References of "Marichal, Thomas"
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See detailImmunology of asthma : when myeloid cells appear on stage
Marichal, Thomas ULiege

Scientific conference (2019, December)

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See detailImmunology of asthma : when myeloid cells appear on stage
Marichal, Thomas ULiege

Scientific conference (2019, October 04)

Detailed reference viewed: 14 (2 ULiège)
See detailImmunology of asthma : when myeloid cells appear on stage
Marichal, Thomas ULiege

Scientific conference (2019, June 13)

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See detailOzone-primed neutrophils promote early steps of tumor cell metastasis to lungs by enhancing their NET production
Rocks, Natacha ULiege; Vanwinge, Céline ULiege; Radermecker, Coraline ULiege et al

in Thorax (2019), 0

Air pollution, including particulates and gazes such as ozone (O3), is detrimental for patient’s health and has repeatedly been correlated to increased morbidity and mortality in industrialized countries ... [more ▼]

Air pollution, including particulates and gazes such as ozone (O3), is detrimental for patient’s health and has repeatedly been correlated to increased morbidity and mortality in industrialized countries. Although studies have described a link between ambient particulate matter and increased lung cancer morbidity, no direct relation has yet been established between O3 exposure and metastatic dissemination to lungs. [less ▲]

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See detailLocally instructed neutrophils mediate environment-driven allergic asthma onset
Marichal, Thomas ULiege

Scientific conference (2019, May 20)

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See detailImmunology of asthma : when myeloid cells appear on stage
Marichal, Thomas ULiege

Scientific conference (2019, April 03)

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See detailTwo distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Chakarov, S.; Lim, H. Y.; Tan, L. et al

in Science (2019), 363(6432),

Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively ... [more ▼]

Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined. Here we studied IMs from murine lung, fat, heart, and dermis. We identified two independent IM subpopulations that are conserved across tissues: Lyve1 lo MHCII hi CX3CR1 hi (Lyve1 lo MHCII hi ) and Lyve1 hi MHCII lo CX3CR1 lo (Lyve1 hi MHCII lo ) monocyte-derived IMs, with distinct gene expression profiles, phenotypes, functions, and localizations. Using a new mouse model of inducible macrophage depletion (Slco2b1 flox/DTR ), we found that the absence of Lyve1 hi MHCII lo IMs exacerbated experimental lung fibrosis. Thus, we demonstrate that two independent populations of IMs coexist across tissues and exhibit conserved niche-dependent functional programming. 2017 © The Authors. [less ▲]

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See detailTowards a better understanding of lung interstitial macrophage diversity
Marichal, Thomas ULiege

Conference (2018, October 25)

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See detailNeutrophils in allergic asthma
Marichal, Thomas ULiege

in Proceedings of the ECI (2018, September 03)

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See detailLung Interstitial Macrophages: Past, Present, and Future
Schyns, Joey ULiege; Bureau, Fabrice ULiege; Marichal, Thomas ULiege

in Journal of Immunology Research (2018), 2018

For a long time, investigations about the lung myeloid compartment have been mainly limited to the macrophages located within the airways, that is, the well-known alveolar macrophages specialized in ... [more ▼]

For a long time, investigations about the lung myeloid compartment have been mainly limited to the macrophages located within the airways, that is, the well-known alveolar macrophages specialized in recycling of surfactant molecules and removal of debris. However, a growing number of reports have highlighted the complexity of the lung myeloid compartment, which also encompass different subsets of dendritic cells, tissue monocytes, and nonalveolar macrophages, called interstitial macrophages (IM). Recent evidence supports that, in mice, IM perform important immune functions, including the maintenance of lung homeostasis and prevention of immune-mediated allergic airway inflammation. In this article, we describe lung IM from a historical perspective and we review current knowledge on their characteristics, ontogeny, and functions, mostly in rodents. Finally, we emphasize some important future challenges for the field. [less ▲]

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See detailLung-resident eosinophils contribute to lung immunophysiology
Marichal, Thomas ULiege

Scientific conference (2018)

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See detailThe interstitial macrophage: A long-neglected piece in the puzzle of lung immunity
Liégeois, Maude ULiege; Legrand, Céline ULiege; Desmet, Christophe ULiege et al

in Cellular Immunology (2018), 330

Lung macrophages have mostly been studied considering only their most accessible and well-de fined representative, the alveolar macrophage (AM). In contrast, the identity and putative immune functions of ... [more ▼]

Lung macrophages have mostly been studied considering only their most accessible and well-de fined representative, the alveolar macrophage (AM). In contrast, the identity and putative immune functions of their tissue counterpart, the interstitial macrophage (IM), have long remained much more elusive. Yet, recent evidence supports the notion that IMs perform important immune functions in the lung, notably in terms of innate immunoregulation. Here, we review current knowledge on the phenotype, ontogeny and function of IMs and propose strategies for the unambiguous identification and study of this important and dynamic lung innate immune cell population [less ▲]

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See detailApproaches to target IgE antibodies in allergic diseases.
Balbino, Bianca; Conde, Eva; Marichal, Thomas ULiege et al

in Pharmacology and Therapeutics (2018)

IgE is the antibody isotype found at the lowest concentration in the circulation. However IgE can undeniably play an important role in mediating allergic reactions; best exemplified by the clinical ... [more ▼]

IgE is the antibody isotype found at the lowest concentration in the circulation. However IgE can undeniably play an important role in mediating allergic reactions; best exemplified by the clinical benefits of anti-IgE monoclonal antibody (omalizumab) therapy for some allergic diseases. This review will describe our current understanding of the interactions between IgE and its main receptors FcepsilonRI and CD23 (FcepsilonRII). We will review the known and potential functions of IgE in health and disease: in particular, its detrimental roles in allergic diseases and chronic spontaneous urticaria, and its protective functions in host defense against parasites and venoms. Finally, we will present an overview of the drugs that are in clinical development or have therapeutic potential for IgE-mediated allergic diseases. [less ▲]

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See detailGenetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity.
Gaudenzio, Nicolas; Marichal, Thomas ULiege; Galli, Stephen J. et al

in Frontiers in Immunology (2018), 9

Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS ... [more ▼]

Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS responses to secrete diverse products, including some with pro-inflammatory and anti-inflammatory functions. Conflicting results have been obtained regarding pathogenic versus protective roles of MCs in CHS, and this has been attributed in part to the limitations of certain models for studying MC functions in vivo. This review discusses recent advances in the development and analysis of mouse models to investigate the roles of MCs and MC-associated products in vivo. Notably, fluorescent avidin-based two-photon imaging approaches enable in vivo selective labeling and simultaneous tracking of MC secretory granules (e.g., during MC degranulation) and MC gene activation by real-time longitudinal intravital microscopy in living mice. The combination of such genetic and imaging tools has shed new light on the controversial role played by MCs in mouse models of CHS. On the one hand, they can amplify CHS responses of mild severity while, on the other hand, can limit the inflammation and tissue injury associated with more severe or chronic models, in part by representing an initial source of the anti-inflammatory cytokine IL-10. [less ▲]

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See detailNeutrophil extracellular traps are major determinants of airway allergy
Marichal, Thomas ULiege

Conference (2017, December 15)

Detailed reference viewed: 13 (1 ULiège)
See detailCharacterization and regulation of the intestinal epithelial cell response to colitogenic triggers
El Abbas, Sophie ULiege; Beguin, C; Schyns, Joey ULiege et al

in Proceedings of Annual meeting of the French Society for Immunology (SFI) (2017, November 07)

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See detailRab guanine nucleotide exchange factor 1 (Rabgef1) restricts intestinal inflammation by limiting pro-inflammatory signals in Intestinal Epithelial Cells (IECs)
El Abbas, Sophie ULiege; Beguin, Charline ULiege; Schyns, Joey ULiege et al

in Proceedings: 4th FARAH-DAY (2017, October 13)

Rab guanine nucleotide exchange factor (GEF-)1 (Rabgef1), a multifunctional protein whose in vivo functions remained unknown until recently, is highly expressed in mouse and human epithelial cells. The ... [more ▼]

Rab guanine nucleotide exchange factor (GEF-)1 (Rabgef1), a multifunctional protein whose in vivo functions remained unknown until recently, is highly expressed in mouse and human epithelial cells. The aim of this study is to investigate the role of Rabgef1 in intestinal epithelial cells (IECs) and intestinal homeostasis in mice. We performed conditional deletion of Rabgef1 gene using the cre-lox system to obtain mice lacking Rabgef1 specifically in IECs (Rabgef1IEC-KO), under the wild-type (WT) or the colitis-prone Interleukin-10 (Il-10)-deficient background. In addition, we used the CRISPR-Cas9 technology to obtain a murine IEC line deficient in Rabgef1. Rabgef1IEC-KO mice under the WT background did not develop spontaneous intestinal abnormalities but exhibited an altered intestinal microbial composition associated with minor changes in IEC pro-inflammatory gene expression profile. Moreover, Rabgef1IEC-KO mice exhibited an increased susceptibility to inflammation in a dextran sodium sulfate (DSS)-induced model of colitis under the WT background, as well as in a constitutive model of colitis under the Il-10-¬deficient background. In vitro, we showed that mouse IECs lacking Rabgef1 significantly overexpressed several pro-inflammatory cytokines and chemokines as compared to control cells. Taken together, these results support that Rabgef1 acts as a regulator of intestinal homeostasis and inflammation, and that dysregulated Rabgef1 expression could contribute to intestinal barrier dysfunction in inflammatory conditions of the gut. [less ▲]

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See detailTowards a better understanding of lung interstitial macrophage diversity
Marichal, Thomas ULiege

Conference (2017, October)

Detailed reference viewed: 13 (1 ULiège)