References of "Chylinski, Daphné"
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See detailSleep fragmentation is associated with brain tau but not amyloid-β burden in healthy older adults
Chylinski, Daphné ULiege; Rudzik, Franziska; Coppieters't Wallant, Dorothe ULiege et al

Conference (2018, November 09)

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See detailArousals during sleep are associated with brain tau burden in healthy older individuals
Chylinski, Daphné ULiege; Rudzik, Franziska; Coppieters't Wallant, Dorothe ULiege et al

Poster (2018, October 19)

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See detailArousals during sleep are associated with brain tau and amyloid-β burden in healthy older adults
Chylinski, Daphné ULiege; Rudzik, Franziska; Coppieters't Wallant, Dorothe ULiege et al

Conference (2018, September)

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See detailRelationship between cerebral amyloid burden and cerebral microstructure measured by quantitative MRI in healthy aging
Villar Gonzalez, Pamela ULiege; Chylinski, Daphné ULiege; Narbutas, Justinas ULiege et al

in Frontiers (2018, August 22)

The presence of Alzheimer’s disease (AD) biomarkers in the brain of healthy older individuals has been associated with decreased myelin and increased iron deposits in the brain (Bartzokis, 2011). Novel ... [more ▼]

The presence of Alzheimer’s disease (AD) biomarkers in the brain of healthy older individuals has been associated with decreased myelin and increased iron deposits in the brain (Bartzokis, 2011). Novel Magnetic Resonance Imaging (MRI) techniques, like quantitative multiparameter mapping (MPM), allow to gain insight in the microstructure of the brain and could help to address the link between myelin and iron in the brain (Callaghan et al., 2014) and AD biomarkers. Our aim was, therefore, to relate the amount of myelin and iron content to the cortical amyloid burden. We acquired MPM sequences in a 3T scanner and [18F]flutemetamol positron-emission tomography (PET) images in 55 cognitively healthy adults (35 women), aged 50-70 (mean: 59.5 ± 5.5). We used MPM to infer myelin content, based on magnetization transfer saturation (MT) and longitudinal relaxation rate (R1), and iron content, based on effective transverse relaxation rate (R2*). Cortical beta-amyloid burden was measured with [18F]flutemetamol PET. Multiparameter maps were created and normalised with the hMRI (Balteau et al., 2018) toolbox for MATLAB (The Mathworks Inc, Natick, MA, USA). Correlations between MPM maps and amyloid burden were conducted with SPM12 framework (Wellcome Trust Centre for Neuroimaging, London) p<.05 FWE corrected. As expected (Dean et al., 2017), we observed a link between increased amyloid burden and increased iron content in frontal areas mainly but also in parietal and occipital areas. However, there was an unexpected negative correlation between amyloid burden and white matter iron content in the left superior temporal area. Moreover, a positive association between amyloid burden and myelin content was found in the frontal and temporal lobes in both grey and white matter. Furthermore, R1 values, which depend on both iron and myelin storage, present positive correlations with amyloid burden in both grey and white matter of frontal, temporal and occipital areas. The finding that increased iron in frontoparietal and occipital areas are associated with increased amyloid burden fits with previous studies. However, current results also indicate that individuals with higher cortical amyloid burden have higher myelin water fraction in frontotemporal areas. This would suggest that, in cognitively healthy middle-aged individuals, the presence of amyloid in the brain, which represents a risk factor for AD, is accompanied by both cerebral microstructural decline in some areas and enhanced –possibly compensatory- microstructure properties in other areas. [less ▲]

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See detailSleep Deprivation Triggers Cognitive Control Impairments in Task-Goal Switching
Slama, Hichem; Chylinski, Daphné ULiege; Deliens, Gaétane et al

in Sleep (2018)

Study Objectives: This study investigates the impact of sleep deprivation (SD) on task-goal switching, a key component of cognitive flexibility. Methods: Task-goal switching performance was tested after ... [more ▼]

Study Objectives: This study investigates the impact of sleep deprivation (SD) on task-goal switching, a key component of cognitive flexibility. Methods: Task-goal switching performance was tested after one night of regular sleep (n = 17 participants) or of total SD (n = 18). To understand the relationships between task-switching performance and other cognitive processes following SD, participants were tested for other key attentional (alertness and vigilance) and executive (inhibition and working memory) functions. Spontaneous eye blink rate (EBR) was also measured as an indirect marker of striatal dopaminergic function. Results: SD negatively affects task-goal switching as well as attentional and inhibition measures, but not working memory. Changes in task-goal switching performance were not significantly correlated with changes in objective and subjective markers of fatigue and sleepiness, response inhibition, or spontaneous EBR. Conclusions: Altogether, our results show differentiated effects of SD on key executive functions such as working memory,inhibition, and task-goal switching. [less ▲]

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See detailComplexity and compositionality in fluid intelligence
Duncan, John; Chylinski, Daphné ULiege; Mitchell, Daniel J. et al

in Proceedings of the National Academy of Sciences of the United States of America (2017)

Compositionality, or the ability to build complex cognitive structures from simple parts, is fundamental to the power of the human mind. Here we relate this principle to the psychometric concept of fluid ... [more ▼]

Compositionality, or the ability to build complex cognitive structures from simple parts, is fundamental to the power of the human mind. Here we relate this principle to the psychometric concept of fluid intelligence, traditionally measured with tests of complex reasoning. Following the principle of compositionality, we propose that the critical function in fluid intelligence is splitting a complex whole into simple, separately attended parts. To test this proposal, we modify traditional matrix reasoning problems to minimize requirements on information integration, working memory, and processing speed, creating problems that are trivial once effectively divided into parts. Performance remains poor in participants with low fluid intelligence, but is radically improved by problem layout that aids cognitive segmentation. In line with the principle of compositionality, we suggest that effective cognitive segmentation is important in all organized behavior, explaining the broad role of fluid intelligence in successful cognition. [less ▲]

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See detailThe effects of one night of sleep deprivation on task-goal switching
Chylinski, Daphné ULiege; Slama, Hichem; Deliens, Gaétane et al

Poster (2015)

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See detailCortical correlates of updating processes in working memory: a fNIRS investigation
Guerrero-Mosquera, Carlos; Borragan, Guillermo; Chylinski, Daphné ULiege et al

Poster (2014, October)

Detailed reference viewed: 17 (1 ULiège)