References of "CHANTRAINE, Frédéric"
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See detailAbnormally adherent and invasive placenta: a spectrum disorder in need of a name
Collins, Sally; CHANTRAINE, Frédéric ULiege; Morgan, Terry et al

in Ultrasound in Obstetrics and Gynecology (2018)

There is little doubt that the worldwide Cesarean delivery epidemic has led to an increased incidence of abnormally adherent and invasive placentation. The significant impact that this disorder has on ... [more ▼]

There is little doubt that the worldwide Cesarean delivery epidemic has led to an increased incidence of abnormally adherent and invasive placentation. The significant impact that this disorder has on maternal morbidity and mortality has led to a flurry of publications in the literature concerning all aspects of the condition. These papers have arisen from many sources, notably pathologists, epidemiologists, obstetricians and radiologists. [less ▲]

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See detailRe: Prediction of delivery time in second stage of labor using transperineal ultrasound.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in Obstetrics and Gynecology (2017), 49(5), 663-664

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See detailBrain plasticity after implanted peroneal nerve electrical stimulation to improve gait in chronic stroke patients: Two case reports.
Thibaut, Aurore ULiege; Moissenet, Florent; Di Perri, Carol ULiege et al

in NeuroRehabilitation (2017), 40(2), 251-258

BACKGROUND: Recent studies have shown that stimulation of the peroneal nerve using an implantable 4-channel peroneal nerve stimulator could improve gait in stroke patients. OBJECTIVES: To assess ... [more ▼]

BACKGROUND: Recent studies have shown that stimulation of the peroneal nerve using an implantable 4-channel peroneal nerve stimulator could improve gait in stroke patients. OBJECTIVES: To assess structural cortical and regional cerebral metabolism changes associated with an implanted peroneal nerve electrical stimulator to correct foot drop related to a central nervous system lesion. METHODS: Two stroke patients presenting a foot drop related to a central nervous system lesion were implanted with an implanted peroneal nerve electrical stimulator. Both patients underwent clinical evaluations before implantation and one year after the activation of the stimulator. Structural magnetic resonance imaging (MRI) and [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) were acquired before and one year after the activation of the stimulator. RESULTS: Foot drop was corrected for both patients after the implantation of the stimulator. After one year of treatment, patient 1 improved in three major clinical tests, while patient 2 only improved in one test. Prior to treatment, FDG-PET showed a significant hypometabolism in premotor, primary and supplementary motor areas in both patients as compared to controls, with patient 2 presenting more widespread hypometabolism. One year after the activation of the stimulator, both patients showed significantly less hypometabolism in the damaged motor cortex. No difference was observed on the structural MRI. CONCLUSION: Clinical improvement of gait under peroneal nerve electrical stimulation in chronic stroke patients presenting foot drop was paralleled to metabolic changes in the damaged motor cortex. [less ▲]

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See detailL'utilisation du ratio sFlt-1/PlGF dans la preeclampsie : une analyse retrospective monocentrique.
Verbeurgt, Lievine ULiege; CHANTRAINE, Frédéric ULiege; DE MARCHIN, Jérôme et al

in Revue Médicale de Liège (2017), 72(9), 393-398

Soluble Fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts in preeclampsia and implicated in endothelial dysfunction. sFlt-1/PlGF ratio is used in the prediction ... [more ▼]

Soluble Fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts in preeclampsia and implicated in endothelial dysfunction. sFlt-1/PlGF ratio is used in the prediction of preeclampsia. An sFlt-1/PlGF ratio inferior to 38 predicts the short-term absence of preeclampsia. A ratio ? 85 (early-onset PE) or ? 110 (late-onset of PE) could diagnose preeclampsia. In this study, sFlt-1/PlGF ratio has been measured in 183 patients. Sixty-seven preeclampsia have been diagnosed preeclamptic at delivery. The median sFlt-1/PlGF ratio was 100.3. The median ratio among women with preeclampsia (N=67) versus no preeclampsia (N=116) was 212.7 versus 35.4. In accordance with this analysis, an sFlt-1/PlGF ratio ? 38 has a sensibility of 95,5 % and a specificity of 73.3 %. The positive predictive value and the negative predictive value were 67.4 % and 96.6 %, respectively. These results suggest that sFlt-1/PlGF ratio is helpful in the diagnosis of preeclampsia. [less ▲]

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See detailComputed tomography and ultrasound to determine fetal head station.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in Obstetrics and Gynecology (2017), 49(2), 279-280

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See detailDysregulated circulating miRNAs in pre-eclampsia
Tebache, Linda; Munaut, Carine ULiege; Blacher, Silvia ULiege et al

Conference (2016, September 25)

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See detailDysregulated circulating miRNAs in preeclampsia.
Munaut, Carine ULiege; TEBACHE, Linda ULiege; Blacher, Silvia ULiege et al

in Biomedical Reports (2016), 5(6), 686-692

Preeclampsia (PE) is a pregnancy-related disease with potentially severe consequences with respect to foeto-maternal morbidity and mortality. However, the molecular pathogenesis of PE remains largely ... [more ▼]

Preeclampsia (PE) is a pregnancy-related disease with potentially severe consequences with respect to foeto-maternal morbidity and mortality. However, the molecular pathogenesis of PE remains largely unknown. Recent reports have shown that microRNAs (miRNAs or miRs) may play important roles in the development of PE. Analysing the miRNAs in sera from preeclamptic women may improve our understanding of the pathophysiological mechanisms of the disease. The aim of this retrospective study was to identify whether circulating miRNAs were differentially expressed in PE patients compared with controls. Serum samples from 23 women who developed PE were compared with samples from 44 pregnant controls. Seventeen circulating miRNAs previously described in PE were chosen for evaluation of their expression by reverse transcription quantitative polymerase chain reaction (RT-qPCR). In the maternal serum, the miR-210-3p, miR-210-5p, miR-1233-3p, and miR-574-5p levels were found to be significantly higher in the PE patients than in the controls (P<0.05). Using a logistic regression model, we evaluated the discriminant power of those differentially expressed miRNAs, and the combination of miR-210-5p and miR-574-5p yielded an area under the curve of 0.7223 for discriminating PE patients from the controls. In conclusion, the fact that four circulating miRNAs (miR-210-3p, miR-210-5p, miR-1233-3p, and miR-574-5p) were differentially expressed in the sera of women who developed PE compared with controls confirms the possible pathophysiological role of miRNAs in PE. [less ▲]

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See detailSoluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio and Time to Delivery in Women With Suspected Preeclampsia.
Zeisler, Harald; Llurba, Elisa; CHANTRAINE, Frédéric ULiege et al

in Obstetrics and Gynecology (2016), 128(2), 261-9

OBJECTIVE: To assess the association of a serum soluble fms-like tyrosine kinase 1-to-placental growth factor (sFlt-1-to-PlGF) ratio of greater than 38 with time to delivery and preterm birth. METHODS ... [more ▼]

OBJECTIVE: To assess the association of a serum soluble fms-like tyrosine kinase 1-to-placental growth factor (sFlt-1-to-PlGF) ratio of greater than 38 with time to delivery and preterm birth. METHODS: Secondary analysis of an observational cohort study that included women 18 years of age or older from 24 to 36 6/7 weeks of gestation at their first study visit with suspected (not confirmed) preeclampsia. Participants were recruited from December 2010 to January 2014 at 30 sites in 14 countries. A total of 1,041 women were included in time-to-delivery analysis and 848 in preterm birth analysis. RESULTS: Women with an sFlt-1-to-PlGF ratio greater than 38 (n=250) had a 2.9-fold greater likelihood of imminent delivery (ie, delivery on the day of the test) (Cox regression hazard ratio 2.9; P<.001) and shorter remaining time to delivery (median 17 [interquartile range 10-26] compared with 51 [interquartile range 30-75] days, respectively; Weibull regression factor 0.62; P<.001) than women with an sFlt-1-to-PlGF ratio of 38 or less, whether or not they developed preeclampsia. For women who did not (n=842) and did develop preeclampsia (n=199), significant correlations were seen between an sFlt-1-to-PlGF ratio greater than 38 and preterm birth (r=0.44 and r=0.46; both P<.001). Among women who did not develop preeclampsia, those who underwent iatrogenic preterm delivery had higher median sFlt-1-to-PlGF ratios at their first visit (35.3, interquartile range 6.8-104.0) than those who did not (8.4, interquartile range 3.4-30.6) or who delivered at term (4.3, interquartile range 2.4-10.9). CONCLUSIONS: In women undergoing evaluation for suspected preeclampsia, a serum sFlt-1-to-PlGF ratio greater than 38 is associated with a shorter remaining pregnancy duration and a higher risk of preterm delivery. [less ▲]

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See detailPredictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
Zeisler, Harald; Llurba, Elisa; CHANTRAINE, Frédéric ULiege et al

in New England Journal of Medicine (2016), 374(1), 13-22

BACKGROUND: The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in ... [more ▼]

BACKGROUND: The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its predictive value in women with suspected preeclampsia is unclear. METHODS: We performed a prospective, multicenter, observational study to derive and validate a ratio of serum sFlt-1 to PlGF that would be predictive of the absence or presence of preeclampsia in the short term in women with singleton pregnancies in whom preeclampsia was suspected (24 weeks 0 days to 36 weeks 6 days of gestation). Primary objectives were to assess whether low sFlt-1:PlGF ratios (at or below a derived cutoff) predict the absence of preeclampsia within 1 week after the first visit and whether high ratios (above the cutoff) predict the presence of preeclampsia within 4 weeks. RESULTS: In the development cohort (500 women), we identified an sFlt-1:PlGF ratio cutoff of 38 as having important predictive value. In a subsequent validation study among an additional 550 women, an sFlt-1:PlGF ratio of 38 or lower had a negative predictive value (i.e., no preeclampsia in the subsequent week) of 99.3% (95% confidence interval [CI], 97.9 to 99.9), with 80.0% sensitivity (95% CI, 51.9 to 95.7) and 78.3% specificity (95% CI, 74.6 to 81.7). The positive predictive value of an sFlt-1:PlGF ratio above 38 for a diagnosis of preeclampsia within 4 weeks was 36.7% (95% CI, 28.4 to 45.7), with 66.2% sensitivity (95% CI, 54.0 to 77.0) and 83.1% specificity (95% CI, 79.4 to 86.3). CONCLUSIONS: An sFlt-1:PlGF ratio of 38 or lower can be used to predict the short-term absence of preeclampsia in women in whom the syndrome is suspected clinically. (Funded by Roche Diagnostics.). [less ▲]

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See detailRe: Angle of fetal head progression measured using transperineal ultrasound as a predictive factor of vacuum extraction failure.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in Obstetrics and Gynecology (2016), 48(5), 668-669

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See detailProposal for standardized ultrasound descriptors of abnormally invasive placenta (AIP)
Collins, Sally; Anna, Ashcroft; Braun, Thorsten et al

in Ultrasound in Obstetrics and Gynecology (2016)

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See detailAnti-D Prophylaxis Reviewed in the Erea of Foetal RHD Genotyping
MINON, Jean-Marc; GERARD, CH; CHANTRAINE, Frédéric ULiege et al

in Journal of Blood Disorders and Transfusion (2015), 6(5),

A few years ago, the prevention of anti-D immunization was currently based on systematic postnatal prophylaxis associated with targeted antenatal injection in high-risk situations of foeto-maternal ... [more ▼]

A few years ago, the prevention of anti-D immunization was currently based on systematic postnatal prophylaxis associated with targeted antenatal injection in high-risk situations of foeto-maternal haemorrhage. The failures of prevention are mainly due to the non-respect of established guidelines for RhIG prophylaxis, and to spontaneous undetected foetal-maternal haemorrhages without any obvious cause during the third trimester of pregnancy. In order to reduce the rate of residual post-pregnancy anti-D immunization, several countries decided to associate the classical prophylaxis to a routine antenatal anti-D prophylaxis (RAADP) during the 28th or 29th week of gestation. Since about ten years, the foetal RHD genotyping in maternal plasma enables us to limit the antenatal prophylaxis only to those D- women carrying a D+ foetus. This paper deals with: the advantages of an antenatal prevention in the light of non invasive foetal RHD genotyping, the rules rendering prevention protocols efficient whatever the algorithm applied, and the recommended immuno-haematology follow-up of women who have received RhIG. [less ▲]

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See detailImplementation of the sFlt-1/PlGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy: implications for clinical practice
Stepan, Holger; Herraiz, Ignaz; Schlembach, Dietmar et al

in Ultrasound in Obstetrics and Gynecology (2015), 45(3), 241-6

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See detailExpulsion of a uterine myoma in a patient treated with ulipristal acetate
CHANTRAINE, Frédéric ULiege; POISMANS, Gaëlle ULiege; Nwachuku, Julia et al

in Clinical Case Reports (2015)

Description of a spontaneous expulsion of a submucosal myoma in a patient treated with ulipristal acetate.

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See detailIN UTERO INFECTION BY SCHMALLENBERG VIRUS INDUCES ARTHROGRYPOSIS MULTIPLEXA CONGENITA IN OVINE FETUSES
Boseret, Géraldine ULiege; Claine, Francoise; Coupeau, Damien et al

Poster (2014, December)

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See detailPREDICTION OF SHORT-TERM OUTCOME IN PREGNANT WOMEN WITH SUSPECTED PREECLAMPSIA: THE PROGNOSIS STUDY
Zeisler, Harald; Llurba, Elisa; CHANTRAINE, Frédéric ULiege et al

Poster (2014, December)

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See detailSonographische Diagnostik bei abnorm invasiver Plazenta
Tutschek, Boris; CHANTRAINE, Frédéric ULiege; Braun, Thorsten et al

in Gynakologe (Der) (2014), 47

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine ... [more ▼]

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine surgery is the main risk factor. It may be speculated that with the rise in Caesarean delivery rates the incidence of AIP will also increase. Prenatal detection of AIP is mandatory to reduce the perinatal morbidity. Obstetrical ultrasound should be used as a screening tool for AIP. There are well known sonographic signs in B-mode, color Doppler and dynamic ultrasound that form the basis for prenatal detection. This review highlights these ultrasound markers and shows clinical examples. [less ▲]

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See detailResektion der Plazentahaftstelle bei pathologischer Plazentainvasion
CHANTRAINE, Frédéric ULiege; PETIT, Philippe ULiege; Langhoff-Roos, Jens

in Gynakologe (Der) (2014), 47

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity ... [more ▼]

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity and even mortality. Prenatal AIP screening using ultra- sound allows referral to a specialized centre in suspected cases in order to optimize the chances for mother and child. Caesarean hys- terectomy or placenta in situ methods are the currently known and recommended management options. This article describes the techniques of elective resection of the placental bed including AIP which allow conserving the uterus and preserving fertility. Furthermore, it seems that morbidity of this technique is lower when compared to the standard treatment options. Whether this is due to a selection of less severe AIP cases for resection or really represents a lower complication rate in cases of resection has to be demonstrated by further prospective studies. [less ▲]

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