References of "BEKAERT, Sandrine"
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See detailSilane influence on bonding to CAD-CAM composites: An interfacial fracture toughness study.
Eldafrawy, Maher; Greimers, Laura; BEKAERT, Sandrine ULiege et al

in Dental Materials (2019)

OBJECTIVES: To evaluate silane influence on the interfacial fracture toughness (IFT) of composite cement, with the two sub-classes of CAD-CAM composites, polymer-infiltrated ceramic networks (PICN) and ... [more ▼]

OBJECTIVES: To evaluate silane influence on the interfacial fracture toughness (IFT) of composite cement, with the two sub-classes of CAD-CAM composites, polymer-infiltrated ceramic networks (PICN) and dispersed fillers (DF), after hydrofluoric acid etching (HF) or airborne-particle abrasion (AB). A secondary objective was to correlate results with developed interfacial area ratio (Sdr) and surface wettability. METHODS: Experimental PICN and DF blocks were cut into equilateral half-prisms, which were treated with HF or AB, then treated with an experimental silane or not and bonded to their counterparts with an experimental light-cure resin cement. After thermocycling, samples (n=30 per group) were tested for IFT using the notchless triangular prism test in a water bath at 36°C. Moreover, profilometry and contact angle measurement were performed on rectangular samples of each group. Finally, bonding interface was analysed by SEM. RESULTS: PICN-HF treated with silane showed the highest IFT significantly. Three-way ANOVA revealed the influence of silane, material class and surface pre-treatment (HF or AB) on IFT (p<0.05). When silane was used, IFT was correlated with Sdr, while surface wettability was increased. Silane application significantly increased IFT for PICN but not for DF, while PICN performed better with HF and DF with AB. SIGNIFICANCE: Silane increases IFT of composite cement with PICNs, but not with DF materials. Results suggest that silane increases the micromechanical bond by promoting resin cement spreading and penetration in surface roughness. This roughness is significantly higher for pre-treated PICNs than for DF due to their specific honeycomb microstructure when etched, which explains their better bonding properties. [less ▲]

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See detailIn Vivo Low Thermal Degradation of Monolithic Zirconia Restorations
KOENIG, Vinciane ULiege; Wulfman, Claudine; DUPONT, Nathalie ULiege et al

in Journal of Dental Research (2018)

To evaluate In vivo low thermal degradation (LTD) of zirconia monolithic implant and tooth restorations, particularly in-mouth zirconia crystalline microstructure changes, as well as influence of occlusal ... [more ▼]

To evaluate In vivo low thermal degradation (LTD) of zirconia monolithic implant and tooth restorations, particularly in-mouth zirconia crystalline microstructure changes, as well as influence of occlusal stress and glaze protection on this process. Secondary objectives included the investigation of restorations’ general clinical behaviour and material wear. [less ▲]

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See detailOne-Step No-Prep Treatment of Worn Dentition using PICNs
Oudkerk, Julie ULiege; Eldafrawy, Maher ULiege; BEKAERT, Sandrine ULiege et al

in Journal of Dental Research (2018)

The objective of this study was to evaluate a one-step treatment approach of worn dentition (One-step No-prep), using a Polymer Infiltrated Ceramic Network (PICN) CAD-CAM composite material, (Vita Enamic ... [more ▼]

The objective of this study was to evaluate a one-step treatment approach of worn dentition (One-step No-prep), using a Polymer Infiltrated Ceramic Network (PICN) CAD-CAM composite material, (Vita Enamic,Vita Zahnfabrik, Germany). [less ▲]

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See detailSilane Influence on PICN Interfacial Fracture Toughness with Resin Cement
Eldafrawy, Maher ULiege; Greimers, Laura; BEKAERT, Sandrine ULiege et al

in Journal of Dental Research (2018)

To evaluate the influence of silane on Interfacial Fracture Toughness (IFT) of composite cement with two sub-classes of CAD-CAM composites, polymer-infiltrated ceramic network (PICN) and dispersed filler ... [more ▼]

To evaluate the influence of silane on Interfacial Fracture Toughness (IFT) of composite cement with two sub-classes of CAD-CAM composites, polymer-infiltrated ceramic network (PICN) and dispersed filler (DF), after etching or gritblasting. Secondary objectives were to correlate results with developed interfacial area ratio (Sdr) and surface wettability. [less ▲]

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See detailInflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
BEKAERT, Sandrine ULiege; Fillet, Marianne ULiege; Detry, Benoit et al

in Cancer Growth and Metastasis (2017), 10

Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer ... [more ▼]

Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer dissemination to specific tissues. Using different mouse models, we demonstrate the role of inflammation-generated extracellular matrix fragments ac-PGP (N-acetyl-proline-glycine-proline) on tumor cells dissemination to lung parenchyma. In mice exposed to cigarette smoke or lipopolysaccharide, lung neutrophilic inflammation produces increased levels of MMP-9 (matrix metalloproteinase 9) that contributes to collagen breakdown and allows the release of ac-PGP tripeptides. By silencing CXCR2 gene expression in tumor cells, we show that these generated ac-PGP tripeptides exert a chemotactic activity on tumor cells in vivo by binding CXCR2. [less ▲]

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See detailLow Thermal Degradation of monolithic zirconia dental prostheses: 1-yr results of a prospective clinical study with ex vivo analyses
KOENIG, Vinciane ULiege; Wulfman, Claudine; DUPONT, Nathalie ULiege et al

in European Cells and Materials (2017, June)

Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a well-known problem ... [more ▼]

Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a well-known problem with zirconia hip prostheses. This phenomenon could be accentuated by masticatory mechanical stress. Until now zirconia LTD process has only been studied in vitro. The main objective of this study was to evaluate the in vivo LTD of zirconia restorations on implants and natural teeth using an original protocol including ex vivo analyses of zirconia crystalline microstructure, focusing on the effect of occlusal stress and protection by a glaze layer. Secondary objectives included the investigation of the general behaviour of monolithic restorations and the study of material wear process. [less ▲]

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See detailOne-step and no-prep treatment of worn dentition using PICNs. A prospective clinical study
OUDKERK, Julie ULiege; Eldafrawy, Maher ULiege; BEKAERT, Sandrine ULiege et al

in European Cells and Materials (2017, June)

Computer-Aided Design and Manufacturing (CAD-CAM) composite materials offer new possibilities in terms of minimally invasive treatment strategies of worn dentition. Among those materials, Polymer ... [more ▼]

Computer-Aided Design and Manufacturing (CAD-CAM) composite materials offer new possibilities in terms of minimally invasive treatment strategies of worn dentition. Among those materials, Polymer Infiltrated Ceramic Network (PICN) materials, (Vita Enamic, Vita Zahnfabrik, Bad Sackingen, Germany) exhibit mechanical properties significantly superior to conventional composites1. Their ability to be milled in very low thickness allows to perform very thin bonded restorations without further elimination of tooth tissues (no-prep). Yet, the treatment is complex particularly with respect to the provisional restoration realization, which is intended to test and determine the new vertical dimension of occlusion (VDO). On the other hand, some authors have previously reported that VDO determination remains empirical and that it can be increased in one time up to 5mm (in the front zone) without engendering any adverse effects. Therefore, the objective of the present study is to evaluate a new treatment approach of worn dentition using PICNs, entitled “One step-No prep” [less ▲]

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See detailIn vivo Low Thermal Degradation of monolithic zirconia restorations
Wulfman, Claudine; KOENIG, Vinciane ULiege; DUPONT, Nathalie ULiege et al

in Dental Materials (2017)

A 5-year clinical study was designed to evaluate the in vivo low thermal degradation (LTD) of zirconia monolithic restorations on implants and natural teeth. Additionally, general behavior of restorations ... [more ▼]

A 5-year clinical study was designed to evaluate the in vivo low thermal degradation (LTD) of zirconia monolithic restorations on implants and natural teeth. Additionally, general behavior of restorations and material wear were studied. This work focuses on ex vivo analysis of zirconia phase transformation and on the influence of glaze protection and occlusal mechanical stress on this process. [less ▲]

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See detailImplication of adamalysin proteases in mesothelioma
Sepult, Christelle ULiege; Rocks, Natacha ULiege; BEKAERT, Sandrine ULiege et al

Conference (2015, September 30)

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See detailInvolvement of adamalysin proteases in modulations of tumor microenvironment and premetastatic niches
Donati, Kim ULiege; BEKAERT, Sandrine ULiege; Sepult, Christelle ULiege et al

in European Respiratory Journal (2015, September), 46(59),

Detailed reference viewed: 39 (14 ULiège)
See detailImplication of adamalysin proteases in mesothelioma physiopathology
Sepult, Christelle ULiege; Rocks, Natacha ULiege; BEKAERT, Sandrine ULiege et al

Conference (2015, May 06)

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See detailRole of adamalysin proteases in modulations of tumor microenvironment and premetastatic niches
Donati, Kim ULiege; BEKAERT, Sandrine ULiege; Sepult, Christelle ULiege et al

in Revue des Maladies Respiratoires (2015, March), 32

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See detailA hybrid human-computer approach for large-scale image-based measurements using web services and machine learning
Marée, Raphaël ULiege; Rollus, Loïc ULiege; Stevens, Benjamin ULiege et al

in Proceedings IEEE International Symposium on Biomedical Imaging (2014, May)

We present a novel methodology combining web-based software development practices, machine learning, and spatial databases for computer-aided quantification of regions of interest (ROIs) in large-scale ... [more ▼]

We present a novel methodology combining web-based software development practices, machine learning, and spatial databases for computer-aided quantification of regions of interest (ROIs) in large-scale imaging data. We describe our main methodological choices, and then illustrate the benefits of the approach (workload reduction, improved precision, scalability, and traceability) on hundreds of whole-slide images of biological tissue slices in cancer research. [less ▲]

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See detailOxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis.
Pichavant, M.; Remy, G.; Bekaert, Sandrine ULiege et al

in Mucosal Immunology (2013)

Chronic obstructive pulmonary disease (COPD) is a major clinical challenge mostly due to cigarette smoke (CS) exposure. Invariant natural killer T (iNKT) cells are potent immunoregulatory cells that have ... [more ▼]

Chronic obstructive pulmonary disease (COPD) is a major clinical challenge mostly due to cigarette smoke (CS) exposure. Invariant natural killer T (iNKT) cells are potent immunoregulatory cells that have a crucial role in inflammation. In the current study, we investigate the role of iNKT cells in COPD pathogenesis. The frequency of activated NKT cells was found to be increased in peripheral blood of COPD patients relative to controls. In mice chronically exposed to CS, activated iNKT cells accumulated in the lungs and strongly contributed to the pathogenesis. The detrimental role of iNKT cells was confirmed in an acute model of oxidative stress, an effect that depended on interleukin (IL)-17. CS extracts directly activated mouse and human dendritic cells (DC) and airway epithelial cells (AECs) to trigger interferongamma and/or IL-17 production by iNKT cells, an effect ablated by the anti-oxidant N-acetylcystein. In mice, this treatment abrogates iNKT-cell accumulation in the lung and abolished the development of COPD. Together, activation of iNKT cells by oxidative stress in DC and AECs participates in the development of experimental COPD, a finding that might be exploited at a therapeutic level.Mucosal Immunology advance online publication, 30 October 2013; doi:10.1038/mi.2013.75. [less ▲]

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See detailCurcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer.
Rocks, Natacha ULiege; Bekaert, Sandrine ULiege; Coia, I et al

in British Journal of Cancer (2012), 107(7), 1083-92

Background:Overall clinical outcome for advanced lung cancer remains very disappointing despite recent advances in treatment. Curcumin has been reported as potentially active against cancer.Methods:Owing ... [more ▼]

Background:Overall clinical outcome for advanced lung cancer remains very disappointing despite recent advances in treatment. Curcumin has been reported as potentially active against cancer.Methods:Owing to poor curcumin solubility, we have used cyclodextrins (CD) as an excipient allowing a considerable increase of aqueous solubility and bioavailability of curcumin. The effects of solubilised curcumin have been evaluated in cell cultures as well as in an in vivo orthotopic lung tumour mouse model.Results:Cell proliferation was reduced while apoptosis rates were increased when lung epithelial tumour cells were cultured in the presence of curcumin-CD complexes. For in vivo experiments, cells were grafted into lungs of C57Bl/6 mice treated by an oral administration of a non-soluble form of curcumin, CDs alone or curcumin-CD complexes, combined or not with gemcitabine. The size of orthotopically implanted lung tumours was reduced upon curcumin complex administration as compared with treatments with placebo or non-solubilised curcumin. Moreover, curcumin potentiated the gemcitabine-mediated antitumour effects.Conclusion:Our data demonstrate that curcumin, when given orally in a CD-solubilised form, reduces lung tumour size in vivo. In vitro experiments show impaired tumour cell proliferation and increased cell apoptosis. Moreover, our data underline a potential additive effect of curcumin with gemcitabine thus providing an efficient therapeutic option for antilung cancer therapy. [less ▲]

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