References of "Mathieu, Françoise"
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See detailDietary mineral intakes of young Tibetan children living in areas endemic for Kashin-Beck disease: preliminary results of a cross-sectional survey
DERMIENCE, Michael ULiege; Mathieu, Françoise; Li, Xiaowei et al

Conference (2015, September 18)

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy whose etiology remains unclear. Environmental factors are assumed to be involved, among which the selenium and iodine deficiency is ... [more ▼]

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy whose etiology remains unclear. Environmental factors are assumed to be involved, among which the selenium and iodine deficiency is frequently cited. The prevalence rate may be high in some rural areas of the Tibet Autonomous Region. The diet of the rural community is significantly different from the other communities (nomads and city-dwellers), who remains unaffected by KBD. Because their foods are mainly derived from local agriculture and artisanal production, their mineral composition may show significant discrepancies when compared with food composition data. The present survey aims at assessing the mineral dietary intakes of young Tibetan children living in rural areas endemic for the Kashin-Beck disease. A cross-sectional survey enrolling 250 children was carried out. The intakes were recorded for two days, on two different seasons, by the 24-hour food recall method. The minerals investigated were selected for their implication in bone metabolism and a specific food composition table was compiled from the China Food composition (book 1, 2nd edition), the USDA Food search for Windows (Version 1.0, Database version SR23), and a broad investigation on mineral composition of local and traditional Tibetan foods (Dermience et al., 2014). The calculation of daily intakes for the first season is now complete and some trends are emerging. Preliminary results suggest, inter alia, that the intakes of calcium are too low with unfavorable calcium to phosphorus ratio. On the contrary, sodium and manganese intakes are too high and could exceed tolerable upper levels. [less ▲]

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See detailEffects of thirty elements on bone metabolism
DERMIENCE, Michael ULiege; Lognay, Georges ULiege; Mathieu, Françoise et al

in Journal of Trace Elements in Medicine and Biology (2015), (32), 86-106

The human skeleton, made of 206 bones, plays vital roles including supporting the body, protecting organs, enabling movement, and storing minerals. Bones are made of organic structures, intimately ... [more ▼]

The human skeleton, made of 206 bones, plays vital roles including supporting the body, protecting organs, enabling movement, and storing minerals. Bones are made of organic structures, intimately connected with an inorganic matrix produced by bone cells. Many elements are ubiquitous in our environment, and many impact bone metabolism. Most elements have antagonistic actions depending on concentration. Indeed, some elements are essential, others are deleterious, and many can be both. Several pathways mediate effects of element deficiencies or excesses on bone metabolism. This paper aims to identify all elements that impact bone health and explore the mechanisms by which they act. To date, this is the first time that the effects of thirty minerals on bone metabolism have been summarized. [less ▲]

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See detailMinerals and trace elements in traditional foods of rural areas of Lhasa Prefecture, Tibet Autonomous Region (P.R. China)
DERMIENCE, Michael ULiege; Li, Xiao Wei; Mathieu, Françoise et al

in Journal of Food Composition and Analysis (2014), 35(2),

Traditional foods play a major role in the diet of rural people living in the Tibet Autonomous Region of the People's Republic of China. Because these foods are mainly derived from local agriculture as ... [more ▼]

Traditional foods play a major role in the diet of rural people living in the Tibet Autonomous Region of the People's Republic of China. Because these foods are mainly derived from local agriculture as well as artisanal production, their mineral composition may show significant discrepancies when compared with food composition data. This study aims at providing relevant data on the mineral composition of the main Tibetan foods. Sixteen different foodstuffs were sampled, including water, concentrated brewed black tea, chang, tsampa, wheat flour, dried cheese, dried yak meat, dried mutton, blood sausage, dried wild peaches, dried Chinese radish, and dried nettles. They were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) for 19 minerals: Na, K, P, Ca, Mg, Fe, Zn, Mn, Cu, Ni, Se, Mo, Al, As, Cr, Co, Cd, Pb, and V. The validity of the results was ensured by the use of standard reference materials. A statistical comparison of the mean mineral contents of the analyzed foods against food composition data from the China Food Composition (CFC) table was carried out. It revealed significant discrepancies, emphasizing the importance of food analysis for nutritional assessment in Tibet autonomous region. To the best of our knowledge, the mineral compositions of some traditional Tibetan foods are here reported for the first time. [less ▲]

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See detailFood intake of Tibetan children living in Kashin Beck disease endemic areas in Central Tibet
Rooze, Shancy; de Voghel, Pauline; Mathieu, Françoise et al

Conference (2013, October 14)

Introduction: Kashin-Beck disease (KBD) is a bone and joint pathology. KBD begins during childhood, causes deformities, pain, lack of mobility, and short stature. The pathophysiology of the disease is ... [more ▼]

Introduction: Kashin-Beck disease (KBD) is a bone and joint pathology. KBD begins during childhood, causes deformities, pain, lack of mobility, and short stature. The pathophysiology of the disease is unknown. Nutrition possibly plays a role. Children living in KBD endemic areas in Central Tibet present severe growth retardation, signs of chronic malnutrition and a high prevalence of rickets. A food consumption study was conducted. We have focused our attention on total energy intake, calcium, phosphorus and vitamin D. Material and methods: Prospective food intake measurements have been performed. The investigation concerned children from 9 to 16 years old living in KBD endemic areas. All food and drinks have been measured during several days at the 4 seasons of the year. Anthropometric data were obtained. Results: 30,5% of the children presented with stunting (height for age ratio below -2 z score); 13,8% of the cohort suffered from acute malnutrition (body mass index below -2 z score). Mean total energy intake was 87% of the recommended value. Calcium and vitamin D intakes never covered the needs (44 % and 14 %, respectively). Phosphorus intake was high. Mean Ca / P ratio was 0.54. Conclusion: Calcium and vitamin D deficiency may play a role in the etiology of bone and joint diseases in this population. To improve the nutritional status of the children, a large program of calcium and vitamin D supplementation among 0 - 5 years old children living in KDB endemic areas was started. Besides, chemical analyses of locally grown foods are performed, in order to have a more precise evaluation of nutrient intake. In the future, the effect of increased energy intakes will be evaluated. [less ▲]

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See detailThe relevance of food composition data for nutrition surveys in rural Tibet: pilot study in the context of Kashin-Beck Disease
DERMIENCE, Michael ULiege; Mathieu, Françoise; Barthelemy, Jean-Paul ULiege et al

in Biotechnologie, Agronomie, Société et Environnement (2013), 17(1), 32-42

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. The ... [more ▼]

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. The etiology of the disease remains obscure although environmental factors are assumed to be involved. Diet, in particular, differentiates the rural community, affected by KBD, from the other communities (nomads and city-dwellers), who remain unaffected. In anticipation of a nutrition survey, this study aimed to measure the mineral content (Ca, P, Mg, Fe, Zn, Mn, Cu, Ni, Se, Al, Sr, Mo, Cd, As, Pb, Hg, Cr, and Co) of eight Tibetan staple foods and to compare the results against two food composition tables (FCTs). Foods were sampled in twenty households selected from both an endemic and a non-endemic area of rural Tibet. Ten minerals involved in bone metabolism were measured using atomic and molecular spectrometric methods. Results revealed that a very limited number of food/constituent pairs showed a variation in mineral composition during a single year of testing for a given region. In addition, results showed significant differences in mineral content between the endemic and the non-endemic area, especially for wheat flour. Following our analysis of the mineral content of the Tibetan food samples, results were statistically compared with similar foods listed in two food composition tables: the USDA National Nutrient Database (USDA Food Search for Windows, Version 1.0, database version SR23), and the China Food Composition Table (book 1, 2nd edition). More than 50 to 60% of p-values < 0.05 were highlighted, suggesting the inappropriateness of using FCTs as a reference for nutrition surveys in rural Tibet, and emphasizing the need for analysis of traditional foods. Differences were found to be more or less marked depending on the element considered, and calcium content seemed to show the greatest difference. Although it is obviously too early for definite conclusions to be reached (insufficient number of samples by food and insufficient number of foods analyzed), it seems that the present pilot-study indicates significant discrepancies between measured and tabulated values of the mineral content of certain foods. A more complete survey would therefore seem mandatory. [less ▲]

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See detailComparison of mineral intake between children from endemic and non-endemic areas for Kashin-Beck disease in Tibet Autonomous Region: Pilote study
DERMIENCE, Michael ULiege; Maesen, Philippe ULiege; Mathieu, Françoise et al

Poster (2012, June 01)

Background The Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy affecting between 0.74 million and 2.5 million people in the Tibet Autonomous Region and in several provinces of the ... [more ▼]

Background The Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy affecting between 0.74 million and 2.5 million people in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. The etiology remains unclear, although a multifactorial hypothesis has been proposed (selenium/iodine deficiency; high concentration of organic matters in drinking water; and mycotoxin poisoning by fungi infecting cereals). The rural population is almost exclusively affected. Objectives The first objective of this study was to assess and to compare the mineral daily intake between Tibetan preschool children living in endemic areas for the Kashin-Beck disease and those living in non-endemic areas. A second objective was the comparison of children daily intakes with Chinese Dietary Reference Intakes (DRIs). The third objective was to estimate a sample size for a cross-sectional survey aiming to highlight significant differences in mineral intakes between the two groups of preschool children. Materials and Methods Ten Tibetan preschool children were enrolled per group (endemic/non-endemic) for this pilot study. Children had to be weaned and those living in endemic area must have a KBD sibling. The nutrition survey consisted in an interactive simplified 24-hour recall questionnaire. Two 24-hour recalls were recorded for the endemic group, in February 2010 (EAw) and in May 2010 (EAs), while one day has been recorded for the non-endemic group in July 2011 (NEA). At the same time, samples of the main staple foods were collected for chemical analysis. The daily intakes of Ca, P, Mg, Fe, Zn, Cu, and Mn were calculated based on the 24-hour recall records, the chemical analyses, and data from food composition tables (FCTs). Results and discussion We are aware of limitations in the methodological approach of this pilot-study. The number of children, although weak, was empirically decided for the sake of feasibility and because no prior information was available. The interactive 24-hour recalls between the two groups are spaced in time. Nevertheless, the diet of rural Tibetans is far from diversified, and the variability among seasons and years is probably low. Daily intakes in Ca, P, Mg, Fe, Zn, Cu and Mn were calculated for children of each group. Parametric test were applied for comparison of mean daily intakes between groups. A significant difference was highlighted for Cu (p-value<0.01) and Fe (p-value<0.05), no other significant difference was detected. When comparing individual daily intakes and Chinese DRIs, the most striking results concern Ca and Mn. The great majority of children showed severe deficiency in calcium and enormous excess in manganese. A power (1-β) of 80% is commonly accepted when estimating a sample size for a cross-sectional survey. In this case, the maximum sample size is too high and not feasible in practice (several hundred children per group). Oppositely, the power was calculated per mineral, based on 100 children per group. The power is higher than 90% for Mg, Fe, and Cu. For the others minerals, the power is well below 80%. Nevertheless, general deficiencies and excesses have been observed in the two groups for part of these minerals. We believe that it is a statement in itself and trying to highlight small differences between groups in such extremes is not relevant. [less ▲]

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See detailKashin-Beck Disease: evaluation of mineral intake in young Tibetan children from endemic areas
DERMIENCE, Michael ULiege; Maesen, Philippe ULiege; Mathieu, Françoise et al

Poster (2010, October 26)

Kashin-Beck disease is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. Although many ... [more ▼]

Kashin-Beck disease is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. Although many studies have already been conducted and many others are still underway, its ethiology remains unknown. A multifactorial hypothesis has been proposed: selenium deficiency, high concentration of organic matters in drinking water (fulvic acids) and mycotoxin poisoning by fungi infecting cereals. This original study aimed to measure the mineral contents of the food most often consumed in severe endemic regions and then to evaluate the daily intake of minerals in young Tibetan children from endemic areas. The mineral elements were selected in relation to their implications in bone metabolism. A sampling campaign split up into two time periods (winter and spring) was carried out. Ten families from two distinct regions were selected based on three criteria: they live in endemic areas; they include a 3 to 5 year-old child; this child has a KBD brother or sister. At the same time, a nutritional survey was made by the means of a prospective questionnaire in order to list the 24h food intake of the 3 to 5 year-old child. This survey highlighted the extremely monotonous cereal-based Tibetan diet. An analytical method for the minerals was developed as follows: mineralization of samples performed by microwave-assisted wet process; mineralized solutions measured by several atomic absorption or emission spectrometric methods and molecular absorption spectrometric methods. The analytical method was validated by mean of certified reference materials. Mean food contents were calculated and compared to food composition reference tables. High iron contents and selenium deficiencies were highlighted in several foods. Daily intakes were estimated combining mineral measurements and nutritional survey results. These were compared to dietary reference intakes from reference tables. This estimation reveals some crucial points: we confirm a marked deficiency in calcium; Ca/P ratios are always low; iron and copper intakes are excessive; zinc is the most probably deficient; while selenium could be deficient; manganese intakes often exceed toxicity thresholds. Nevertheless, this study encounters some limits. The bioavailability of minerals is a critical point that deserves further investigations. Moreover, a larger study over a longer term covering both endemic and non-endemic regions is required for definite conclusions to be reached. [less ▲]

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See detailKBD is an agro-environmental disease: The south central Tibet input
Haubruge, Eric ULiege; Chasseur, Camille; Lognay, Georges ULiege et al

Conference (2008, August)

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See detailAnalysis of ergosterol and the main Alternaria mycotoxins in cereals from endemic and non endemic KBD areas in TAR
Lognay, Georges ULiege; Denis, Quentin; Chasseur, Camille et al

Conference (2008, August)

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See detailBig bone disease: A multidisciplinary approach of Kashin-Beck disease in Tibet autonomous region (P.R. China)
Malaisse, François ULiege; Mathieu, Françoise

Book published by Presses Agronomiques de Gembloux (2008)

Kashin-Beck disease is probably one of the most neglected diseases. It occurs in only a very limited part of the world, in a crescent shape area situated from South East Siberia to North West China. It ... [more ▼]

Kashin-Beck disease is probably one of the most neglected diseases. It occurs in only a very limited part of the world, in a crescent shape area situated from South East Siberia to North West China. It affects mainly the rural population of these remote regions and more specifically the children. They are suffering from a lot of joint pain and lose their mobility. They stop to grow properly and they became severely handicapped. Since more than 15 years, an international team together with his partner, the Centre for Disease Control and Prevention of Tibet Autonomous Region, are studying this disease with, sometimes, very limited means but always in a marvellous environment. Their daily workmates are the lovely children, the yaks and other animals of the Himalaya region as well as the unique variety of flowers and plants, under the beautiful shadow of some of the highest peaks of the world. Their unique multidisciplinary approach of the complex issue of the Kashin-Beck disease is done with a constant worry of a better knowledge of the environment and its population. Through a lot of beautiful pictures and some more scientific data, the authors, with an immoderate enthusiasm, will drive you along the valleys of the high Tibetan plateau and will accompany you for a visit from one village to another to meet these patients and understand the difficulties of their daily life. [less ▲]

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See detailThe alternative food path or the very little diversified diet hypothesis, chapter 5.3
Malaisse, François ULiege; Lognay, Georges ULiege; Haubruge, Eric ULiege et al

in Big Bone Disease - A multidisciplinary approach of Kashin-Beck disease in Tibet Autonomous Region (P.R. China) (2008)

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See detailProtinet - chapter 5.4
Malaisse, François ULiege; Mathieu, Françoise; Lognay, Georges ULiege et al

in Big Bone Disease - A multidisciplinary approach of Kashin-Beck disease in Tibet Autonomous Region (P.R. China) (2008)

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See detailThe fungal hypotheses (chapter 5.1)
Chasseur, Camille; Lognay, Georges ULiege; Suetens, Carl et al

in Big Bone Disease : A multidisciplinary approach of Kasing-Beck disease in Tibet Autonomous Region (P.R. China) (2008)

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See detailA propos des champignons comestibles du Tibet centro-austral (R.P. China)
Malaisse, François ULiege; De Kesel, A.; Begaux, Françoise et al

in Geo-Eco-Trop (2007), 31

This paper describes the mycological knowledge of the Ü and Tsang populations from South-Central Tibet. The basic ethnomycological data and the local mushroom ethnotaxonomy are presented and treated, as ... [more ▼]

This paper describes the mycological knowledge of the Ü and Tsang populations from South-Central Tibet. The basic ethnomycological data and the local mushroom ethnotaxonomy are presented and treated, as well as some of the possible ways to valorise the wild edible mushrooms used. [less ▲]

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See detailEthno-Ecological approach of Tibet south-central rural environment knowledge as a support to Kashin-Beck disease's etiology
Malaisse, François ULiege; Begaux, Françoise; Chasseur, Camille et al

in Bulletin des Séances de l'Académie Royale des Sciences d'Outre-Mer (2002), 48

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See detailA 4-year study of the mycological aspects of Kashin-Beck disease in Tibet
Chasseur, Camille; Suetens, Carl; Michel, Valérie et al

in International Orthopaedics (2001), 25

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See detailThe prevalence of mycotoxins in Kashin-Beck disease
Haubruge, Eric ULiege; Chasseur, Camille; Debouck, Catherine et al

in International Orthopaedics (2001), 25

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See detailEthno-agricultural approach to the rural environment in the prevention of Kashin-Beck disease
Malaisse, François ULiege; Haubruge, Eric ULiege; Mathieu, Françoise et al

in International Orthopaedics (2001), 25

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See detailLa maladie de Kashin-Beck et le milieu rural au Tibet: un problème agri-environnemental
Haubruge, Eric ULiege; Chasseur, Camille; Mathieu, Françoise et al

in Cahiers Agricultures (2000), 9

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