References of "Fraipont, Audrey"
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See detailMuscle OXPHOS capacities in endurance horses predict racing performance
Votion, Dominique ULiege; Fraipont, Audrey ULiege; Robert, C. et al

in Comparative Exercise Physiology (2018, November), 14

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See detailLONG TERM PROGNOSIS OF MODERATE OR SEVERE LEFT-SIDED CARDIAC VALVULAR REGURGITATIONS IN HORSES
Leroux, Aurélia ULiege; Goudmaeker, Apolline; Fraipont, Audrey ULiege et al

in Proceedings of the 9th ECEIM Congress (2016, November)

Mitral and aortic regurgitations (MR and AR) are common in horses. Unlike mild valvular regurgitations, long-term prognosis of moderate or severe MR and AR is suspected to be guarded since they might ... [more ▼]

Mitral and aortic regurgitations (MR and AR) are common in horses. Unlike mild valvular regurgitations, long-term prognosis of moderate or severe MR and AR is suspected to be guarded since they might induce congestive heart failure (CHF). The aim of this study is to perform a long-term follow-up of horses with moderate or severe MR and/or AR to confirm this prognosis. Firstly medical files of horses with moderate or severe MR and/or AR that had a follow-up, were retrospectively reviewed over a 15-years period (2000-2015). Clinical and echocardiographic data of 25 horses with moderate or severe MR (16/25) or AR (8/25) or both (1/25) were considered. All horses had undergone 2 or more echocardiographic exams 6 months to 10 years apart. Eight horses developed CHF (4 MR and 4 AR) and all died/were euthanized. Diastolic left ventricular internal diameter, left atrial diameter and pulmonary artery diameter were/became above reference values in 17/25 horses but no significant difference was observed between the first and the follow-up measurements (Student's t-test, p<0.05). Secondly follow-up data of additional horses with moderate or severe MR was collected by telephone survey. Owners of 27 horses agreed to answer the survey 1 to 6 years after diagnosis. Ten horses with CHF had died, 3/27 had developed CHF, 10/27 had remained clinically stable and 4/27 had died of non-cardiac causes. Results of this study confirm that moderate or severe MR and AR carry a guarded to poor long-term prognosis as 40% (21/52) of the studied horses developed CHF. [less ▲]

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See detailDetermination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis
Houben, Rosa ULiege; Leleu, Claire; Fraipont, Audrey ULiege et al

in Mitochondrion (2016), 24

This prospective cohort study evaluated the potential of high-resolution respirometry applied to permeabilized muscle fibers for fitness evaluation in French Standardbred racehorses. Fitness evaluation by ... [more ▼]

This prospective cohort study evaluated the potential of high-resolution respirometry applied to permeabilized muscle fibers for fitness evaluation in French Standardbred racehorses. Fitness evaluation by means of respirometric parameters did not correlate with racing performance registered over the following racing season. However, altered mitochondrial energy metabolism was associated with higher risk of developing exertional rhabdomyolysis, a common cause of exercise intolerance in racehorses. These data represent a first step towards establishing reference values for muscle OXPHOS capacity in this breed. [less ▲]

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See detailExpression microarray as a tool to identify candidate blood biomarkers in horses suffering from inflammatory airway disease
Ramery, Eve ULiege; Fraipont, Audrey ULiege; Art, Tatiana ULiege et al

in Veterinary Clinical Pathology (2015), 44(1), 37-46

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires ... [more ▼]

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires sedation. Objectives: The purpose of this study was to identify candidate blood biomarkers of IAD using species-specific expression microarrays. Methods: Horse Gene Expression Microarrays were used to investigate global mRNA expression in circulating leukocytes from healthy and IAD-affected standardbreds and endurance horses. Results: Nine genes were significantly differentially regulated in standardbreds and 61 in endurance horses (P < 0.001). These genes were mainly related to inflammation (eg. ALOX15B, PLA2G12B and PENK), oxidant/antioxidant balance (eg. DUOXA2 and GSTO1-1) and stress (eg. V1aR, GRLF1, Homer-2 and MAOB). DUOXA2, ALOX15B, PLA2G12B, MAOB and GRLF1 variations of expression were further validated by RT-qPCR. The deregulation of the oxidant/antioxidant balance was demonstrated at the protein level by an increase of glutathione peroxidase (GPx) activity in heparinised whole blood of IAD-affected standardbreds (P = 0.0025) and endurance horses (P = 0.0028). There was good correlation (r = 0.7354) between BAL neutrophil percentage and whole blood GPx activity in all horses. Conclusions: There is accumulating evidence that, even when systemic clinical signs are not evident, circulating leukocyte gene expression can reflect responses of other tissues, leading to potential diagnostic applications in the future. Although not specific for IAD, whole blood GPx activity appears to reflect BAL neutrophil percentage. This finding should be further assessed by testing a larger number of horses. [less ▲]

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See detailÉtiopathogénie de la myopathie atypique et gestion raisonnée des cas
Votion, Dominique ULiege; Patarin, Florence; Cerri, Simona ULiege et al

in In Proceedings: Journée AVEF (Association des Vétérinaires Equins Français) (2013, December)

Atypical myopathy is an acute intoxication resulting from the ingestion of a toxin contained in the seeds of some trees of the genus Acer (i.e. « maple trees »). The causes of the emergence of the disease ... [more ▼]

Atypical myopathy is an acute intoxication resulting from the ingestion of a toxin contained in the seeds of some trees of the genus Acer (i.e. « maple trees »). The causes of the emergence of the disease due to trees naturalized for many decades remain undetermined. Currently, there is no cure for atypical myopathy but symptomatic treatment may be revisited on the basis of knowledge of the aetio-pathogenesis of the disease. This paper compiles recommendations following a discussion on treatment of atypical myopathy held in October 2013 at the University of Liege (Belgium) to provide emergency treatment distinguishing clinical management (1) at hospital, (2) in the field and (3) preventive measures to protect pasture companions. [less ▲]

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See detailEarly indicators for exertional rhabdomyolysis in standardbred racehorses using high-resolution respirometry
Houben, R.; Leleu, C.; Fraipont, Audrey ULiege et al

Scientific conference (2013, October 11)

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See detailAssessing fitness in endurance horses
Fraipont, Audrey ULiege; Van Erck, Emmanuelle; Ramery, Eve ULiege et al

in Canadian Veterinary Journal (2012), 53

A field test and a standardized treadmill test were used to assess fitness in endurance horses. These tests discriminated horses of different race levels: horses participating in races of 120km and more ... [more ▼]

A field test and a standardized treadmill test were used to assess fitness in endurance horses. These tests discriminated horses of different race levels: horses participating in races of 120km and more showed higher values of VLA4 (velocity at which blood lactate reached 4 mmol/L) and V200 (velocities at which heart rates reached 200 beats per min) than horses of lower race levels. [less ▲]

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See detailMesure de la respiration musculaire par respirométrie à haute résolution
Votion, Dominique ULiege; Fraipont, Audrey ULiege; Robert, Céline et al

in Pratique Vétérinaire Équine (2011), 43(170), 35-37

This technical note describes the reference method for screening the mitochondrial function in horses.

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See detailAltered diastolic and systolic left ventricular function in horses completing a long distance endurance race.
Amory, Hélène ULiege; Votion, Dominique ULiege; Fraipont, Audrey ULiege et al

in In Proccedings of the First Benelux Congress of Physiology and Pharmacology (PHYSPHAR) (2011, March 18)

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See detailSubclinical diseases underlying poor performance in endurance horses: diagnostic methods and predictive tests.
Fraipont, Audrey ULiege; Van Erck, E.; Ramery, Eve ULiege et al

in Veterinary Record: Journal of the British Veterinary Association (2011), 169(6), 154

Thirty-eight endurance horses underwent clinical and ancillary examinations, including haematological and biochemical evaluation, standardised exercise tests both on a treadmill and in the field, Doppler ... [more ▼]

Thirty-eight endurance horses underwent clinical and ancillary examinations, including haematological and biochemical evaluation, standardised exercise tests both on a treadmill and in the field, Doppler echocardiography, impulse oscillometry, video endoscopy and collection of respiratory fluids. All of the examined poorly performing horses were affected by subclinical diseases, and most of them had multiple concomitant disorders. On the contrary, the well-performing horses were free of any subclinical disease. The most frequently diagnosed diseases were respiratory disorders, followed by musculoskeletal and cardiac problems. Poor performers exhibited lower speeds at blood lactate concentration of 4 mmol/l (VLA4) and at heart rates of 160 (V160) and 200 bpm (V200) on the treadmill and in the field, as well as slower recovery of heart rate. [less ▲]

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See detailAlterations in mitochondrial respiratory function in response to endurance training and endurance racing
Votion, Dominique ULiege; Fraipont, Audrey ULiege; Goachet, A.G et al

in In proceedings: 8th International Conference on Equine Exercise Physiology (2010, November)

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See detailLa microbiopsie musculaire : un nouvel outil pour le suivi sportif et la détection précoce des dysfonctions musculaires
Votion, Dominique ULiege; Fraipont, Audrey ULiege; Robert, Céline et al

in 36ème Journée de la Recherche Equine (2010)

The objective of this study was to confirm the practical value of high-resolution respirometry (HRR) applied to biopsies to determine, in horses, the level of training, their athletic ability and for the ... [more ▼]

The objective of this study was to confirm the practical value of high-resolution respirometry (HRR) applied to biopsies to determine, in horses, the level of training, their athletic ability and for the early detection of muscular dysfunction. Materials and methods – The muscle mitochondrial respiration was determined by HRR in 20 endurance horses and 10 trotters sampled at the triceps brachii at different stages of their training. Results – Training increases mitochondrial respiration, in addition, the best performers had the highest rate of respiration. A trotter had abnormally low levels of muscle mitochondrial respiration for its level of training. This horse has presented several episodes of rhabdomyolysis during its racing season. Discussion – The biopsy is easily achievable by the attending veterinarian. This study shows that the athletic ability of horses is closely linked to respiratory muscle function, and suggests the value of HRR for performance prediction. In addition, the RHR has the ability to demonstrate mitochondrial dysfunction potentially responsible for exercise-induced rhabdomyolysis. [less ▲]

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See detailCharacterization of pentraxin 3 in the horse and its expression in airways.
Ramery, Eve ULiege; Fievez, Laurence ULiege; Fraipont, Audrey ULiege et al

in Veterinary Research (2010), 41(2), 18

The long pentraxin 3 (PTX3) plays an important role in host defence and its over-expression may contribute to airway injury. The aim of the present study was therefore to characterize in more detail PTX3 ... [more ▼]

The long pentraxin 3 (PTX3) plays an important role in host defence and its over-expression may contribute to airway injury. The aim of the present study was therefore to characterize in more detail PTX3 and its expression in the horses airway. Six healthy horses and six horses affected by recurrent airway obstruction (R.A.O.) were submitted to a dusty environment challenge. PTX3 DNA and cDNA were cloned and sequenced. PTX3 expression was evaluated by RT-qPCR, western blotting and immuno-histochemistry in bronchoalveolar lavage fluid (BALF) cells, BALF supernatant and bronchial epithelial cells. An alternative splicing of the second exon of PTX3 occurred, resulting in two forms of the protein: spliced (32 kDa) and full length (42 kDa). PTX3 was detected in BALF macrophages, neutrophils and bronchial epithelial cells. It was over-expressed in the BALF supernatant from R.A.O.-affected horses in crisis. However, dust was unable to induce PTX3 in BALF cells ex vivo, indicating that dust is an indirect inducer of PTX3. Dust exposure in-vivo induced PTX3 in BALF macrophages but there was no significant difference between healthy and R.A.O.-affected horses. Conversely, PTX3 was over-expressed in the bronchial epithelial cells from R.A.O-affected horses in crisis. These data indicate a differential regulatory mechanism in inflammatory and bronchial epithelial cells and offer therapeutically interesting perspectives. [less ▲]

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See detailAltered diastolic and systolic left ventricular function in horses completing a long distance endurance race
Amory, Hélène ULiege; Votion, Dominique ULiege; Fraipont, Audrey ULiege et al

in In Proceedings of the 8th International Conference on Equine Exercise Physiology (ICEEP) (2010)

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See detailPulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentration after aerosol administration of cefquinome to horses
Art, Tatiana ULiege; Ramery, Eve ULiege; Fraipont, Audrey ULiege et al

in Equine Veterinary Education (2010), 22(9), 473-479

The administration of antibiotics by aerosol to horses suffering from respiratory infections may partially circumvent the limitations of antimicrobial therapy, e.g. large injection volumes, low ... [more ▼]

The administration of antibiotics by aerosol to horses suffering from respiratory infections may partially circumvent the limitations of antimicrobial therapy, e.g. large injection volumes, low bioavailability and risk of diarrhea. Only injectable formulations are available currently and usually contain other substances that could irritate the mucosa and induce coughing and bronchospasm. In addition, the quality of the aerosol, particularly in terms of the delivery of antibiotics to the deep parts of the lung, is unknown. Although used under field conditions, cefquinome delivered by aerosol has never been studied in horses. This study examined the safety of cefquinome injectable solution, administered by aerosol at a dose of 225 mg/inhalation to 7 healthy horses, by assessing (1) pulmonary function before and 15 min after a single inhalation, at the first day (Day 1) and the fifth day (Day 5) of a 5 day period treatment; and (2) the inflammatory status of the lung, i.e. percentage neutrophils and myeloperoxidase concentration, based on bronchoalveolar lavage (BAL) at D1 and D5. In addition, cefquinome concentrations were measured in bronchoalveolar lavage fluid after aerosol, intravenous (i.v.) and intramuscular (i.m.) administrations. A single aerosol of cefquinome injectable solution did not induce any immediate nor delayed pulmonary side effects in healthy horses and produced cefquinome concentrations in bronchoalveolar lavage (BAL) within 30 min that were higher than the minimal inhibitory concentration of the main equine respiratory pathogens. These results should stimulate further studies, especially in horses suffering from bronchial hyper-reactivity. Aerosol delivery of antibiotics may well have a role in equine therapeutics. [less ▲]

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See detailHydratation and electrolyte balance in horses during an endurance season
Robert, Céline; Goachet, Anne-Gaëlle; Fraipont, Audrey ULiege et al

in Equine Veterinary Journal. Supplement (2010), 42(38), 98-104

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