References of "Block, Sébastien"
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See detailN1,N2,N3-trisisopentenyl guanidine and N1,N2-diisopentenyl guanidine, two cytotoxic alkaloids from Alchornea cordifolia (Schumach.& Thonn.) Mull. Arg. (Euphorbiaceae) root barks.
Mavar-Manga, H.; Chapon, David; Hoet, Sara et al

in Natural Product Communications (2006), 1(12), 1097-1100

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See detailInduction of Apoptosis in Human Promyelocytic Leukemia Cells by a Natural Trachylobane Diterpene
Block, Sébastien; Gerkens, Pascal; Peulen, Olivier ULiege et al

in Anticancer Research (2005), 25(1A), 363-368

Background: Trachylobane diterpenes are secondary metabolites quite rare in nature and their bioactivities are poorly known. Recently we have described the cytotoxic activity of ent- trachyloban-3‚-ol ... [more ▼]

Background: Trachylobane diterpenes are secondary metabolites quite rare in nature and their bioactivities are poorly known. Recently we have described the cytotoxic activity of ent- trachyloban-3‚-ol isolated from the leaves of Croton zambesicus, a plant used in African folk medicine. Materials and Methods: Cell viability on several cell lines, cell morphology, DNA laddering, annexin V and caspase-3 activation experiments were undertaken in order to analyse the cytotoxicty of trachylobane diterpene and to determine if this compound is able to induce apoptosis. Results: ent-trachyloban-3‚-ol exerts a dose-dependent cytotoxic effect and which varies between cell lines. Induction of apoptosis in HL-60 cells could be detected at a concentration of 50 ÌM after 24-h treatment. Conclusion: We show here, for the first time, that a trachylobane diterpene is able to induce apoptosis in human promyelocytic leukemia cells via caspase-3 activation in a concentration-dependent manner. [less ▲]

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See detailDiterpenes from the leaves of Croton Zambesicus
Block, Sébastien; Baccelli, Chiara; Tinant, Bernard et al

in Phytochemistry (2004), 65

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus ... [more ▼]

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, b-sitosterol, a-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines. [less ▲]

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See detailInduction of apoptosis in HL-60 by a trachylobane diterpene from Croton Zambesicus
Block, Sébastien; De Pauw-Gillet, Marie-Claire ULiege; Gerkens, Pascal et al

Poster (2002, September)

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See detailSearch for apoptotic compounds in Croton zambesicus
Mavar-Manga, H; Block, Sébastien; De Pauw-Gillet, Marie-Claire ULiege et al

Conference (2002, March)

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See detailEnt-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus
Block, Sebastien; Stevigny, Caroline; De Pauw-Gillet, Marie-Claire ULiege et al

in Planta Medica (2002), 68

The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A ... [more ▼]

The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 ùg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene. [less ▲]

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