References of "BECKERS, Albert"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLe phénotype d’Akhenaton ; revue critique entre canons artistiques et expression pathologique.
JEDIDI, Zayd ULiege; JEDIDI, Haroun ULiege; LAVEAUX, Elisabeth ULiege et al

in Revue Médicale de Liège (in press)

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 ... [more ▼]

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 years after their time. Tenth pharaoh of this dynasty and father of Tutankhamun, Akhenaten (Amenhotep/Amenhotep IV) still fascinates Egyptologists and history lovers through the many questions surrounding his atypical rule. One of the most striking aspects of the so-called Amarna period concerns the representations of the pharaoh himself, very confusing compared to the traditional iconography of the New Kingdom. These intriguing portraits of Pharaoh raised a whole lot of medical assumptions, more or less substantiated. We review here the main theories developed throughout history. [less ▲]

Detailed reference viewed: 212 (59 ULiège)
Full Text
Peer Reviewed
See detailPheochromocytomas and pituitary adenomas in three patients with MAX exon deletions
Daly, Adrian ULiege; CASTERMANS, Emilie ULiege; Oudijk, Lindsey et al

in Endocrine-Related Cancer (2018)

Copy number variations (CNV), an important genetic mechanism in inherited tumor genetics, can affect large genetic regions or can be limited to smaller regions within genes, such deletions of single exons ... [more ▼]

Copy number variations (CNV), an important genetic mechanism in inherited tumor genetics, can affect large genetic regions or can be limited to smaller regions within genes, such deletions of single exons. Such exon deletions can be challenging to identify and sequencing can be normal in these cases. Multiplex ligation dependent probe amplification (MLPA) can identify CNV of individual exons. Mutations in the MAX gene are associated with a risk of sporadic and hereditary pheochromocytoma. As mutations in other pheochromocytoma related genes can also cause pituitary tumors (3P-Association), we studied whether MAX exon deletions were involved in the etiology of patients with an unexplained association of multiple endocrine neoplasia including pituitary adenoma and pheochromocytoma. Using MLPA we identified three patients with pheochromocytoma and pituitary adenomas who had normal MAX sequencing but presented germline heterozygous MAX exon deletions. The three patients had either acromegaly (n=2) or prolactinoma (n=1) in association with bilateral or recurrent pheochromocytoma. Two had germline heterozygous deletions of single exons of MAX, the other had a germline heterozygous deletion of MAX exons 1-3. MAX immunohistochemical staining was lost in the pheochromocytomas of all three patients and genetic analysis confirmed loss of heterozygosity in tumor DNA. A MAX exon deletion was also transmitted from one patient to a currently asymptomatic offspring. Screening studies of pheochromocytoma patients should take into account the potential for co-existing pituitary tumors. MLPA or other techniques to identify discrete MAX exon deletions should be considered in individuals with pheochromocytoma that are negative following comprehensive sequencing. [less ▲]

Detailed reference viewed: 22 (1 ULiège)
See detailLiege Acromegaly Survey : Les derniers résultats
Beckers, Albert ULiege

Scientific conference (2018, February 02)

Detailed reference viewed: 18 (1 ULiège)
Full Text
Peer Reviewed
See detailRESISTANT PEDIATRIC SOMATOTROPINOMAS DUE TO AIP MUTATIONS: ROLE OF PEGVISOMANT
Joshi, Kriti; Daly, Adrian ULiege; BECKERS, Albert ULiege et al

in Hormone Research in Paediatrics (2018)

Detailed reference viewed: 23 (4 ULiège)
Full Text
Peer Reviewed
See detailPituitary Tumors Associated With Multiple Endocrine Neoplasia Syndromes
Rostomyan, Liliya ULiege; Daly, Adrian ULiege; BECKERS, Albert ULiege

in Huhtamiemi, Ilpo (Ed.) Encyclopedia of Endocrine Diseases (2018)

Detailed reference viewed: 16 (3 ULiège)
Full Text
Peer Reviewed
See detailParaneoplastic secretion in parathyroid carcinoma: serum hCG as a tumor marker
VALDES SOCIN, Hernan Gonzalo ULiege; BETEA, Daniela ULiege; Daly, Adrian ULiege et al

in Acta Clinica Belgica (2017), 72(2), 5

Introduction Parathyroid carcinoma (PCa) is a rare presentation of primary hyperparathyroidism (PHPT), accounting for less than 1 % of cases. Differentiating parathyroid cancer from adenoma is clinically ... [more ▼]

Introduction Parathyroid carcinoma (PCa) is a rare presentation of primary hyperparathyroidism (PHPT), accounting for less than 1 % of cases. Differentiating parathyroid cancer from adenoma is clinically challenging. Rubin et al (2008) et al. suggested that urinary hCG might be a marker of disease progression in PCa. In this study, we aimed to investigate whether the hCG+β kit from Roche Diagnostics could distinguish PCa patients from PHPT. Material and methods We studied a series of 8 patients suffering from advanced PCa, referred to the CHU de Liege. A control group of 20 PHPT patients was used as comparative. hCG+β kit on Cobas (Roche Diagnostics) uses 2 monoclonal antibodies that recognize holo-hCG, nicked hCG, β-core fragment and free β-subunit. Limits of hCG detection and quantification are <0.1 and <0.6 mUI/mL. In non pregnant and postmenopausal women and in men, hCG (p95) is <1 (5.3), <7 mUI/mL (8.3) and <2 (2.6) mUI/mL, respectively. Results. The 8 PCa patients (3 women) presented high serum hCG values at: 1.29, 3.46, 5.7, 24.2, 31.2, 34.1, 36.5 and 164 mUI/mL. Values of 1.29 and 3.46 were obtained in 2 postmenopausal women. The lowest value was presented by the only still alive patient. There was a significant correlation (r=0.786; ρ <0.05) between hCG and PTH and a borderline correlation (r=0.750; ρ =0.05) between hCG and calcium concentrations. All PHP patients presented undetectable hCG values. Conclusions These results suggest that serum hCG might have the potential to discriminate between parathyroid adenomas and carcinomas, with a sensibility of 75% (6/8) and a specificity of 100% (0/20). The only patient still alive presented the lowest hCG values. If hCG could be predictive of PCa survival needs to be studied in a larger series of patients. [less ▲]

Detailed reference viewed: 26 (3 ULiège)
See detailGigantism
Beckers, Albert ULiege

Scientific conference (2017, November)

Detailed reference viewed: 15 (1 ULiège)
Full Text
See detailLong-term management of resistant acromegaly with pasireotide LAR in 2 cases with a familial AIP Mutation
Rostomyan, Liliya ULiege; Daly, Adrian ULiege; Pellegata, N et al

in Acta Clinica Belgica (2017, October 07)

Detailed reference viewed: 22 (6 ULiège)
See detailA clinician's Guide to familial pituitary tumors
Beckers, Albert ULiege

Scientific conference (2017, October)

Detailed reference viewed: 15 (1 ULiège)
Full Text
See detailPassé et présent de la prise en charge de l'acromégalie et ses complications
NECHIFOR, Iulia ULiege; Beckers, Albert ULiege

in Médecine Clinique Endocrinologie & Diabète (2017), 90

Detailed reference viewed: 16 (1 ULiège)
Full Text
See detailInsuffisance ovarienne prématurée chez une femme symphalangie : études biologiques et génétiques
VALDES SOCIN, Hernan Gonzalo ULiege; Desir, J; LIBIOULLE, Cécile ULiege et al

in Annales d'Endocrinologie - Abstract book (2017, October)

Detailed reference viewed: 19 (2 ULiège)
See detailAcromegaly-Journey from the Specific to the General
BECKERS, Albert ULiege

Scientific conference (2017, September 08)

Detailed reference viewed: 19 (1 ULiège)
See detailEpidemiology of Prolactinomas
Beckers, Albert ULiege

Scientific conference (2017, September 07)

Detailed reference viewed: 13 (1 ULiège)
Full Text
Peer Reviewed
See detailAcromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) database.
PETROSSIANS, Patrick ULiege; Daly, Adrian ULiege; Natchev, Emil et al

in Endocrine-Related Cancer (2017)

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly ... [more ▼]

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liege Acromegaly Survey (LAS) database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs. 46.4 years; p<0.001). The median delay from first symptoms to diagnosis was two years longer in females (p=0.015). Ages at diagnosis and first symptoms increased significantly over time (p<0.001). Tumors were larger in males than females (p<0.001); tumor size and invasion were inversely related to patient age (p<0.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (p<0.001). GH was inversely related to age in both sexes (p<0.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in <5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6-4.4% had experienced a fracture. This study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis. [less ▲]

Detailed reference viewed: 55 (5 ULiège)
Full Text
Peer Reviewed
See detailLuteinizing Hormone Deficiency: Historical Views and Perspectives
VALDES SOCIN, Hernan Gonzalo ULiege; Daly, Adrian ULiege; BECKERS, Albert ULiege

in Austin Andrology (2017), 2(1), 1-2

Fertility in men requires normal testicular development, which is controlled by chorionic gonadotropin (hCG) in utero and thereafter by luteinizing hormone (LH) and follicle-stimulating hormone (FSH ... [more ▼]

Fertility in men requires normal testicular development, which is controlled by chorionic gonadotropin (hCG) in utero and thereafter by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Some rare observations, such as, mutations in the luteinizing hormone subunit beta gene [2] have contributed substantially to our understanding of reproductive development and male infertility. In this editorial we summaryze current knowledge about beta LH mutations and polymorphism in men and discuss fertility issues. [less ▲]

Detailed reference viewed: 29 (4 ULiège)