References of "Jaspar, Mathieu"
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See detailFatigue-related risk perception among emergency physicians working extended shifts.
Berastegui, Pierre ULiege; Jaspar, Mathieu ULiege; Ghuysen, Alexandre ULiege et al

E-print/Working paper (in press)

There is a growing body of studies indicating that extended shift duration has an adverse effect on fatigue, consequently leading to reduced work performance and higher risk of accident. Following modern ... [more ▼]

There is a growing body of studies indicating that extended shift duration has an adverse effect on fatigue, consequently leading to reduced work performance and higher risk of accident. Following modern fatigue risk management systems (FRMS), acceptable performance could be maintained by the mobilization of appropriate mitigation strategies. However, the effective deployment of such strategies assume that workers are able to assess their own level of fatigue-related impairments. In this study, we sought to determine whether emergency physicians’ subjective feelings of sleepiness could provide accurate knowledge of actual fatigue-related impairments while working extended shifts. We conducted a prospective observational study with a within-subjects repeated measures component. We collected sleep logs, sleepiness ratings and reaction times on a Psychomotor Vigilance Task (PVT) at different time points during shifts. Our results show that the PVT is sensitive to sleep loss and fatigue, with a 10% increase in mean reaction time across the shift. Subjective sleepiness, however, showed no significant association with time since awakening and was not a significant predictor of PVT performance. Our results are consistent with experimental studies showing that individuals tend to underestimate fatigue-related impairments when sleep deprived or functioning under adverse circadian phase. The discrepancy between subjective sleepiness and actual fatigue-related impairments may give workers the illusion of being in control and hinder the deployment of mitigation strategies. Further research is needed to determine the relative weight of circadian phase shifting and cumulative sleep deprivation in the decline of self-knowledge in extended shifts. [less ▲]

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See detailInformal fatigue-related risk management in the emergency department: a trade-off between doing well and feeling well?
Berastegui, Pierre ULiege; Jaspar, Mathieu ULiege; Ghuysen, Alexandre ULiege et al

E-print/Working paper (in press)

The effect of shift work on health and safety has long been a concern of public authorities, and increasingly stringent directives have been issued over the past decades. However, there are evidences that ... [more ▼]

The effect of shift work on health and safety has long been a concern of public authorities, and increasingly stringent directives have been issued over the past decades. However, there are evidences that current directives still represent a hazard in some work settings by disturbing the sleep/wake regulation processes. Emergency physicians are known to be particularly vulnerable to sleep deprivation due to inconsistent shift rotation, extended duty periods and overnight calls. However, naturalistic studies have actually failed to systematically demonstrate that sleep deprivation is associated with poorer work performance in emergency physicians. The inconsistency of these results could reside in physicians’ ability to compensate for fatigue-related impairments. Our aim is to identify informal fatigue management strategies used by emergency physicians and to assess the efficiency in terms of fatigue, work performance and associated risks for physician burnout. We conducted a prospective longitudinal study with 28 emergency physicians for a total of 182 shifts. At enrolment, participants answered the Maslach Burnout Inventory and the Fatigue Management Survey. During shifts, we measured fatigue using the Psychomotor Vigilance Task and work performance using an adapted version of the Physician Achievement Review. Our results show that emergency physicians working at this public sector hospital use different types of compensatory strategies to manage fatigue-related risk, and that some of these strategies might result in a trade-off between work performance and occupational burnout. We propose further considerations for the implementation and follow-up of a fatigue risk management system in the emergency department. [less ▲]

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See detailAging reduces the circadian modulation of cortical reactivity during sleep loss and modifies its link with cognition
Gaggioni, Giulia ULiege; Ly, Julien; Muto, Vincenzo ULiege et al

in Neurobiology of Aging (2019), in press

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See detailNew spectral analysis method to identify trait-like features in NREM sleep power spectra
Hammad, Grégory ULiege; Muto, Vincenzo ULiege; Gaggioni, Giulia ULiege et al

Conference (2018, September 26)

Introduction: Variability among individuals in sleep/wake biology and behaviour is pervasive. Sleep/wake-related variability involves individual trait-like features (ITLF). In order to study ITLF, we ... [more ▼]

Introduction: Variability among individuals in sleep/wake biology and behaviour is pervasive. Sleep/wake-related variability involves individual trait-like features (ITLF). In order to study ITLF, we developed an advanced spectral analysis method (ASAM) to compare in a systematic and reproducible way 3 features of NREM power spectra (PS). As sleep spindles (SS) have been reported several times to be an important ITLF, we focused on a broad range of sigma activity (10 − 18Hz). Methods: The ASAM is composed of three main steps. First, EEG sleep recording is preprocessed and the NREM PS is computed for each channel of interest. Second, three characteristic features from the NREM PS related to sigma peak activity are extracted: magnitude, peak location and standard deviation. Third, the intra-individual stability and the inter-individual variability of these features, as well as the influence of sleep perturbations, are statistically tested using the Intra-Class Correlation (ICC) coefficient and the Wald Z-test. The performance of the ASAM was assessed using different polysomnography-derived sleep recordings from 16 healthy young male subjects (18-30 years). For each subject, these recordings were acquired in 5 different “sleep contexts”: the acquisition was varied from 4h to 12h and was performed at different circadian phases. Results: All three features of sigma activity (magnitude, peak location and its standard deviation) were recognized as important ITLFs (ICC = 0.74, 0.94 and 0.63 respectively). Furthermore, the inter-individual variability of these three features was significant different from zero (Wald Z-test ps < 0.05). Conclusion: Three aspects of NREM PS sigma activity are recognized as important ITLFs. It is also showed that even though these features changed according to sleep context, they remained specific to the individuals. Establishing the trait-specific nature of variability in sleep/wake parameters could elucidate genetic mechanisms. [less ▲]

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See detailFatigue‐related risk management in the emergency department: a focus‐group study
Berastegui, Pierre ULiege; Jaspar, Mathieu ULiege; GHUYSEN, Alexandre ULiege et al

in Internal and Emergency Medicine (2018)

Fatigue has major implications on both patient safety and healthcare practitioner’s well-being. Traditionally, two approaches can be used to reduce fatigue-related risk: reducing the likelihood of a ... [more ▼]

Fatigue has major implications on both patient safety and healthcare practitioner’s well-being. Traditionally, two approaches can be used to reduce fatigue-related risk: reducing the likelihood of a fatigued operator working (i.e. fatigue reduction), or reducing the likelihood that a fatigued operator will make an error (i.e. fatigue proofing). Recent progress mainly focussed on fatigue reduction strategies such as reducing work hours. Yet it has to be recognized that such approach has not wholly overcome the experience of fatigue. Our purpose is to investigate individual proofing and reduction strategies used by emergency physicians to manage fatigue-related risk. 25 emergency physicians were recruited for the study. Four focus groups were formed which consisted of an average of six individuals. Qualitative data were collected using a semi-structured discussion guide unfolding in two parts. First, the participants were asked to describe how on-the-job fatigue a ected their e ciency at work. A mind map was progressively drawn based upon the participants’ perceived effects of fatigue. Second, participants were asked to describe any strategies they personally used to cope with these effects. We used inductive qualitative content analysis to reveal content themes for both fatigue effects and strategies. Emergency physicians reported 28 fatigue effects, 12 reduction strategies and 21 proofing strategies. Content analysis yielded a further classification of proofing strategies into self-regulation, task re-allocation and error monitoring strategies. There is significant potential for the development of more formal processes based on physicians’ informal strategies. [less ▲]

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See detailEmergency Medical Services: When Fatigue Becomes The Norm.
Berastegui, Pierre ULiege; Jaspar, Mathieu ULiege; GHUYSEN, Alexandre ULiege et al

Conference (2017, June 27)

BACKROUND: Emergency Medical Services (EMS) routinely work at the very limit of their capacity due to growing emergency rooms visits and residents’ shortage. In this context, EMS workers are regularly ... [more ▼]

BACKROUND: Emergency Medical Services (EMS) routinely work at the very limit of their capacity due to growing emergency rooms visits and residents’ shortage. In this context, EMS workers are regularly asked to work more than 10 hours a day, on varying shifts and with short recuperation breaks. Two approaches can be used to reduce fatigue-related risk: reducing the likelihood a fatigued operator is working (i.e. fatigue reduction), or reducing the likelihood a fatigued operator will make an error (i.e. fatigue proofing). In Emergency Medical Services, formal risk control mainly focuses on reduction strategies such as reducing work hours while proofing strategies develops as an implicit element of the safety system. OBJECTIVE: Our purpose is to identify individual proofing and reduction strategies used by emergency residents and to investigate how they relate to fatigue, performance and patient safety indicators. METHODS: First, we conducted 4 focus-group sessions with a total of 25 EMS residents to elicit perceived consequences of fatigue and strategies used to cope with them. Focus group results were used to design a questionnaire assessing how often EMS residents personally used any of the strategies reported during sessions. Second, we administered the questionnaire to a larger sample and conducted a prospective observational study with a repeated within-subjects component. A total of 35 EMS residents participated in the study for a total of 200 shifts analyzed. We gathered sleep diaries, subjective sleepiness, reaction time, self-reported medical errors and performance ratings at different time point during both day and night shift using an android-based application. Sleep time and activity levels were confirmed using wrist actigraphy. DISCUSSION: We will discuss what can be drawn from our results in terms of individual and collective resilience processes with a focus on the potential for implementation of more formal processes at a system level.  [less ▲]

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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULiege; Simon, Jessica ULiege; Bahri, Mohamed Ali ULiege et al

Poster (2017, March 23)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

Detailed reference viewed: 48 (2 ULiège)
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See detailIMPACT OF IMAGE BRIGHTNESS REDUCTION ON PERCEIVED QUALITY OF 3D EXPERIENCE FOR 3D CINEMA SPECTATORS
Loock, Severin; Grogna, David ULiege; Jaspar, Mathieu ULiege et al

in International Conference on 3D Imaging (IC3D) (2017)

3D movies are calibrated to meet a certain screen bright- ness standard. Therefore, what would be the consequences on the quality of the 3D experience for spectators watching a 3D movie when movie ... [more ▼]

3D movies are calibrated to meet a certain screen bright- ness standard. Therefore, what would be the consequences on the quality of the 3D experience for spectators watching a 3D movie when movie theaters do not respect this standard? First, we attempted to better understand which factors were important for a spectator by conducting an experiment where participants watched a 3D movie and filled out an exploratory questionnaire. Then, we aimed to investigate the link between image brightness loss and the quality of the 3D experience as perceived by the spectator. First results show no perceived difference in the quality of the 3D experience between a nor- mal brightness and a brightness decreased by 10% for four factors, i.e. (1) the appreciation of the movie, (2) the con- tent of the movie, (3) the 3D quality of the movie, and (4) the quality of the 3D experience in general. [less ▲]

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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULiege; Simon, Jessica ULiege; Bahri, Mohamed Ali ULiege et al

in Cortex: A Journal Devoted to the Study of the Nervous System and Behavior (2016), 85

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailAge-related differences in the dynamics of cortical excitability and cognitive inhibition during prolongedwakefulness
Gaggioni, Giulia ULiege; Chelllappa, S.; Ly, J. et al

Conference (2016, September)

Detailed reference viewed: 121 (15 ULiège)
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See detailLocal modulation of human brain responses by circadian rhythmicity and sleep debt
Muto, Vincenzo ULiege; Jaspar, Mathieu ULiege; Meyer, Christelle et al

in Science (2016), 351(6300),

Detailed reference viewed: 284 (53 ULiège)
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See detailEffects of aging on task- and stimulus-related cerebral attention networks
Kurth, Sophie ULiege; Majerus, Steve ULiege; Bastin, Christine ULiege et al

in Neurobiology of Aging (2016), 44

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]

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See detailSeasonal variation in human COGNITIVE brain responses
Meyer, Christelle; Muto, Vincenzo ULiege; Jaspar, Mathieu ULiege et al

Poster (2016, June)

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See detailThe impact of dopaminergic genes on inhibitory processes and cognitive control.
Jaspar, Mathieu ULiege; Muto, Vincenzo ULiege; Meyer, Christelle et al

Poster (2016, March 18)

Detailed reference viewed: 37 (7 ULiège)
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See detailModulating effect of COMT genotype on brain areas underlying cognitive control processes
Collette, Fabienne ULiege; Jaspar, Mathieu ULiege

Conference (2016, March 18)

Catechol-O-methyltransferase (COMT) is an important enzyme which degrades catecholamines, such dopamine, notably in the prefrontal cortex. A large number of studies reported an effect on executive ... [more ▼]

Catechol-O-methyltransferase (COMT) is an important enzyme which degrades catecholamines, such dopamine, notably in the prefrontal cortex. A large number of studies reported an effect on executive functioning of COMT genotype, each genotype being associated with a different COMT enzymatic activity. In this talk, I will present some of our studies that explored the neural substrates of inhibitory processes according to COMT genotype. These studies showed that COMT genotype modulates the brain-level implementation of proactive and reactive inhibitory control processes. We will discuss how individual differences related to DA-mediated signaling can differently influence inhibition in function of the form of cognitive control required by the task, but also regarding the specific inhibitory mechanism induced by the task. [less ▲]

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See detailSeasonality in human cognitive brain responses
Meyer, Christelle ULiege; Muto, Vincenzo ULiege; Jaspar, Mathieu ULiege et al

in Proceedings of the National Academy of Sciences of the United States of America (2016)

Detailed reference viewed: 160 (22 ULiège)
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See detailAutomatic artifacts and arousals detection in whole-night sleep EEG recordings
Coppieters't Wallant, Dorothe ULiege; Muto, Vincenzo ULiege; Gaggioni, Giulia ULiege et al

in Journal of Neuroscience Methods (2016), 258

In sleep electroencephalographic (EEG) signals, artifacts and arousals marking are usually part of the processing. This visual inspection by a human expert has two main drawbacks: it is very time ... [more ▼]

In sleep electroencephalographic (EEG) signals, artifacts and arousals marking are usually part of the processing. This visual inspection by a human expert has two main drawbacks: it is very time consuming and subjective. To detect artifacts and arousals in a reliable, systematic and reproducible automatic way, we developed an automatic detection based on time and frequency analysis with adapted thresholds derived from data themselves. The automatic detection performance is assessed using 5 statistic parameters, on 60 whole night sleep recordings coming from 35 healthy volunteers (male and female) aged between 19 and 26. The proposed approach proves its robustness against inter- and intra-, subjects and raters’ scorings, variability. The agreement with human raters is rated overall from substantial to excellent and provides a significantly more reliable method than between human raters. Existing methods detect only specific artifacts or only arousals, and/or these methods are validated on short episodes of sleep recordings, making it difficult to compare with our whole night results. The method works on a whole night recording and is fully automatic, reproducible, and reliable. Furthermore the implementation of the method will be made available online as open source code. [less ▲]

Detailed reference viewed: 88 (40 ULiège)