References of "Albert, Adelin"
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See detailHumor Associated with Positive Outcomes in Individual Psychotherapy
Panichelli, Christophe ULiege; Albert, Adelin ULiege; Donneau, Anne-Françoise ULiege et al

in American Journal of Psychotherapy (in press), APT-2018-0021

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy ... [more ▼]

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy outcomes in a real-life population of 110 adult psychotherapy clients who attended at least 10 therapy sessions. Clients and their therapist evaluated the frequency and intensity of humorous events, as well as therapy effectiveness, therapeutic alliance, perceived hope and pleasure to participate in therapy sessions. We found a strong positive correlation between humor and therapy effectiveness, in both client (rs = .40; p < .0001) and therapist perspectives (rs = .37; p < .0001). The link between humor and effectiveness remained significant in more severe subgroups of clients, even though these clients reported less humor in their therapies. Further research is needed to determine if humor actually enhances therapy outcomes, or if positive outcomes trigger the occurrence of humor. [less ▲]

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See detailIs the triple stimulation technique a better quantification tool of motor dysfunction than motor evoked potentials in multiple sclerosis?
GIFFROY, Xavier ULiege; DIVE, Dominique ULiege; KAUX, Jean-François ULiege et al

in Acta Neurologica Belgica (in press)

The triple stimulation technique (TST) was rarely used in multiple sclerosis (MS). This study aimed to compare TST and motor evoked potentials (MEP) for the quantification of motor dysfunction. Central ... [more ▼]

The triple stimulation technique (TST) was rarely used in multiple sclerosis (MS). This study aimed to compare TST and motor evoked potentials (MEP) for the quantification of motor dysfunction. Central motor conduction based on MEP (four limbs) and TST (upper limbs) was assessed in 28 MS patients with a median Expanded Disability Status Scale (EDSS) of 4. EDSS, timed 25-foot walk (T25FW), grasping strength and motor components of the MS functional composite (MSFCm) were evaluated. Regression analysis was used to assess the relationship between MEP, TST and clinical findings. TST was negatively correlated with EDSS (r = -0.74, p<0.0001) and to a lesser extent with T25FW (r = -0.47, p<0.05), and grasping strength (r = -0.43, p<0.05). A multiple regression analysis underlined the better correlation between clinical data and TST (R2 = 0.56, p<0.0005) than with MEP (0.03<R2<0.22, p>0.05). This study evidenced the value of TST as a quantification tool of motor dysfunction. TST appeared to reflect a global disability since it was correlated not only to hand function but also to walking capacity. [less ▲]

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See detailEffects of rapid maxillary expansion on respiratory events in children: are we doing no harm?
HENDRIX, Charlotte ULiege; Bruwier, Annick ULiege; SEIDEL, Laurence ULiege et al

Conference (2018, November 09)

Introduction: Rapid maxillary expansion devices are used in children with upper maxillary transverse deficit and cross-bite. They were consistently shown to improve obstructive apnoea syndrome in children ... [more ▼]

Introduction: Rapid maxillary expansion devices are used in children with upper maxillary transverse deficit and cross-bite. They were consistently shown to improve obstructive apnoea syndrome in children. However, the impact of the device in place into the child’s mouth has never been studied. The aim of our study was to quantify the effect of the device on respiratory events while in place. Secondary endpoints were to evaluate its impact on quality of life and on respiratory events after treatment. Material and Methods: 12 consecutive children with maxillary cross-bite were prospectively included in this cohort study. Respiratory events were recorded before, during and after rapid maxillary expansion using a validated type 3 polygraphy including jaw movements. Subjective outcomes were evaluated using Obstructive Sleep Apnea (OSA)-18 quality-of-life questionnaire (OSA-18). Maxillary width and 16/26 distance were evaluated before and after RME on anterior radiography. Results: Estimated apnea hypopnea index increased from 2.67/h (±1.31/h) to 2.9/h (±2.4/h) with the device in place. Respiratory effort characterized by jaw motion > 0.4mm during the respiratory cycle increased from 7.58% (±10.01%) to 16.05% (±15.53%). Sleep-related breathing impairment was confirmed by parents’ questionnaires. Conclusion: While rapid maxillary expansion is an effective treatment for obstructive apnea syndrome in children, our study suggested a transient worsening of sleep breathing while the device is in place. It may be related to an incorrect tongue position and/or to the crowding of the device into the mouth. [less ▲]

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See detailA new method to evaluate the part of stress in pain: injection of dextrose 5% (neural prolotherapy) on acupuncture points corresonponding to stellate, coeliac and mesenteric ganglions. A pilot study
BECO, Jacques ULiege; Mouchel, Jack; SEIDEL, Laurence ULiege et al

in Pelviperineology : Multidisciplinary Pelvic Floor Journal (2018), 37

In neuralgia (neuropathic pain), the skin rolling test is painful (allodynia to pinch) but when painful everywhere on the body (polyneuralgia) it often indicates that the patient is in a stress state, in ... [more ▼]

In neuralgia (neuropathic pain), the skin rolling test is painful (allodynia to pinch) but when painful everywhere on the body (polyneuralgia) it often indicates that the patient is in a stress state, in a fight or flight situation. Thus, when starting a treatment, it is important to differentiate between these patients and those who have perineal pain only. The aim of this study was to evaluate the effect on pain and stress of a neural prolotherapy treatment (dextrose 5% injections) at seven acupuncture points linked with orthosympathetic ganglia. The studied population comprised 55 patients treated in two private clinical settings (authors 1 and 2). The short-term effect on pain was studied by comparing the pain induced by the arm skin rolling test before and 15 minutes after injections. To evaluate the long term effect on pain, the average level of body pain during the two weeks preceding the treatment was compared with that following treatment. The World Health Organization (WHO) Five Well-Being Index was used to evaluate the patient’s level of stress before and two weeks after injections. Fifteen minutes after dextrose injections, pain induced by the skin rolling test at the arm was decreased (-3.0 ± 1.6; p<0.0001). Two weeks after treatment, the global body pain score was significantly reduced (-2.0 ± 2.4; p<0.0001) and the total WHO score increased (+21.0 ± 20.5; p<0.0001). Treatment of polyneuralgic patients with neural prolotherapy of seven acupuncture points significantly improves well-being sensation and reduces pain. [less ▲]

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See detailLong-term stability of open bite treatments
Bruwier, Annick ULiege; THONNART, François ULiege; Gelin, Emilie ULiege et al

in Long-term stability of combined orthodontic and orthognathic treatments (2018, February 23)

The long-term stability of open bite treatments is very difficult to obtain due to several parameters (genetic, myofunctional or/and parafunctional diseases). Methods :17 adult patients suffering from ... [more ▼]

The long-term stability of open bite treatments is very difficult to obtain due to several parameters (genetic, myofunctional or/and parafunctional diseases). Methods :17 adult patients suffering from basal open bite were treated by a combined orthodontic treatment and orthognathic surgery. The surgery protocol was always a Lefort I osteotomy, except in case of class II, where a sagittal mandibular osteotomy was also performed in the same operation. Five parameters were taken into account to assess the long term stability of the treatment : Angle class, occlusal plane rotation, type and duration of retention after orthodontic treatment, tongue position and overbite. Results : we had a minimum 2-years observation after a combined orthodontic/orthognathic surgery treatment to evaluate the long-term stability of this type of treatment. Cephalometric parameters (Angle class, occlusal plane rotation, tongue position and overbite) measured at T2 and T3 showed a good long term stability after 2 years (T3). Conclusions : The posterior maxillar impaction must be more important than the anterior maxillar impaction to be the key to a long-term stability in open bite treatments. The tongue position is also a relevant element to maintain the right dental occlusion. A minimum one year combined with bimaxillar retention is also required to obtain a good and stable result of treatment. [less ▲]

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See detailHeterogeneity of estrogen receptor alpha and progesterone receptor distribution in lesions of deep infiltrating endometriosis of untreated women or during exposure to various hormonal treatments.
BRICHANT, Géraldine ULiege; NERVO, Patricia ULiege; Albert, Adelin ULiege et al

in Gynecological Endocrinology (2018)

Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a ... [more ▼]

Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a functional heterogeneity of these lesions. To evaluate the phenotype heterogeneity of cells in DIE, we measured the expression of estrogen receptor alpha (ERalpha) and of progesterone receptor (PR) in DIE of untreated women or under various treatments. We analyzed the luminal epithelial height (LEH), immunoreactive epithelial staining (IRS) and stromal staining intensity (SSI) of ERalpha and PR. We observed a high variability in the same gland, among distinct glands in the same sample and among distinct patients receiving the same treatment. LEH variability was primarily due to epithelial cells heterogeneity in a gland, secondarily to the glands randomly evaluated on the same section, and tertiary to the patient category. Variability in IRS and SSI scores was primarily the consequence of their heterogeneity in the same woman and to a lesser extent to variability among patients. LEH and SSI were not modified according to treatment. IRS for PR was lower in treated patients. This heterogeneity of ERalpha and PR distribution could explain why endocrine treatments are unable to cure this condition. [less ▲]

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See detailEfficacy of bio-optimized extracts of turmeric and essential fennel oil on the quality of life in patients with irritable bowel syndrome
Di Ciaula, Agostino; Portincasa, Piero; MAES, Nathalie ULiege et al

in Annals of Gastroenterology (2018), 31(6), 685-691

Background: The use of herbal products to treat irritable bowel syndrome (IBS), a disease that frequently affects the quality of life (QoL), is still under evaluation. This open pilot study assessed the ... [more ▼]

Background: The use of herbal products to treat irritable bowel syndrome (IBS), a disease that frequently affects the quality of life (QoL), is still under evaluation. This open pilot study assessed the efficacy of bio-optimized extracts of turmeric and essential fennel oil (Enterofytol(R)) in IBS patients. Methods: A total of 211 patients (14% diarrhea-predominant, IBS-D; 24% constipation-predominant, IBS-C; 62% mixed, IBS-M) were enrolled by general practitioners and completed questionnaires measuring symptom severity and QoL before and after Enterofytol(R), two capsules b.i.d. for one month, followed by two capsules q.d. for another month. Results: IBS severity index and QoL were inversely related. A significant reduction in the severity index and an improvement in QoL were evident following treatment in all IBS subgroups. IBS-D patients showed the worst clinical picture at entry, with the highest IBS severity index and the lowest QoL score, compared with IBS-C and IBS-M subtypes. IBS-D patients, however, also showed the most pronounced response to therapy, considering both scores. The improvement in the IBS severity index was independent of age and sex. Conclusions: Results from this "real-life" study show that the combination of turmeric and essential fennel oil over two months improves both symptoms and QoL in IBS patients, irrespectively of age, sex, initial severity of symptoms and IBS-subtypes, suggesting a potential role for the natural treatment of IBS. [less ▲]

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See detailPelvic trauma and pudendal syndrome (post-traumatic pudendal syndrome)
BECO, Jacques ULiege; ANTOLAK, Stanley; SEIDEL, Laurence ULiege et al

in Pelviperineology : Multidisciplinary Pelvic Floor Journal (2018)

The pudendal syndrome can result from pelvic trauma but the link is difficult to prove. The study was intended to disentangle potentially linking elements of the post-traumatic pudendal syndrome, in ... [more ▼]

The pudendal syndrome can result from pelvic trauma but the link is difficult to prove. The study was intended to disentangle potentially linking elements of the post-traumatic pudendal syndrome, in particular perineodynia (perineal pain), one of the salient symptoms of the pudendal syndrome. Two case reports were used to illustrate the point. The study was based on 394 female patients of whom 216 (54.8%) had a history of pelvic trauma. Patients were further classified into mutually exclusive groups according to presence/absence of perineodynia and, for those with pelvic trauma, according to latency of pain appearance (pain before trauma, early onset, or late onset). Urge urinary incontinence, cystalgia, anal incontinence and proctalgia fugax were found statistically more frequent in the pelvic trauma group. Perineodynia visual analog score, NHI-CPSI score and Wexner’s score were also significantly greater in traumatic patients. The three pudendal syndrome clinical signs were significantly more present in pelvic trauma patients than in non-trauma subjects. In the three post-traumatic perineodynia groups with different latency, only minor significant symptoms frequency differences were observed but importantly urge incontinence, cystalgia, anal incontinence and proctalgia fugax remained more frequent than in the non-trauma perineodynia group for similar pain scores. Post-traumatic pudendal syndrome is a reality. Perineodynia, urge incontinence, anal incontinence, proctalgia fugax and cystalgia are the most frequently symptoms encountered. These findings recommend performing a detailed history search for any symptom of the pudendal syndrome and a comprehensive clinical examination including its three clinical signs after any significant pelvic trauma. [less ▲]

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See detailEndoscopic transperineal pudendal nerve decompression: operative pudendoscopy.
Beco, Jacques; SEIDEL, Laurence ULiege; Albert, Adelin ULiege

in Surgical Endoscopy (2018), 32(8), 3720-3731

BACKGROUND: Pudendal nerve entrapment can produce a pudendal syndrome comprising perineodynia together with urinary, sexual, and anorectal symptoms. This syndrome can be treated surgically by the ... [more ▼]

BACKGROUND: Pudendal nerve entrapment can produce a pudendal syndrome comprising perineodynia together with urinary, sexual, and anorectal symptoms. This syndrome can be treated surgically by the transperineal approach. By using an endoscope during the procedure ("operative pudendoscopy"), the surgeon has close-up visual control of each decompression steps, demonstrates the different levels of entrapment, and cuts the sacrospinous ligament under visual control. The aim of this study was to describe the technical details of this new technique and its outcome in the treatment of the pudendal syndrome. METHODS: A series of 113 patients with severe pudendal syndrome underwent operative pudendoscopy. A complete history, pain visual analog scale (VAS) for perineodynia, and four scores evaluating the main symptoms (ICIQ-SF, NHI-CPSI, St Mark's, and Wexner) were obtained before and at least 24 months after surgery. The three clinical signs of pudendal syndrome (abnormal pinprick sensitivity, painful skin rolling test, and painful pudendal nerve) and perineal descent were analyzed before and after surgery in 91 patients. RESULTS: The mean operating time per side was 50.3 +/- 15.2 min and the average hospital stay was 2.1 +/- 0.4 days. Perineodynia VAS dropped from 7.2 +/- 1.4 to 4.5 +/- 2.9 after surgery (p < 0.0001) and the symptoms scores significantly improved. Frequency of sexual arousal syndrome, dyspareunia, and cystalgia was also significantly reduced. Pathological perineal descent (>/= 1.5 cm measured with a Perineocaliper(R)) observed in 13 patients was reduced from 1.81 to 0.77 cm after surgery (p < 0.0001). The only significant complication was severe hemorrhage in one patient induced by an inferior gluteal vessel laceration and successfully treated by arterial embolization. CONCLUSIONS: A complete pudendal nerve decompression, from the distal branches to the sacral foramina, safely performed under visual control by using operative pudendoscopy markedly improves clinical signs and symptoms of the pudendal syndrome. [less ▲]

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See detailPatient compliance and orthodontic treatment efficacy of Planas functional appliances with TheraMon microsensors
CHARAVET, Carole ULiege; LE GALL, Michel; Albert, Adelin ULiege et al

in Angle Orthodontist (2018)

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See detailFDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer.
LOVINFOSSE, Pierre ULiege; POLUS, Marc ULiege; VAN DAELE, Daniel ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2018)

PURPOSE: The aim of this study was to investigate the prognostic value of baseline 18F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC ... [more ▼]

PURPOSE: The aim of this study was to investigate the prognostic value of baseline 18F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC underwent 18F-FDG PET/CT before treatment. Maximum and mean standard uptake values (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), histogram-intensity features, as well as 11 local and regional textural features, were evaluated. The relationships of clinical, pathological and PET-derived metabolic parameters with disease-specific survival (DSS), disease-free survival (DFS) and overall survival (OS) were assessed by Cox regression analysis. Logistic regression was used to predict the pathological response by the Dworak tumor regression grade (TRG) in the 66 patients treated with neoadjuvant chemoradiotherapy (nCRT). RESULTS: The median follow-up of patients was 41 months. Seventeen patients (19.7%) had recurrent disease and 18 (20.9 %) died, either due to cancer progression (n = 10) or from another cause while in complete remission (n = 8). DSS was 95% at 1 year, 93% at 2 years and 87% at 4 years. Weight loss, surgery and the texture parameter coarseness were significantly associated with DSS in multivariate analyses. DFS was 94 % at 1 year, 86 % at 2 years and 79 % at 4 years. From a multivariate standpoint, tumoral differentiation and the texture parameters homogeneity and coarseness were significantly associated with DFS. OS was 93% at 1 year, 87% at 2 years and 79% after 4 years. cT, surgery, SUVmean, dissimilarity and contrast from the neighborhood intensity-difference matrix (contrastNGTDM) were significantly and independently associated with OS. Finally, RAS-mutational status (KRAS and NRAS mutations) and TLG were significant predictors of pathological response to nCRT (TRG 3-4). CONCLUSION: Textural analysis of baseline 18F-FDG PET/CT provides strong independent predictors of survival in patients with LARC, with better predictive power than intensity- and volume-based parameters. The utility of such features, especially coarseness, should be confirmed by larger clinical studies before considering their potential integration into decisional algorithms aimed at personalized medicine. [less ▲]

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See detailQuality of life perception by inmates in the Central Prison of Mbuji-Mayi, Democratic Republique of Congo
Kalonji, Muasa Patoka ULiege; Okenge Ngongo, Leon; Ilunga Ilunga, Félicien et al

in International Journal of Medecal Research & Health Sciences (2017)

Summary Introduction: In developing countries, quality of prison life remains a challenge in public health. The present study aimed at determining the quality of life as perceived by inmates during their ... [more ▼]

Summary Introduction: In developing countries, quality of prison life remains a challenge in public health. The present study aimed at determining the quality of life as perceived by inmates during their imprisonment at the Central Prison of Mbuji-Mayi, Democratic Republic of Congo. Materials and Methods: This cross-sectional study was carried out over a 3-month period (between December 2015 and February 2016) at the Central Prison of Mbuji-Mayi. Three hundred inmates participated to the survey. The World Health Organisation Quality of Life Scale (WHOQOL-BREF) was used to estimate health and problems affecting inmates’ everyday life. Results: Mean age of inmates was 33 ± 10 years (range: 18-70 years) and most of them were male (88.7%). The quality of life score they estimated was below 50, on the WHOQOL-BREF scale weighted over 100 points (average overall score: 26±7). When considering each WHOQOL-BREF domain, the lowest scores (0-100 normalised scale) were registered for: perception of physical health (24±11), psychological health (18±8), social relationship (39±15) and environmental relationships (24±8). Overall, inmates aged over 30 years old presented an average score slightly lower than younger inmates (25±6 vs. 27±7; p=0.005). Depending on the length of incarceration, the average score was lower for inmates imprisoned for more than 6 months compared to others (26±6 vs. 28 ± 8; p= 0.015). Correlations between domain scores were low but statistically significant; no correlation was highlighted between environment and mental health domains. Conclusion: Most inmates considered their quality of life as negative, regardless of the WHOQOL-BREF domain. Efforts to improve quality of life should remain a priority for political authorities. [less ▲]

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See detailSepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study
LAYIOS, Nathalie ULiege; Delierneux, Céline ULiege; Hego, Alexandre ULiege et al

in Intensive Care Medicine Experimental (2017), 5(1), 32

Background: Platelets have been involved in both surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with ... [more ▼]

Background: Platelets have been involved in both surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to sepsis in critical illness remains unknown. The aim of this work was to identify platelet markers that could predict sepsis occurrence in critically ill injured patients. Results: This single-center, prospective, observational, 7-month study was based on a cohort of 99 non-infected adult patients admitted to ICUs for elective cardiac surgery, trauma, acute brain injury and post-operative prolonged ventilation and followed up during ICU stay. Clinical characteristics and severity score (SOFA) were recorded on admission. Platelet activation markers, including fibrinogen binding to platelets, platelet membrane P-selectin expression, plasma soluble CD40L, and platelet-leukocytes aggregates were assayed by flow cytometry at admission and 48h later, and also at the time of sepsis diagnosis (Sepsis-3 criteria) and 7 days later for sepsis patients. Hospitalization data and outcomes were also recorded. Of the 99 patients, 19 developed sepsis after a median time of 5 days. SOFA at admission was higher; their levels of fibrinogen binding to platelets (platelet-Fg) and of D-dimers were significantly increased compared to the other patients. Levels 48h after ICU admission were no longer significant. Platelet-Fg % was an independent predictor of sepsis (P = 0.030). By ROC curve analysis cutoff points for SOFA (AUC=0.85) and Platelet-Fg (AUC=0.75) were 8 and 50%, respectively. The prior risk of sepsis (19%) increased to 50% when SOFA was above 8, to 46% when Platelet-Fg was above 50%, and to 87% when both SOFA and Platelet-Fg were above their cutoff values. By contrast, when the two parameters were below their cutoffs, the risk of sepsis was negligible (3.8%). Patients with sepsis had longer ICU and hospital stays and higher death rate. Conclusion: In addition to SOFA, platelet-bound fibrinogen levels assayed by flow cytometry within 24h of ICU admission help identifying critically ill patients at risk of developing sepsis. [less ▲]

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See detailAppareil Fonctionnel d'Expansion Transversale de Planas : Compliance et Efficacité
LEROY, Sophie; Albert, Adelin ULiege; BRUWIER, Annick ULiege et al

Poster (2017, November)

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See detailDoes Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review
Bacevic, Miljana ULiege; Brkovic, Bozidar; Albert, Adelin ULiege et al

in Calcified Tissue International (2017)

Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms ... [more ▼]

Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration. [less ▲]

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