References of "Coupeau, Damien"
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See detailSchmallenberg virus, cyclical reemergence in the core region: a seroepidemiologic study in wild cervids, Belgium, 2012-2017.
Bayrou, Calixte ULiege; Lesenfants, Christophe ULiege; Paternostre, Julien et al

in Transboundary and emerging diseases (2021)

Schmallenberg virus emerged in 2011 in Europe. The epicenter of primordial spreading was the region straddling Germany, the Netherlands and Belgium. One of the key questions is whether the newcomer would ... [more ▼]

Schmallenberg virus emerged in 2011 in Europe. The epicenter of primordial spreading was the region straddling Germany, the Netherlands and Belgium. One of the key questions is whether the newcomer would establish a lasting presence on the continent. The apparent seroprevalence in southern Belgium wild deer populations was followed for 6 years. Two years of intense circulation were revealed, 2012 and 2016, characterized by a peak seroprevalence in the two studied populations (Capreolus capreolus and Cervus elaphus). Between the peak years and after 2016, apparent seroprevalences declined rapidly among adults and became nil among juveniles. The general pattern of apparent seroprevalence evolution observed is consistent with a cyclic circulation of Schmallenberg virus, similar to what is observed for other Orthobunyaviruses in endemic areas. These data also suggest that wild cervids play no central role in the circulation dynamics of the virus. [less ▲]

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See detailHost-dependence of in vitro reassortment dynamics among the Sathuperi and Shamonda Simbuviruses.
Coupeau, Damien; Bayrou, Calixte ULiege; Baillieux, Pierre et al

in Emerging Microbes and Infections (2019), 8(1), 381-395

Orthobunyaviruses are arboviruses (Arthropod Borne Virus) and possess multipartite genomes made up of three negative RNAs corresponding to the small (S), medium (M) and large (L) segments. Reassortment ... [more ▼]

Orthobunyaviruses are arboviruses (Arthropod Borne Virus) and possess multipartite genomes made up of three negative RNAs corresponding to the small (S), medium (M) and large (L) segments. Reassortment and recombination are evolutionary driving forces of such segmented viruses and lead to the emergence of new strains and species. Retrospective studies based on phylogenetical analysis are able to evaluate these mechanisms at the end of the selection process but fail to address the dynamics of emergence. This issue was addressed using two Orthobunyaviruses infecting ruminants and belonging to the Simbu serogroup: the Sathuperi virus (SATV) and the Shamonda virus (SHAV). Both viruses were associated with abortion, stillbirth and congenital malformations occurring after transplacental transmission and were suspected to spread together in different ruminant and insect populations. This study showed that different viruses related to SHAV and SATV are spreading simultaneously in ruminants and equids of the Sub-Saharan region. Their reassortment and recombination potential was evaluated in mammalian and in insect contexts. A method was set up to determine the genomic background of any clonal progeny viruses isolated after in vitro coinfections assays. All the reassortment combinations were generated in both contexts while no recombinant virus was isolated. Progeny virus populations revealed a high level of reassortment in mammalian cells and a much lower level in insect cells. In vitro selection pressure that mimicked the host switching (insect-mammal) revealed that the best adapted reassortant virus was connected with an advantageous replicative fitness and with the presence of a specific segment. [less ▲]

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See detailIN UTERO INFECTION BY SCHMALLENBERG VIRUS INDUCES ARTHROGRYPOSIS MULTIPLEXA CONGENITA IN OVINE FETUSES
Boseret, Géraldine ULiege; Claine, Francoise; Coupeau, Damien et al

Poster (2014, December)

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