References of "Brichant, Géraldine"
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See detailOptimizing the outcomes of ovarian tissue transplantation.
Nisolle, Michelle ULiege; Brichant, Géraldine ULiege; HENRY, Laurie ULiege

in Fertility and sterility (2020), 113(3), 547-548

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See detailUse of methotrexate in the treatment of ectopic pregnancies: a retrospective single center study.
Beguin, C.; Brichant, Géraldine ULiege; De Landsheere, L. et al

in Facts, views & vision in ObGyn (2020), 11(4), 329-335

INTRODUCTION: The aim of this study was to evaluate the efficacy of methotrexate (MTX) in the treatment of ectopic pregnancies. We identified predictive factors of success or failure and compared our ... [more ▼]

INTRODUCTION: The aim of this study was to evaluate the efficacy of methotrexate (MTX) in the treatment of ectopic pregnancies. We identified predictive factors of success or failure and compared our results with previous studies to make recommendations for its use. MATERIAL AND METHODS: A cohort of 61 patients from a single center was retrospectively analyzed. Inclusion criteria were a diagnosis of ectopic pregnancy and treatment with a single-dose injection of MTX. The need to perform surgery despite MTX was defined as treatment failure while needing a second MTX injection was not. RESULTS: In our cohort, MTX demonstrated a success rate of 80%. This rate rose to 84% when patients with human Chorionic Gonadotropin (hCG ) > 5,000 IU/L were excluded. Twenty percent underwent surgery for pain, increased mass size and/or suboptimal hCG kinetics. Low hCG levels on days 0, 4 and 7 as well as the absence of pain, metrorrhagia and hemoperitoneum were predictive of success. MTX was also efficient in the treatment of persisting pregnancies of unknown location (PUL). CONCLUSION: Our results are consistent with previous studies and emphasize the fact that MTX is less effective above a certain level of hCG. We obtained a cut-off value of 2439 IU/L with a sensitivity of 66.7% and a specificity of 93.9%. MTX should not be used when hCG is higher than 5,000 IU/L and laparoscopic surgery should be performed. Our results bring additional data about the efficacy of MTX in the management of persisting pregnancies of unknown location. [less ▲]

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See detailSuivi du bilan thyroïdien chez la femme enceinte: bonnes pratiques endocrinologiques et gynécologiques.
VALDES SOCIN, Hernan Gonzalo ULiege; BRICHANT, Géraldine ULiege

Scientific conference (2019, December 20)

Dans cette présentation nous abordons la physiopathologie et l aprise en charge de différents problèmes thyroïdiens telles que la maladie de Basedow, la maladie de Hashimoto et le cancer thyroidien au ... [more ▼]

Dans cette présentation nous abordons la physiopathologie et l aprise en charge de différents problèmes thyroïdiens telles que la maladie de Basedow, la maladie de Hashimoto et le cancer thyroidien au cours de la grossesse. Nous discutons ensuite, à partir d’une révision critique de la littérature et d'une approche multidisciplinaire, les recommendations vis à vis de la prise en charge des mères et de leur enfants depuis la période foetale jusqu’à la naissance. [less ▲]

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See detailChoosing the right technique for deep endometriosis
Nisolle, Michelle ULiege; BRICHANT, Géraldine ULiege; TEBACHE, Linda ULiege

in Best Practice and Research. Clinical Obstetrics and Gynaecology (2019)

The surgical management of bowel endometriosis is a real challenge. In addition to the fact that only symptomatic patients should undergo surgery, no consensus has been approved in the literature. Among ... [more ▼]

The surgical management of bowel endometriosis is a real challenge. In addition to the fact that only symptomatic patients should undergo surgery, no consensus has been approved in the literature. Among the surgical techniques, the surgeon has to choose between rectal shaving, disc excision, or segmental colorectal resection. All those procedures are associated with complications, but the risk of rectovaginal fistula is higher if a disc excision or segmental colorectal resection is performed. It is therefore of utmost importance to evaluate preoperatively the bowel infiltration by several imaging techniques to estimate the feasibility of a deep rectal shaving with possible incomplete removal of the endometriotic lesions or to discuss with the patient about the indication of a segmental bowel resection. Because of the risk of major preoperative and postoperative complications, proper patient counseling is mandatory. © 2019 [less ▲]

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See detailFallopian tube and endometriosis : an ambiguous relationship
Audebert, Alain; TIMMERMANS, Marie ULiege; Lismonde, Aurore et al

in European Gynecology & Obstetrics (2019), 1(1), 18-23

The Fallopian tube, or oviduct, plays an essential role in mammalian reproduction. Endometriosis affects 2 to 10% of women of reproductive age. Infertility and nulliparity are regarded as risk factors for ... [more ▼]

The Fallopian tube, or oviduct, plays an essential role in mammalian reproduction. Endometriosis affects 2 to 10% of women of reproductive age. Infertility and nulliparity are regarded as risk factors for endometriosis, therefore an increased prevalence of this affliction in the population of infertile women may be expected. The literature shows that endometriosis affects 30% to 68% of infertile women. However, its prevalence varies considerably depending on the type of infertility (i.e. male or female), the presence of chronic pelvic pain, and whether or not a previous exploratory laparoscopy was performed. The effects of endometriosis on fertility are still debated. While the impact of moderate or severe endometriosis on fertility is well established, especially in the presence of adhesions, the role of minimal or mild lesions, which are the most common in infertile women, is still controversial. Therefore, different possible underlying mechanisms have been proposed, including tubal alterations associated with endometriosis. Conclusion: Tubal pathologies have an influence on fertility in these patients. This short review analyzes the effect of tubal endometriosis on fertility. [less ▲]

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See detailEndometriosis-related spontaneous hemoperitoneum in pregnancy (SHiP): report of two cases and review of the literature
BRICHANT, Géraldine ULiege; Laurent, Noémie ULiege; Hamra, Faouzi ULiege et al

in EGO: European Gynecology and Obstetrics (2019), 1(1), 24-26

Spontaneous hemoperitoneum in pregnancy (SHiP) is a rare but life-threatening complication, for both the mother and the fetus. Its exact incidence is unknown. Several pathophysiological mechanisms have ... [more ▼]

Spontaneous hemoperitoneum in pregnancy (SHiP) is a rare but life-threatening complication, for both the mother and the fetus. Its exact incidence is unknown. Several pathophysiological mechanisms have been suggested. However, the etiology of SHiP remains unknown. Endometriosis, whose incidence is increasing, is currently recognized as a major risk factor in its development. We report the case of a patient with spontaneous rupture of the right uterine venous plexus revealed by a severe abdominal pain during delivery, and another case with spontaneous rupture of the right uterine artery revealed by hypovolemic shock and fetal distress. In both patients, exploratory laparotomy revealed hemoperitoneum and active bleeding. Hemostasis and hemodynamic stability were obtained after right adnexectomy in the first case, and uterine artery suturing in the second. These two patients with a diagnosis of SHiP had both previously been diagnosed with and treated for endometriotic lesions. [less ▲]

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See detailHeterogeneity of estrogen receptor alpha and progesterone receptor distribution in lesions of deep infiltrating endometriosis of untreated women or during exposure to various hormonal treatments.
BRICHANT, Géraldine ULiege; NERVO, Patricia ULiege; Albert, Adelin ULiege et al

in Gynecological Endocrinology (2018)

Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a ... [more ▼]

Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a functional heterogeneity of these lesions. To evaluate the phenotype heterogeneity of cells in DIE, we measured the expression of estrogen receptor alpha (ERalpha) and of progesterone receptor (PR) in DIE of untreated women or under various treatments. We analyzed the luminal epithelial height (LEH), immunoreactive epithelial staining (IRS) and stromal staining intensity (SSI) of ERalpha and PR. We observed a high variability in the same gland, among distinct glands in the same sample and among distinct patients receiving the same treatment. LEH variability was primarily due to epithelial cells heterogeneity in a gland, secondarily to the glands randomly evaluated on the same section, and tertiary to the patient category. Variability in IRS and SSI scores was primarily the consequence of their heterogeneity in the same woman and to a lesser extent to variability among patients. LEH and SSI were not modified according to treatment. IRS for PR was lower in treated patients. This heterogeneity of ERalpha and PR distribution could explain why endocrine treatments are unable to cure this condition. [less ▲]

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See detailLa prise en charge multidisciplinaire des douleurs pelviennes chroniques
BRICHANT, Géraldine ULiege; TEBACHE, Linda ULiege; NISOLLE, Michelle ULiege

in Réalités en Gynécologie-Obstétrique (2018)

La douleur pelvienne chronique (DPC) est définie par la présence d’une douleur située dans le pelvis, sous l’ombilic, depuis plus de 6 mois, suffisamment sévère pour entraîner une incapacité ou nécessiter ... [more ▼]

La douleur pelvienne chronique (DPC) est définie par la présence d’une douleur située dans le pelvis, sous l’ombilic, depuis plus de 6 mois, suffisamment sévère pour entraîner une incapacité ou nécessiter un traitement médical et/ou chirurgical. Elle concerne entre 2 et 24 % des femmes selon les études et son incidence est comparable à celle de l’asthme ou des lombalgies. Différents organes peuvent être touchés par de multiples pathologies, parfois en association, ce qui rend la prise en charge complexe. Les différentes étiologies possibles, la nature chronique de la DPC et l’influence de facteurs biologiques, sociaux et comportementaux encouragent à une prise en charge multidisciplinaire incluant médecins, kinésithérapeutes et psychologiques. [less ▲]

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See detailPéritonite chimique compliquant la rupture spontanée d'un kyste dermoïde de l'ovaire
El Moussaoui, Majdouline ULiege; CLOSON, François ULiege; Brichant, Géraldine ULiege et al

in Revue Médicale de Liège (2018), 73(7-8), 413-418

Mature ovarian teratoma is the most frequent benign tumor in premenopausal women. It is usually asymptomatic but complications are possible such as adnexal torsion, infection, malignant transformation or ... [more ▼]

Mature ovarian teratoma is the most frequent benign tumor in premenopausal women. It is usually asymptomatic but complications are possible such as adnexal torsion, infection, malignant transformation or cystic rupture. The latter can be spontaneous or more often occurs during surgery of excision of dermoid cyst. It can rarely result in chemical peritonitis, which is due to the irritation of the peritoneal serosa by the aseptic content of the tumour. We report the case of a patient who undrewent an emergency laparotomy for a chemical peritonitis following a spontaneous rupture of a dermoid cyst. Afterwards, she developed an acute respiratory distress syndrome that required an admission in the intensive care unit and subsequent surgery. © 2018 Revue Medicale de Liege. All rights reserved. [less ▲]

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See detailChronic pelvic pain and the role of exploratory laparoscopy as diagnostic and therapeutic tool: a retrospective observational study
BRICHANT, Géraldine ULiege; Denef, Marie ULiege; TEBACHE, Linda ULiege et al

in Gynecological Surgery (2018), 15(13),

Background: Forty percent of exploratory laparoscopies are performed for chronic pelvic pain (CPP). However, a final diagnosis is still unreported in 35% of the patients. We decided to evaluate the ... [more ▼]

Background: Forty percent of exploratory laparoscopies are performed for chronic pelvic pain (CPP). However, a final diagnosis is still unreported in 35% of the patients. We decided to evaluate the identification of pathological lesions and the improvement of painful symptoms in patients with CPP and normal physical examination and imaging and who are scheduled for exploratory laparoscopy. The prospective study was designed in a tertiary referral center for endometriosis. Forty-eight patients complaining of CPP and scheduled for exploratory laparoscopy were included. Pelvic pain intensity was assessed using the visual analogue pain scale (VAS), and at inclusion, negative clinical and imaging assessments were required. During exploratory laparoscopy, the recognized lesions were reported and different surgical treatment options were performed depending on the location of the lesion. Results: In 98% of the cases, exploratory laparoscopy demonstrated the presence of pelvic anomalies that had not been diagnosed at the time of clinical and imaging examination. After surgery, a significant improvement of CPP has been demonstrated in 24 (59%) patients with VAS < 5 postoperatively. Conclusions: Exploratory laparoscopy is reasonable in patients complaining of CPP, allowing a final diagnosis in a high percentage of patients and a significant improvement in pain symptom in 59% of the cases. This study was retrospectively registered by our local Ethics Committee on February 7, 2018 (B412201835729). [less ▲]

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See detailSyndrome d'Asherman. Prise en charge apres curetage suite a une retention placentaire post-natale et revue de la litterature.
Tchente, Nguefack C.; BRICHANT, Géraldine ULiege; Nisolle, Michelle ULiege

in Revue Médicale de Liège (2018), 73(10), 508-512

Asherman's syndrome (AS) is a partial or complete obliteration of the uterine cavity after intrauterine trauma. Approximately 90 % of severe AS cases occur after abortion curettage or postpartum curettage ... [more ▼]

Asherman's syndrome (AS) is a partial or complete obliteration of the uterine cavity after intrauterine trauma. Approximately 90 % of severe AS cases occur after abortion curettage or postpartum curettage. Clinical signs and symptoms are abnormalities of the cycle (hypomenorrhoea or amenorrhoea) and fertility disorders. We have reviewed the recent literature on AS following the description of a typical clinical case. The management of AS is not easy. It must be done by experienced surgeons. Realization of several surgeries is sometimes mandatory, with the use of anti-adhesive devices between interventions. Its complex management encourages insistence on the avoidance of its risk factors. [less ▲]

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See detailLes infections gynécologiques basses
BRICHANT, Géraldine ULiege; TEBACHE, Linda ULiege; NISOLLE, Michelle ULiege

Conference (2017, November 25)

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See detailDrainage vaginal spontané d'un abcès appendiculaire chez une fillette de 7 mois.
BRICHANT, Géraldine ULiege; FRERE, Julie ULiege; El Hachemi, Mounia et al

Poster (2017, October)

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See detailPrise en charge multidisciplinaire de la douleur pelvienne chronique
BRICHANT, Géraldine ULiege; NISOLLE, Michelle ULiege

Conference (2017, August 31)

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See detailLes mutilations génitales féminines: la situation à Liège
Swenen, Laurie ULiege; BRICHANT, Géraldine ULiege; Kaluanga, Armand et al

in Revue Médicale de Liège (2017), 72(1), 25-31

En raison des flux migratoires actuels, le praticien obstétricien sera amené à prendre en charge des patientes porteuses de mutilations génitales féminines (MGF). Cet article reprend les principales ... [more ▼]

En raison des flux migratoires actuels, le praticien obstétricien sera amené à prendre en charge des patientes porteuses de mutilations génitales féminines (MGF). Cet article reprend les principales complications obstétricales en relation avec celles-ci. Nous avons comparé un groupe de patientes ayant subi une MGF (n = 69) à un groupe contrôle (n = 162) et étudié les données concernant la patiente, la grossesse en cours, l’accouchement, le nouveau-né, le post-partum et la durée du séjour hospitalier. Dans le groupe MGF, 44 % des patientes sont porteuses de streptocoque B contre 23 % dans le groupe contrôle (p inférieur a 0,01). Concernant le périnée, dans le groupe MGF, une épisiotomie est pratiquée chez 31 % des patientes versus 35 % dans le groupe contrôle; une déchirure survient dans 42 % des accouchements par voie basse dans le groupe MGF contre 26 % dans le groupe contrôle. [less ▲]

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