiology that emerged 15 years ago. Indeed, anticancer agent-related cardiac dysfunction has been a nonanticipated adverse event in a phase 3 trial testing trastuzumab for metastatic breast cancer that overexpresses HER2. We propose hereby a description of the different strategies worked out to prevent cardiac dysfunction attributable to trastuzumab when it was evaluated in the adjuvant setting. This approach is still the fact of the studies designed since that and now, as a panel of cardiac toxicity has been associated with the development of these targeted therapies. © 2017 Elsevier Inc. All rights reserved. [less ▲]

Detailed reference viewed: 24 (1 ULiège)
Full Text
Peer Reviewed
See detailLa cardiotoxicité des traitements anti-cancéreux
FRERES, Pierre ULiege; PONCIN, Aurélie ULiege; MOONEN, Marie ULiege et al

in Revue Médicale de Liège (2016), 71(9), 382-387

Les cancers sont de plus en plus fréquents et leurs traitements de plus en plus agressifs. En conséquence, les médecins se trouvent régulièrement confrontés aux effets secondaires des traitements ... [more ▼]

Les cancers sont de plus en plus fréquents et leurs traitements de plus en plus agressifs. En conséquence, les médecins se trouvent régulièrement confrontés aux effets secondaires des traitements cytotoxiques. La cardiotoxicité induite par les traitements anti-cancéreux est une complication gravissime, car elle peut être mortelle et provoque un arrêt temporaire, voire définitif, des traitements. Dans cet article, nous décrivons les mécanismes, le dépistage et la prise en charge multidisciplinaire de la cardiotoxicité des agents anti-cancéreux. [less ▲]

Detailed reference viewed: 121 (22 ULiège)
Full Text
Peer Reviewed
See detailRoLE OF EXERCISE STRESS TESTING
LANCELLOTTI, Patrizio ULiege; MOONEN, Marie ULiege; magne, Julien

in ASE's comprehensive echocardiography, second edition (2016)

Detailed reference viewed: 34 (7 ULiège)
Full Text
Peer Reviewed
See detailNew biomarkers for primary mitral regurgitation.
Deroyer, Céline ULiege; Magne, Julien; Moonen, Marie ULiege et al

in Clinical Proteomics (2015), 12

BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered ... [more ▼]

BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological deregulation. The purpose of this study was to highlight new biomarkers of mitral regurgitation in order to decipher the underlying pathological mechanism as well as to allow the diagnosis and the monitoring of the disease. RESULTS: Modulation of various blood proteins expression was examined in patients suffering from different grades of mitral regurgitation (mild, moderate and severe) compared to healthy controls. To this end, several routine clinical assays and the multi analyte profile technology targeting 184 proteins were used. High-density lipoprotein, apolipoprotein-A1, haptoglobin and haptoglobin-alpha2 chain levels significantly decreased proportionally to the degree of mitral regurgitation when compared to controls. High-density lipoprotein and apolipoprotein-A1 levels were associated with effective regurgitant orifice area and regurgitant volume. Apolipoprotein-A1 was an independent predictor of severe mitral regurgitation. Moreover, with ordinal logistic regression, apolipoprotein-A1 remained the only independent factor associated with mitral regurgitation. In addition, myxomatous mitral valves were studied by immunocytochemistry. We observed an increase of LC3, the marker of autophagy, in myxomatous mitral valves compared with healthy mitral valves. CONCLUSION: These potential biomarkers of mitral regurgitation highlighted different cellular processes that could be modified in myxomatous degenerescence: reverse cholesterol transport, antioxidant properties and autophagy. [less ▲]

Detailed reference viewed: 63 (25 ULiège)
Full Text
Peer Reviewed
See detailHypertrophic cardiomyopathy: obstruction flushed out with exercise echocardiography.
MARCHETTA, Stella ULiege; MOONEN, Marie ULiege; DULGHERU, Raluca Elena ULiege et al

in Acta Cardiologica (2015), 70(2), 244-5

Detailed reference viewed: 110 (7 ULiège)
Full Text
Peer Reviewed
See detailRepeatability, variability and reference values of pulsed wave Doppler echocardiographic measurements in healthy Saanen goats.
Leroux, Aurélia ULiege; Farnir, Frédéric ULiege; Moonen, Marie ULiege et al

in BMC Veterinary Research (2012), 8

Background Pulsed wave (PW) Doppler echocardiography has become a routine non invasive cardiac diagnostic tool in most species. However, evaluation of intracardiac blood flow requires reference values ... [more ▼]

Background Pulsed wave (PW) Doppler echocardiography has become a routine non invasive cardiac diagnostic tool in most species. However, evaluation of intracardiac blood flow requires reference values, which are poorly documented in goats. The aim of this study was to test the repeatability, the variability, and to establish the reference values of PW measurements in healthy adult Saanen goats. Using a standardised PW Doppler echocardiographic protocol, 10 healthy adult unsedated female Saanen goats were investigated three times at one day intervals by the same observer. Mitral, tricuspid, aortic and pulmonary flows were measured from a right parasternal view, and mitral and aortic flows were also measured from a left parasternal view. The difference between left and right side measurements and the intra-observer inter-day repeatability were tested and then the reference values of PW Doppler echocardiographic parameters in healthy adult female Saanen goats were established. Results As documented in other species, all caprine PW Doppler parameters demonstrated a poor inter-day repeatability and a moderate variability. Tricuspid and pulmonary flows were best evaluated on the right side whereas mitral and aortic flows were best obtained on the left side, and reference values are reported for healthy adult Saanen goats. Conclusions PW Doppler echocardiography allows the measurement of intracardiac blood flow indices in goats. The reference values establishment will help interpreting these indices of cardiac function in clinical cardiac cases and developing animal models for human cardiology research. [less ▲]

Detailed reference viewed: 84 (32 ULiège)
Full Text
Peer Reviewed
See detailAnimal Models of Mitral Regurgitation Induced by Mitral Valve Chordae Tendineae Rupture.
Leroux, Aurélia ULiege; Moonen, Marie ULiege; Pierard, Luc ULiege et al

in Journal of Heart Valve Disease (2012), 21

Background – Mitral regurgitation (MR) is a common valvular disease throughout the world. Various diagnostic techniques have been developed to assess the causes and severity of MR, and the therapeutic ... [more ▼]

Background – Mitral regurgitation (MR) is a common valvular disease throughout the world. Various diagnostic techniques have been developed to assess the causes and severity of MR, and the therapeutic approaches to this disease have been widely documented. However, treatments for chronic MR remain controversial, and various animal models of chronic MR (including chordae tendineae rupture, rapid pacing and ischemia) have been developed to study the pathophysiology and therapeutic approaches to this disease. The objective of this paper is to review the animal MR models that have been developed using a mitral valve chordae tendineae rupture technique. Animal models – Dogs and sheep have been the animals most commonly used in MR models induced by mitral valve chordae tendineae rupture, mainly due to considerations of cardiac size. Chordae tendineae cutting is performed using closed or open chest techniques. In the closed chest model, long flexible grasping forceps are positioned percutaneously in order to tear the mitral valve chordae. In the open chest model, cardiopulmonary bypass is performed and either selected chordae are cut under direct visualization, or a non specified number of chordae are cut using a metal device inserted through the left ventricular apex. Whatever the model used, MR has been found to become chronic 3 to 6 months after the induction of MR by chordae rupture. The reported mortality and complication rates of these models are high. Conclusion – In the long term, experimental evolution of chronic MR is similar to the evolution occurring naturally in patients suffering from chronic MR. These models could thus be useful in understanding the disease better and in testing new therapeutic modalities. This review summarizes the physiological effects of each of these techniques and compares the advantages and disadvantages of each procedure. [less ▲]

Detailed reference viewed: 97 (17 ULiège)
Full Text
Peer Reviewed
See detailTwo-dimensional and M-mode echocardiographic reference values in healthy adult Saanen goats
Leroux, Aurélia ULiege; Moonen, Marie ULiege; Farnir, Frédéric ULiege et al

in Veterinary Record: Journal of the British Veterinary Association (2012), 170(6), 154

Echocardiography has become a routine non invasive cardiac diagnostic tool in most species. Accurate measurement of cardiac dimensions requires reference values, which are poorly documented in goats. The ... [more ▼]

Echocardiography has become a routine non invasive cardiac diagnostic tool in most species. Accurate measurement of cardiac dimensions requires reference values, which are poorly documented in goats. The aim of this study was to test the inter-day repeatability and to establish the reference values of two-dimensional (2D-) and time-motion (M-) mode echocardiographic variables in healthy adult Saanen goats. Six goats were investigated three times by the same observer at one day interval using a standardized 2D- and M-mode echocardiographic protocol. The intra-observer inter-day repeatability was tested using analysis of variance, calculation of the coefficient of variation and confidence intervals. A single echocardiographic examination was performed in 6 other goats, and values obtained in the 12 goats were used to establish the 2D- and M-mode echocardiographic reference values in healthy adult female Saanen goats. Statistical analysis revealed a good inter-day repeatability of the echocardiographic cardiac measurements. Echocardiographic reference values obtained in healthy adult Saanen goats seemed slightly higher than those reported in healthy Swedish domestic goats and were similar to those reported in healthy adult sheep. [less ▲]

Detailed reference viewed: 106 (36 ULiège)
Full Text
Peer Reviewed
See detailRecommandations Europeennes 2011 pour la prise en charge du syndrome coronarien aigu sans elevation du segment ST (Partie 2). Revascularisation coronaire: indications.
Lempereur, Mathieu ULiege; Moonen, Marie ULiege; GACH, Olivier ULiege et al

in Revue Médicale de Liège (2012), 67(1), 8-10

New European guidelines about the management of non-ST elevated acute coronary syndromes emphasize the importance of early risk stratification. This article summarizes the modifications in the guidelines ... [more ▼]

New European guidelines about the management of non-ST elevated acute coronary syndromes emphasize the importance of early risk stratification. This article summarizes the modifications in the guidelines about risk stratification and invasive management of these syndromes. [less ▲]

Detailed reference viewed: 63 (14 ULiège)
Full Text
Peer Reviewed
See detailRecommandations Europeennes 2011 pour la prise en charge des maladies cardiovasculaires pendant la grossesse. Partie 1: valvulopathies et anticoagulation.
Legrand, D.; Moonen, Marie ULiege; LANCELLOTTI, Patrizio ULiege

in Revue Médicale de Liège (2012), 67(9), 452-7

In this article, we describe the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of valvular heart disease and ... [more ▼]

In this article, we describe the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of valvular heart disease and anticoagulation.We will also describe cardiologic conditions in which pregnancy is contraindicated and the preferred way of delivery. [less ▲]

Detailed reference viewed: 20 (1 ULiège)
Full Text
Peer Reviewed
See detailRecommandations Europeennes 2011 pour la prise en charge des maladies cardiovasculaires pendant la grossesse. Partie 2: Prise en charge de l'hypertension arterielle.
Moonen, Marie ULiege; Legrand, D.; LANCELLOTTI, Patrizio ULiege

in Revue Médicale de Liège (2012), 67(10), 509-12

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders ... [more ▼]

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders are the most frequent cardiovascular complications in pregnancy. [less ▲]

Detailed reference viewed: 22 (4 ULiège)
Full Text
Peer Reviewed
See detailStructural model of the mitral valve included in a cardiovascular closed loop model
Paeme, Sabine ULiege; Moorhead, Kate; Chase, J. Geoffrey et al

Poster (2011, December)

A minimal cardiovascular system (CVS) model including mitral valve dynamics has been previously validated in silico. However parameters of this model are difficult to link with structural and anatomical ... [more ▼]

A minimal cardiovascular system (CVS) model including mitral valve dynamics has been previously validated in silico. However parameters of this model are difficult to link with structural and anatomical components of the valve. This research describes the integration of a structural model of the mitral valve in an existing closed-loop cardiovascular system (CVS) model [less ▲]

Detailed reference viewed: 20 (0 ULiège)
Full Text
Peer Reviewed
See detailMathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency
Paeme, Sabine ULiege; Moorhead, Katherine; Chase, J. Geoffrey et al

in BioMedical Engineering OnLine (2011), 10(1), 86

Valve dysfunction is a common cardiovascular pathology. Despite significant clinical research, there is little formal study of how valve dysfunction affects overall circulatory dynamics. Validated models ... [more ▼]

Valve dysfunction is a common cardiovascular pathology. Despite significant clinical research, there is little formal study of how valve dysfunction affects overall circulatory dynamics. Validated models would offer the ability to better understand these dynamics and thus optimize diagnosis, as well as surgical and other interventions. A cardiovascular and circulatory system (CVS) model has already been validated in silico, and in several animal model studies. It accounts for valve dynamics using Heaviside functions to simulate a physiologically accurate “open on pressure, close on flow” law. However, it does not consider real-time valve opening dynamics and therefore does not fully capture valve dysfunction, particularly where the dysfunction involves partial closure. This research describes an updated version of this previous closed-loop CVS model that includes the progressive opening of the mitral valve, and is defined over the full cardiac cycle. Simulations of the cardiovascular system with healthy mitral valve are performed, and, the global hemodynamic behaviour is studied compared with previously validated results. The error between resulting pressure-volume (PV) loops of already validated CVS model and the new CVS model that includes the progressive opening of the mitral valve is assessed and remains within typical measurement error and variability. Simulations of ischemic mitral insufficiency are also performed. Pressure-Volume loops, transmitral flow evolution and mitral valve aperture area evolution follow reported measurements in shape, amplitude and trends. The resulting cardiovascular system model including mitral valve dynamics provides a foundation for clinical validation and the study of valvular dysfunction in vivo. The overall models and results could readily be generalised to other cardiac valves. [less ▲]

Detailed reference viewed: 86 (35 ULiège)