References of "Henrotin, Yves"
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See detailFib3-3 as a biomarker for osteoarthritis in a rat model with metabolic dysregulation
de Visser, Huub; Sanchez, Christelle ULiege; Mastbergen, Simon et al

in Cartilage (in press)

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See detailA systematic review of the secretome of skeletal muscle cells
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

Poster (2019, May 03)

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease ... [more ▼]

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease, exercise or metabolic stress. [less ▲]

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See detailSécrétome des cellules musculaires squelettiques: revue systématique de la littérature
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

Conference (2019, April 04)

Présentation des résultats préliminaires d'une revue systématique en cours de rédaction portant sur le sécrétome des cellules musculaires squelettiques. L'étude du sécrétome de ces cellules pourrait ... [more ▼]

Présentation des résultats préliminaires d'une revue systématique en cours de rédaction portant sur le sécrétome des cellules musculaires squelettiques. L'étude du sécrétome de ces cellules pourrait permettre de comprendre les mécanismes liés au vieillissement mais également de permettre la découverte de biomarqueurs et de cibles thérapeutiques de certaines maladies [less ▲]

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See detailSyndecan-4 is increased in osteoarthritic knee, but nor ip or shoulder, articular hypertrophic chondrocytes
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Dubuc, Jean-Emile et al

in Osteoarthritis and Cartilage (2019, April), 27(Suppl 1), 159-160

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See detailIdentification et caractérisation de nouveaux biomarqueurs de la sarcopénie
Henrotin, Yves ULiege; Cordier, Benoit; Labasse, Alain et al

Conference (2019, April)

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See detailLa Fondation Arthrose récompense trois chercheurs
Henrotin, Yves ULiege; Mathy, Céline ULiege; MALAISE, Olivier ULiege et al

in Rhumatos (2019), 16

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See detailThe secretome of skeletal muscle cells: A systematic review
Florin, Antoine ULiege; Lambert, Cécile ULiege; Sanchez, Christelle ULiege et al

Poster (2019, February 20)

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease ... [more ▼]

This poster presents the preliminary results of a systematic review that summarized recent mass-spectrometry based proteomics discoveries of the secretome of skeletal muscle cells in response to disease, exercise or metabolic stress. [less ▲]

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See detailLes nouveaux biomarqueurs de l'arthrose
Henrotin, Yves ULiege

in Lettre du Rhumatologue (2019), 449

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See detailMolecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes.
Mobasheri, Ali; van Spil, Willem Evert; Budd, Emma et al

in Current Opinion in Rheumatology (2019), 31(1), 80-89

PURPOSE OF REVIEW: This review focuses on the molecular taxonomy of osteoarthritis from the perspective of molecular biomarkers. We discuss how wet biochemical markers may be used to understand disease ... [more ▼]

PURPOSE OF REVIEW: This review focuses on the molecular taxonomy of osteoarthritis from the perspective of molecular biomarkers. We discuss how wet biochemical markers may be used to understand disease pathogenesis and progression and define molecular endotypes of osteoarthritis and how these correspond to clinical phenotypes. RECENT FINDINGS: Emerging evidence suggests that osteoarthritis is a heterogeneous and multifaceted disease with multiple causes, molecular endotypes and corresponding clinical phenotypes. Biomarkers may be employed as tools for patient stratification in clinical trials, enhanced disease management in the primary care centres of the future and for directing more rational and targeted osteoarthritis drug development. Proximal molecular biomarkers (e.g synovial fluid) are more likely to distinguish between molecular endotypes because there is less interference from systemic sources of biomarker noise, including comorbidities. SUMMARY: In this review, we have focused on the molecular biomarkers of four distinct osteoarthritis subtypes including inflammatory, subchondral bone remodelling, metabolic syndrome and senescent age-related endotypes, which have corresponding phenotypes. Progress in the field of osteoarthritis endotype and phenotype research requires a better understanding of molecular biomarkers that may be used in conjunction with imaging, pain and functional assessments for the design of more effective, stratified and individualized osteoarthritis treatments. [less ▲]

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See detailLe syndécan-4 est un marqueur de l’hypertrophie des chondrocytes du genou arthrosique
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Dubuc, JE et al

in Revue du Rhumatisme (2018, November), 85S

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See detailLe peptide chimérique synthétique P7 réduit la douleur et protège le cartilage chez le rat souffrant d’arthrose après méniscectomie partielle et section du ligament croisé
Montjean, R; Escaich, S; Vêtu, C et al

in Revue du Rhumatisme (2018, November), 85S

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See detailGlycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo
Legrand, Catherine; Ahmed, U.; Anwar, A. et al

in Arthritis Research and Therapy (2018), 20(1), 131

Background: Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques ... [more ▼]

Background: Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms have recently been found to provide improved diagnosis and typing of early-stage arthritis of the knee, including osteoarthritis (OA), in patients. The association of glycated, oxidized, and nitrated amino acids released from the joint with development and progression of knee OA is unknown. We studied this in an OA animal model as well as interleukin-1β-activated human chondrocytes in vitro and translated key findings to patients with OA. Methods: Sixty male 3-week-old Dunkin-Hartley guinea pigs were studied. Separate groups of 12 animals were killed at age 4, 12, 20, 28 and 36 weeks, and histological severity of knee OA was evaluated, and cartilage rheological properties were assessed. Human chondrocytes cultured in multilayers were treated for 10 days with interleukin-1β. Human patients with early and advanced OA and healthy controls were recruited, blood samples were collected, and serum or plasma was prepared. Serum, plasma, and culture medium were analyzed for glycated, oxidized, and nitrated amino acids. Results: Severity of OA increased progressively in guinea pigs with age. Glycated, oxidized, and nitrated amino acids were increased markedly at week 36, with glucosepane and dityrosine increasing progressively from weeks 20 and 28, respectively. Glucosepane correlated positively with OA histological severity (r = 0.58, p < 0.0001) and instantaneous modulus (r = 0.52-0.56; p < 0.0001), oxidation free adducts correlated positively with OA severity (p < 0.0009-0.0062), and hydroxyproline correlated positively with cartilage thickness (p < 0.0003-0.003). Interleukin-1β increased the release of glycated and nitrated amino acids from chondrocytes in vitro. In clinical translation, plasma glucosepane was increased 38% in early-stage OA (p < 0.05) and sixfold in patients with advanced OA (p < 0.001) compared with healthy controls. Conclusions: These studies further advance the prospective role of glycated, oxidized, and nitrated amino acids as serum biomarkers in diagnostic algorithms for early-stage detection of OA and other arthritic disease. Plasma glucosepane, reported here for the first time to our knowledge, may improve early-stage diagnosis and progression of clinical OA. © 2018 The Author(s). [less ▲]

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See detailEFFICACY OF BIO-OPTIMISED CURCUMA EXTRACT (FLEXOFYTOL®) FOR PAINFUL KNEE OSTEOARTHRITIS: DATA FROM COPRA, A MULTICENTER RANDOMISED CONTROLLED STUDY
Henrotin, Yves ULiege; Malaise, Michel ULiege; Wittoek, R et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 790

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See detailHYALURONAN DERIVATIVE HYMOVIS® INCREASES CARTILAGE VOLUME AND TYPE II COLLAGEN TURNOVER IN OSTEOARHRITIC KNEE: DATA FROM MOKHA STUDY
Henrotin, Yves ULiege; Bannuru, R; Malaise, Michel ULiege et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 1614

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See detailProteomic analysis of osteoblasts secretome provides new insights in mechanisms underlying osteoarthritis subchondral bone sclerosis
Sanchez, Christelle ULiege; Mazzucchelli, Gabriel ULiege; Comblain, Fanny et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 894

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See detailTHE COLL2–1 PEPTIDE OF COLLAGEN TYPE II: A NEW ACTOR OF SYNOVITIS IN OSTEOARTHRITIS
Lambert, Cécile ULiege; Borderie, D; Rannou, F et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 890

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See detailGLUCOSEPANE : A NEW BIOMARKER OF THE SEVERITY OF OSTEOARTHRITIS
Rabbani, N; Ahmed, U; Lambert, Cécile ULiege et al

in Annals of the Rheumatic Diseases (2018, June), 77(supplement 2), 181

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See detailEUROVISCO Guidelines for the Design and Conduct of Clinical Trials Assessing the Disease-Modifying Effect of Knee Viscosupplementation
Henrotin, Yves ULiege; Chevalier, X.; Raman, R. et al

in Cartilage (2018)

Objectives: Hyaluronic acid viscosupplementation is a commonly used intra-articular treatment for osteoarthritis (OA). Some recent preclinical and clinical trials have demonstrated a potential for its ... [more ▼]

Objectives: Hyaluronic acid viscosupplementation is a commonly used intra-articular treatment for osteoarthritis (OA). Some recent preclinical and clinical trials have demonstrated a potential for its disease-modifying effects. The goal of this expert opinion, consensus-driven exercise is to provide guidelines for the design and conduct of clinical trials assessing the disease-modifying effect of viscosupplementation in the knee. Methods: The EUROVISCO group constitutes 10 members who had expertise in clinical research methodology in the field of OA and viscosupplementation. They initially drafted issues through an iterative process and had to vote on their degree of agreement on these recommendations. The scores were pooled to generate a median agreement score for each recommendation. Results: The document includes 31 recommendations regarding study population, imaging, clinical and biological assessment of disease-modifying effects of viscosupplementation. Agreements were reached on some recommendations. In particular, the experts reached unanimous agreement on double-blind study design, imaging primary outcomes, time interval between 2 radiographs, x-ray procedure standardization, and the combined use of imaging and biological markers. The group did not recommend the use of ultrasonography, computed tomography (CT) scan and CT arthrography as a tool for OA diagnosis or to assess progression over time. Conclusion: In summary, the working group identified 31 recommendations that represent the current best practices regarding clinical trials that target the assessment of viscosupplementation disease-modifying effects in patients with knee OA. These recommendations integrate new imaging technologies and soluble biomarkers. © 2018, The Author(s) 2018. [less ▲]

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See detailNatural Products for Promoting Joint Health and Managing Osteoarthritis
Henrotin, Yves ULiege; Mobasheri, A.

in Current Rheumatology Reports (2018), 20(11), 72

Purpose of Review: Osteoarthritis, the most common joint disease, is associated with substantial medical costs, lost productivity, and reduced quality of life. However, available pharmaceutical treatments ... [more ▼]

Purpose of Review: Osteoarthritis, the most common joint disease, is associated with substantial medical costs, lost productivity, and reduced quality of life. However, available pharmaceutical treatments have limitations in terms of efficacy and long-term safety. Recent Findings: In vitro evidence suggests that some natural products may possess anti-inflammatory and anti-oxidative properties and may inhibit the release of key osteoarthritis-related cytokines. There is, therefore, ongoing interest in identifying natural products that safely promote joint health and treat osteoarthritis. Numerous plant extracts, including curcumin, Boswellia extract, and pycnogenol, have shown effect sizes (ES) for reducing pain and functional disability larger than those observed with analgesics and products such as glucosamine and chondroitin. The ES for methylsulfonylmethane and avocado/soybean unsaponifiables are also considered to be clinically relevant. Summary: Data from a small number of studies using natural products for treating osteoarthritis are promising but require confirmation in further well-designed clinical trials. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. [less ▲]

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