References of "LEBRETHON, Marie-Christine"
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See detailROHHAD(NET) Syndrome: Systematic review of the clinical timeline and recommendations for diagnosis and prognosis.
HARVENGT, Julie ULiege; Gernay, Caroline; Mastouri, Meriem et al

in The Journal of clinical endocrinology and metabolism (2020)

CONTEXT: Rapid onset Obesity with Hypothalamic dysfunction, Hypoventilation, Autonomic Dysregulation and Neural Tumor Syndrome (ROHHHAD(NET)) is a rare and potentially fatal disease. No specific ... [more ▼]

CONTEXT: Rapid onset Obesity with Hypothalamic dysfunction, Hypoventilation, Autonomic Dysregulation and Neural Tumor Syndrome (ROHHHAD(NET)) is a rare and potentially fatal disease. No specific diagnostic biomarker is currently available, making prompt diagnosis challenging. Since its first definition in 2007, a complete clinical analysis leading to specific diagnosis and follow-up recommendations is still missing. OBJECTIVE: To describe the clinical timeline of symptoms of ROHHAD(NET) and propose recommendations for diagnosis and follow-up. DESIGN: We conducted a systematic review of all ROHHAD(NET) case studies and report a new ROHHAD patient with early diagnosis and multidisciplinary care. METHODS: All the articles that meet the definition of ROHHAD(NET) and provide chronological clinical data were reviewed according to the PRISMA individual patient data (IPD) guidelines. The data were grouped into 7 categories: hypothalamic dysfunction, autonomic dysregulation, hypoventilation, NET, psychiatric symptoms, other clinical manifestations, outcome. RESULTS: 43 IPD were analyzed. The timeline of the disease shows rapid onset obesity followed shortly afterwards by hypothalamic dysfunction. Dysautonomia was reported at a median age of 4.95 years and hypoventilation at 5.33 years, or 2,2 years after the initial obesity. A NET was reported in 56% of the patients and 70% of these tumors were diagnosed within 2 years after initial weight gain. CONCLUSION: Since early diagnosis improves the clinical management and the prognosis in ROHHAD(NET), this diagnosis should be considered for any child with a rapid and early obesity. We propose guidance for systematic follow-up and advise multidisciplinary management with the aim of improving prognosis and life expectancy. [less ▲]

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See detailA series of 9 pregnancies with hyperthyroidism and Graves disease : fetal and maternal follow up
DELANNOY, Pauline ULiege; GRANDFILS, Sébastien ULiege; LEBRETHON, Marie-Christine ULiege et al

in Abstract book : Annual congress of the Belgian Society of Internal Medicine (2019, December)

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See detailPremature adrenarche : DHEA Sulfate by Immunoassay or LC-MS/MS ?
LE GOFF, Caroline ULiege; Gilson, Maud ULiege; Lahr, Mara ULiege et al

Poster (2019, May 21)

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See detailEndocrine consequences of neuroblastoma treatment in children: 20 years’ experience of a single center
Geurten, Claire ULiege; Geurten, Marie ULiege; HOYOUX, Claire ULiege et al

in Journal of Pediatric Endocrinology and Metabolism (2019), 32(4), 347-354

Background: Neuroblastoma (NBL) is a child neoplasia affecting extracranial tissue of neuroectodermal origin. It accounts for 10% of solid malignancies in children and is characterized by a survival rate ... [more ▼]

Background: Neuroblastoma (NBL) is a child neoplasia affecting extracranial tissue of neuroectodermal origin. It accounts for 10% of solid malignancies in children and is characterized by a survival rate approaching 70%, confronting physicians with the emergence of an adult survivor population who have been previously exposed to surgery, cytotoxic drugs, radiation therapy or metaio- dobenzylguanidine (MIBG) therapy. All these treatments potentially affect the endocrine system. Our study consists in a retrospective review of late endocrine effects arising in survivors treated for NBL during childhood. Methods: The medical files of 47 patients (M/F = 26/21) treated for NBL were reviewed. Collected data consisted of age, height, weight and biological hormonal values at diagnosis and at the last follow-up consultation. The inci- dence of late effects in our sample was compared to the data from the literature. Results: Patients were between 0 and 15.8 years of age at diagnosis (median: 1.16 years) and between 1 and 25 years of age at last follow-up (median: 16 years). Twenty-six patients were treated with chemotherapy (CT), 11 under- went CT and radiation therapy and five were treated with CT and MIBG therapy. Ten percent of the patients died before reaching the end of therapy. Late effects occurred in 54% of the patients. Thirty-six percent of patients had non-endocrine complications (musculoskeletal, neuro- logical, hematological or hepatic chronic conditions). Endocrine complications (28%) affected mainly patients treated with CT and consisted of gonadal dysfunction (up to 42% patients of over 12 years of age at follow-up) and hypothyroidism (21%). Our analysis revealed that CT had a significant impact on final height (p < 0.05). Conclusions: Treatment for childhood malignancies exposes children to late effects affecting the endocrine sys- tem. In children treated for NBL, hypothyroidism, gonadal failure and impaired growth appear to be the main endo- crine complications. Close follow-up of survivors is thus appropriate. [less ▲]

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See detailPoor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria.
Straetemans, Saartje; Thomas, Muriel; Craen, Margarita et al

in International Journal of Pediatric Endocrinology (2018), 2018

Background: There is no consensus on the definition of poor growth response after the first year of growth hormone (GH) treatment. We determined the proportion of poor responders identified by different ... [more ▼]

Background: There is no consensus on the definition of poor growth response after the first year of growth hormone (GH) treatment. We determined the proportion of poor responders identified by different criteria in children with GH deficiency (GHD) and born small for gestational age (SGA). The second aim was to analyze the IGF-1 response in poor growth responders. Methods: First-year height data of 171 SGA and 122 GHD children who remained prepubertal during the first GH treatment year were retrieved from the BESPEED database and analyzed. Criteria for poor first-year response/responsiveness were: change in height (Ht) SDS<0.3 or<0.5, height velocity (HV) SDS<0.5 or <1 based on the population reference, HV SDS<- 1 based on the KIGS expected HV curve (HV Ranke SDS), studentized residual (SR) <- 1 in the KIGS first-year prediction model. Results: Ht SDS<0.5 gave the highest percentage poor responders (37% SGA, 26% GHD). Although % poor responders were comparable for Ht SDS<0.3, HV SDS<+ 0.5, HV SDS<+ 1, SR<- 1, and HV Ranke SDS<- 1, these criteria did not always identify the same patients as poor responders. Among the poor growth responders 24% SGA and 14% GHD patients had an IGF-1 increase < 40%. Conclusions: The different response criteria yield high but comparable percentages poor responders, but identify different patients. This study does not provide evidence that one criterion is better than another. A limited IGF-1 generation is not the major reason for a poor growth response in the first year of GH treatment in SGA and GHD children. Trial registration: Retrospectively registered. [less ▲]

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See detailAdult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study.
Thomas, M.; Beckers, D.; Brachet, C. et al

in International Journal of Endocrinology (2018), 2018

Objectives: Information on the efficacy of GH treatment in short SGA children starting their treatment in adolescence is limited. Therefore, adult height (AH), total height gain, and pubertal height gain ... [more ▼]

Objectives: Information on the efficacy of GH treatment in short SGA children starting their treatment in adolescence is limited. Therefore, adult height (AH), total height gain, and pubertal height gain were evaluated in short SGA children who started GH treatment at pubertal onset. Patient and Methods: Growth data of 47 short SGA adolescents (22 boys) who started GH treatment at pubertal onset (PUB group) were compared with results from 27 short SGA patients (11 boys) who started GH therapy at least 1 year before pubertal onset (PrePUB group). Results: The PUB group achieved a mean (+/-SD) total height gain of 0.8 +/- 0.7 SDS and an AH of -2.5 +/- 0.7 SDS after 4.1 +/- 1.1 years of GH treatment with a dosage of 41.8 +/- 8.4 mug/kg/day. These results were comparable with those in the PrePUB group, which was treated for a longer duration (5.8 +/- 2.1 years), resulting in a total height gain of 1.1 +/- 0.7 SDS and an AH of -2.1 +/- 1.0 SDS. Multiple regression analysis showed a significantly lower height gain in pubertal patients, females, and patients weighing less at start of GH treatment. An AH above -2 SDS and above the parent-specific lower limit of height was, respectively, reached in 28% and 70% of PUB and 44% and 67% of PrePUB patients (NS). AH SDS was positively correlated with the height SDS at start of GH. Conclusions: Short SGA adolescents starting GH therapy at an early pubertal stage have a modest and variable height gain. A normal AH can be expected in one third of the patients, especially in those with a smaller height deficit at onset of GH treatment. [less ▲]

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See detailLow/medium doses of inhaled corticosteroids can cause adrenal insufficiency
FUDVOYE, Julie ULiege; LEBRETHON, Marie-Christine ULiege; Parent, Anne-Simone ULiege

in Belgian Journal of Paediatrics (2017, March), 19(1),

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See detailEtude rétrospective du bilan thyroïdien: définition de valeurs de référence pédiatriques
LADANG, Aurélie ULiege; VRANKEN, Laura ULiege; LUYCKX, Françoise ULiege et al

in Revue Médicale de Liège (2017)

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range ... [more ▼]

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range for TSH, FT3 and FT4 for Cobas C6000 analyzer. To do so, we have taken in account 0 to 18 year old outclinic patients. During the first year of life, thyroid hormone levels change dramatically before getting stabilized around 3 years old. We also compared our results to those obtained in a Canadian large-scale prospective study (the CALIPER initiative). [less ▲]

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See detailValidation of Prediction Models for Near Adult Height in Children with Idiopathic Growth Hormone Deficiency Treated with Growth Hormone A Belgian Registry Study
Straetemans, Saartje; De Schepper, Jean; THOMAS, Muriel et al

in Hormone Research in Paediatrics (2016), 86

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See detailAsociacion de craneofaringioma y sindrome de Klinefelter en la transicion puberal : un desafio diagnostico
Mocarbel, Y; Arebalo de cross, G; LEBRETHON, Marie-Christine ULiege et al

in Archivos Argentinos de Pediatria (2016)

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See detailDesign and implementation of a ‘physical activity day’ for overweight and obese youth
Cloes, Marc ULiege; DEWANDRE, Anne-Cécile ULiege; LEBRETHON, Marie-Christine ULiege et al

Conference (2015, March)

This study aimed to analyze the development and implementation of an adapted physical activity day expected to underline to overweight/obese youth the role of PA and hw they could be more active in their ... [more ▼]

This study aimed to analyze the development and implementation of an adapted physical activity day expected to underline to overweight/obese youth the role of PA and hw they could be more active in their daily life. [less ▲]

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See detailJAWAC evolving technologies to study sleep disturbance in obese adolescents - a preliminary study
Barrea, Christophe ULiege; HARVENGT, Julie ULiege; LEBRETHON, Marie-Christine ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015, January), 17(1), 107

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See detailPromotion of physical activity among children and adolescents followed for overweight or obesity in
DEWANDRE, Anne-Cécile ULiege; HARVENGT, Julie ULiege; LAGASSE, Celine ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015, January), 17(1), 40

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See detailAutoimmune thyroid diseases in early childhood three case reports
Guffins, Amandine ULiege; HARVENGT, Julie ULiege; LUYCKX, F. et al

in Tijdschrift van de Belgische Kinderarts (2015, January), 17(1), 41

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See detailChanges in pubertal timing: Past views, Recast issues
Bourguignon, Jean-Pierre ULiege; DOMINE, Françoise ULiege; Glowacz, Fabienne ULiege et al

in Bourguignon, Jean-Pierre; Carel, Jean-Claude; Christen, Yves (Eds.) Brain Crosstalk in Puberty in Adolescence (2015)

Abstract The aim of this article is to review some common opinions on changes in pubertal timing and shed new light both on the indicators used in assessing pubertal timing and the underlying mechanisms ... [more ▼]

Abstract The aim of this article is to review some common opinions on changes in pubertal timing and shed new light both on the indicators used in assessing pubertal timing and the underlying mechanisms. While emphasis is usually on advancement in timing of female puberty, it appears that timing also changes in males, both towards earliness for the initial pubertal stages and towards lateness for the final stages. Such findings suggest that the environmental influences on pubertal timing are more complex than initially thought. Moreover, self-evaluated pubertal timing versus peers provides information that is not always consistent with observations at physical examination, suggesting that both perspectives should be considered, especially when studying the correlation between pubertal timing and psychosocial aspects. The mechanisms of changes in pubertal timing may involve both central neuroendocrine control and peripheral effects in tissues targeted by gonadal steroids. Though energy availability is certainly a clue to the mechanism of pubertal development, changes in the control of both energy balance and control of reproduction may vary under the influence of common determinants such as endocrine-disrupting chemicals. These effects can take place right before puberty as well as much earlier, during fetal and neonatal life. Finally, environmental factors can interact with genetic factors in determining changes in pubertal timing. Therefore, the variance in pubertal timing is no longer to be considered under the absolutely separate control of environmental and genetic determinants.  [less ▲]

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See detailDevelopment of educational info capsules proposing instructional strategies aiming to deal with overweight and obese students
Cloes, Marc ULiege; LEBRETHON, Marie-Christine ULiege; Feron, Isaline

Conference (2014, February 13)

Irwin et al. (2003) pointed out the principles that quality PE teachers should incorporate into their pedagogical practice in order to take into account the increasing number of overweight and obese ... [more ▼]

Irwin et al. (2003) pointed out the principles that quality PE teachers should incorporate into their pedagogical practice in order to take into account the increasing number of overweight and obese students in their classes. Fighting against obesity is so complex that no simple solution can be proposed. It means that the development of specific tools providing PE teachers with new instructional strategies inspired from public health is needed (Prusak et al., 2011). Inclusion of overweight students into PE can be linked with a social ecological model (Li & Rukavina, 2012). Even if PE teachers are able to develop and implement specific instructional strategies, it seems that they need support from health experts (Cloes et al., 2013). Internet, continuing professional development activities, and educational info capsules were identified as the preferred supports to be used by the practitioners (Cloes et al., 2014). The aims of this study were to produce and validate three pedagogical capsules focusing on specific concerns of PE teachers as well as to analyze the procedure of validation. Using an extensive analysis of the literature, the researchers first identified theoretical and practical resources to be mobilized in the understanding and development of solutions for the selected problems: (1) Students’ lack of awareness about the risks of overweight and obesity; (2) Constraints associated with the motor/physical disabling; (3) Parents’ lack of awareness about PA impact on health. The capsules were then submitted to 11 experts (health specialists, health educators, psychologists, PE teachers) who had to analyze the documents. They acknowledged the content and form of the capsules. Minor changes were requested in order to finalize them. The proposed evaluation sheet was also validated but face-to-face assessment was recommended. Dissemination of the existing capsules as well as development of additional ones should be the next steps of this project. [less ▲]

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