References of "Bigazzi, William"
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See detailSupercritical fluid methods: an alternative to conventional methods to prepare liposomes
Bigazzi, William ULiege; Penoy, Noémie ULiege; Evrard, Brigitte ULiege et al

in Chemical Engineering Journal (2019)

Liposomes are used as nanovectors to encapsulate several active molecules with a prolongation of the drug effect, to target specific tissues or to reduce certain side effects. Innovative therapies using ... [more ▼]

Liposomes are used as nanovectors to encapsulate several active molecules with a prolongation of the drug effect, to target specific tissues or to reduce certain side effects. Innovative therapies using nanovectors have been developed and accepted for clinical trials, however their conventional methods of production suffer from drawbacks such as the use of large amounts of organic solvents, the small quantities produced and the many steps involved in the production that prevent the production at industrial scale. For several years, supercritical fluid-based preparation processes have been considered as a good alternative to conventional liposome preparation methods. A number of supercritical fluid processes allowing the liposome preparation are described depending on the role of the supercritical fluid with respect to the liposome raw materials. The supercritical fluid can act as a solvent or a cosolvent for the lipids material which are next put in contact with an aqueous solution before or during the depressurization. The supercritical fluid can also be used as an antisolvent to induce the formation of proliposomes which can be easily converted into liposomes by hydration. Finally the supercritical fluid can be used as a dispersing agent in order to finely disperse the lipid molecules into an aqueous medium. Several of these methods using supercritical fluids to produce liposomes are described in the literature. The aim of this review article is to summarize and classify the current supercritical fluid-based liposome preparation methods according to the function of the supercritical fluid within the process and compare them in terms of liposome’s physicochemical properties, hydration methods, molecules that can be encapsulated, encapsulation efficiencies and the use or not of organic solvents. [less ▲]

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See detailLiposome production by innovative method using supercritical fluids
Penoy, Noémie ULiege; Bigazzi, William ULiege; Piel, Géraldine ULiege et al

Scientific conference (2018, December 19)

Detailed reference viewed: 59 (25 ULiège)
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See detailInterest of cylodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide
Bigazzi, William ULiege; Dufour, Gilles; De Tullio, Pascal ULiege et al

Poster (2017, June)

The present study aim at developing cyclodextrin-based spray-dried microparticles containing a corticosteroid (budesonide) with an efficient lung delivery and efficacy. Complexation between budesonide and ... [more ▼]

The present study aim at developing cyclodextrin-based spray-dried microparticles containing a corticosteroid (budesonide) with an efficient lung delivery and efficacy. Complexation between budesonide and hydroxypropyl-beta-cyclodextrin (HPBCD) has been investigated and production of spray-dried powder was optimized based on a design of experiments. Wrinkled particles associated with a low bulk density and improved respirable fraction in comparison to a marketed product were obtained. An in vitro test showed that HPBCD is able to decrease the permeability of budesonide across the bronchial epithelium by a sustained release effect. In conclusion, this work reports that the use of cyclodextrin in the formulation of dry powder for inhalation is of a double interest as it both improves respirable fraction and lung residence time of budesonide. [less ▲]

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See detailDry powder of budesonide/hydroxypropyl-beta-cyclodextrin complex for inhalation as a new potential antiasthmatic treatment
Bigazzi, William ULiege; Dufour, Gilles; Mingeot-Leclercq, Marie-Paule et al

Conference (2016, October 17)

Asthma is a respiratory disease characterized by chronic airway inflammation which can lead, if not correctly managed, to tissue remodeling associated with an irreversible decline in lung function ... [more ▼]

Asthma is a respiratory disease characterized by chronic airway inflammation which can lead, if not correctly managed, to tissue remodeling associated with an irreversible decline in lung function. Hypersensitivity of the respiratory tract to non-specific stimuli, which causes triggering of asthma attacks, is also observed. Despite medical advances, asthma remains an important socio-economic and public health concern since this condition affects 300 million people and causes more than 300 000 deaths worldwide every year. Furthermore its annual cost is estimated at over 30 billion euros in Europe. These issues can be partially linked to an inadequate control of asthma due to undesirable effects of existing medication such as corticosteroids. Hence, the development of new medications with improved effectiveness and reduced adverse effects could allow a better management of the disease. It has been recently discovered that inhaled solution of hydroxylpropyl-beta-cyclodextrin (HPBCD) is able to reduce allergen-induced bronchoconstriction in asthmatic patients, with no toxicity observed in healthy patients further to administration. Based on these results, our project seeks to develop new antiasthmatic medication containing an association of HPBCD and budesonide, a widely used corticosteroid in long-term treatment of asthma. Thus, we investigated complexation between the two molecules. Interestingly, it was observed that when budesonide is complexed with HPBCD, its permeability across a Calu-3 cell layer is reduced. Several experiments in mouse models confirmed that HPBCD acts as a sustained delivery system which progressively releases budesonide into the lung parenchyma, leading to a prolonged anti-inflammatory effect. Due to high Peclet number of HPBCD, the spray dried complex exhibited wrinkled particles whose interest in dry powder for inhalation is well known. Thanks to its anti-inflammatory effect and its sustained release potential, HPBCD could significantly reduce corticosteroids needed doses for management of asthma. However, a clinical study has to be performed to determine the optimal budesonide/HPBCD ratio and the minimal effective dose of complex. Further investigations are also needed to exploit the potential of spray dried HPBCD and develop a powder for inhalation by particle engineering. [less ▲]

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See detailInterest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide
Dufour, Gilles ULiege; Bigazzi, William ULiege; Wong, Nelson et al

in International Journal of Pharmaceutics (2015), 495(2), 869-878

Detailed reference viewed: 92 (36 ULiège)