References of "Makrygiannis, Georgios"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailRisk Factor Assessment in a Greek Cohort of Patients With Large Abdominal Aortic Aneurysms
MAKRYGIANNIS, Georgios ULiege; Mourmoura, Evanthia; SPANOS et al

in Angiology (2019)

Detailed reference viewed: 17 (1 ULiège)
Full Text
Peer Reviewed
See detailExtending abdominal aortic aneurysm detection to older age groups: preliminary results from the Liege screening programme.
MAKRYGIANNIS, Georgios ULiege; Labalue, Philippe; Erpicum, Marie ULiege et al

in Annals of Vascular Surgery (2016)

BACKGROUND: There is evident benefit in terms of reduced aneurysm related mortality from screening programmes of abdominal aortic aneurysm (AAA) in men aged 65 and more. Recent studies in UK and Sweden ... [more ▼]

BACKGROUND: There is evident benefit in terms of reduced aneurysm related mortality from screening programmes of abdominal aortic aneurysm (AAA) in men aged 65 and more. Recent studies in UK and Sweden have shown a decline of the prevalence of AAA in the general population. Current screening policies (e.g. men aged 65-74 years) however do not account for ageing and increased life expectancy of western populations. This study investigated AAA detection by extending the target population to older age groups (75-85 years). METHODS: AAA screening was conducted in the County of Chaudfontaine (Liege, Belgium) on the population of elderly (N=3,054). The participation rate was 36%. The 1,101 participants (722 men aged 65-85 and 379 women aged 74-85 years) were examined by ultrasound (US) scan. AAA was defined as an infrarenal aortic outer-outer diameter of at least 3 cm. Demographics, clinical parameters and risk factors were also recorded. AAA prevalence was estimated and patients with and without AAA were compared by logistic regression. RESULTS: The overall AAA prevalence was 3.6% (n=40). In female participants, AAA prevalence was low (1.3%). In men, it amounted 2.7% in the 65-74 age group but rose to 7.3% in the age-extended group (75-85 years). Further in addition to age, height, current smoking, history of coronary artery disease, hypercholesterolemia, peripheral artery disease of the lower limbs and varicose veins were significantly associated with the presence of AAA. CONCLUSION: These preliminary findings, based on a representative sample of the elderly population of the Liege region, support the idea that current AAA screening policies should be updated to cover an increasingly ageing population. The presence of varicose veins as a potential risk factor for AAA should also be considered during screening. [less ▲]

Detailed reference viewed: 47 (9 ULiège)
Full Text
Peer Reviewed
See detailCervical artery dissections and type A aortic dissection in a family with a novel missense COL3A1 mutation of vascular type Ehlers-Danlos syndrome.
Makrygiannis, Georgios ULiege; Loeys, Bart; Defraigne, Jean-Olivier ULiege et al

in European Journal of Medical Genetics (2015)

Cervical artery dissection (CeAD) is a rare condition. One of the causes is the vascular type of Ehlers-Danlos syndrome (vEDS). A novel missense mutation in COL3A1 was found in a young patient with CeAD ... [more ▼]

Cervical artery dissection (CeAD) is a rare condition. One of the causes is the vascular type of Ehlers-Danlos syndrome (vEDS). A novel missense mutation in COL3A1 was found in a young patient with CeAD as the single manifestation of vEDS. This is a heterozygous c.953G>A mutation in exon 14, disrupting the normal Gly-X-Y repeats of type III procollagen, by converting glycine to aspartic acid. [less ▲]

Detailed reference viewed: 104 (6 ULiège)
Full Text
Peer Reviewed
See detailSex Differences in Abdominal Aortic Aneurysm: the Role of Sex Hormones.
Makrygiannis, Georgios ULiege; Courtois, Audrey ULiege; Drion, Pierre ULiege et al

in Annals of Vascular Surgery (2014), 28(8), 1946-1958

Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in males, whereas women have a greater risk of rupture and more frequently ... [more ▼]

Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in males, whereas women have a greater risk of rupture and more frequently have concomitant thoracic aortic aneurysms. Moreover, women are diagnosed with AAA about 10 years later and seem to be protected by female sex hormones. In this MEDLINE-based review of literature we examined human and animal, in vivo and in vitro studies, to further deepen our understanding of the sexual dimorphism of AAA. We focus on the role of sex hormones during the formation and growth of AAA. Endogenous estrogens and exogenous 17beta-estradiol were found to exert favorable actions protecting from AAA in animal models, whereas exogenous hormone replacement therapy in humans had inconclusive results. Androgens, known to have detrimental effects in the vasculature, in sufficient levels maintain the integrity of the aortic wall through their anabolic actions and act differentially in males and females, whereas lower levels of testosterone have been associated with AAA in humans. In conclusion, sex differences remain an important area of AAA research, but further studies especially in humans are needed. Furthermore, differential molecular mechanisms of sex hormones constitute a potential therapeutic target for AAA. [less ▲]

Detailed reference viewed: 188 (45 ULiège)
Full Text
Peer Reviewed
See detailPreliminary data from the Liège Screening programme suggests the reported decline in AAA prevalence is not global
Makrygiannis, Georgios ULiege; EL HACHEMI, Mounia ULiege; Labalue, Philippe et al

in Aorta (2014, October 01), 2(5), 212253

Background: Population based studies have shown evident benefit in terms of mortality from screening for Abdominal Aortic Aneurysm (AAA) among men aged over 65. However, recent studies from USA, UK and ... [more ▼]

Background: Population based studies have shown evident benefit in terms of mortality from screening for Abdominal Aortic Aneurysm (AAA) among men aged over 65. However, recent studies from USA, UK and Sweden suggest a decrease in the prevalence of AAA in the general population. Whether these findings are generalizable for the rest of Europe is unknown. Thus we decided to set up a screening program in order to detect AAA in Liege, Belgium. Material and Methods: During our ongoing study, over a first 3-month period, abdominal aortic ultrasound was performed on 541 participants, (198 women 343 men) to measure the maximal suprarenal and infrarenal aortic outer-outer diameter as well as the maximal diameter of the common iliac arteries. Moreover, we have measured arm and ankle blood pressure in each subject and the clinical characteristics of the patients, were collected. Results: The overall AAA prevalence was 4.62% (n = 25). In female participants aged ≥ 74 years the AAA prevalence amounted 1.01 %. While in male patients aged ≥ 65 years, it rose to 6.71%. Statistical analysis showed that male gender, aging, history of ischemic heart diseases, hyperlipidemia and varicose veins were significantly associated with AAA. Conclusion: Despite a reported declining prevalence of AAA in some recent population-based studies, we found that the prevalence of AAA in Liège population remains high in men aged 65 years or more. The prevalence of AAA seems to vary in different geographical regions. However, we need a larger sample to confirm our preliminary findings. [less ▲]

Detailed reference viewed: 44 (20 ULiège)
Full Text
Peer Reviewed
See detailPlasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change.
Jakobsen, Marianne U.; Dethlefsen, Claus; Due, Karen M. et al

in Obesity Facts (2011), 4(4), 312-8

OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change ... [more ▼]

OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population. [less ▲]

Detailed reference viewed: 30 (8 ULiège)
Full Text
Peer Reviewed
See detailSerum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies.
Rinaldi, Sabina; Cleveland, Rebecca; Norat, Teresa et al

in International Journal of Cancer (2010), 126(7), 1702-15

Several prospective studies have shown a moderate positive association between increasing circulating insulin-like growth factor-I (IGF-I) levels and colorectal cancer risk. However, the associations were ... [more ▼]

Several prospective studies have shown a moderate positive association between increasing circulating insulin-like growth factor-I (IGF-I) levels and colorectal cancer risk. However, the associations were often statistically nonsignificant, and the relationship of cancer risk with IGF-I's major binding protein, IGFBP-3, showed major discrepancies between studies. We investigated the association of colorectal cancer risk with serum IGF-I, total and intact IGFBP-3, in a case-control study nested within the EPIC cohort (1,121 cases of colorectal cancer and 1,121 matched controls). Conditional logistic regression was used to adjust for possible confounders. Our present study results were combined in a meta-analysis with those from 9 previous prospective studies to examine the overall evidence for a relationship of prediagnostic serum IGF-I with colorectal cancer risk. In the EPIC study, serum concentrations of IGF-I and IGFBP-3 showed no associations with risk of colorectal cancer overall. Only in subgroup analyses did our study show moderate positive associations of IGF-I levels with risk, either among younger participants only (and only for colon cancer) or among participants whose milk intakes were in the lowest tertile of the population distribution (RR for an increase of 100 ng/ml = 1.43 [95% CI = 1.13-1.93]). Nevertheless, in the meta-analysis a modest positive association remained between serum IGF-I and colorectal cancer risk overall (RR = 1.07 [1.01-1.14] for 1 standard deviation increase in IGF-I). Overall, data from our present study and previous prospective studies combined indicate a relatively modest association of colorectal cancer risk with serum IGF-I. [less ▲]

Detailed reference viewed: 25 (3 ULiège)
Full Text
Peer Reviewed
See detailLifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Suzuki, Reiko; Allen, Naomi E.; Appleby, Paul N. et al

in Cancer causes & control : CCC (2009), 20(6), 811-21

OBJECTIVE: To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men. METHODS: We conducted a cross-sectional analysis of the ... [more ▼]

OBJECTIVE: To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men. METHODS: We conducted a cross-sectional analysis of the association of lifestyle factors with circulating concentrations of androstenedione (A-dione), 3-alpha-androstanediol glucuronide (A-diol-g), testosterone (T), SHBG (sex hormone-binding globulin), and free testosterone (FT) among 636 men in the European Prospective Investigation into Cancer and Nutrition. RESULTS: Compared with the youngest age group (40-49 years), the oldest (70-79 years) had a higher mean concentration of SHBG (by 44%) and lower mean concentrations of A-diol-g (by 29%) FT (19%). Men in the highest BMI group (> or =29.83 kg/m(2)) had a higher mean A-diol-g concentration (by 38%) and lower mean concentration of T (by 20%) SHBG (29%) compared with the lowest (<24.16 kg/m(2)). Current smokers had higher mean concentrations of T (by 13%), SHBG (14%), and A-dione (15%) compared with never smokers. Physical activity and dietary factors were not associated with androgen concentrations, although men in the highest fifth of alcohol intake had higher mean concentrations of A-dione (by 9%), FT (11%) compared with the lowest. CONCLUSION: Our results suggest that age, body weight, smoking, and alcohol intake are associated with circulating androgen concentrations in men. [less ▲]

Detailed reference viewed: 47 (6 ULiège)