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See detailCorrelation between faecal microbiota and serum levels of Hypoglycin A and MCPA-carnitine in horses with atypical myopathy.
Cesarini Latorre, Carlota ULiege; Votion, Dominique ULiege; BOEMER, François ULiege et al

Conference (2018, November 09)

Equine atypical myopathy (AM) results from hypoglycin A (HGA) ingestion. Both HGA and its principal metabolite, methylenecyclopropyl acetic acid-carnitine (MCPA-carnitine), are found in serum of horses ... [more ▼]

Equine atypical myopathy (AM) results from hypoglycin A (HGA) ingestion. Both HGA and its principal metabolite, methylenecyclopropyl acetic acid-carnitine (MCPA-carnitine), are found in serum of horses with clinical signs of AM. Not all horses ingesting HGA develop AM, suggesting potential protective factors at horse level. The aim of this study was to assess the correlation between faecal microbiota and serum levels of HGA and MCPA-carnitine in horses with AM. Faecal and serum samples were obtained from 19 horses with a history and clinical signs suggestive of AM. Determination of MCPAcarnitine serum concentrations using tandem mass spectrometry and HGA quantification using a modified aTRAQ® assay helped to confirm the disease. Bacterial taxonomy profiling was obtained by V1 V3 16S amplicon sequencing from faeces. Comparison between both groups was performed with a two-tailed Mann-Whitney test (P < 0.05). Spearman rank correlation between bacterial taxa and HGA and MCPA-carnitine were performed with MOTHUR. A total of 190 000 sequences were analysed and clustered to 296 genus level operational taxonomic units. Serum levels of HGA were positively correlated with the relative abundance of the Prevotellaceae family (rs 0,64) and MCPA-carnitine levels were negatively correlated with the relative abundance of the Lachnospiraceae family (rs−0,66). Previous work had shown a significantly lower relative abundance of the Lachnospiraceae family in AM affected horses when compared to healthy co-grazers. Results of this pilot study suggest that Lachnospiraceae could play a preventative role in the development of clinical disease. The role of intestinal microbiome in the development of AM deserves further investigation. [less ▲]

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See detailAcylcarnitines profile best predicts survival in horses with atypical myopathy
BOEMER, François ULiege; Detilleux, Johann ULiege; CELLO, Christophe ULiege et al

in PLoS ONE (2017)

Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary ... [more ▼]

Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe sign of acute rhabdomyolysis in both groups [less ▲]

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See detailEuropean outbreaks of atypical myopathy in grazing horses (2006-2009): Determination of indicators for risk and prognostic factors
Van Galen, Gaby ULiege; Saegerman, Claude ULiege; Marcillaud-Pitel, Christel et al

in Equine Veterinary Journal (2012), DOI: 10.1111/j.2042-3306.2012.00555.x

Appropriate management of atypical myopathy (AM) requires the establishment of an accurate diagnosis and prognosis. Furthermore, preventive measures to avoid AM need to be refined. The aims of the study ... [more ▼]

Appropriate management of atypical myopathy (AM) requires the establishment of an accurate diagnosis and prognosis. Furthermore, preventive measures to avoid AM need to be refined. The aims of the study were as follows: 1) to improve the diagnosis of AM; 2) to identify prognostic predictors; and 3) to refine recommended preventive measures based on indicators of risk factors. [less ▲]

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See detailassessment of acid base imbalances in horses suffering from atypical myopathy
Van Galen, Gaby ULiege; Cerri, Simona ULiege; Porter, Sarah et al

in proceedings AAEP 2011 (2011, November 11)

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See detailExploratory survey on acid base derangements in horses suffering from atypical myopathy
Van Galen, Gaby ULiege; Cerri, Simona ULiege; Porter, Sarah et al

in Proceedings BEVA 2011 (2011, September 08)

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See detailEuropean outbreak of atypical myopathy in the autumn 2009.
Van Galen, Gaby ULiege; Amory, Hélène ULiege; Busschers, Evita et al

in Journal of Veterinary Emergency and Critical Care (2010)

Background: Atypical myopathy (AM) is an acute, severe rhabdomyolysis occurring in grazing horses. Since In the beginning of October 2009, a new outbreak affects started in several European countries ... [more ▼]

Background: Atypical myopathy (AM) is an acute, severe rhabdomyolysis occurring in grazing horses. Since In the beginning of October 2009, a new outbreak affects started in several European countries. Geographic, demographic and clinical data of the reported cases in the month October 2009 are described. Key Findings: The survival rate over the month October 2009 was 25%. The most frequently observed clinical signs were congestedive mucous membranes, dyspnea, tachycardia, depression, weakness, stiffness, recumbency, trembling, transpirationsweating, and myoglobinuria. Non-survivors were significantly more often likely to be recumbent than survivors. Prognostic factors, symptomatic treatment and preventive measures are discussed. Significance: Slight differences were encountered during the described outbreak of AM in October 2009 compared to previous studies. Equine practitioners should be alert aware that previous epidemiological studies have shown that after a high prevalence this autumn, for new cases are likely to occur in the upcoming spring 2010. [less ▲]

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