References of "D'aloia, Violetta"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailAmphiphilic copolymers of epsilon-caprolactone and gamma-substituted epsilon-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles
Gautier, Sandrine; D'Aloia, Violetta; Halleux, Olivier et al

in Journal of Biomaterials Science. Polymer Edition (2003), 14(1), 63-85

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were ... [more ▼]

Fully biodegradable and surface-functionalized poly(D,L-lactide) (PLA) nanoparticles have been prepared by a co-precipitation technique. Novel amphiphilic random copolyesters P(CL-co-gamma XCL) were synthesized by controlled copolymerization of epsilon-caprolactone and epsilon-caprolactone substituted in the gamma-position by a hydrophilic X group, where X is either a cationic pyridinium (gamma-Py-CL) or a non-ionic hydroxyl (gamma-OH-CL). Nanoparticles were prepared by co-precipitation of PLA with the P(CL-co-gamma-XCL) copolyester from a DMSO solution. Small amounts of cationic P(CL-co-gamma-Py-CL) copolymers are needed to quantitatively form stable nanoparticles (ca. 10 mg/100 mg PLA), although larger amounts of non-ionic P(CL-co-gamma-OH-CL) copolymers are needed (ges12.5 mg/100 mg PLA). Copolymers with a low degree of polymerization (ca. 40) are more efficient stabilizers, probably because of faster migration towards the nanoparticle-water interface. The nanoparticle diameter decreases with the polymer concentration in DMSO, e.g. from ca. 160 nm (16 mg/ml) to ca. 100 nm (2 mg/ml) for PLA/P(CL-co-gamma-Py-CL) nanoparticles. Migration of the P(CL-co-gamma-XCL) copolyesters to the nanoparticle surface was confirmed by measurement of the zeta potential, i.e. ca. +65 mV for P(CL-co-gamma-Py-CL) and -7 mV for P(CL-co-gamma-OH-CL). The polyamphiphilic copolyesters stabilize PLA nanoparticles by electrostatic or steric repulsions, depending on whether they are charged or not. They also impart functionality and reactivity to the surface, which opens up new opportunities for labelling and targeting purposes. [less ▲]

Detailed reference viewed: 66 (5 ULiège)
Full Text
See detailSynthesis of new hydrophilic γ-substituted poly-ε-caprolactones
Lecomte, Philippe ULiege; D'aloia, Violetta; Mazza, Michaël et al

Conference (2000, August 20)

Detailed reference viewed: 24 (2 ULiège)
See detailγ-bromo-ε-caprolactone, a versatile lactone for the synthesis of new functional aliphatic polyesters
D'Aloia, Violetta; Gautier, Sandrine; Halleux, Olivier et al

Poster (2000, May 02)

Detailed reference viewed: 42 (8 ULiège)
Full Text
See detailSynthesis of new hydrophilic γ-substituted poly(ε-caprolactone)s
Lecomte, Philippe ULiege; D'aloia, Violetta; Mazza, Michaël et al

in Polymer Preprints (2000), 41(2), 1534-1535

Detailed reference viewed: 30 (1 ULiège)