References of "BARREA, Christophe"
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See detailComment j’explore. Une macrocéphalie.
Vanden Brande, Laura ULiege; ALKAN, Serpil ULiege; BARREA, Christophe ULiege et al

in Revue medicale de Liege (2022), 77(1), 56-62

Macrocephaly is a frequent reason for seeking advice in a pediatric neurology consultation. It is a non-specific neurological sign that can be isolated, be the sign of a serious acquired pathology or be ... [more ▼]

Macrocephaly is a frequent reason for seeking advice in a pediatric neurology consultation. It is a non-specific neurological sign that can be isolated, be the sign of a serious acquired pathology or be part of a syndromic picture. Clinical history, physical examination and imaging are key elements of the diagnostic strategy. Signs of intracranial hypertension require an emergency work-up. Genetics, exome in particular, has enabled the characterization of various syndromes associating macrocephaly and neurodevelopmental delay. In this article, we propose an update of practices based on clinical signs. [less ▲]

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See detailComment j'explore... un trouble du spectre de l'autisme
Barrea, Christophe ULiege; JADOT, Annick ULiege; DEBRAY, François-Guillaume ULiege et al

in Revue Médicale de Liège (2021), 76(10), 761-767

Le trouble du spectre de l’autisme (TSA) est une pathologie neurodéveloppementale complexe, caractérisée par des déficits de la communication et des interactions sociales associés à un caractère restreint ... [more ▼]

Le trouble du spectre de l’autisme (TSA) est une pathologie neurodéveloppementale complexe, caractérisée par des déficits de la communication et des interactions sociales associés à un caractère restreint et répétitif des comportements, des intérêts et des activités. Etant donné le caractère très hétérogène du trouble et l’absence de biomarqueur, son approche diagnostique doit être globale, multidisciplinaire, et répondre aux critères des classifications internationales. Par ailleurs, les TSA résultent d’un modèle multifactoriel dont l’étiologie demeure inconnue dans la majorité des cas. Afin d’optimiser le rendement exploratoire et d’homogénéiser les pratiques, ce document propose un cadre pour la mise au point des TSA en pédiatrie. [less ▲]

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See detailRecurrent Ataxia and Dystonia with Anti-Neurochondrin Autoantibodies
BARREA, Christophe ULiege; DEPIERREUX, Frédérique ULiege

in Neuropediatrics (2021)

We report the case of a 7-years-old boy who developed severe recurrent episodes of ataxia. Following the persistence of intrathecal pleocytosis and oligoclonal bands, auto-immune workup was performed and ... [more ▼]

We report the case of a 7-years-old boy who developed severe recurrent episodes of ataxia. Following the persistence of intrathecal pleocytosis and oligoclonal bands, auto-immune workup was performed and anti-neurochondrin antibodies in the cerebro-spinal fluid were discovered. Other investigations returned normal, no oncologic accompaniments were found. Clinical examination identified cerebellar ataxia, cervical dystonia, choreic movements of the upper limbs, action tremor, opsoclonus, dysarthria and akathisis (Video 1). Cognitive affective cerebellar syndrome, including neuropsychological impairment associated with significant emotional lability, was also found. Initial corticosteroid therapy (intravenous methylprednisolone 30mg/kg for 3 days) resulted in significant improvement. However, following the third relapse, a long-term corticotherapy with monthly intravenous methylprednisolone 500mg/m² was initiated. After 8 months, in order to avoid side effects, this treatment was replaced by mycophenolic acid. No relapse was observed since then. The child currently keeps slightly ataxic gait as well as significant cognitive impairment. Autoimmune etiologies of movement disorders are increasingly recognized, even in children. Unexplained repeated episodes of ataxia of subacute onset may require a workup with comprehensive neural IgG screening, especially since immune therapies seem more effective than what is observed in adults. [less ▲]

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See detailComment j’explore… Un trouble du développement intellectuel chez l'enfant
BARREA, Christophe ULiege; LEROY, Patricia ULiege; DEBRAY, François-Guillaume ULiege et al

in Revue Médicale de Liège (2020), 75(10), 686-691

Global developmental delay (GDD) and intellectual development disorder (IDD) are common but heterogeneous pediatric conditions. Guided by a rigorous clinical and anamnestic examination, the diagnostic ... [more ▼]

Global developmental delay (GDD) and intellectual development disorder (IDD) are common but heterogeneous pediatric conditions. Guided by a rigorous clinical and anamnestic examination, the diagnostic approach is a dynamic process which is not limited to the intelligence quotient measurement. A large panel of paraclinical tests allows etiological exploration; this generally includes biological, genetic, metabolic and iconographic examinations. To maximize therapeutic efficiency and standardize practices, this document provides a guideline for the management of pediatric GDD/IDD. [less ▲]

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See detailComment j’explore… Une pathologie organique à l’origine d’un trouble pédopsychiatrique
BARREA, Christophe ULiege; DEBRAY, François-Guillaume ULiege; SIMON, Michaël ULiege et al

in Revue Médicale de Liège (2020), 75(1),

Psychiatric disorders in children may be the expression of underlying organic conditions. These are numerous and varied. The clinical presentation is often frustrating: psychiatric signs can remain ... [more ▼]

Psychiatric disorders in children may be the expression of underlying organic conditions. These are numerous and varied. The clinical presentation is often frustrating: psychiatric signs can remain isolated for years before other more specific organic signs appear. More recently, new treatments have been developed, making it possible to improve the prognosis of some of these organic diseases; screening them is therefore a daily concern for the child psychiatrist. This literature review discusses various paediatric treatable organic disorders that may have an isolated psychiatric presentation, to finally propose a decision tree algorithm based on somatic and psychiatric complaints reported. [less ▲]

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See detailGenetic and phenotypic spectrum associated with IFIH1 gain-of-function
Rice, Gillian I.; DEBRAY, François-Guillaume ULiege; HARVENGT, Julie ULiege et al

in Human Mutation (2020)

IFIH1 gain‐of‐function has been reported as a cause of a type I interferonopathy encompassing a spectrum of autoinflammatory phenotypes including Aicardi–Goutières syndrome and Singleton Merten syndrome ... [more ▼]

IFIH1 gain‐of‐function has been reported as a cause of a type I interferonopathy encompassing a spectrum of autoinflammatory phenotypes including Aicardi–Goutières syndrome and Singleton Merten syndrome. Ascertaining patients through a European and North American collaboration, we set out to describe the molecular, clinical and interferon status of a cohort of individuals with pathogenic heterozygous mutations in IFIH1. We identified 74 individuals from 51 families segregating a total of 27 likely pathogenic mutations in IFIH1. Ten adult individuals, 13.5% of all mutation carriers, were clinically asymptomatic (with seven of these aged over 50 years). All mutations were associated with enhanced type I interferon signaling, including six variants (22%) which were predicted as benign according to multiple in silico pathogenicity programs. The identified mutations cluster close to the ATP binding region of the protein. These data confirm variable expression and nonpenetrance as important characteristics of the IFIH1 genotype, a consistent association with enhanced type I interferon signaling, and a common mutational mechanism involving increased RNA binding affinity or decreased efficiency of ATP hydrolysis and filament disassembly rate. [less ▲]

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See detailOdalisque's Position as a Geste Antagoniste in a Variant Phenotype of Ataxia‐Telangiectasia
BARREA, Christophe ULiege; DEPIERREUX, Frédérique ULiege; Servais, Laurent ULiege

in Movement Disorders Clinical Practice (2019)

We report the case of a young boy suffering from a variant phenotype of ataxia-telangiectasia and presenting with dystonia among other movement disorders. We observed a particular form of geste ... [more ▼]

We report the case of a young boy suffering from a variant phenotype of ataxia-telangiectasia and presenting with dystonia among other movement disorders. We observed a particular form of geste antagoniste (sensory trick) evocative of the "Odalisque" painted by H. Matisse. [less ▲]

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See detailCentral Nervous System Complications due to Human Herpesvirus 6 Infection in Pediatric Age Group
BARREA, Christophe ULiege; Demonceau, Nathalie; Loeckx, Isabelle et al

in Journal of Pediatric Neurology (2019)

Human herpesvirus 6 (HHV-6) has been demonstrated to be a neurotropic virus and has been linked to several neurological complications associated with a wide range of clinical outcomes. Here, we present ... [more ▼]

Human herpesvirus 6 (HHV-6) has been demonstrated to be a neurotropic virus and has been linked to several neurological complications associated with a wide range of clinical outcomes. Here, we present data from immunocompetent children with a central neurological condition and intrathecal DNA detection of HHV-6 virus. Through these cases, physiopathology, investigations, and outcome of the disease will be described. Finally, specific treatment will be discussed. [less ▲]

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See detailKinsbourne syndrome as complication of a Mycoplasma pneumoniae infection
ADOUANE, Linda ULiege; Hoyoux, Marie ULiege; FRERE, Julie ULiege et al

in Belgian Journal of Paediatrics (2019), 21

Few cases of Kinsbourne syndrome secondary to Mycoplasma pneumoniae infection are described in present literature. Here, we present the rare case of a young boy who spontaneously demonstrated a favorable ... [more ▼]

Few cases of Kinsbourne syndrome secondary to Mycoplasma pneumoniae infection are described in present literature. Here, we present the rare case of a young boy who spontaneously demonstrated a favorable evolution without immunomodulatory treatment. [less ▲]

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See detailMethotrexate-induced Acute Myelopathy in a Teenager With High-risk Acute Lymphoblastic Leukemia
Geurten, Claire ULiege; FORGET, Patricia ULiege; LEROY, Patricia ULiege et al

in Journal of Pediatric Hematology/Oncology (2018)

Acute lymphoblastic leukemia (ALL) is one of the most frequent malignancies in childhood whose long-term survival has increased up to 80% thanks to modern therapy enhancements. Nevertheless, methotrexate ... [more ▼]

Acute lymphoblastic leukemia (ALL) is one of the most frequent malignancies in childhood whose long-term survival has increased up to 80% thanks to modern therapy enhancements. Nevertheless, methotrexate (MTX) remains a mainstay of ALL therapy, but also represents one of the major causes of neurotoxicity in patients with ALL. MTX-induced toxicity occurs in about 9% of patients treated for ALL. It usually affects deep white matter region leading to leukoencephalopathy, which has varying clinical manifestations ranging from acute neurological disturbances to seizures or chronic permanent encephalopathy. Here we describe a 13-year-old girl affected with ALL who developed lower limbs hypesthesia and static ataxia due to transverse myelopathy after intrathecal administration of MTX therapy. A high-dose corticotherapy combined to vitamin supplementation and rehabilitation was tested. Neurological evolution was characterized by slow and partial recovery. [less ▲]

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See detailPhenotype-genotype correlation in children with neurofibromatosis type 1
BARREA, Christophe ULiege; VAESSEN, Sandrine ULiege; BULK, Saskia ULiege et al

in Neuropediatrics (2018)

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See detailStunted growth and alopecia totalis: A case report
Boodhoo, Fadil Mohammud ULiege; BARREA, Christophe ULiege; Lombet, Jacques ULiege et al

in Belgian Journal of Paediatrics (2018, March), 20(1),

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See detailHorner syndrome in children: a clinical condition with serious underlying disease
Barrea, Christophe ULiege; Vigouroux, Tiphaine ULiege; Karam, Joe ULiege et al

in Neuropediatrics (2016), 47(4), 268-272

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See detailPourquoi dort-on?
BARREA, Christophe ULiege

in Congrès du GBPF (2015, November)

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See detailMono- and Biallelic deletion of neurexin - à propos of 3 cases
Barrea, Christophe ULiege; RAMAEKERS, Vincent ULiege; Seghaye, Marie-Christine ULiege

in Tijdschrift van de Belgische Kinderarts (2015, January), 17(1), 107

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