References of "Hindré, François"
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See detailHybrid Gd3+/cisplatin cross-linked polymer nanoparticles enhance platinum accumulation and formation of DNA adducts in glioblastoma cell lines
Lajous, Hélène ULiege; Riva, Raphaël ULiege; Lelièvre, Bénédicte et al

in Biomaterials Science (2018), 6(9), 2386-2409

Glioblastoma is the most frequent and aggressive primary malignant tumor of the central nervous system with a gloomy prognosis. Platinum derivatives and one among them, cisplatin, exhibited promising ... [more ▼]

Glioblastoma is the most frequent and aggressive primary malignant tumor of the central nervous system with a gloomy prognosis. Platinum derivatives and one among them, cisplatin, exhibited promising results when locally administered into the brain of glioblastoma bearing rats. Nanovectorization of anticancer agents through polymeric nanoparticles may even promote drug accumulation within cells, thus concen- trating the drug efficiently at its target. Anchorage of gadolinium complexes on the corona of such smart drug delivery systems could further allow magnetic resonance imaging (MRI) monitoring of the nanoplat- form biodistribution in the damaged parenchyma and its therapeutic benefit. For this purpose, a biocom- patible amphiphilic triblock copolymer, made of degradable polyester and polycarbonate and bioelimin- able polyethylene oxide (PEO), was synthesized by successive ring-opening polymerizations. After micelli- zation in water, gadolinium complexes were grafted onto the PEO micelle corona and the carboxylate functions, located at the surface of the micelle’s core, were able to cross-link with Pt(II) complexes. A macromolecular prodrug was therefore recovered in which more than one third of the carboxylate func- tions were linked to a platinum atom. By this strategy, stable cisplatin cross-linked nanoparticles were for- mulated with a mean size in the range of 100.63 ± 12.04 nm consistent with biological investigations. Relaxometry measurements both in water and in plasma at 7 T, 25 °C, confirmed the intrinsic potential of these hybrid nanoparticles as alternative MRI contrast agents with a substantial increase in the r2/r1 ratio by a factor of 3.3 and 2.7, respectively, compared to the conventional low molar mass Gd-DTPA. As a result, their infusion within the striatum of glioblastoma-bearing mice resulted in a hypersignal on T2- weighted MR images that persisted over time. Ultimately, the formulated prodrug exhibited up to 50-fold increased accumulation in human glioblastoma cell lines and up to 32-fold enhanced subsequent Pt- DNA adduct formation in comparison with free cisplatin, thus supporting the potential of this innovative bimodal tool for further applications. [less ▲]

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See detail68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular Carcinoma: Radiolabeling and Preliminary In Vivo Rat Studies
Verger, Elise ULiege; Drion, Pierre ULiege; MEFFRE, Geneviève ULiege et al

in PLoS ONE (2016)

This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain ... [more ▼]

This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain a unique theranostic vector for the treatment of Hepatocellular Carcinoma. METHODS: Optimal labeling conditions and composition of freeze-dried kits were defined by monitoring the radiochemical purity while varying several parameters. In vitro stability studies were carried out, as well as an in vivo biodistribution as a preliminary approach with the intra-arterial injection of 68Ga radiolabeled SBMP into the hepatic artery of DENA-induced rats followed by PET/CT imaging. RESULTS: Kits were optimized for 188Re and 68Ga with high and stable radiochemical purity (>95% and >98% respectively). The in vivo preliminary study was successful with more than 95% of activity found in the liver and mostly in the tumorous part. CONCLUSION: SBMP are a promising theranostic agent for the Selective Internal Radiation Therapy of Hepatocellular carcinoma [less ▲]

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See detail188Re and 68Ga radiolabeled Starch-Based Microparticles as potential theranostic radiopharmaceutical for Hepatocellular Carcinoma
Verger, Elise ULiege; Drion, Pierre ULiege; MEFFRE, Geneviève ULiege et al

in Journal of Nuclear Medicine (2016, May 01), 57(suppl. 2),

The SBMP as a unique vector is a promising theranostic agent for the SIRT of HCC.

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See detailMicroparticules à base d’amidon radiomarquées au 188Re et 68Ga comme agent théranostique pour la radiothérapie interne sélective du carcinome hépatocellulaire
Verger, Elise ULiege; Drion, Pierre ULiege; MEFFRE, Geneviève ULiege et al

in Médecine Nucléaire: Imagerie Fonctionnelle et Métabolique (2016, May), 40(3), 182

Les microparticules SBMP, en étant capable d'être radiomarquées rapidement, de manière reproductible, sous forme de kits prêt-à-l‘emploi, par du 188Re et du 68Ga, se révèlent être un outil théranostique ... [more ▼]

Les microparticules SBMP, en étant capable d'être radiomarquées rapidement, de manière reproductible, sous forme de kits prêt-à-l‘emploi, par du 188Re et du 68Ga, se révèlent être un outil théranostique prometteur pour le traitement du carcinome hépatocellulaire. [less ▲]

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See detailA theranostic tool for Hepatocellular carcinoma: the Starch-Based Microparticles
Verger, Elise ULiege; Cikankowitz, Annabelle; Bouvier, Antoine et al

Conference (2015)

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See detailRadiolabelling of starch microparticles with Rhenium-188 for hepatocellular carcinoma’s therapy
Verger, Elise ULiege; Bouvier, Antoine; Benoit, Jean-Pierre et al

in European Journal of Nuclear Medicine and Molecular Imaging (2014, October), 41(Supplement 2), 443-444

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See detailRadiomarquage au 188Re des microparticules à base d’amidon pour la thérapie du carcinome hépatocellulaire
Verger, Elise ULiege; Bouvier, Antoine; Benoit, Jean-Pierre et al

Poster (2014)

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See detailStarch based microparticles radiolabelling with 99mTc and 188Re for diagnostic and therapy of Hepatocellular carcinoma
Verger, Elise ULiege; Cikankowitz, Annabelle; Bouvier, Antoine et al

Conference (2014)

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See detailNanomédecines et micromédecines pour la radiothérapie vectorisée appliquée au traitement du Carcinome Hepato-Cellulaire
Verger, Elise ULiege; Lacoeuille, Franck; Couturier, Olivier et al

Poster (2013)

Detailed reference viewed: 26 (6 ULiège)
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See detailNanomedicines and micromedicines for vectorised radiotherapy of Hepatocellular Carcinoma
Verger, Elise ULiege; Belloche, Camille; Cikankowitz, Annabelle et al

Poster (2013)

Detailed reference viewed: 37 (4 ULiège)