References of "Merveille, Anne-Christine"
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See detailChapter 41: POCUS: Cardiovascular
Gommeren, Kris ULiege; Darnis, Elodie ULiege; Merveille, Anne-Christine ULiege

in Lisciandro, Greg (Ed.) Point-of-Care Veterinary Ultrasound Techniques for the Small Animal Practitioner (in press)

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See detailInter-breed variation in biomarkers of lipid and glucose metabolism
Gomez Fernandez Blanco, Carlos ULiege; Peeters, Dominique ULiege; Moyse, Evelyne ULiege et al

in Veterinary Clinical Pathology (in press)

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See detailInterbreed variation in serum serotonin (5-hydroxytryptamine) concentration in healthy dogs.
Höglund, Katja; Häggström, Jens; Hanas, S et al

in Journal of Veterinary Cardiology (2018)

INTRODUCTION: Serotonin (5-hydroxytryptamine [5-HT]) has several biological functions. In different species, excessive 5-HT has been linked to valvular lesions, similar to those seen in dogs with ... [more ▼]

INTRODUCTION: Serotonin (5-hydroxytryptamine [5-HT]) has several biological functions. In different species, excessive 5-HT has been linked to valvular lesions, similar to those seen in dogs with myxomatous mitral valve disease. Previous studies suggest higher 5-HT in healthy Cavalier King Charles Spaniels (CKCSs), a breed highly affected by myxomatous mitral valve disease, compared to other breeds. OBJECTIVE: To investigate potential interbreed variation in serum 5-HT in healthy dogs. ANIMALS: 483 healthy dogs of nine breeds aged 1-7 years. METHODS: Dogs were examined at five European centers. Absence of cardiovascular, organ-related, or systemic diseases was ensured by thorough clinical investigations including echocardiography. Serum was frozen and later analyzed by enzyme-linked immunosorbent assay (ELISA). RESULTS: Median 5-HT concentration was 252.5 (interquartile range = 145.5-390.6) ng/mL. Overall breed difference was found (p<0.0001), and 42% of pairwise breed comparisons were significant. Univariate regression analysis showed association between serum 5-HT concentration and breed, center of examination, storage time, and sex, with higher 5-HT in females. In multiple regression analysis, the final model had an adjusted R2 of 0.27 with breed (p<0.0001), center (p<0.0001), and storage time (p=0.014) remaining significant. Within centers, overall breed differences were found at 3/5 centers (p≤0.028), and pairwise comparisons within those centers showed breed differences in 42% of comparisons. Among the included breeds, Newfoundlands, Belgian Shepherds and CKCSs had highest 5-HT concentrations. CONCLUSIONS: Interbreed variation in serum 5-HT concentration was found in healthy dogs aged 1-7 years. These differences should be taken into account when designing clinical studies. [less ▲]

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See detailEstablishment of reference values of the caudal vena cava by fast-ultrasonography through different views in healthy dogs
Darnis, Elodie ULiege; Boysen, Soren; Merveille, Anne-Christine ULiege et al

in Journal of Veterinary Internal Medicine (2018), 32

BACKGROUND: Clinical assessment of intravascular volume status is challenging. In humans, ultrasonographic assessment of the inferior vena cava diameter, directly or as a ratio to the aortic diameter is ... [more ▼]

BACKGROUND: Clinical assessment of intravascular volume status is challenging. In humans, ultrasonographic assessment of the inferior vena cava diameter, directly or as a ratio to the aortic diameter is used to estimate intravascular volume status. OBJECTIVES: To ultrasonographically obtain reference values (RV) for caudal vena cava diameter (CVCD ), area (CVCa ) and aortic ratios using 3 views in awake healthy dogs. ANIMALS: One hundred and twenty-six healthy adult dogs from clients, students, faculty, or staff. METHODS: Prospective, multicenter, observational study. Two observer pairs evaluated CVCD by a longitudinal subxiphoid view (SV), a transverse 11th-13th right hepatic intercostal view (HV), and a longitudinal right paralumbar view (PV). Inter-rater agreements were estimated using concordance correlation coefficients (CCC). For body weight (BW)-dependent variables, RVs were calculated using allometric scaling for variables with a CCC ≥ 0.7. RESULTS: The CCC was ≤0.43 for the CVC/aorta ratio at the PV and ≤0.43 in both inspiration and expiration for CVC at the SV. The RVs using allometric scaling for CVCa at the HV for inspiration, expiration, and for CVCD at the PV were 6.16 × BW0.762 , 7.24 × BW0.787 , 2.79 × BW0.390 , respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: The CVCD , measured at the HV and PV in healthy awake dogs of various breeds has good inter-rater agreement suggesting these sites are reliable in measuring CVCD . Established RVs for CVCD for these sites need further comparison to results obtained in hypovolemic and hypervolemic dogs to determine their usefulness to evaluate volume status in dogs. [less ▲]

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See detailBeta-hydroxybutyrate and adiponectin in overweight healthy dogs
Gomez Fernandez Blanco, Carlos ULiege; Moyse, Evelyne ULiege; Höglund, Katja et al

Poster (2018)

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See detailCor triatriatum dexter: diagnostic chez 2 chiens
Porato, Mathilde ULiege; Merveille, Anne-Christine ULiege; Bolen, Géraldine ULiege et al

in Point Vétérinaire: Expert Canin (2017), 48(381), 56-60

Cet article rapporte deux cas de cor triatriatum dexter (CTD) chez des chiens adultes, avec des présentations cliniques différentes. Le premier cas concerne un cairn terrier femelle de 2 ans et demi ... [more ▼]

Cet article rapporte deux cas de cor triatriatum dexter (CTD) chez des chiens adultes, avec des présentations cliniques différentes. Le premier cas concerne un cairn terrier femelle de 2 ans et demi, présenté pour une distension abdominale survenue brutalement. Le second cas se rapporte à un spitz moyen mâle de 2 ans, présenté pour l’investigation d’un souffle cardiaque. L’échocardiographie révèle la présence d’une membrane perforée divisant l’atrium droit en deux chambres. Dans le second cas, le CTD est associé à une sténose pulmonaire sévère expliquant le souffle. Cette découverte est atypique dans les deux cas, étant donné l’âge adulte des chiens et l’absence de symptôme pour le second cas. [less ▲]

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See detailCAUDAL VENA CAVA ASSESSMENT IN DOGS WITH RIGHT-SIDED CONGESTIVE HEART FAILURE: A PILOT STUDY
Merveille, Anne-Christine ULiege; Darnis, Elodie ULiege; Boysen, Soren et al

in Journal of Veterinary Internal Medicine (2017)

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See detailDiagnostic Value of PV/PA ratio in dogs with PH of pre-capillary origin
Roels, Elodie ULiege; Merveille, Anne-Christine ULiege; Malaize, Pierre-Louis et al

in Journal of Veterinary Internal Medicine (2016, September)

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See detailCongenital venous aneurysm of the right external jugular vein in a great dane
Lefebvre, Michaël ULiege; Merveille, Anne-Christine ULiege; Rizza, Maïlis ULiege et al

in Veterinary Record Case Reports (2016)

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See detailEffect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs
Höglund, Katja; Lequarré, Anne-Sophie ULiege; Ljungvall, Ingrid et al

in Journal of Veterinary Internal Medicine (2016), 30

BACKGROUND: There are breed differences in several blood variables in healthy dogs. OBJECTIVE: Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum ... [more ▼]

BACKGROUND: There are breed differences in several blood variables in healthy dogs. OBJECTIVE: Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration. ANIMALS: Five-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center). METHODS: Prospective observational study. Circulating concentrations of ET-1 and cortisol, and renin activity, were measured using commercially available assays. Absence of organ-related or systemic disease was ensured by thorough clinical investigations, including blood pressure measurement, echocardiography, ECG, blood and urine analysis. RESULTS: Median ET-1 concentration was 1.29 (interquartile range [IQR], 0.97-1.82) pg/mL, median cortisol concentration 46.0 (IQR, 29.0-80.8) nmol/L, and median renin activity 0.73 (IQR, 0.48-1.10) ng/mL/h in all dogs. Overall, breed differences were found in ET-1 and cortisol concentrations, and renin activity (P < .0001 for all). Pair-wise comparisons between breeds differed in 67% of comparisons for ET-1, 22% for cortisol, and 19% for renin activity, respectively. Within centers, breed differences were found at 5/5 centers for ET-1, 4/5 centers for cortisol, and 2/5 centers for renin activity. Newfoundlands had highest median ET-1 concentration, 3 times higher than Cavalier King Charles Spaniels, Doberman Pinschers, and Dachshunds. Median renin activity was highest in Dachshunds, twice the median value in Newfoundlands and Boxers. Median cortisol concentration was highest in Finnish Lapphunds, almost 3 times higher than in Boxers. CONCLUSIONS AND CLINICAL IMPORTANCE: Breed variation might be important to take into consideration when interpreting test results in clinical studies. [less ▲]

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See detailUn cas de thrombo-embolie pulmonaire chez un chat de 10 ans
Malaize, Pierre-Louis; Merveille, Anne-Christine ULiege; Girod, Maud et al

in Monde Vétérinaire (2016)

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See detailInter-Breed Variation in Circulating Concentrations of Serotonin (5HT) in Healthy Dogs
Höglund, Katja; Häggström, Jens; Hanas, S et al

in Journal of Veterinary Internal Medicine (2016)

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See detailBiochemical parameters related to the metabolic syndrome in healthy dogs and their relationships with body condition score
Gomez Fernandez Blanco, Carlos ULiege; Farnir, Frédéric ULiege; Höglund, Katja et al

in Journal of Veterinary Internal Medicine (2016)

The concept of "metabolic syndrome" (MS) gathers all pathophysiological changes that derive from excess body fat in humans. Obese dogs share some components of the MS, such as hypercholesterolemia ... [more ▼]

The concept of "metabolic syndrome" (MS) gathers all pathophysiological changes that derive from excess body fat in humans. Obese dogs share some components of the MS, such as hypercholesterolemia, hypertriglyceridemia and insulin resistance. However, unlike people, dogs seem to be resistant to obesity-related diseases like atherosclerosis or type-II diabetes mellitus. Elucidating the effects of body composition on lipid metabolism and glucose homeostasis in dogs may allow better understanding of the MS. The aim of this study was to investigate, in healthy dogs, potential associations between body conditions score (BCS) and biochemical parameters involved in the MS. Data from 534 dogs were retrieved as part of the European LUPA project, and included 419 males (15 Boxer, 125 Belgian Shepherd Dog, 35 Cavalier King Charles Spaniel, 40 Dachshund, 39 Doberman, 45 Finnish Lapphund, 66 German Shepherd Dog, and 52 Labrador Retriever) and 115 females (73 Labrador Retriever and 44 Newfoundland). Ages ranged from 2 to 6 years old. Dogs were weighed, a BCS was assigned (using a 1 to 9 scale), and those over 7 or under 2 were excluded. Dogs were considered as healthy based on history, physical examination, CBC, biochemistry, and complete cardiovascular work-up. Circulating concentrations of cholesterol, free fatty acids (FFA), triglycerides, C-reactive protein (CRP), insulin, glucose, fructosamine, cortisol and aldosterone were measured. Spearman's correlations with a Bonferroni-corrected p-value (0,0007) were computed between all variables, both in the overall group and within breeds. A Mann-Whitney test was used to compare dogs categorised into "lean" (BCS < or = 5) and "overweight" (BCS > 5), and ANCOVA was used to test the effect of breed along with the BCS. Taking all dogs into account, BCS was positively correlated with cholesterol, triglycerides and fructosamine, cholesterol with triglycerides and fructosamine, FFA with triglycerides, insulin with CRP and glucose, and fructosamine with cortisol and glucose. Aldosterone was correlated negatively with age and positively with triglycerides and cortisol. Some of these correlations were also observed when testing within breeds. The "overweight" group had significantly higher cholesterol, FFA, triglycerides, fructosamine and aldosterone, and were significantly older than the "lean" group. An effect of BCS persisted on cholesterol, insulin and age despite correction for the different breeds. Metabolic changes occur in association with overweight body condition in otherwise healthy dogs, although breed effects also contribute. Further characterisation of the interactions between body fat deposition and glucose and lipid metabolism may provide insights into canine obesity-related metabolic disturbances [less ▲]

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