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See detailPRP dans les discopathies
Kaux, Jean-François ULiege; Vanderthommen, Marc ULiege; Charneux, Laurent ULiege

Conference (2018, May 28)

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See detailPlasma riche en plaquettes (PRP) et lésions discales : revue de la littérature
Charneux, Laurent ULiege; Demoulin, Christophe ULiege; Vanderthommen, Marc ULiege et al

in Neuro-Chirurgie (2017), 63(6), 473-477

The spine has been the subject of extensive clinical research since it is the source of many painful complaints. However, there is little scientific evidence concerning the therapeutic proposals. During ... [more ▼]

The spine has been the subject of extensive clinical research since it is the source of many painful complaints. However, there is little scientific evidence concerning the therapeutic proposals. During the course of life, the intervertebral disc degenerates, which over time diminishes its damping capacity and facilitates the expulsion of the nucleus pulposus through the annulus fibrosus. The degeneration of the intervertebral disc (DDI) is the origin of some back pain and various specific treatments have been developed. These include the infiltration at the center of the intervertebral disc of plasma rich platelet (PRP), composed of multiple growth factors which act on the disc degeneration. This treatment is recent and less invasive than surgery. Preliminary results seem promising. However, many gray areas and several parameters remained to be clarified. In an attempt to do this, a literature review was conducted based on bibliographic databases Pubmed, Medline and Scopus® using the following Mesh terms : PRP, platelet-rich plasma, intradiscal disc degeneration, disc, intradiscal, discogenic. This analysis reveals that at the present time, no reported study has a sufficient perspective to judge the effectiveness of the infiltration of PRP. Early harvest results will be used to set the limits of this treatment. Accordingly, it is therefore currently recommended to introduce PRP injection as a complementary solution to comprehensive care of the spine. Future research will need to generate randomized controlled studies including comparing the results with conservative treatment and measure the cost-benefit relationship. [less ▲]

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See detailEtude des effets du Plasma Riche en Plaquettes (PRP) sur les monodiscopathies peu évoluées
Charneux, Laurent ULiege

Master's dissertation (2016)

Objectives: Pre-clinical testing to study the potential tissue regeneration of Platelet-Rich Plasma (PRP) in the case of a monodiscopathy. After analysing the available literature on the subject, a ... [more ▼]

Objectives: Pre-clinical testing to study the potential tissue regeneration of Platelet-Rich Plasma (PRP) in the case of a monodiscopathy. After analysing the available literature on the subject, a research team was established at the CHU. The objective is to standardise the PRP and use it within the restrictive framework of the monodiscopathy on the human in order to supplement knowledge relating to this biological therapy. Equipment and Method: The recruitment of a panel of ten patients was launched in January 2016. Once admitted in the study, the patients are followed for one year with an MRI, an EVA, an inclinometry and the questionnaires of Roland Morris and Tampa. The infiltration of PRP is carried out in the middle of the nucleus pulposus using a discography. Results: Only one patient underwent the intervention, which could not be finished because we were unable to reach the L5-S1 disc. The objective was to inject 1.5 ml of PRP within the L5-S1 disc. Conclusions: The infiltration of PRP still needs to be studied in order to set the limits, the advantages and the disadvantages of this infiltration. The literature suggests that this might be an effective solution, however it is impossible to make generalised conclusions due to the lack of uniformity between existing studies. [less ▲]

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