References of "Jacquemin, Denise"
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See detailCarcinome spinocellulaire cutané localement avancé et métastatique traité par cemiplimab.
Vanhakendover, Louise ULiege; LEBAS, Eve ULiege; Libon, Florence ULiege et al

in Revue medicale de Liege (2019), 74(7-8), 436-440

The treatment of locally advanced or metastatic cutaneous squamous cell carcinoma (cSCC) essentially relies on surgery and eventually radiotherapy of the treated site and afferent lymph nodes ... [more ▼]

The treatment of locally advanced or metastatic cutaneous squamous cell carcinoma (cSCC) essentially relies on surgery and eventually radiotherapy of the treated site and afferent lymph nodes. Unfortunately, some cases are no candidates for surgery or radiotherapy and a systemic treatment may be indicated. Chemotherapies are only partially efficacious and associated with potential toxicities. A recent study evaluating the efficacy and tolerance of cemiplimab, a PD1 antagonist for locally advanced and metastatic cSCC demonstrated an objective response rate of 49 % and 47 % for locally advanced and metastatic cSCC, while maintaining a response of at least 6 months of 63 % and 60 %, respectively. We present a clinical case of a patient with a locally advanced cSCC of the forehead with bone resorption and cervical lymphadenopathies. After failure of multiple surgical interventions and radiotherapies, he responded partially to cemiplimab immunotherapy with a good safety profile. [less ▲]

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See detailPatient avec un carcinome spinocellulaire cutané localement avancé et métastatique traité par Cemiplimab
Vanhakendover, Louise ULiege; LEBAS, Eve ULiege; Libon, Florence ULiege et al

in Revue Médicale de Liège (2019), (74), 1-5

Le traitement du carcinome spinocellulaire cutané (cSCC) localement avancé et/ou métastasique repose essentiellement sur la chirurgie et, éventuellement, une radiothérapie de la zone chirurgicale et de ... [more ▼]

Le traitement du carcinome spinocellulaire cutané (cSCC) localement avancé et/ou métastasique repose essentiellement sur la chirurgie et, éventuellement, une radiothérapie de la zone chirurgicale et de l’aire ganglionnaire afférente. Malheureusement, certains cas ne sont plus opérables ou accessibles à la radiothérapie et un traitement systémique est alors indiqué. Les chimiothérapies sont peu efficaces et potentiellement toxiques. Une étude récente évaluant l’efficacité et la tolérance du cemiplimab, un antagoniste PD1, dans les cSCC localement avancés et métastasiques démontre une réponse objective confirmée de 49 % et de 47 %, respectivement, avec un maintien de la réponse d’au moins 6 mois de 63 % et de 60 %, respectivement. Nous présentons le cas d’un patient avec un cSCC localement avancé au niveau du front, avec effraction osseuse et adénopathies cervicales, ayant eu de multiples chirurgies et radiothérapies. Il a présenté une réponse partielle au cemiplimab avec un profil de tolérance satisfaisant. [less ▲]

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See detailAdmission des enfants au Centre des Brules du CHU de Liege : etude retrospective epidemiologique et clinique.
TAXHET, Arnaud ULiege; Jacquemin, Denise ULiege

in Revue Médicale de Liège (2017), 72(4), 187-192

In Belgium, epidemiological data are rare, and most often extrapolated, for burn injuries, especially in the pediatrician population. The purpose of this study was to obtain data for the pediatrician ... [more ▼]

In Belgium, epidemiological data are rare, and most often extrapolated, for burn injuries, especially in the pediatrician population. The purpose of this study was to obtain data for the pediatrician population in Liege. It retrospectively analyzed burns in the pediatrician population treated in the Burn Center Liege, during five years. Overall 844 patients (379 girls, 465 boys) were included for the first part of this study (burns localization and etiology, sex ratio, age), with a mean age of 4.2 years old. Over this five years period, the number of pediatrician patients admitted increased by 47 %. The most frequent burn site was the hand (32.8 %) and the burn cause was scalds (49.4 %). For the second part of the study (hospitalisation and treatment duration, hypertrophic scars), 712 patients were included (321 girls and 391 boys). Hypertrophic scars were found in 9.27 %. Our results show that burn injury is more often found in boys, and this injury occurs mostly in children under 5 years of age. [less ▲]

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See detailAlkali injuries may lead to errors of diagnosis and mistreatment (161)
JACQUEMIN, Denise ULiege

Conference (2015, September)

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See detailPurpura fulminans secondaire à une méningococcémie
De Roover, Christophe ULiege; JACQUEMIN, Denise ULiege

in Revue Médicale de Liège (2014), 69(3), 117-118

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See detailA methodological evaluation of volumetric measurement techniques including three-dimensional imaging in breast surgery
HOEFFELIN, Harry; JACQUEMIN, Denise ULiege; Defaweux, Valérie ULiege et al

in BioMed Research International (2014), 2014

Breast surgery currently remains very subjective and each intervention depends on the ability and experience of the operator. To date, no objective measurement of this anatomical region can codify surgery ... [more ▼]

Breast surgery currently remains very subjective and each intervention depends on the ability and experience of the operator. To date, no objective measurement of this anatomical region can codify surgery. In this light, we wanted to compare and validate a new technique for 3D scanning (LifeViz 3D) and its clinical application. Materials and methods. - We tested the use of the 3D LifeViz system (Quantificare) to perform volumetric calculations in various settings ("in situ" in cadaveric dissection, of control prostheses and in clinical patients) and we compared this system to other techniques (CT scanning and Archimedes' principle) under the same conditions. Results. - We were able to identify the benefits (feasibility, safety, portability, low patient stress) and limitations (underestimation of the “in situ” volume, subjectivity of contouring, and patient selection) of the LifeViz 3D system, concluding that the results are comparable with other measurement techniques. Conclusion. - The prospects of this technology seem promising in numerous applications in clinical practice to limit the subjectivity of breast surgery. [less ▲]

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See detailLa prise en charge précoce du patient brûlé en kinésithérapie.
REMY, Christophe ULiege; JACQUEMIN, Denise ULiege; MASSAGE, Patrick ULiege et al

in Réanimation (2013), 22(5), 543-551

Profonde ou atteignant une large surface cutanée, la brûlure engendre souvent des séquelles fonctionnelles impor- tantes. Ces séquelles se constituent précocement et ont des répercussions non négligeables ... [more ▼]

Profonde ou atteignant une large surface cutanée, la brûlure engendre souvent des séquelles fonctionnelles impor- tantes. Ces séquelles se constituent précocement et ont des répercussions non négligeables sur la qualité de vie des patients. Pour les prévenir et les traiter, le kinésithérapeute est un acteur important dans leur prise en charge précoce. Il devra évaluer les fonctions respiratoires, musculaires, orthopédiques mais également cutanées. L’objectif est de définir des stratégies de traitement faisant appel à des techniques de kinésithérapie classiques adaptées à cette pathologie spécifique. [less ▲]

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See detailHow a topic treatment can worsen the situation: A new type of iatrogenic "burn".
REMY, Christophe ULiege; LAUNGANI, Alexis; MAGNETTE, André ULiege et al

Poster (2011, September 15)

Many studies showed the high frequency of cutaneous intolerances to ketoprofen but in 85 percent of them, these are photoallergies. The Belgian dematologists published an article a few years ago ... [more ▼]

Many studies showed the high frequency of cutaneous intolerances to ketoprofen but in 85 percent of them, these are photoallergies. The Belgian dematologists published an article a few years ago, demonstrating that it is important to avoid prescription of topical ketoprofen during sunny periods. Our experience showed the risks of lesions without exposing to UV radiations. These gels, on free sale, are widely used by the public. In physiotherapy, they are also regularly used by practitioners who rarely know the risk of photoallergies and often ignore the possibility of burn. In France, many questions have already been asked about these gels and they were even the object of a temporary withdrawal. [less ▲]

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See detailCouverture de pertes de substance du tibia distal par lambeau pedicule perforant en helice : deux cas cliniques.
Bous, Aurélie ULiege; Ronsmans, C.; NIZET, Jean-Luc ULiege et al

in Annales de Chirurgie Plastique Esthetique (2011)

Distal lower leg soft tissue defect is frequently a challenge to repair, particularly on the tibial crest. The coverage of this kind of lesion has some limitations because of regional minimal blood supply ... [more ▼]

Distal lower leg soft tissue defect is frequently a challenge to repair, particularly on the tibial crest. The coverage of this kind of lesion has some limitations because of regional minimal blood supply and paucity of local soft-tissue flaps. The perforator pedicled propeller (PPP) method tries to find a new place in lower leg reconstruction in bringing similar tissues at the recipient site and avoiding long and difficult free flap transfer or muscular sacrifice. The authors report on the use of PPP method for a tibial crest exposure after trauma and for a soft tissue defect with osteomyelitis on the tibial crest. [less ▲]

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See detailShoulder function after latissimus dorsi transfer in breast reconstruction
Forthomme, Bénédicte ULiege; Heymans, Olivier; Jacquemin, Denise ULiege et al

in Clinical Physiology and Functional Imaging (2010), 30(6), 406-412

Background ⁄ Aims: Latissimus dorsi (LD) transfer in the case of breast reconstruction remains frequently used because this muscle provides a good size source of tissue in reconstructive surgery. Given ... [more ▼]

Background ⁄ Aims: Latissimus dorsi (LD) transfer in the case of breast reconstruction remains frequently used because this muscle provides a good size source of tissue in reconstructive surgery. Given that, the consequences of the LD removal on shoulder function and the actual loss of maximal strength developed must be investigated. Methods: Twenty women (50 ± 7Æ5 years old) were evaluated before surgery, 3 and 6 months after an unilateral transfer of a pedicle flap of LD muscle used for breast reconstruction. Women performed a bilateral shoulder isokinetic assessment [for the internal rotators (IRs) and external rotators and for the abductor and adductor (ADD) muscles] allowing the establishment of bilateral muscular deficit status and the study of agonist ⁄ antagonist muscle ratios. The algofunctional and clinical status of the shoulders was analysed by the means of Constant score and specific shoulder clinical tests. The women did not perform any specific strengthening of muscle shoulder after surgery. Results: The isokinetic assessment showed a muscle weakness 3 and 6 months after LD transfer, mainly on the ADDs (33 ± 9% at 6 months) and on the IRs (16 ± 11% at 6 months). The Constant score significantly decreased after surgery on the operated shoulder. Women with a Constant score impairment showed pain during specific shoulder clinical tests. We also found a correlation between Constant score impairment and internal rotators weakness or rotator muscle imbalance. Conclusion: Given those results, we could advocate a specific shoulder strengthening after LD transfer, focused mainly on the IRs and ADDs. [less ▲]

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See detailRisk factors for major joints heterotopic ossification after thermal injury
REMY, Christophe ULiege; COLMAN, David ULiege; LEDOUX, Didier ULiege et al

in Burns: Journal of the International Society for Burn Injuries (2009)

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See detailAnalgésie par blocs nerveux périphériques continus dans le cadre des soins de plaies cutanées
Lecoq, Jean-Pierre; Jacquemin, Denise ULiege; Lamy, Maurice ULiege et al

in Revue Médicale de Liège (2008), 63(1), 3-16

We present the case of a patient with a circumferential venous ulcer at the level of the calf. She is hospitalized for surgical treatment by continuous aspiration dressing and coverage with skin graft ... [more ▼]

We present the case of a patient with a circumferential venous ulcer at the level of the calf. She is hospitalized for surgical treatment by continuous aspiration dressing and coverage with skin graft. This patient presents a history of chronic pain, on which classical medications have few effects and are accompanied by side effects. After discussion with the patient, a double continuous peripheral nervous block (femoral and sciatic nerve) is set up to improve the tolerance to wound dressing. This technique presents favorable antalgic results. The indications and the different techniques of block performance (by electrostimulation or echo-guided) are described. The infectious risks related to the presence of catheter near cutaneous wounds are clarified according to recent data of literature. The relevance of these techniques in correlation with the development of chronic pain and on the trophicity of the wounds are also discussed. [less ▲]

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See detailDelayed reepithelialization and scarring deregulation following drug-induced toxic epidermal necrolysis.
Paquet, Philippe ULiege; Jacob, E.; Quatresooz, Pascale ULiege et al

in Burns: Journal of the International Society for Burn Injuries (2007), 33(1), 100-4

A 51-year-old Caucasian woman developed severe drug-induced toxic epidermal necrolysis (TEN) due to allopurinol. The withdrawal of the culprit drug was unfortunately delayed, and dramatic retardation of ... [more ▼]

A 51-year-old Caucasian woman developed severe drug-induced toxic epidermal necrolysis (TEN) due to allopurinol. The withdrawal of the culprit drug was unfortunately delayed, and dramatic retardation of reepithelialization was observed. At that stage of disease evolution, an inflammatory cell infiltrate was present in the dermis. Coverage of eroded lesions by frozen cultured keratinocyte allografts failed to hasten reepithelialization compared to ungrafted sites. This unusual protracted TEN evolution was followed by the development of extensive hypertrophic and keloid scars. Several biopsies were taken over 6 months. The histologic presentation of the grafted and ungrafted eroded scar tissues looked similar. Both the number and size of the Factor XIIIa-positive dermal dendrocytes, as well as the number of alpha-actin-positive myofibroblasts showed a marked increase between weeks 2 and 12 after grafting. They were reduced after 6 months when the scarring process was stabilized. alpha1 [IV] collagen was never expressed over the eroded scars. Similar to burn patients, delayed reepithelialization might be a risk factor for abnormal scarring in TEN. Cultured keratinocyte allograft apparently offered no improvement in reepithelialization and did not prevent abnormal scarring in this TEN patient. [less ▲]

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See detailLe cas clinique du mois. Carcinome basocellulaire pédicule et pigmenté: une présentation inhabituelle.
Azzam, C.; Arrese Estrada, Jorge ULiege; Jacquemin, Denise ULiege et al

in Revue Médicale de Liège (2006), 61(9), 614-6

Basal cell carcinomas (BCC) are the most common malignant neoplasms in humans. Clinical misdiagnoses are not uncommon. These cancers are classified according to their histological and clinical ... [more ▼]

Basal cell carcinomas (BCC) are the most common malignant neoplasms in humans. Clinical misdiagnoses are not uncommon. These cancers are classified according to their histological and clinical characteristics which exhibit distinct malignant behaviours. It is important to be aware of the different clinical presentations both for the accurate diagnosis and tumour management. We report the case of a 78-year-old man, who presented an unusual pedunculated and pigmented BCC. This combined aspect is rarely encountered. [less ▲]

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See detailRupture of a Thoracic Aneurysm in the Left Bronchus
SCHILS, F.; Deprez, A. F.; CREEMERS, Etienne ULiege et al

in Acta Chirurgica Belgica (2000), 100(2), 74-6

Aortobronchic fistula is a very unusual complication of thoracic aneurysm. We report the case of a 71-year old man with rupture of a thoracic aortic aneurysm in the left main bronchus. The patient had ... [more ▼]

Aortobronchic fistula is a very unusual complication of thoracic aneurysm. We report the case of a 71-year old man with rupture of a thoracic aortic aneurysm in the left main bronchus. The patient had suffered a car crash fifteen years ago, without any evidence of aortic rupture at the time. Thereafter, he developed an aortic isthmic dilation (36 mm in diameter). The patient suffered from long standing pulmonary insufficiency and emphysema and was admitted several times on an urgent basis for acute dyspnea. During an hospitalization for respiratory distress, he presented haemoptysis and left lung hyperinflation secondary to partial fistulization and extrinsic compression of the main left bronchus. Isthmic aortic resection and prosthetic grafting was performed and the left main bronchus was closed by an autologous pericardial patch. Ten days later, following an air-leak from the bronchial closure, a transposed latissimus dorsi flap was used by the plastic surgeon to repair the defect. Nevertheless, the patient died from multisystemic failure six weeks later. [less ▲]

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