References of "Koch, Nathan"
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See detailImpregnation of mesoporous silica with poor aqueous soluble molecule using pressurized carbon dioxide: is the solubility in the supercritical and subcritical phase a critical parameter?
Koch, Nathan ULiege; Jennotte, Olivier ULiege; Grignard, Bruno ULiege et al

in European Journal of Pharmaceutical Sciences (2020), 150

Recently, mesoporous silica (MS) has been used as a material able to maintain amorphous state of active compounds and therefore, enhance the oral bioavailability of BCSII drugs. Among impregnation methods ... [more ▼]

Recently, mesoporous silica (MS) has been used as a material able to maintain amorphous state of active compounds and therefore, enhance the oral bioavailability of BCSII drugs. Among impregnation methods of MS, techniques using supercritical carbon dioxide (sc-CO2) are promising tools. Solubility of compounds in sc-CO2 is reported as one of the most critical parameters, which usually limits its use in drug formulation. Indeed, most of compounds have poor solubility in sc-CO2. The aim of this work is to compare different MS and to study alternative processes using pressurized CO2 for insoluble molecule in sc-CO2. By using high pressure reactor, DSC, HPLC and in vitro dissolution tests, the crystallinity and dissolution profiles of MS with different pore size (6.6 nm, 25.0 nm and 2.5 nm) impregnated with fenofibrate (FF) under sc-CO2 were compared to select the most appropriate carrier. Then, the selected MS has been impregnated under supercritical, subcritical and atmospheric conditions. We have shown that the MS pore size of 6.6 nm provides the higher amorphous drug loading capacity as well as the faster and higher drug dissolution. In addition, FF-MS formulations produced with pressurized CO2 as fusion medium, both in subcritical and supercritical conditions; give similar crystallinity and dissolution results compared to those produced with supercritical fluids as solvent. Through this study, we show new possibilities of using CO2 for insoluble compounds in this fluid. [less ▲]

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See detailCannabidiol aqueous solubility enhancement: comparison of three amorphous formulations strategies using different type of polymers
Koch, Nathan ULiege; Jennotte, Olivier ULiege; Gasparrini, Youri ULiege et al

in International Journal of Pharmaceutics (2020)

Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to ... [more ▼]

Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on trial-error processes. The amorphous form of CBD provided higher aqueous solubility as well as faster dissolution rate in comparison with crystalline CBD. Nevertheless, amorphous forms of CBD tend to recrystallize. The aim of this study was to use three different strategies based on the stabilization of the amorphous form. Cyclodextrins (CH3CD, HPβCD and HPγCD.), mesoporous silicas (Silsol® and Syloid® AL-1FP) and water soluble polymers (Kollidon® VA64, Kollidon® 12PF and Soluplus®) were processed by using the following techniques: freeze-drying, spray-drying, subcritical carbon dioxide impregnation or hot-melt extrusion. All the obtained formulations provided complete amorphous CBD, although the drug loading depend highly of the excipients. CBD-cyclodextrin formulations, processed by freeze-drying or spray-drying, and CBD-mesoporous silica formulations, processed by subcritical CO2 or by atmospheric impregnation, provided significant increase of aqueous solubility. While the use of Kollidon® 12PF did not provided significant increased solubility within 90 min, Kollidon® VA64 has been highlighted as the excipient that exhibits the highest increase of aqueous solubility of this study. Finally, all formulations, excepted CBD-ALFP formulations, showed adequate stability within at least two months. [less ▲]

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See detailThree-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: a review
Jennotte, Olivier ULiege; Koch, Nathan ULiege; Lechanteur, Anna ULiege et al

in International Journal of Pharmaceutics (2020)

Poor aqueous solubility of active pharmaceutical ingredients (API) is nowadays a major issue in the pharmaceutical field. The combinatorial chemistry provides more and more API with a great therapeutic ... [more ▼]

Poor aqueous solubility of active pharmaceutical ingredients (API) is nowadays a major issue in the pharmaceutical field. The combinatorial chemistry provides more and more API with a great therapeutic potential, but with a low aqueous solubility. Among the strategies to overcome this drawback, the use of amorphous solid dispersions (ASD), as well as the increase of surface area, is widely used. The three dimensional (3D) printing technologies appear to be innovative tools allowing the construction of any unconventional forms with different composition, structure or infill; especially by using ASD materials. This review aims to deliver notions about the different 3D printing techniques found in the literature to improve aqueous solubility of several API, namely nozzle-based method, inkjet methods and laser-based methods, as well as guide formulator in terms of formulation parameters that have to be optimized to allow the most suitable impression of innovative medicines. [less ▲]

Detailed reference viewed: 69 (18 ULiège)
See detailHot-melt extrusion as a solvent-free technique for the formation of a polymeric amorphous solid dispersion of atorvastatin
Jennotte, Olivier ULiege; Koch, Nathan ULiege; Lechanteur, Anna ULiege et al

Conference (2019, December 11)

Hot-melt extrusion for the formation of an amorphous solid dispersion of atorvastatin in order to enhance its aqueous solubility

Detailed reference viewed: 36 (3 ULiège)
See detailDevelopment of new manufacturing processes for amorphous solid dispersions
Jennotte, Olivier ULiege; Koch, Nathan ULiege; Rocks, Natacha ULiege et al

Conference (2019, May 20)

Use of the hot-melt extrusion form amorphous solid dispersions of atorvastatin calcium trihydrate with a selection of three polymers in order to enhance its aqueous solubility

Detailed reference viewed: 36 (5 ULiège)
See detailHot melt extrusion as a solvent-free technique for the formation of a polymeric amorphous solid dispersion of atorvastatin
Jennotte, Olivier ULiege; Koch, Nathan ULiege; Collard, Laurence ULiege et al

Poster (2019, March 26)

Hot-melt extrusion as a solvent-free technique for the enhancement of BCSII molecules.

Detailed reference viewed: 28 (6 ULiège)
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See detailUtilisation de la nystatine dans la candidose oropharyngée au CHU de Liège
Vercheval, Christelle ULiege; GILLET, Manon ULiege; Koch, Nathan ULiege et al

in Journal de Pharmacie de Belgique (2019)

Le Groupe de Gestion de l’Antibiothérapie du Centre Hospitalier Universitaire de Liègea souligné une utilisation importante et nonjustifiée de nystatine sous forme de bain debouche. Devant ce constat ... [more ▼]

Le Groupe de Gestion de l’Antibiothérapie du Centre Hospitalier Universitaire de Liègea souligné une utilisation importante et nonjustifiée de nystatine sous forme de bain debouche. Devant ce constat, nous avons réalisé une revue de la littérature sur l’efficacité et l’innocuité de la nystatine dans la candidose oropharyngée (COP) et nous partageons dans cet article quelques recommandations pratiques institutionnelles. La COP est une infection fongique fréquente avec un bon pronostic si elle est diagnostiquée et traitée de manière appropriée. La nystatine sous forme de pastille ou de suspension buvable est recommandée comme traitement alternatif en cas de COP bénigne par la Société Américaine des Maladies Infectieuses. Néanmoins, la littérature évaluant l’efficacité et la sécurité de la nystatine dans la COP est pauvre. En Belgique, la nystatine est commercialisée sous forme de suspension buvable et sous forme de matière première. Aucun consensus national n’est disponible sur la formulation, le dosage ou encore la durée de traitement de la nystatine en cas de COP. Au CHU de Liège, il a été décidé d’arrêter la préparation de bain de bouche à base de nystatine et de privilégier l’utilisation d’une suspension de nystatine en cas de COP bénigne. [less ▲]

Detailed reference viewed: 129 (24 ULiège)
See detailHot melt extrusion as a solvent-free technique for the formation of a polymeric amorphous solid dispersion of atorvastatin
Jennotte, Olivier ULiege; Koch, Nathan ULiege; Collard, Laurence ULiege et al

Scientific conference (2018, December 19)

Water-solubility enhancement of atorvastatin using the hot melt extrusion for the production of a polymeric amorphous solid dispersion

Detailed reference viewed: 54 (16 ULiège)