References of "Emmanuel, Noémie"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailTransitioning from conventional batch to microfluidic processes for the efficient singlet oxygen photooxygenation of methionine
Mendoza Gallego, Carlos ULiege; Emmanuel, Noémie ULiege; Pàez Martinez, Carlos ULiege et al

in Journal of Photochemistry and Photobiology A : Chemistry (2018), 356

Singlet oxygen-based photocatalytic oxygenation reactions have emerged as an efficient technology to synthesize value-added organic molecules. Among organic substrates, bio-sourced molecules such as ... [more ▼]

Singlet oxygen-based photocatalytic oxygenation reactions have emerged as an efficient technology to synthesize value-added organic molecules. Among organic substrates, bio-sourced molecules such as aminoacids or terpenes have a promising forecast as synthetic building blocks. A pseudo first-order kinetic study for the photocatalytic oxygenation of natural amino acid (L)-methionine was carried out in a macroscopic batch reactor. Various parameters were studied, including the effect of the photosensitizer (Rose Bengal, RB) concentration, the intensity of the light and the O2 flow in terms of apparent kinetic constants and space-time yields. The identification of important limiting parameters as pressure, gas flow or light efficiency during the photocatalytic oxygenation of methionine allowed its transition from macroscopic batch reactor to continuous-flow microreactor. [less ▲]

Detailed reference viewed: 64 (22 ULiège)
Full Text
See detailIntegrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
Emmanuel, Noémie ULiege; Mendoza Gallego, Carlos ULiege; Winter, Marc et al

Poster (2018, February 06)

Detailed reference viewed: 29 (6 ULiège)
Full Text
Peer Reviewed
See detailContinuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges
Gerardy, Romaric ULiege; Emmanuel, Noémie ULiege; Toupy, Thomas ULiege et al

in European Journal of Organic Chemistry (2018)

: This review intends to provide the reader with a clear and concise overview of how preparative continuous flow organic chemistry could potentially impact on current important societal challenges. These ... [more ▼]

: This review intends to provide the reader with a clear and concise overview of how preparative continuous flow organic chemistry could potentially impact on current important societal challenges. These societal challenges include health/well-being and sustainable development. Continuous flow chemistry has enabled significant advances for the manufacturing of pharmaceuticals, as well as for biomass valorization toward a biosourced chemical industry. Examples related to pharmaceutical production are herein focused on (a) the implementation of flow chemistry to reduce the occurrence of drug shortages, (b) continuous flow manufacturing of orphan drugs, (c) continuous flow preparation of active pharmaceuticals listed on the WHO list of essential medicines and (d) perspectives for the manufacturing of peptide-based pharmaceuticals. Examples related to sustainable development are focused on the valorization of biosourced platform molecules. Besides positive impacts on societal challenges, this review also illustrates some of the potentially most threatening perspectives of continuous flow technology within the actual context of terrorism and drug abuse. [less ▲]

Detailed reference viewed: 30 (8 ULiège)
Full Text
Peer Reviewed
See detailIntegrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
Emmanuel, Noémie ULiege; Monbaliu, Jean-Christophe ULiege

Conference (2017, July 06)

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side ... [more ▼]

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side-reactions or product degradation due to overexposure. The recent implementation of photochemical processes in microreactors under continuous-flow conditions appeared to be much more powerful than its batch analogue in terms of irradiation efficiency and light penetration. Furthermore, the fine control of residence time ensures an accurate control of the irradiation time, avoiding side-reactions and degradation. The scalable photooxidation of (L)-methionine with singlet oxygen using Rose Bengal as a sensitizer was successfully implemented in a microreactor setup and led to total and selective conversion into methionine sulfoxide, an important building block for the organic synthesis of peptides or functionalized amino acid. The reaction was performed in less than 1 min while the same reaction in batch took 2 h. Other substrates as α-terpinene or citronellol were also photooxidized into high added value compounds using the same conditions. [less ▲]

Detailed reference viewed: 18 (1 ULiège)
Full Text
Peer Reviewed
See detailIntegrated continuous flow photoreactors: Photooxidation of (L)-methionine derivatives with singlet oxygen
Emmanuel, Noémie ULiege; Monbaliu, Jean-Christophe ULiege

Conference (2017, May 09)

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side ... [more ▼]

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side-reactions or product degradation due to overexposure. The recent implementation of photochemical processes in microreactors under continuous-flow conditions appeared to be much more powerful than its batch analogue in terms of irradiation efficiency and light penetration. Furthermore, the fine control of residence time ensures an accurate control of the irradiation time, avoiding side-reactions and degradation. The photooxidation of (L)-methionine with singlet oxygen using Rose Bengal as a sensitizer was successfully implemented in a microreactor setup and led to total and selective conversion into methionine sulfoxide, an important building block for the organic synthesis of peptides or functionalized amino acid. The reaction was performed in 1 min while the same reaction in batch took 2 h. [less ▲]

Detailed reference viewed: 28 (2 ULiège)
Full Text
Peer Reviewed
See detailScalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions
Emmanuel, Noémie ULiege; Mendoza Gallego, Carlos ULiege; Winter, Marc et al

in Organic Research Process & Development (2017)

Highly efficient and chemoselective singlet oxygen oxidation of unprotected methionine was performed in water using a continuous mesofluidic reactor. Sustainable process engineering and conditions were ... [more ▼]

Highly efficient and chemoselective singlet oxygen oxidation of unprotected methionine was performed in water using a continuous mesofluidic reactor. Sustainable process engineering and conditions were combined to maximize process efficiency and atom-economy, with virtually no waste generation and safe operating conditions. Three water soluble metal-free photosensitizers (Rose Bengal, Methylene Blue, and tetrakis(4-carboxyphenyl)porphyrin) were assessed. The best results were obtained with Rose Bengal (0.1 mol%) at room temperature under white light irradiation and a slight excess of oxygen. Process and reaction parameters were monitored in real-time with in-line NMR. Other classical organic substrates (alpha-terpinene and citronellol) were oxidized under similar conditions with excellent performances. [less ▲]

Detailed reference viewed: 43 (8 ULiège)
Full Text
Peer Reviewed
See detailExploring the Fundamentals of Microreactor Technology with Multidisciplinary Lab Experiments Combining the Synthesis and Characterization of Inorganic Nanoparticles
Emmanuel, Noémie ULiege; Emonds-Alt, Gauthier ULiege; Lismont, Marjorie et al

in Journal of Chemical Education (2017)

Multidisciplinary lab experiments combining microfluidics, nanoparticle synthesis and characterization are presented. These experiments rely on the implementation of affordable yet efficient microfluidic ... [more ▼]

Multidisciplinary lab experiments combining microfluidics, nanoparticle synthesis and characterization are presented. These experiments rely on the implementation of affordable yet efficient microfluidic setups based on PFA capillary coils and standard HPLC connectors in upper undergraduate chemistry labs. Fundamental principles and concepts, as well as practical tips for the rapid deployment of microfluidics are presented. In-line membrane separation, segmented-flow regime, high temperature experiments, and in-line analytical techniques are illustrated with the preparation of inorganic nanoparticles (silver, gold, cadmium selenide or telluride) in microreactors. Besides microfluidics, analytical techniques for nanoparticle analysis are also illustrated. [less ▲]

Detailed reference viewed: 40 (10 ULiège)
Full Text
See detailIntegrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
Emmanuel, Noémie ULiege; Mendoza Gallego, Carlos ULiege; Lismont, Marjorie ULiege et al

Poster (2016, December 08)

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side ... [more ▼]

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side-reactions or product degradation due to overexposure. The recent implementation of photochemical processes in microreactors under continuous-flow conditions appeared to be much more powerful than its batch analogue in terms of irradiation efficiency and light penetration. Furthermore, the fine control of residence time ensures an accurate control of the irradiation time, avoiding side-reactions and degradation. The photooxidation of (L)-methionine with singlet oxygen using Rose Bengal as a sensitizer was successfully implemented in a microreactor setup and led to total and selective conversion into methionine sulfoxide, an important building block for the organic synthesis of peptides or functionalized amino acid. The reaction was performed in 2 min while the same reaction in batch took 2h. [less ▲]

Detailed reference viewed: 45 (17 ULiège)
Full Text
Peer Reviewed
See detailExpanding chemistry’s horizon with continuous-flow reactors  
Monbaliu, Jean-Christophe ULiege; Emmanuel, Noémie ULiege; Gerardy, Romaric ULiege

in Chimie Nouvelle (2016), 122

Continuous-flow micro- and mesofluidic reactors come with inherent properties that can be advantageously utilized for expanding the horizon of preparative chemistry. Accurate control over local process ... [more ▼]

Continuous-flow micro- and mesofluidic reactors come with inherent properties that can be advantageously utilized for expanding the horizon of preparative chemistry. Accurate control over local process parameters, even under extreme conditions, inherent safety, production homogeneity and seamless scale-up are amongst the most important assets of continuous-flow chemistry. Besides, flow chemistry enables the design of efficient multistep processes with significantly reduced footprints. In this note, we discuss some of the most fascinating aspects of continuous-flow micro- and mesofluidic reactors in the specific context of preparative organic chemistry. [less ▲]

Detailed reference viewed: 26 (6 ULiège)
Full Text
See detailIntegrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
Emmanuel, Noémie ULiege; Mendoza Gallego, Carlos ULiege; Lismont, Marjorie ULiege et al

Poster (2016, October 13)

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side ... [more ▼]

Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side-reactions or product degradation due to overexposure. The recent implementation of photochemical processes in microreactors under continuous-flow conditions appeared to be much more powerful than its batch analogue in terms of irradiation efficiency and light penetration. Furthermore, the fine control of residence time ensures an accurate control of the irradiation time, avoiding side-reactions and degradation. The photooxidation of (L)-methionine with singlet oxygen using Rose Bengal as a sensitizer was successfully implemented in a microreactor setup and led to total and selective conversion into methionine sulfoxide, an important building block for the organic synthesis of peptides or functionalized amino acid. The reaction was performed in 20 min while the same reaction in batch took 2h. [less ▲]

Detailed reference viewed: 77 (24 ULiège)