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See detailIntegrated backscatter for the in vivo quantification of supraphysiological vitamin D(3)-induced cardiovascular calcifications in rats.
Roosens, Bram; Droogmans, Steven; Hostens, Jeroen et al

in Cardiovascular Toxicology (2011), 11(3), 244-52

Cardiovascular calcifications are frequently found in the aging population and are independent predictors of future cardiovascular events. Integrated backscatter (IB) of ultrasound reflectivity can easily ... [more ▼]

Cardiovascular calcifications are frequently found in the aging population and are independent predictors of future cardiovascular events. Integrated backscatter (IB) of ultrasound reflectivity can easily quantify calcifications. For this purpose, 30 male Wistar rats received 25,000 IU/kg/day of vitamin D(3) (group 1, n = 8), 18,800 IU/kg/day (group 2, n = 8), or injections with the vehicle only (group 3, n = 14), for 10 weeks. Echocardiographic calibrated IB (cIB) was measured and calculated at baseline and after 10 weeks, followed by ex vivo micro-CT and histopathology of the aortic valve, ascending aorta, and myocardium. After 10 weeks, the mean cIB value of the aortic valve was significantly higher for vitamin D(3)-dosed animals compared to controls. The mean cIB value of the ascending aorta and the myocardium was also significantly higher in group 1 compared to group 3. In vivo IB results were confirmed by ex vivo micro-CT and histopathology. In conclusion, IB is a non-ionizing, feasible, and reproducible tool to quantify cardiovascular calcifications in an in vivo rat model. The integration of IB in the standard echocardiographic examination for the quantification of cardiovascular calcifications could be useful for serial evaluation of treatment efficacy and for prognosis assessment. [less ▲]

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See detailUse of contrast echocardiography in intensive care and at the emergency room.
Cosyns, Bernard; Roossens, Bram; Hernot, Sophie et al

in Current Cardiology Reviews (2011), 7(3), 157-62

Bedside echocardiography in emergency room (ER) or in intensive care unit (ICU) is an important tool for managing critically ill patients, to obtain a timely accurate diagnosis and to immediately stratify ... [more ▼]

Bedside echocardiography in emergency room (ER) or in intensive care unit (ICU) is an important tool for managing critically ill patients, to obtain a timely accurate diagnosis and to immediately stratify the risk to the patient's life. It may also render invasive monitoring unnecessary. In these patients, contrast echocardiography may improve quality of imaging and also may provide additional information, especially regarding myocardial perfusion in those with suspected coronary artery disease. This article focuses on the principle of contrast echocardiography and the clinical information that can be obtained according to the most frequent presentations in ER and ICU. [less ▲]

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See detailComparison of contrast enhanced three dimensional echocardiography with MIBI gated SPECT for the evaluation of left ventricular function
Cosyns, Bernard; Haberman, David; Droogmans, Steven et al

in Cardiovascular Ultrasound (2009), 7

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See detailSafety of ultrasound contrast agents: "Primum non nocere"?
Cosyns, Bernard; Pasquet, Agnes; Van Camp, Guy et al

in Acta Cardiologica (2009), 64(4), 547-52

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