References of "FARHAT, Nesrine"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailOutcome of paediatric portopulmonary hypertension in the modern management era: A case report of 6 patients.
Joye, Raphael; Lador, Frédéric; Aggoun, Yacine et al

in Journal of hepatology (2020), 74(3), 742-747

Portopulmonary hypertension is a rare but serious complication of portal hypertension or portosystemic shunting. Portopulmonary hypertension is an indication for liver transplantation or shunt closure ... [more ▼]

Portopulmonary hypertension is a rare but serious complication of portal hypertension or portosystemic shunting. Portopulmonary hypertension is an indication for liver transplantation or shunt closure. However, liver transplantation is contraindicated in patients with severe pulmonary arterial hypertension. Reported mortality rates are high in children with portopulmonary hypertension and there are scarce recommendations on its management. Our aim was to report on our real-world experience of managing portopulmonary hypertension in a specialised centre. We describe a series of 6 children with portopulmonary hypertension. Their median age at diagnosis was 13 years (range 10-15). The underlying liver conditions were cirrhosis of unknown origin (1), congenital portocaval shunts (3), biliary atresia (1), and portal vein cavernoma with surgical mesenterico-caval shunt (1). Median mean pulmonary arterial pressure was 47 mmHg (range 32-70), and median pulmonary vascular resistance was 6.6 Wood units (range 4.3-15.4). All patients except one were treated with a combination of pulmonary arterial hypertension-specific therapy (phosphodiesterase type 5 inhibitors and/or endothelin receptor antagonists and/or prostacyclin analogues). Three patients then benefited from shunt closure and the others underwent liver transplantation. Five patients showed improvement or stabilisation of pulmonary arterial hypertension with no deaths after a mean follow-up of 39 months. Based on our limited experience, early and aggressive treatment with a combination of pulmonary arterial hypertension-specific therapy significantly improves patients' haemodynamic profile and enables the performance of liver transplantation and shunt closure with satisfactory outcomes. [less ▲]

Detailed reference viewed: 32 (1 ULiège)
Full Text
Peer Reviewed
See detailRight Atrial Myocardial Remodeling in Children With Atrial Septal Defect Involves Inflammation, Growth, Fibrosis, and Apoptosis.
Rouatbi, Hatem; FARHAT, Nesrine ULiege; Heying, Ruth et al

in Frontiers in pediatrics (2020), 8

Introduction: Myocardial remodeling due to large atrial septum defect (ASD) is macroscopically characterized by dilation of the right-sided cardiac cavities secondary to volume overload, the cellular ... [more ▼]

Introduction: Myocardial remodeling due to large atrial septum defect (ASD) is macroscopically characterized by dilation of the right-sided cardiac cavities secondary to volume overload, the cellular mechanisms of which are not yet understood. We postulated that inflammation, fibrosis, and cell death are actors of right atrial remodeling secondary to ASD. Patients and Methods: In 12 children with large ASD (median age: 63 months), expression of genes coding for proteins involved in the response to cell stress and -protection, inflammation, growth and angiogenesis, fibrosis, and apoptosis was assessed by RT-PCR in right atrial myocardial biopsies taken during cardiac surgery. The presence of cytokines in myocardial cells was confirmed by immunohistochemistry and effective apoptosis by TUNEL assay. Results: In all patients investigated, a cellular response to early mechanical stress with the initiation of early protective mechanisms, of inflammation (and its control), -growth, and -angiogenesis, of fibrosis and apoptosis was present. The apoptotic index assessed by TUNEL assay averaged 0.3%. Conclusions: In children with large ASD, macroscopic right atrial remodeling relates to cellular mechanisms involving the expression of numerous genes that either still act to protect cells and tissues but that also harm as they initiate and/or sustain inflammation, fibrosis, and cell death by apoptosis. This may contribute to long term morbidity in patients with ASD. [less ▲]

Detailed reference viewed: 36 (2 ULiège)
Full Text
Peer Reviewed
See detailROHHAD(NET) Syndrome: Systematic review of the clinical timeline and recommendations for diagnosis and prognosis.
HARVENGT, Julie ULiege; Gernay, Caroline; Mastouri, Mériem ULiege et al

in The Journal of clinical endocrinology and metabolism (2020)

CONTEXT: Rapid onset Obesity with Hypothalamic dysfunction, Hypoventilation, Autonomic Dysregulation and Neural Tumor Syndrome (ROHHHAD(NET)) is a rare and potentially fatal disease. No specific ... [more ▼]

CONTEXT: Rapid onset Obesity with Hypothalamic dysfunction, Hypoventilation, Autonomic Dysregulation and Neural Tumor Syndrome (ROHHHAD(NET)) is a rare and potentially fatal disease. No specific diagnostic biomarker is currently available, making prompt diagnosis challenging. Since its first definition in 2007, a complete clinical analysis leading to specific diagnosis and follow-up recommendations is still missing. OBJECTIVE: To describe the clinical timeline of symptoms of ROHHAD(NET) and propose recommendations for diagnosis and follow-up. DESIGN: We conducted a systematic review of all ROHHAD(NET) case studies and report a new ROHHAD patient with early diagnosis and multidisciplinary care. METHODS: All the articles that meet the definition of ROHHAD(NET) and provide chronological clinical data were reviewed according to the PRISMA individual patient data (IPD) guidelines. The data were grouped into 7 categories: hypothalamic dysfunction, autonomic dysregulation, hypoventilation, NET, psychiatric symptoms, other clinical manifestations, outcome. RESULTS: 43 IPD were analyzed. The timeline of the disease shows rapid onset obesity followed shortly afterwards by hypothalamic dysfunction. Dysautonomia was reported at a median age of 4.95 years and hypoventilation at 5.33 years, or 2,2 years after the initial obesity. A NET was reported in 56% of the patients and 70% of these tumors were diagnosed within 2 years after initial weight gain. CONCLUSION: Since early diagnosis improves the clinical management and the prognosis in ROHHAD(NET), this diagnosis should be considered for any child with a rapid and early obesity. We propose guidance for systematic follow-up and advise multidisciplinary management with the aim of improving prognosis and life expectancy. [less ▲]

Detailed reference viewed: 513 (6 ULiège)
Full Text
Peer Reviewed
See detailVasoreactive Pulmonary Arterial Hypertension Manifesting With Misleading Epileptic Seizure: Diagnostic and Treatment Pitfalls.
FARHAT, Nesrine ULiege; Cools, Bjorn; Gewillig, Marc et al

in Frontiers in pediatrics (2019), 7

A 5-year-old girl presented with acute nocturnal episodes of loss of consciousness following abdominal pain and crying. Epilepsy was primarily diagnosed but the course of the disease was suggestive of ... [more ▼]

A 5-year-old girl presented with acute nocturnal episodes of loss of consciousness following abdominal pain and crying. Epilepsy was primarily diagnosed but the course of the disease was suggestive of pulmonary hypertension. An adapted invasive assessment of pulmonary pressure and pharmacological challenge allowed for diagnosing vasoreactive pulmonary arterial hypertension. Initial treatment with sildenafil was not effective. Thus, calcium channel blockers were introduced when positive vasoreactivity was confirmed and permitted to stop the occurrence of the syncope and dramatically improved clinical status. At 2 years follow-up she is well without any complaint and in functional class I. Echocardiography shows a slightly enlarged but not hypertrophied right ventricle with a nearly normalized estimated right ventricular pressure. The last catheterization shows subnormal values of pulmonary arterial pressure (mean pulmonary artery pressure: 24 mmHg) and pulmonary vascular resistance (5, 4 Wood units(*)m(2)), normalizing with inhaled Nitric Oxide (mean pulmonary artery pressure of 14 mmHg and pulmonary vascular resistance of 1.5 Wood units(*)m(2)). Vasoreactive pulmonary arterial hypertension is a rare entity in children but it should not be misdiagnosed with seizures due to the presence of syncopal episodes. According to current knowledge, this form seems to have a better prognosis than non-reactive pulmonary arterial hypertension and the treatment of choice remains as calcium channel blockers. The management of this case was characterized by successive mishaps and potentially harmful mistakes and underscores the potential risk with pediatric PH evaluation in non-expert centers. [less ▲]

Detailed reference viewed: 28 (3 ULiège)
Full Text
Peer Reviewed
See detailDiagnosis and treatment of pediatric pulmonary arterial hypertension.
FARHAT, Nesrine ULiege; Lador, Frederic; Beghetti, Maurice

in Expert review of cardiovascular therapy (2019), 17(3), 161-175

INTRODUCTION: Pediatric pulmonary arterial hypertension (PAH) remains a rare and severe disease with a poor prognosis. PAH may be idiopathic, heritable or associated with systemic conditions in particular ... [more ▼]

INTRODUCTION: Pediatric pulmonary arterial hypertension (PAH) remains a rare and severe disease with a poor prognosis. PAH may be idiopathic, heritable or associated with systemic conditions in particular associated with congenital heart disease. Areas covered: A thorough and extensive diagnostic approach is required for a correct diagnosis. The outcome has improved over the last decade with a better diagnostic approach and with the initiation of new targeted therapies. However, there is still significant progress to achieve as there is still no cure for this devastating disease. Expert opinion: Adapted clinical studies to define the best therapeutic approach are needed. Even if the treatment approach is still mainly derived from adult data and expert consensus, several studies and registries are currently underway and should deliver important information in the next future. This review aims to give an overview of the current diagnosis and treatment strategies of PAH. [less ▲]

Detailed reference viewed: 33 (3 ULiège)
Full Text
Peer Reviewed
See detailRight-sided pulmonary venous return to the inferior vena cava: an exceptional malformation.
ELLOUZE, Nesrine ULiege; FARHAT, Nesrine ULiege; Desprechins, Brigitte ULiege et al

in Acta Cardiologica (2017), 72(4), 489-490

Detailed reference viewed: 43 (8 ULiège)
Full Text
Peer Reviewed
See detailPrimary pulmonary hypertension in children : a severe disease not to be missed
Dutilleux, Tanguy ULiege; Depuis, Zoé ULiege; FARHAT, Nesrine ULiege et al

in Belgian Journal of Paediatrics (2017, March), 19(1), 31

Detailed reference viewed: 64 (6 ULiège)
Full Text
Peer Reviewed
See detailSeptal hypertrophy and myocardial cell damage in a neonate born from a mother with pregestational diabetis
Zambelli, Laura ULiege; Balthasar, Virginie ULiege; FARHAT, Nesrine ULiege et al

in Belgian Journal of Paediatrics (2017, March), 19(1), 30

Detailed reference viewed: 38 (10 ULiège)
Full Text
Peer Reviewed
See detailExercise-triggered chest pain as an isolated symptom of myocarditis in children
Tshimanga, Prisca ULiege; Daron, Benoît; FARHAT, Nesrine ULiege et al

in Clinics and Practice (2016), 6:843

Detailed reference viewed: 59 (15 ULiège)
Full Text
Peer Reviewed
See detailLa simulation haute-fidélité: un nouvel outil de formation et de recherche en pédiatrie
Bragard, Isabelle ULiege; FARHAT, Nesrine ULiege; Seghaye, Marie-Christine ULiege et al

in Revue Médicale de Liège (2016), 71(10), 455-460

Detailed reference viewed: 85 (21 ULiège)
Full Text
Peer Reviewed
See detailLe syndrome de Marfan chez l'enfant et l'adolescent : cas clinique
Magotteaux, S.; BULK, Saskia ULiege; FARHAT, Nesrine ULiege et al

in Revue Médicale de Liège (2016), 71(7-8), 342-348

Detailed reference viewed: 138 (6 ULiège)
Full Text
Peer Reviewed
See detailRole of inflammatory- and growth factors in the pathophysiology of gestational diabetes-related complications in neonates
Guffins, Amandine; FARHAT, Nesrine ULiege; GKIOUGKI, Evangelia ULiege et al

in Belgian Journal of Paediatrics (2016), 18(1), 82

Detailed reference viewed: 35 (1 ULiège)
Full Text
Peer Reviewed
See detailQuand une anomalie encerclante des arcs aortiques se cache derrière des symptômes respiratoires et digestifs de l'enfant
SOLOWIANIUK, Marie ULiege; SOULATGES, C.; FARHAT, Nesrine ULiege et al

in Revue Médicale de Liège (2016), 71(11), 502-508

Aortic arch anomalies are relatively frequent and account for 15 to 20 % of all congenital cardiovascular malformations. They can be discovered in case of symptoms of airway- or esophageal compression ... [more ▼]

Aortic arch anomalies are relatively frequent and account for 15 to 20 % of all congenital cardiovascular malformations. They can be discovered in case of symptoms of airway- or esophageal compression such as dysphagia, chronic cough, stridor, wheezing and recurrent respiratory infections. We report the cases of two children with encircling aortic arch anomaly. The 3-year-old boy had complained of chronic respiratory symptoms such as laryngitis and asthma since the age of 4 months. The 20-month-old boy presented with intermittent stridor, dysphagia and frequent vomiting. In both patients, the cervico-thoracic CT-scan showed a right aortic arch with retro-esophageal left subclavian artery and Kommerell’s diverticulum. Surgery was curative. The understanding of normal and abnormal embryologic development of the aortic arch, and the knowledge of the different types of vascular compression and their clinical signs are mandatory for the early diagnosis and adequate treatment of such malformations. [less ▲]

Detailed reference viewed: 48 (6 ULiège)
Full Text
Peer Reviewed
See detailParaspinal arterio-venous fistula in children: two more cases of an exceptional malformation
FARHAT, Nesrine ULiege; DESPRECHINS, Brigitte ULiege; OTTO, Bernard ULiege et al

in Clinics and Practice (2015), 5(2), 707-709

Detailed reference viewed: 49 (12 ULiège)
Full Text
Peer Reviewed
See detailDoes gestational diabetes influence foetal organ function ?
Guffins, Amandine ULiege; FARHAT, Nesrine ULiege; GKIOUGKI, Evangelia ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015, January), 17(1), 99

Detailed reference viewed: 32 (5 ULiège)
Full Text
Peer Reviewed
See detailPaucisymptomatic presentation of viral myocarditis in children
TSHIMANGA, Prisca ULiege; DARON, B.; FARHAT, Nesrine ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015, January), 17(1), 98

Detailed reference viewed: 30 (2 ULiège)
Full Text
Peer Reviewed
See detailRespiratory distress or eating disorder could: it be a vascular ring ?
Solowianiuk, Marie ULiege; FARHAT, Nesrine ULiege; HOLZKI, Josef ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015, January), 17(1), 98

Detailed reference viewed: 19 (1 ULiège)