References of "Li, Xuefang"
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See detailCan we trust laboratory scale models of urban flooding? Uncertainty in laboratory modelling of urban flooding
Li, Xuefang ULiege; Erpicum, Sébastien ULiege; Bruwier, Martin ULiege et al

Poster (2019, April 08)

Worldwide, flood losses are particularly severe in urban environments. To support urban flood risk management, accurate risk modelling tools are needed; but such tools remain limited by a lack of reliable ... [more ▼]

Worldwide, flood losses are particularly severe in urban environments. To support urban flood risk management, accurate risk modelling tools are needed; but such tools remain limited by a lack of reliable field validation data. We will focus on the issue of scaling, particularly for lab experiments representing urban flooding at the district level. [less ▲]

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See detailUncertainties in laboratory modelling of urban flooding
Li, Xuefang ULiege; Erpicum, Sébastien ULiege; Mignot, Emmanuel et al

in Geophysical Research Abstracts (2019, April)

In the first part of this communication, we will discuss the main uncertainties affecting laboratory scale modelling of urban flooding and their relative importance. These include uncertainties in ... [more ▼]

In the first part of this communication, we will discuss the main uncertainties affecting laboratory scale modelling of urban flooding and their relative importance. These include uncertainties in hydrological data, on roughness representation, on exchanges between overland flow and the drainage network, measurement uncertainties as well as the influence of overlooked processes. In a second part, we will focus on the issue of scaling, particularly for lab experiments representing urban flooding at the district level. Laboratory scale models of urban flooding tend to use distinct scale factors (ratio between prototype and model dimensions) along the horizontal and vertical directions (to avoid millimetre-scale water depths in the lab, or giant lab setups hardly possible to fit in a hydraulic lab). This leads to so-called geometrically distorted scale models. It is believed that this strategy ensures improved accuracy and representativeness of the measurements; but specific artefacts also arise from the model distortion. Here, we provide first quantitative insights into the effects of model distortion, based on a recent reanalysis of existing experimental datasets. In the tested configurations, the influence of model distortion on the predicted values of water depth and street discharges is found of the order of 10%. We will conclude with recommendations on the way to go to make the optimal use of laboratory scale modelling for addressing the needs of the flood risk community. [less ▲]

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See detailTechnical note: Laboratory modelling of urban flooding: strengths and challenges of distorted scale models
Li, Xuefang ULiege; Erpicum, Sébastien ULiege; Mignot, Emmanuel et al

in Hydrology and Earth System Sciences (2019), 23

Laboratory experiments are a viable approach for improving process understanding and generating data for the validation of computational models. However, laboratoryscale models of urban flooding in street ... [more ▼]

Laboratory experiments are a viable approach for improving process understanding and generating data for the validation of computational models. However, laboratoryscale models of urban flooding in street networks are often distorted, i.e. different scale factors are used in the horizontal and vertical directions. This may result in artefacts when transposing the laboratory observations to the prototype scale (e.g. alteration of secondary currents or of the relative importance of frictional resistance). The magnitude of such artefacts was not studied in the past for the specific case of urban flooding. Here, we present a preliminary assessment of these artefacts based on the reanalysis of two recent experimental datasets related to flooding of a group of buildings and of an entire urban district, respectively. The results reveal that, in the tested configurations, the influence of model distortion on the upscaled values of water depths and discharges are both of the order of 10 %. This research contributes to the advancement of our knowledge of small-scale physical processes involved in urban flooding, which are either explicitly modelled or parametrized in urban hydrology models. [less ▲]

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See detailExperimental modelling of urban flooding: a review
Mignot, Emmanuel; Li, Xuefang ULiege; Dewals, Benjamin ULiege

in Journal of Hydrology (2019)

We review the 45 available studies of urban flooding based on laboratory experiments. We distinguish between the studies focusing on the flow in (i) a single street intersection, (ii) surface-sewer ... [more ▼]

We review the 45 available studies of urban flooding based on laboratory experiments. We distinguish between the studies focusing on the flow in (i) a single street intersection, (ii) surface-sewer exchanges, (iii) an array of obstacles and (iv) quasi-realistic urban districts. We discuss the main flow processes which are covered in the various studies and detail which flow variables were recorded. This enables identifying flow processes for which comprehensive experimental datasets are available from those which require additional experimental research. We also highlight the typical ranges of scale factors used, which depend mainly on the extent of the studied area (from very local up to the district level). This review aims at helping computational modellers to pinpoint the most suitable dataset for validating their numerical approaches and laboratory modellers to identify gaps in current experimental knowledge of urban flooding. [less ▲]

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See detailDimensional analysis for hydraulic modelling of urban flooding
Li, Xuefang ULiege; Erpicum, Sébastien ULiege; Mignot, Emmanuel et al

Report (2018)

This document conducts a dimensional analysis for the experimental models of urban flooding. It highlights the key parameters for the flow characteristics of urban flood. The experimental test program is ... [more ▼]

This document conducts a dimensional analysis for the experimental models of urban flooding. It highlights the key parameters for the flow characteristics of urban flood. The experimental test program is also defined. [less ▲]

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See detailDesign of experimental urban flood model
Li, Xuefang ULiege; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

Conference (2018, June 11)

In this Master class, I presented the detailed design of the experimental model of my PhD research, including the model geometry design, laboratory setup and the measurement techniques. Useful discussions ... [more ▼]

In this Master class, I presented the detailed design of the experimental model of my PhD research, including the model geometry design, laboratory setup and the measurement techniques. Useful discussions were acheived for the model design, which confirms also the deep scientific interest of the PhD project. [less ▲]

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See detailA brief review of urban flood experimental models, with a focus on laboratory model at the district level
Li, Xuefang ULiege; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

in Armanini, Aronne; Nucci, Elena (Eds.) New challenges in hydraulic research and engineering (2018, June)

This communication provides brief review of recent experimental research on urban flooding. It highlights the most studied research questions and proposes a classification of the various experimental ... [more ▼]

This communication provides brief review of recent experimental research on urban flooding. It highlights the most studied research questions and proposes a classification of the various experimental models. The communication will focus on models at the district level, and will identify knowledge gaps. [less ▲]

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See detailReview of urban flood experimental models and preliminary design of a laboratory setup of urban flooding
Li, Xuefang ULiege; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

E-print/Working paper (2018)

In this study, we will investigate a study on an urban flood experimental model. Firstly, a literature review of urban flood experimental models is addressed to summarize the studies in this sector ... [more ▼]

In this study, we will investigate a study on an urban flood experimental model. Firstly, a literature review of urban flood experimental models is addressed to summarize the studies in this sector (Section 2). Next, a strategy of experimental model design will be proposed (section 3.1). Particularly, we are interested in analyzing the influence of model distortion to the flow characteristics (Section 3) and the effect of the interaction between surface flow and underground space (Section 4). [less ▲]

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See detailThe effect of sarcoplasmic protein phosphorylation on glycolysis in postmortem ovine muscle
Chen, L.; Li, Z.; Li, Xuefang ULiege et al

in International Journal of Food Science and Technology (2018)

Protein phosphorylation is a key modulator in glycolysis metabolism and regulates the activity of glycometabolic enzymes. The phosphorylation levels of sarcoplasmic proteins were investigated in ... [more ▼]

Protein phosphorylation is a key modulator in glycolysis metabolism and regulates the activity of glycometabolic enzymes. The phosphorylation levels of sarcoplasmic proteins were investigated in relationship to the glycolysis rate in postmortem ovine muscle in the present study. The global phosphorylation levels of sarcoplasmic proteins increased early postmortem and then decreased afterwards in postmortem ovine muscle. Protein bands of different phosphorylation levels were identified as glycometabolism-related enzymes. The phosphorylation levels of Glycogen phosphorylase and Pyruvate kinase maybe one possible reason for the different glycolytic rates at 0.5 h postmortem. The glycolytic rate attributes were negatively correlated with four bands which were probably phosphofructokinase, enolase and adenylate kinase isoenzyme. In summary, the phosphorylation of sarcoplasmic proteins is related to muscle pH decline early postmortem, influencing the meat rigour mortis and quality development. International Journal of Food Science and Technology © 2018 Institute of Food Science and Technology. [less ▲]

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See detailEffect of sub-freezing storage (-6, -9 and -12 °C) on quality and shelf life of beef
Qian, S.; Li, Xuefang ULiege; Wang, H. et al

in International Journal of Food Science and Technology (2018)

Based on the results of low field nuclear magnetic resonance (LF-NMR) in our current study (the frozen state of -6, -9 and -12 °C were nearly the same with extremely low free water content), -6, -9 and ... [more ▼]

Based on the results of low field nuclear magnetic resonance (LF-NMR) in our current study (the frozen state of -6, -9 and -12 °C were nearly the same with extremely low free water content), -6, -9 and -12 °C was designated as sub-freezing temperatures. The effects of sub-freezing storage compared with conventional chilling (4 °C), superchilling (-1 °C) and conventional freezing (-18 °C) on the quality and shelf life of beef were analysed. Results showed that the shelf life of beef is extended to 84 and 126 day at -6 °C and -9 °C, respectively. However, the TVB-N values of the samples stored at -12 °C and -18 °C remained below 15 mg/100 g even on 168 day. Furthermore, shear force, colour, pH, thiobarbituric acid reactive substances (TBARS) and sensory properties were also measured. Consequently, the sub-freezing storage has significantly extended the shelf life of beef compared to chilling and superchilling (P < 0.05). Moreover, no significant difference (P > 0.05) was found between the indicators for quality and shelf life of samples stored at -12 and -18 °C throughout 168 days. © 2018 Institute of Food Science and Technology. [less ▲]

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See detailModelling flow under baffle sluice gates
Le Faucheux, Pierre; Dorchies, David; Li, Xuefang ULiege et al

in Advances in hydroinformatics (2017, June)

The characteristics of the flow under a sluice gate are investigated experimentally. Velocities and pressure profiles as long as the contraction coefficient are measured for various flow rates and used to ... [more ▼]

The characteristics of the flow under a sluice gate are investigated experimentally. Velocities and pressure profiles as long as the contraction coefficient are measured for various flow rates and used to validate numerical simulations. In this paper, 2D and 3D simulations are conducted with open sources software OpenFOAM, Reynolds Stresses Model is used to model the turbulence and volume of fluids method to track the interface. [less ▲]

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See detailModelling flow under baffle sluice gates
Le Faucheux, Pierre; Dorchies, David; Li, Xuefang ULiege et al

in Advances in hydroinformatics (2017, June)

The characteristics of the flow under a sluice gate are investigated experimentally. Velocities and pressure profiles as long as the contraction coefficient are measured for various flow rates and used to ... [more ▼]

The characteristics of the flow under a sluice gate are investigated experimentally. Velocities and pressure profiles as long as the contraction coefficient are measured for various flow rates and used to validate numerical simulations. In this paper, 2D and 3D simulations are conducted with open sources software OpenFOAM, Reynolds Stresses Model is used to model the turbulence and volume of fluids method to track the interface. [less ▲]

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See detailEvolocumab and clinical outcomes in patients with cardiovascular disease
Sabatine, M. S.; Giugliano, R. P.; Keech, A. C. et al

in New England Journal of Medicine (2017), 376(18), 1713-1722

BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether ... [more ▼]

BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets. © 2017 Massachusetts Medical Society. [less ▲]

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