References of "Gilles, Christine"
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See detailOzone-primed neutrophils promote early steps of tumor cell metastasis to lungs by enhancing their NET production
Rocks, Natacha ULiege; Vanwinge, Céline ULiege; Radermecker, Coraline ULiege et al

in Thorax (2019), 0

Air pollution, including particulates and gazes such as ozone (O3), is detrimental for patient’s health and has repeatedly been correlated to increased morbidity and mortality in industrialized countries ... [more ▼]

Air pollution, including particulates and gazes such as ozone (O3), is detrimental for patient’s health and has repeatedly been correlated to increased morbidity and mortality in industrialized countries. Although studies have described a link between ambient particulate matter and increased lung cancer morbidity, no direct relation has yet been established between O3 exposure and metastatic dissemination to lungs. [less ▲]

Detailed reference viewed: 32 (4 ULiège)
See detailCharacterization of EMT-shifted coagulant CTC
Genna, Anthony ULiege; Van Loo, Stéphanie ULiege; Vanwynsberghe, Aline ULiege et al

Conference (2019, February 01)

Detailed reference viewed: 12 (3 ULiège)
See detailCharacterization of EMT-shifted coagulant CTC
Genna, Anthony ULiege; Van Loo, Stéphanie ULiege; Vanwynsberghe, Aline ULiege et al

Conference (2019, January 28)

Detailed reference viewed: 18 (3 ULiège)
See detailTargeting a coagulation-EMT axis in early metastasis
Vanwynsberghe, Aline ULiege; Genna, Anthony ULiege; Gilles, Christine ULiege

Conference (2019, January 28)

Detailed reference viewed: 19 (5 ULiège)
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See detailADAM10 mediates malignant pleural mesothelioma invasiveness
Sepult, Christelle ULiege; Bellefroid, Marine ULiege; Rocks, Natacha ULiege et al

in Oncogene (2019)

Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited therapeutic options and treatment efficiency. Even if the latency period between asbestos exposure, the main risk factor, and ... [more ▼]

Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited therapeutic options and treatment efficiency. Even if the latency period between asbestos exposure, the main risk factor, and mesothelioma development is very long, the local invasion of mesothelioma is very rapid leading to a mean survival of one year after diagnosis. ADAM10 (A Disintegrin And Metalloprotease) sheddase targets membrane-bound substrates and its overexpression is associated with progression in several cancers. However, nothing is known about ADAM10 implication in MPM. In this study, we demonstrated higher ADAM10 expression levels in human MPM as compared to control pleural samples and in human MPM cell line. This ADAM10 overexpression was also observed in murine MPM samples. Two mouse mesothelioma cell lines were used in this study including one primary cell line obtained by repeated asbestos fibre injections. We show, in vitro, that ADAM10 targeting through shRNA and pharmacological (GI254023X) approaches reduced drastically mesothelioma cell migration and invasion, as well as for human mesothelioma cells treated with siRNA targeting ADAM10. Moreover, ADAM10 downregulation in murine mesothelioma cells significantly impairs MPM progression in vivo after intrapleural cell injection. We also demonstrate that ADAM10 sheddase downregulation decreases the production of a soluble N-cadherin fragment through membrane N-cadherin, which stimulated mesothelioma cell migration. Taken together, we demonstrate that ADAM10 is overexpressed in MPM and takes part to MPM progression through the generation of N-cadherin fragment that stimulates mesothelioma cell migration. ADAM10 inhibition is worth considering as a therapeutic perspective in mesothelioma context. [less ▲]

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See detailTransitions Epithélio-Mésenchymateuses, Coagulation, Cellules Tumorales Circulantes
Gilles, Christine ULiege

Conference (2018, November 15)

Detailed reference viewed: 10 (2 ULiège)
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See detailEMT-driven coagulation: impact for Circulating Tumor Cells
Gilles, Christine ULiege

Conference (2018, May 03)

Detailed reference viewed: 19 (8 ULiège)
See detailTargeting a coagulation-EMT axis in early metastasis
Vanwynsberghe, Aline ULiege; Lambert, Justine ULiege; Francart, Marie-Emilie ULiege et al

Poster (2018, February 01)

Detailed reference viewed: 25 (13 ULiège)
See detailEMT-induced TF as a targetable pathway in early metastasis
Vanwynsberghe, Aline ULiege; Lambert, Justine ULiege; Francart, Marie-Emilie ULiege et al

Conference (2018, January 27)

Detailed reference viewed: 9 (2 ULiège)
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See detailEpithelial-Mesenchymal Plasticity and Circulating Tumor Cells: Travel Companions to Metastases
Francart, Marie-Emilie ULiege; Lambert, Justine ULiege; Vanwynsberghe, Aline ULiege et al

in Developmental Dynamics (2018), 247(3), 432-450

Detailed reference viewed: 149 (10 ULiège)
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See detailL’expérimentation animale reste indispensable (OPINION)
Amorim, Christiani; Andris, Fabienne; Arckens, Lut et al

Article for general public (2017)

Trop fréquemment, l’expérimentation animale est présentée comme une pratique archaïque. Elle a bien changé. Et 100 % des patients traités le sont grâce aux concepts et techniques développés grâce à elle.

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See detailDusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner
Vandereyken, Maud; Jacques, Sophie ULiege; Van Overmeire, Eva et al

in PLoS ONE (2017)

Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers. In mouse model, DUSP3 deletion ... [more ▼]

Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers. In mouse model, DUSP3 deletion prevents neo-angiogenesis and b-FGF-induced microvessel out- growth. Considering the importance of angiogenesis in metastasis formation, our study aimed to investigate the role of DUSP3 in tumour cell dissemination. Using a Lewis Lung carcinoma (LLC) experimental metastasis model, we observed that DUSP3-/- mice devel- oped larger lung metastases than littermate controls. DUSP3-/- bone marrow transfer to lethally irradiated DUSP3+/+ mice was sufficient to transfer the phenotype to DUSP3+/+ mice, indicating that hematopoietic cells compartment was involved in the increased tumour cell dissemination to lung tissues. Interestingly, we found a higher percentage of tumour- promoting Ly6Cint macrophages in DUSP3-/- LLC-bearing lung homogenates that was at least partially due to a better recruitment of these cells. This was confirmed by 1) the pres- ence of higher number of the Ly6Bhi macrophages in DUSP3-/- lung homogenates and by 2) the better migration of DUSP3-/- bone marrow sorted monocytes, peritoneal macrophages and bone marrow derived macrophages (BMDMs), compared to DUSP3+/+ monocytes, macrophages and BMDMs, in response to LLC-conditioned medium. Our study demon- strates that DUSP3 phosphatase plays a key role in metastatic growth through a mechanism involving the recruitment of macrophages towards LLC-bearing lungs. [less ▲]

Detailed reference viewed: 73 (29 ULiège)