References of "Comblain, Fanny"
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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

Poster (2017, April 27)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2017, April), 25

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histo- logical lesions with the mechanical properties of cartilage. [less ▲]

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See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

in Osteoarthritis and Cartilage (2017, April)

Detailed reference viewed: 37 (3 ULiège)
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See detailA randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis
Comblain, Fanny ULiege; Barthelemy, Nicolas ULiege; Lefebvre, Michaël ULiege et al

in BMC Veterinary Research (2017), 13

Background: We have previously demonstrated that a mixture of Curcuminoids extract, hydrolyzed COllagen and green Tea extract (CCOT) inhibited inflammatory and catabolic mediator's synthesis by bovine and ... [more ▼]

Background: We have previously demonstrated that a mixture of Curcuminoids extract, hydrolyzed COllagen and green Tea extract (CCOT) inhibited inflammatory and catabolic mediator's synthesis by bovine and human chondrocytes. A randomly allocated, double-blind, prospective, placebo-controlled study was performed to evaluate the efficacy of a diet containing this CCOT mixture on dogs with naturally occurring osteoarthritis (OA). Therefore, 42 owner's dogs with OA were randomly assigned to receive for 3months an experimental diet (control) or the same diet supplemented with CCOT. Results: Ground reaction forces did not show statistical differences between groups. After 3months of feeding, there was a significant reduction of pain at manipulation in the CCOT group, but not in the control group. The evolution for pain at manipulation depended on the diet. The three other parameters evaluated by veterinary subjective assessment (lameness, pain at palpation and joint mobility) did not show statistical differences. Concerning owner subjective assessment, pain severity score worsened in the control group but remained stable in CCOT group. The evolution for pain severity depended on the diet. No statistical difference was found for pain interference, except for the ability to rise to standing from lying down, which was significantly improved in the CCOT compared to the control group. Serum OA biomarkers did not show statistical differences. Conclusions: Objective variables measured, such as ground reaction forces and OA biomarkers, did not show statistical differences. However, indicators of pain appeared reduced in dogs receiving CCOT mixture for 3months. The difference of evolution between groups suggests that a greater number of dogs may be necessary to reach a stronger effect on other parameters. © 2017 The Author(s). [less ▲]

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Cartilage (2017)

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no ... [more ▼]

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA. [less ▲]

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See detailChitosan : a promising polymer for cartilage repair and viscosupplementation
Comblain, Fanny ULiege; Rocasalbas, Guillem; Gautier, Sandrine et al

in Bio-medical Materials and Engineering (2017)

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See detailUn hydrogel de chitosan d’origine non-animale restaure la fonction rhéologique du fluide synovial arthrosique : étude ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

Poster (2016, December)

Detailed reference viewed: 38 (1 ULiège)
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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

Poster (2016, November 16)

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan content, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histological lesions with the mechanical properties of cartilage. [less ▲]

Detailed reference viewed: 39 (4 ULiège)
Peer Reviewed
See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

Poster (2016, September)

Detailed reference viewed: 55 (2 ULiège)
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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

Detailed reference viewed: 52 (12 ULiège)
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See detailOsteoarthritic sclerotic subchondral osteoblasts secreted elevated concentration of fibulin-3 fragments in vitro
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 83

Detailed reference viewed: 42 (9 ULiège)
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See detailIdentification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed by Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract
Comblain, Fanny ULiege; Dubuc, Jean-Emile; Lambert, Cécile ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(Supp 1), 353

Detailed reference viewed: 42 (10 ULiège)
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See detailRandomized, Double-Blinded, Controlled Clinical Trial Evaluating the Efficacy of a Diet Supplemented with Curcuminoids Extract, Hydrolysed Collagen and Green Tea Extract in Dogs with Osteoarthritis
Barthélémy, Nicolas; Comblain, Fanny ULiege; Lesponne, Isabelle et al

in Veterinary and Comparative Orthopaedics and Traumatology (2016)

Detailed reference viewed: 60 (12 ULiège)
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See detailReview of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014
Comblain, Fanny ULiege; Serisier, Samuel; Barthelemy, Nicolas ULiege et al

in Journal of Veterinary Pharmacology and Therapeutics (2016), 39

Detailed reference viewed: 152 (9 ULiège)