References of "Cavalier, Etienne"
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See detailNatural history of mineral metabolism, bone turnover and bone mineral density in de novo renal transplant recipients treated with a steroid minimization immunosuppressive protocol.
Evenepoel, Pieter; Claes, Kathleen; Meijers, Bjorn et al

in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (in press)

The skeletal effects of renal transplantation are not completely understood, especially in patients managed with a steroid minimization immunosuppressive protocol and long term. We enrolled 69 adult ... [more ▼]

The skeletal effects of renal transplantation are not completely understood, especially in patients managed with a steroid minimization immunosuppressive protocol and long term. We enrolled 69 adult transplant recipients (39 males; ages 51.1 +/- 12.2 years), free of antiresorptive therapy and managed with a steroid minimization immunosuppressive protocol, into a 5-year prospective observational study to evaluate changes in areal bone mineral density (aBMD), mineral metabolism and bone remodelling. Dual energy X-ray absorptiometry, laboratory parameters of mineral metabolism (including parathyroid hormone, sclerostin and fibroblast growth factor 23) and non-renal cleared bone turnover markers (BTMs) (bone-specific alkaline phosphatase, trimeric N-terminal propeptide and tartrate-resistant acid phosphatase 5b) were assessed at baseline and 1 and 5 years post-transplantation. The mean cumulative methylprednisolone exposure at 1 and 5 years amounted to 2.5 +/- 0.8 and 5.8 +/- 3.3 g, respectively. Overall, bone remodelling activity decreased after transplantation. Post-transplant aBMD changes were minimal and were significant only in the ultradistal radius during the first post-operative year {median -2.2% [interquartile range (IQR) -5.9-1.2] decline, P = 0.01} and in the lumbar spine between Years 1 and 5 [median 1.6% (IQR -3.2-7.0) increase, P = 0.009]. BTMs, as opposed to mineral metabolism parameters and cumulative corticosteroid exposure, associated with aBMD changes, both in the early and late post-transplant period. Most notably, aBMD changes inversely associated with bone remodelling changes. In summary, in de novo renal transplant recipients treated with a steroid minimization immunosuppressive protocol, BMD changes are limited, highly variable and related to remodelling activity rather than corticosteroid exposure. [less ▲]

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See detailExternal Quality Assessment of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) assays.
Carter, G. D.; Ahmed, F.; Berry, J. et al

in The Journal of steroid biochemistry and molecular biology (in press)

The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)2D3. Several studies have also suggested that a ... [more ▼]

The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)2D3. Several studies have also suggested that a high 25-hydroxyvitamin D3(25-OHD3):24,25(OH)2D3 ratio might provide additional diagnostic information in the investigation of vitamin D deficiency. Measurement of 24,25(OH)2D3 is necessarily restricted to laboratories with mass spectrometry methods although cross reactivity of the metabolite in immunoassays for 25-OHD is a potential cause of misleading results. The international External Quality Assessment (EQA) scheme for vitamin D metabolites (DEQAS) was set up in 1989. In 2013 DEQAS became an accuracy based EQA for 25-OHD with 'target values' assigned by the National Institute of Standards and Technology (NIST) Reference Measurement Procedure (RMP). A pilot scheme for serum 24,25(OH)2D3 was started in 2015 and participants were asked to measure the metabolite on each of the 5 samples sent out for 25-OHD. Inter-laboratory agreement was poor but this may reflect methodological differences, in particular different approaches to assay standardization. An important potential contribution to reducing variability among assays was the development by NIST of a 24,25(OH)2D3 RMP and its use in assigning values to SRMs 972a, 2973 and 2971, supported by the NIH Office of Dietary Supplements (ODS) as part of the Vitamin D Standardization Program (VDSP) effort. [less ▲]

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See detailImpact of participating to a 330 km long ultra-trail versus a 67 km short ultra-trail on muscular and cardiac genetic regulation by microRNAs
Le Goff, Caroline ULiege; Marguerit, K; Kaux, Jean-François ULiege et al

in Bunc, V; Tsolakidis, E (Eds.) Book of abstracts - 24th Annual Congress of the European College of Sport Science (2019, July)

INTRODUCTION: Even though endurance exercise has always shown beneficial action on cardiovascular diseases, the impact of an ultra-endurance experience on the human body has not been studied enough yet ... [more ▼]

INTRODUCTION: Even though endurance exercise has always shown beneficial action on cardiovascular diseases, the impact of an ultra-endurance experience on the human body has not been studied enough yet. Indeed, the consequences of such effort could represent a major issue to the organism and particularly to the myocardial muscle, could lead to sudden cardiac death when experienced too many times - a phenomenon which is more and more linked to the athletic world. The main objective of this study was to measure the impact of high level physical activity on the expression of different microRNAs such as specific to muscular and cardiac suffering (miR-1, miR 133a and miR 208b), specific to muscular suffering (miR 133b, miR 206, miR 499a and miR 499b) specific to cardiac suffering (miR 208a) and specific to fibrosis (miR 21 and miR 29b). METHODS: The study was conducted on two different trails participants: the “Tor des Géants” (TDG), 330 km long and the “Ultra Tour de Liège” (UTL), 67km long. Blood samples were collected at different timings. Timing of sampling were respectively: 4 days before starting (t0), after completing 148 km (t2), finish line (t3) and 3 days after the end of the race for the TDG (t4) , and for the UTL : just before the starting (t0), at the finish line( t2) : and 3 hours after finishing (t3). There was a number of 12 TDG studied volunteers and 10 from the UTL. MicroRNAs were extracted by using miRneasy® Serum/Plasma kit and qRT-PCR has been employed to measure their expression. RESULTS: Only miR-1, miR-133a, miR-133b, miR-206 and miR-499a showed significant variation in their expression during both races. The variation was found to be linked to the exhaustion during the race. From these data, four out of the five miRNAs showed a higher expression level during the shorter trail (UTL). No correlation was found between miR-208a and frequently used cardiac biomarkers (hs-TnT, sST2 and NT-proBNP). No significant variation was found in fibrosis specific microRNAs (miR-21 and miR-29b). CONCLUSION: From the amount of microRNAs tested, the expression of five of them increased significantly during both the races, which showed myocardial and muscular cellular suffering. Moreover, the levels of miRNA never came back to the baseline during recovery times. However, the fibrotic miRNA did not show any significant increase during in any race, suggesting there was no permanent damage of the heart, but this point needs further investigations. [less ▲]

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See detailAre variations of glycated hemoglobin given by the freestyle device accurate?
Senterre, Yseult ULiege; Fombellida, K; CAVALIER, Etienne ULiege et al

Poster (2019, May)

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See detailEvaluation of Metformin impact on vitamin B12 status
VRANKEN, Laura ULiege; FONTAINE, Corentin ULiege; LUKAS, Pierre ULiege et al

Poster (2019, May)

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See detailComparison of cardiac biomarker dynamics in marathon, semimarathon and untrained runners: what is the impact on results interpretation?
Le Goff, Caroline ULiege; Lennartz, Lieselotte; VRANKEN, Laura ULiege et al

in Journal of Laboratory and Precision Medicine (2019), 4(6), 10

Background: Cardiac biomarkers elevations have been described after running exercise. Objective of our study was to check cardiac biomarker dynamics in well trained athletes and untrained middle aged ... [more ▼]

Background: Cardiac biomarkers elevations have been described after running exercise. Objective of our study was to check cardiac biomarker dynamics in well trained athletes and untrained middle aged apparently healthy men and to highlight the impact on the lab results interpretation in emergency department. Methods: Cardiac biomarkers for ischemic condition, cardiac stretch and fibrotic processes were tested in different type of runners before, directly after and 3 hours after running. Markers for inflammation, muscle disease and renal function were also measured. Results: Cardiac biomarker levels between groups were not statistically different in the pre-exercise samples for natriuretic peptides [B-type natriuretic peptide (BNP), N-terminal Pro BNP (NT-ProBNP)] and galectin-3 (Gal-3), only Troponin I levels were higher. Directly after exercise, all cardiac biomarker levels were higher compared to the baseline, Gal-3 and BNP levels decreased 3 hours after completion of the run.Troponin values continued to increase with highest levels 3 hours after exercise. Troponin T, NT-Pro BNP and Gal-3 also showed significant correlation to markers of inflammation, fibrosis and renal function. Conclusions: Exercises of different intensity can be associated with biochemical abnormalities and longterm consequences are unknown. In chest pain patients presenting to the emergency department possible impact of exercise on test results, especially Troponin, should be checked. [less ▲]

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See detailMyostatin and Insulin-Like Growth Factor 1 Are Biomarkers of Muscle Strength, Muscle Mass, and Mortality in Patients on Hemodialysis.
DELANAYE, Pierre ULiege; Bataille; Quinonez, Kevin et al

in Journal of Renal Nutrition (2019)

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See detailParathyroid hormone results interpretation in the background of variable analytical performance
CAVALIER, Etienne ULiege

in Journal of Laboratory and Precision Medicine (2019), 4(1),

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See detailImpact of the creatinine-based equations used on the chronic kidney disease classification in a large laboratory database
masson, grégoire; VRANKEN, Laura ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Nephrology Dialysis Transplantation (2019)

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See detailVitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study
Delvin, E.; Alos, N.; Rauch, F. et al

in Clinical Nutrition (2019)

Background: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk ... [more ▼]

Background: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. Objective: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. Results: Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44–2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5–97.5%iles) intake is 600 IU/d (21.2–1972 IU/d). Sixteen participants are vitamin D deficient (<30 nM) and 66 insufficient (≥30 – <50 nM). Serum 24,25(OH)2D3 concentrations are directly related to those of 25OHD3, and those of 3-epi-25OHD3 below the Lower Limit of Quantification in most samples. The participants' serum concentrations of cross-linked C-telopeptide of type-I collagen and intact amino-terminal pro-peptide of type-I collagen decrease steadily with age, leveling at adulthood, and are at all times higher in males. Conclusion: The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations. © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism [less ▲]

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See detailPerformance of creatinine- or cystatin C-based equations to estimate glomerular filtration rate in sub-Saharan African populations
Bukabau, JB; Yayo, E; Gnionsahé, A et al

in Kidney International (2019), 95(5), 1181-1189

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