References of "KRZESINSKI, Jean-Marie"
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See detailThe European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)—clinical phenotypes and their predictors based on a cohort of 1000 patients.
pappaccogli, marco; Di Monaco, Silva; Warchot-Celinska, Ewa et al

in Cardiovascular Research (2020)

Aims : Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age ... [more ▼]

Aims : Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections. Methods and results : All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12%>_65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients >_65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD. Conclusions : The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD. [less ▲]

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See detailGestion de l’hyperkaliémie lors d’un traitement par inhibiteur du système réinine-angiotensine-aldostérone
KRZESINSKI, Jean-Marie ULiege; van der schueren, Thierry

in Revue de la Médecine Générale (2020), 369

Hyperkalemia is common in patients with chronic renal failure (CKD), diabetes and/or cardiac decompensation (CD) and increases when taking inhibitors of the renin-angiotensin-aldosterone system. Besides ... [more ▼]

Hyperkalemia is common in patients with chronic renal failure (CKD), diabetes and/or cardiac decompensation (CD) and increases when taking inhibitors of the renin-angiotensin-aldosterone system. Besides dietetics, the use of intestinal potassium chelators is frequent but often poorly tolerated. Recently, a new potassium chelator appears to be promising. [less ▲]

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See detailNouveautés dans la prise en charge de l'hypertension artérielle dans la dernière décennie
KRZESINSKI, Jean-Marie ULiege; SAINT-REMY, Annie ULiege

in Revue Médicale de Liège (2020), 75(5-6), 329-335

Hypertension remains one of the most important cardiovascular risk factors. In spite of many efforts for its management, the control of high blood pressure remains insufficient. In the last decade, no new ... [more ▼]

Hypertension remains one of the most important cardiovascular risk factors. In spite of many efforts for its management, the control of high blood pressure remains insufficient. In the last decade, no new antihypertensive drug was released. The main effort to improve blood pressure control was put on the validation of the hypertensive status, the stimulation of home blood pressure measurement and the therapeutic education of the patients. The releasing in 2018 of new guidelines, which are clear and more simple, would help more efficiently fight against hypertension, the still present silent killer. In Europe, the usual blood pressure target has been kept, i.e.a lowering of blood pressure below 140/90 mmHg in all fit patients whatever their age. Lower target could be proposed according to the patient tolerance. Treatment is decided according to cardiovascular risk evaluation. Quickly a combination of two antihypertensive agents in a single pill is proposed to improve efficacy of the treatment. We also need the help of the family, nurses and pharmacists to increase the chance of a better blood pressure control, which is necessary to get an optimal cardiovascular protection. [less ▲]

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See detailNouveautés thérapeutiques en Néphrologie : 10 ans d'avancées
BOVY, Christophe ULiege; DELANAYE, Pierre ULiege; JOURET, François ULiege et al

in Revue Médicale de Liège (2020), 75(5-6), 336-343

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression ... [more ▼]

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression. During the past decade, a better understanding of the pathophysiological mechanisms of glomerular diseases has highlighted the benefits of rituximab. Progresses have also been made in the understanding of the mechanisms of autosomal polycystic kidney disease, the most frequent inherited kidney disease. These observations led to the discovery and validation of tolvaptan, a blocker of the V2 receptor of the antidiuretic hormone as an innovative treatment. Type 2 diabetic disease is the leading cause worldwide of endstage kidney disease and dialysis. The development of new drugs, such as the gliflozins (inhibiting the sodium glucose reabsorption in the proximal tubule), has contributed to an improvement in the management of the cardiovascular and renal risks especially reducing congestive heart failure rate. Another important progress in nephrology since the beginning of the new century concerns a more precise estimation of the kidney function, which allows to better evaluate the slope of CKD progression and test the influence of different therapeutic approaches aiming at correcting anemia, hyperkalemia, metabolic acidosis and disturbances of calcium and phosphate. The present review summarizes all of these major advances in the field of CKD diagnosis and treatment, and envisions the future of nephrology for the next decade. [less ▲]

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See detailIl faut protéger le rein du patient diabétique!
KRZESINSKI, Jean-Marie ULiege

Scientific conference (2019, December 07)

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See detailLa radiothérapie centrée sur le rein atténue les lésions d'ischémie-reperfusion rénale chez la souris
Khbouz, Badr ULiege; Pascal, Rowart; LALLEMAND, François ULiege et al

Conference (2019, December 04)

Introduction: L'irradiation corporelle engendre un conditionnement ischémique rénal. L’impact fonctionnel et pathophysiologique d’une radiothérapie centrée sur les reins est cependant inconnu. Méthodes ... [more ▼]

Introduction: L'irradiation corporelle engendre un conditionnement ischémique rénal. L’impact fonctionnel et pathophysiologique d’une radiothérapie centrée sur les reins est cependant inconnu. Méthodes: Expérience 1: Sous anesthésie, 2 faisceaux de rayons X (225Kv, 13mA) ciblent spécifiquement les reins pour une dose totale de 8,56Gy. Trente jours plus tard, une néphrectomie droite est réalisée et une ischémie du rein gauche est induite pendant 30min. Après 48h de reperfusion, le rein gauche et le sang sont prélevés (n=6 souris). Un groupe témoin (n=6) subit une I/R rénale similaire sans irradiation préalable. Expérience 2: Une irradiation unilatérale des reins gauches (8,56Gy) est réalisée (n=11). Trente jours plus tard, le rein gauche est prélevé. Le rein gauche de souris non irradiées (n=5) est utilisé comme contrôle. L’ARN des reins irradiés et contrôles est extrait pour une transcriptomique comparative (BaseSpace Illumina; DAVID program). Résultats: À la suite d’une I/R rénale, le taux d’urée était significativement plus bas chez les animaux pré-irradiées (148±93mg/dl), comparativement aux contrôles (496±33, p<0,01). Le nombre de cellules en prolifération (PCNA-positives) était significativement inférieur chez les pré-irradiées par rapport aux témoins (131±53 vs. 545±257/mm², p<0,001). L'infiltration rénale par les cellules CD11b-positives (90±32 vs. 414±149/mm²) et les macrophages F4-80 (81±23 vs 179±68/mm²) était significativement réduite dans le groupe irradié. L’analyse transcriptomique montre une up-régulation des voies de signalisation de l'angiogenèse (Hmox1) et de la réponse au stress (Hspa1a, Hspa1b), et une down-régulation de l'oxydoréduction (Nox4). Conclusion: L'irradiation rénale induit un pré-conditionnement ischémique chez la souris, avec une fonction rénale préservée et une inflammation atténuée après I/R rénale. Les voies de signalisation susmentionnées, modulées lors de l’irradiation, participent probablement à la résistance du rein à l'I/R. [less ▲]

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See detailKidney targeted radiotherapy attenuates the renal ischemia-reperfusion injury in mice
Khbouz, Badr ULiege; Rowart, Pascal; LALLEMAND, François ULiege et al

Poster (2019, November 07)

BACKGROUND Whole-body irradiation has been associated with renal ischemic preconditioning in mice. Here, we investigate the functional and fundamental impact of radiotherapy centered on the kidneys before ... [more ▼]

BACKGROUND Whole-body irradiation has been associated with renal ischemic preconditioning in mice. Here, we investigate the functional and fundamental impact of radiotherapy centered on the kidneys before renal ischemia/reperfusion (I/R) in mice. METHODS Experience1: Animals (n=6) were anesthetized and placed in the irradiator. Two beams of X-rays (225Kv, 13 mA) specifically targeted both kidneys to deliver a dose a 8,56Gy. One month later, a right nephrectomy was performed, and a left renal ischemia was induced for 30min. After 48 hours of reperfusion, the left kidney was collected, as well as blood. Control group (n=6) underwent a similar renal I/R procedure, with no prior irradiation. Experience 2: Unilateral irradiation of the left kidney (8.56 Gy) was performed in mice (n=10). One month later, the left (irradiated) kidney was collected. Additionally, the left kidneys were collected from non-irradiated mice (n=5). Total RNAs were extracted from irradiated and control kidneys to perform comparative high-throughput RNA-Seq. BaseSpace Sequence Hub Illumina was used. Functional enrichment analysis was performed using DAVID program. Both experimental protocols have been approved by the IACUC of ULiège, Liège, Belgium. RESULTS Following kidney I/R, blood urea nitrogen (BUN) levels were significantly lower in pre-irradiated mice (148.4±93.1) compared to controls (495.7±33.3, p<0.01). The number of PCNA-positive proliferating cells was significantly lower in pre-irradiated mice (130.8±52.7) compared to controls (545.4±257.3, p<0.001). The renal infiltration by inflammatory CD11b-positive cells (90.2±32.2 vs. 414.5±148.6) and F4-80-positive macrophages (80.6±22.9 vs. 178.5±68) was significantly reduced in pre-irradiated animals vs. controls. Comparative transcriptomics showed a significant up-regulation of various signaling pathways, including angiogenesis (HMOX1) and stress response (HSPA1A, HSPA1B), and a down-regulation of oxidoreduction (NOX4). CONCLUSION Kidney irradiation induces ischemic preconditioning in mice, with improved renal function and decreased inflammation following renal I/R. The aforementioned signaling pathways may play a role in irradiation-associated kidney resistance to I/R. [less ▲]

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See detailQuelle quantité de sel conseiller dans une nutrition équilibrée?
Krzesinski, Jean-Marie ULiege

Conference (2019, October 17)

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See detailKidney-centered radiotherapy attenuates renal ischemia-reperfusion injury in mice
Khbouz, Badr ULiege; Rowart, Pascal ULiege; LALLEMAND, François ULiege et al

Conference (2019, October 11)

Introduction Whole-body irradiation has been associated with renal ischemic preconditioning in mice. Here, we investigate the functional and fundamental impact of radiotherapy centered on the kidneys ... [more ▼]

Introduction Whole-body irradiation has been associated with renal ischemic preconditioning in mice. Here, we investigate the functional and fundamental impact of radiotherapy centered on the kidneys before renal ischemia/reperfusion (I/R) in mice. Materials and Methods Experience1: Animals (n=5) were anesthetized and placed in the irradiator. Two beams of X-rays (225Kv, 13 mA) specifically targeted both kidneys to delivered a dose of 8,56Gy. One month later, a right nephrectomy was performed, and a left renal ischemia was induced for 30min. After 48 hours of reperfusion, the left kidney was collected, as well as blood. Control group (n=6) underwent a similar renal I/R procedure, with no prior irradiation. Experience 2: Unilateral irradiation of left kidneys (8.56 Gy) was performed on mice (N=11). One month later, the left (irradiated) kidney was collected. Additionally, kidneys were collected from non-irradiated mice (N=5). Total RNAs were extracted from irradiated and control kidneys to perform comparative high-throughput RNA-Seq. BaseSpace Sequence Hub Illumina was used. Functional enrichment analysis was performed using DAVID program. Results Following kidney I/R, blood urea nitrogen (BUN) levels were significantly lower in pre-irradiated mice (148.4±93.1) compared to controls (495.7±33.3, p<0.01). The number of PCNA-positive proliferating cells was significantly lower in pre-irradiated mice (130.8±52.7) compared to controls (545.4±257.3, p<0.001). The renal infiltration by inflammatory CD11b-positive cells (90.2±32.2) vs. (414.5±148.6) and F4-80-positive macrophages (80.6±22.9) vs. (178.5±68) was significantly reduced in pre-irradiated animals. Comparative transcriptomics showed a significant up-regulation of signaling pathways involved in angiogenesis (HMOX1) and stress response (HSPA1A, HSPA1B), and a down-regulation of oxidoreduction (NOX4). Conclusion Kidney irradiation induces ischemic preconditioning in mice, with improved renal function and decreased inflammation following renal I/R. The aforementioned signaling pathways may play a role in irradiation-associated kidney resistance to I/R. [less ▲]

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See detailGut Microbiota and Fecal Levels of Short-Chain Fatty Acids Differ Upon 24-Hour Blood Pressure Levels in Men
Huart, Justine ULiege; Leenders, Justine ULiege; Taminiau, Bernard ULiege et al

in Hypertension (2019)

Gut microbiota may influence blood pressure (BP), namely via end products of carbohydrate fermentation. After informed consent, male volunteers were prospectively categorized into 3 groups upon European ... [more ▼]

Gut microbiota may influence blood pressure (BP), namely via end products of carbohydrate fermentation. After informed consent, male volunteers were prospectively categorized into 3 groups upon European Society of Hypertension criteria based on 24-hour ambulatory BP measurements: (1) hypertension, (2) borderline hypertension, and (3) normotension. Stool, urine and serum samples were collected in fasting conditions. Gut microbiota was characterized by 16S amplicon sequencing. Metabolomics, including quantification of short-chain fatty acids, was conducted using nuclear magnetic resonance. Two-way ANOVA combined with Tukey post hoc test, as well as multiple permutation test and Benjamini-Hochberg-Yekutieli false discovery rate procedure, was used. The cohort included 54 males: 38 hypertensive (including 21 under treatment), 7 borderline, and 9 normotensive. No significant difference was observed between groups concerning age, body mass index, smoking habits, and weekly alcohol consumption. The genus Clostridium sensu stricto 1 positively correlated with BP levels in nontreated patients (n=33). This correlation was significant after multiple permutation tests but was not substantiated following false discovery rate adjustment. Short-chain fatty acid levels were significantly different among groups, with higher stool levels of acetate, butyrate, and propionate in hypertensive versus normotensive individuals. No difference was observed in serum and urine metabolomes. Correlation between stool metabolome and 24-hour BP levels was evidenced, with R2 reaching 0.9. Our pilot study based on 24-hour ambulatory BP measurements, 16S amplicon sequencing, and metabolomics supports an association between gut microbiota and BP homeostasis, with changes in stool abundance of short-chain fatty acids. [less ▲]

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See detailPrise en charge de l'HTA résistante. Quoi de neuf en 2019?
KRZESINSKI, Jean-Marie ULiege

Conference (2019, May 12)

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See detailHTA réfractaire et dénervation rénale : regain d'intérêt?
KRZESINSKI, Jean-Marie ULiege; MARTINEZ, Christophe ULiege

Conference (2019, May 11)

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See detailMyostatin and Insulin-Like Growth Factor 1 Are Biomarkers of Muscle Strength, Muscle Mass, and Mortality in Patients on Hemodialysis.
DELANAYE, Pierre ULiege; Bataille; Quinonez, Kevin et al

in Journal of Renal Nutrition (2019), 29(6), 511-520

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See detailMyostatin and insulin growth factor 1 are biomarkers of muscle strength, muscle mass, and mortality in hemodialysis patients
Delanaye, Pierre ULiege; Bataille, P; Quinonez, K et al

in Osteoporosis International (2019), 30(S2), 270

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See detailDiagnostic différentiel des kystes rénaux : importance de l'approche génétique
GHUYSEN, Camille ULiege; Neuville, Marie ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Revue Médicale de Liège (2019), 74(11), 580-585

The incidental finding of renal cysts is a common clinical situation given their high prevalence (~ 50 % after the age of 50) and the continuous improvement of abdomen imaging. Diagnosis is central to ... [more ▼]

The incidental finding of renal cysts is a common clinical situation given their high prevalence (~ 50 % after the age of 50) and the continuous improvement of abdomen imaging. Diagnosis is central to appropriately dictate the management of the patient. During the diagnostic work-up, it is important to consider (i) the aspect of the cysts, (ii) their number, (iii) and their location, as well as (iv) the age of the patient and his/her personal and familial medical history, (v) the presence of extra-renal manifestations, (vi) and the renal function (including the urinary sediment). Starting from an atypical clinical case characterized by a rapidly evolving chronic kidney disease associated with bilateral renal cysts, we review the classical diagnostic work-up of kidney cysts. As a conclusion, we propose a diagnostic algorithm including both acquired and hereditary nephropathies. [less ▲]

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See detailModification of potassium in dialysate: impact on per-dialytic plasma potassium concentrations and electrocardiograms.
DELANAYE, Pierre ULiege; Krzesinski, François; DUBOIS, Bernard ULiege et al

in Nephrology Dialysis Transplantation (2019)

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