References of "Genva, Manon"
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See detailIs it possible to predict the odor of a molecule on the basis of its structure?
Genva, Manon ULiege; Kenne Kemene, Tierry ULiege; Deleu, Magali ULiege et al

in International Journal of Molecular Sciences (in press)

The olfactory sense is the dominant sensory perception for many animals. When Richard Axel and Linda Buck received in 2004 the Nobel Prize for discovering the G-protein coupled receptors role in olfactory ... [more ▼]

The olfactory sense is the dominant sensory perception for many animals. When Richard Axel and Linda Buck received in 2004 the Nobel Prize for discovering the G-protein coupled receptors role in olfactory cells, it highlighted the importance of olfaction to scientific community. Several theories tried to explain how cells are able to distinguish such a wide variety of odorant molecules in a complex context in which enantiomers can result in completely different perceptions and structurally different molecules in the same one. Moreover, sex, age, cultural origin and individual differences contribute to odor perception variations that complicate the picture. Recent advances in olfaction theory will be presented and future trends in human olfaction like structure-based odor prediction or artificial sniffing will be discussed at the frontiers of chemistry, physiology, neurobiology and machine learning. [less ▲]

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See detailStress-related accumulation of arabidopsides: impact on chloroplast membranes
Genva, Manon ULiege; Deleu, Magali ULiege; Andersson, M.X. et al

Poster (2019, April)

Oxylipins are crucial agents in plant defense mechanisms. While free oxylipins are well studied, roles of esterified oxylipins remain unclear. Esterified oxylipins are structurally diverse metabolites ... [more ▼]

Oxylipins are crucial agents in plant defense mechanisms. While free oxylipins are well studied, roles of esterified oxylipins remain unclear. Esterified oxylipins are structurally diverse metabolites that were found in diverse plant species, suggesting that those may be more ubiquitous that currently thought. Among those, galactolipids containing (dn)OPDA were discovered, firstly in A. thaliana, but also in other plants. Those molecules, named arabidopsides, are highly induced under stress conditions, as it accumulates up to 8 percent of plant lipids, but their precise contributions in plant defense mechanisms are still unknown. Arabidopsides are directly formed in plant chloroplast membranes from galactolipids. Accumulation of arabidopsides in such high quantity in chloroplast membranes may modify their properties (e.g. photosynthetic activity). This study aims to understand the impact of arabidopside presence in chloroplast membranes on their properties using biomimetic plant membranes via complementary in silico and in vitro approaches. Interfacial properties of arabidopsides and non-oxidized galactolipids were studied using Langmuir film balance. Results showed that arabidopsides possess different interfacial properties compared to non-oxidized chloroplast lipids. Arabidopsides ability to permeabilize chloroplast membranes was also studied in vitro. Arabidopsides A and B are able to permeabilize chloroplast membranes while arabidopside D is not. In conclusion, arabidopside production by plants under stress conditions may modify chloroplast membrane properties such as its permeability. As chloroplast membrane lipid composition is essential to its photosynthetic ability, such changes may also affect its function. [less ▲]

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See detailNew essential oils with interesting biological activities from endemic plants of Côte d'Ivoire: Zanthoxylum mezoneurispinosum and Zanthoxylum psammophilum
Tanoh, Amenan Evelyne ULiege; Nea, Fatimata ULiege; Kenne Kemene, Tierry ULiege et al

Poster (2019, February 04)

New essential oils with interesting biological activities from endemic plants of Côte d’Ivoire: Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophilum (Ake Assi). Evelyne A. Tanoh1 ... [more ▼]

New essential oils with interesting biological activities from endemic plants of Côte d’Ivoire: Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophilum (Ake Assi). Evelyne A. Tanoh1*, Fatimata Nea1, Tierry K. Kenne2, Manon Genva2, Matthew Saive2, Felix Z. Tonzibo1, Marie-Laure Fauconnier2. 1 Laboratory of Biological Organic Chemistry, UFR-SSMT, University Felix Houphouet-Boigny, BPV 34 Abidjan, Côte d’Ivoire 2 Laboratory of Natural Molecules Chemistry, University of Liège, Gembloux Agro- Bio Tech, 2, Passage of Deportés, B-5030 Gembloux, Belgium According to OMS nearly 80% of the population depend on traditional medicine given the strong growth in the use of natural products from plants1. Many Rutaceae plants are already used in traditional medicine for their biological properties such as anticancer and antioxidant activities. Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophylum (Ake Assi) are endemic Rutaceae to Côte d’Ivoire. In order to determine if those plants could be used in medicine, the aim of this work was to evaluate the chemical composition and the biological activities of essential oils extracted from both plants. Essential oils of our plants isolated from the leaves, trunk bark and roots. Their chemical compositions were determined by GC-MS. In vitro biological properties were determined using two activities: Antioxidant and anti-inflammatory. The analysis of the essential oils of leaves, trunk bark and roots of Z. psammophylum exhibit the predominance of two unusual methyl ketones, 2-undecanone and 2-tridecanone in leaves and trunk bark. These compounds have biological properties according to the literature2. The root is rich in thymol. Z. mezoneurispinosum oil is rich in alpha pinene for leaves and trunk bark, while the root is rich in gamma-elemene and cyclosativene. Cyclosativene is known for its biological activities3. The essential oils of both plants showed in increasing order antioxidant value in the leaves, trunk bark and roots. A measure of anti-inflammatory activity was found to in decreasing order in the root, followed by leaves and trunk bark. These plants could constitute a source of active molecules for traditional medicine in Côte d'Ivoire. However, although these plants are endemic in this country, they are not abundant and it is necessary to limit and protect the distribution of nurseries to produce plants and reintroduce these species into their natural habitat. References 1- O.M.S, 2002. : Besoins et potentiel. N° 4. 6 p. 2- Saini Mukesh and al, (2014). J. Agric. Food. Chem, 62: 4342 – 4348. 3- Kang Min-Seung, Lee Hoi-Seon, (2018). Applied Biological chemistry 61 (6): pp 653 – 659. [less ▲]

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See detailArabidopside interactions with plant membranes
Genva, Manon ULiege; Deleu, Magali ULiege; Andersson, Mats X. et al

Poster (2019, February 04)

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See detailVariability of essential oil composition and biological activities of Lantana rhodesiensis Moldenke from Côte d'Ivoire.
Nea, Fatimata ULiege; Tanoh, Amenan Evelyne ULiege; Kenne Kemene, Tierry ULiege et al

Conference (2019, February)

Lantana rhodesiensis Moldenke is an herb or small shrub under two meters tall which is often multi-stemmed 1. It is used in traditional medicine for several treatments like diabetes1, rheumatism2, and ... [more ▼]

Lantana rhodesiensis Moldenke is an herb or small shrub under two meters tall which is often multi-stemmed 1. It is used in traditional medicine for several treatments like diabetes1, rheumatism2, and arterial hypertension3. The aim of the present study was to determine the variation in the chemical composition of essential oils of L. rhodesiensis from Côte d’Ivoire. It also aimed to evaluate the in vitro antioxidant and anti-inflammatory activities of essential oils. Essential oils were obtained by hydrodistillation from leaves, stems and fruits of L. rhodesiensis from two localities of Northern Côte d’Ivoire. Essential oil composition was determined by GC-MS. The study of the antioxidant activity of leave essential oils was carried out by the DPPH and FRAP method; the anti-inflammatory activity was evaluated by the inhibition of protein denaturation method. Results showed that the main constituents present in most essential oils extracted from leaves, fruits and stems were β-caryophyllene, α-copaene, δ-cadinene and α-humulene. However, thymol was the major component in three leave samples. The stem oils are also dominated by caryophyllene oxide or thymol. It may be concluded that the sesquiterpenes were the predominant molecules in all essential oil samples of L. rhodesiensis from Northern Côte d'Ivoire. The results of the biological activities carried out on the leave essential oil samples showed that these oils have antioxidant and anti-inflammatory activities. This study showed the interest of L. rhodesiensis for the treatment of rheumatism and diabetes in traditional medicine. L. rhodesiensis is a potential source for isolating new antioxidant and anti-inflammatory molecules. 1. Piero, N. M. et al. J Dev. Drugs 4, 2 (2015). 2. Ruffo CK, Birnie A, Tengnas B. Edible wild plants of Tanzania p418 (2002). 3. JeanBangou, M., Kiendrebeogo, M., Compaoré, M. & Coulibaly, A. Y. J. Biol. Sci. 11, 31–38 (2011). [less ▲]

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See detailNew insights into the biosynthesis of esterified oxylipins and their involvement in plant defense and developmental mechanisms
Genva, Manon ULiege; Obounou Akong, Firmin ULiege; Andersson, Mats X. et al

in Phytochemistry Reviews (2018)

Plant oxylipins produced following oxidation of unsaturated fatty acids are structurally diverse metabolites that play crucial developmental and defensive roles. Whereas free oxylipins are well studied ... [more ▼]

Plant oxylipins produced following oxidation of unsaturated fatty acids are structurally diverse metabolites that play crucial developmental and defensive roles. Whereas free oxylipins are well studied, oxylipins esterified in complex lipids such as galacto- and phospholipids are thought to be rare and have unclear roles. In the last few years, new analytical methods have been developed, leading to the discovery of many esterified oxylipins in a variety of plant species. This suggests that these molecules may be ubiquitous plant metabolites. While their precise functions are unclear, esterified oxylipins seem to play important roles in plant development and defense. This review focuses on new insights regarding diversity, biosynthesis and function of those interesting and understudied molecules. [less ▲]

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See detailOxylipins are involved in plant protections processes and are potential biocontrol agents
Deboever, Estelle ULiege; Genva, Manon ULiege; Deleu, Magali ULiege et al

Conference (2018, September 27)

Nowadays, biopesticides have emerged as a main alternative to conventional agriculture. In this context, plant oxylipins, a vast and diverse family of secondary metabolites originated from polyunsaturated ... [more ▼]

Nowadays, biopesticides have emerged as a main alternative to conventional agriculture. In this context, plant oxylipins, a vast and diverse family of secondary metabolites originated from polyunsaturated fatty acids (PUFAs), appear to be crucial agents in plant defence mechanisms. Among plant oxylipins, the 13-hydroperoxy oxylipins (13-HPO) constitute key intermediate oxylipins (KIOs) as they can be converted into jasmonic acid, OPDA, dn-OPDA or traumatic acid, well-characterized components involved in plant resistance mechanisms [1][2]. Their presumed functions include direct antimicrobial effect, stimulation of plant defence gene expression, and/or regulation of plant cell death [3]. Otherwise, OPDA and dn-OPDA were also found esterified in more complex structures such as galactolipids. Those compounds are called arabidopsides. However, the precise contribution of each of those molecules in plant defence remains unknown. The first part of this study aims to understand the oxylipins action mechanisms and especially their membrane activities. As arabidopsides are produced under stress and localized at the chloroplast membranes, their interactions with those were studied using biomimetic membranes via a complementary in silico informatics and in vitro biophysical approaches. On the other hand, as KIOs are found in the literature to be potential biocontrol agents, there effect on different pathogens of agronomic interest were studied in vitro, by the same approach. As far as arabidopsides are concerned, results show that they possess different interfacial properties compared to major chloroplast lipids, which they are produced from. Arabidopsides modify the fluidity and permeabilize chloroplast membranes. As chloroplast membrane lipid composition is essential to its photosynthetic ability, such changes in its composition under stress will affect its function. Concerning KIOs, they seem to interact with pathogens plasma membranes. Indeed, in vitro assays show that KIOs can hinder growth of some plant microbial pathogens, with differences between strains and KIOs forms. [less ▲]

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See detailEvaluation des interactions entre les arabidopsides et les lipides de la membrane plasmique des plantes
Genva, Manon ULiege; Deleu, Magali ULiege; Andersson, Mats X. et al

Poster (2018, January 19)

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See detailEvaluation of interactions between arabidopsides and plant plasma membrane lipids
Genva, Manon ULiege; Deleu, Magali ULiege; Andersson, Mats X. et al

Poster (2018)

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See detailPlant oxylipins: structure-function relationship
Genva, Manon ULiege; Andersson, Mats X.; Nasir, Mehmet Nail ULiege et al

Conference (2017, May 09)

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See detailPlant Oxylipins: Structure-function Relationships
Genva, Manon ULiege; Andersson, Mats X.; Nasir, Mehmet Nail ULiege et al

Poster (2017)

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See detailDevelopment of a new method for arabidopsides extraction and purification
Genva, Manon ULiege; Andersson, Mats X; Nasir, Mehmet Nail ULiege et al

Poster (2016, November 16)

In the present work, a new method for arabidopsides extraction and purification was developed.

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See detailPlant esterified oxylipins: structure – function relationship
Genva, Manon ULiege; Andersson, Mats X.; Nasir, Mehmet Nail ULiege et al

Poster (2016, September)

In the present work, high quantities of arabidopsides were extracted and purified from Arabidopsis thaliana L.

Detailed reference viewed: 54 (17 ULiège)