References of "Votion, Dominique"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLa myopathie atypique des équidés
Votion, Dominique ULiege

E-print/Working paper (2016)

La myopathie atypique est une maladie saisonnière désormais bien présente en France et en Europe. Elle se caractérise par une destruction des muscles posturaux, respiratoires et du myocarde. Des études ... [more ▼]

La myopathie atypique est une maladie saisonnière désormais bien présente en France et en Europe. Elle se caractérise par une destruction des muscles posturaux, respiratoires et du myocarde. Des études récentes ont montré que la cause est une toxine présente dans les graines de certains arbres du genre « Acer » (érable) dont l'Acer pseudoplatanus ou érable sycomore. [less ▲]

Detailed reference viewed: 73 (22 ULiège)
Full Text
Peer Reviewed
See detailAssessing muscle mitochondrial function to improve training, performance and to early detect exertional myopathies in sport horses
Votion, Dominique ULiege; Robert, Céline; Serteyn, Didier ULiege

Poster (2016, June)

High-resolution respirometry is a new advanced technology that measures OXPHOS capacities, i.e. the ability of the muscle cell to produce energy in presence of oxygen. These studies demonstrated that ... [more ▼]

High-resolution respirometry is a new advanced technology that measures OXPHOS capacities, i.e. the ability of the muscle cell to produce energy in presence of oxygen. These studies demonstrated that OXPHOS capacities correlate with fitness level and racing performance. Furthermore, altered OXPHOS capacities indicate risk of developing exercise-induced myopathy thus contributing to maintain welfare by adapting training and management of the horse to this risk. [less ▲]

Detailed reference viewed: 24 (2 ULiège)
Full Text
Peer Reviewed
See detailAtypical myopathy: an update
Votion, Dominique ULiege

in In Practice (2016), 38(5), 241-246

This article gives an overview of atypical myopathy, discussing the mechanism involved, its aetiology and the clinical signs and management (therapeutic and prevention).

Detailed reference viewed: 181 (44 ULiège)
Full Text
Peer Reviewed
See detailÉpidémiologie de la gale d’été
Fievet, Valentine; Detilleux, Johann ULiege; Votion, Dominique ULiege

in Proceeding de la 42ème Journée de la Recherche équine (2016, March 17)

Equine summer eczema (SE) is a hypersensitivity reaction to bites of insects such as Culicoides sp. (midges). Equine SE induces pruritus, typically at the mane, basis of the tail and lower part of the ... [more ▼]

Equine summer eczema (SE) is a hypersensitivity reaction to bites of insects such as Culicoides sp. (midges). Equine SE induces pruritus, typically at the mane, basis of the tail and lower part of the abdomen. This epidemiological survey aimed at describing factors associated with the clinical expression of SE, the treatments used by the owners of horses and their efficacy. On-line questionnaires enabled us to obtain data from 88 horses suffering from SE and from 74 pasture companions considered free of SE by their owner. At the level of horses, an increased risk of developing signs of SE has been identified for ponies (in particular Shetland) and working horses. At the level of the environment, wind exposure and manure spreading significantly decrease the risk of SE. According to owners of horses suffering from SE, the disease affects seriously the welfare but not the sport performances of the animals. The majority of the owners use a combination of mechanical and topical protections to which they attribute an average effectiveness. [less ▲]

Detailed reference viewed: 15 (1 ULiège)
Full Text
Peer Reviewed
See detailDetermination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis
Houben, Rosa ULiege; Leleu, Claire; Fraipont, Audrey ULiege et al

in Mitochondrion (2016), 24

This prospective cohort study evaluated the potential of high-resolution respirometry applied to permeabilized muscle fibers for fitness evaluation in French Standardbred racehorses. Fitness evaluation by ... [more ▼]

This prospective cohort study evaluated the potential of high-resolution respirometry applied to permeabilized muscle fibers for fitness evaluation in French Standardbred racehorses. Fitness evaluation by means of respirometric parameters did not correlate with racing performance registered over the following racing season. However, altered mitochondrial energy metabolism was associated with higher risk of developing exertional rhabdomyolysis, a common cause of exercise intolerance in racehorses. These data represent a first step towards establishing reference values for muscle OXPHOS capacity in this breed. [less ▲]

Detailed reference viewed: 66 (28 ULiège)
Full Text
Peer Reviewed
See detailAtypical myopathy in Denmark confirmed with the aTRAQ Assay
Høffer, Sofie Esbjørn; Votion, Dominique ULiege; Anderberg, Marie et al

in Journal of Equine Veterinary Science (2016), 47

Atypical myopathy is ais widespread in Europe and has been suspected in Denmark but no cases have been confirmed. This study confirmed cases in this country.

Detailed reference viewed: 70 (18 ULiège)
Full Text
Peer Reviewed
See detailMitochondrial function is altered in horse atypical myopathy
Lemieux, Hélène; BOEMER, François ULiege; van Galen, Gaby et al

in Mitochondrion (2016), 30

Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus. The hallmark of atypical ... [more ▼]

Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus. The hallmark of atypical myopathy consists of a severe alteration in the energy metabolism including a severe impairment in muscle mitochondrial respiration that could contribute to its high death rate [less ▲]

Detailed reference viewed: 92 (39 ULiège)
Full Text
See detailAssessment of ways to fight against equin summer eczema
Fievet, Valentine; Detilleux, Johann ULiege; Votion, Dominique ULiege

Scientific conference (2015, October 16)

Detailed reference viewed: 16 (1 ULiège)
Full Text
See detailIdentification of a new prognostic tool for atypical myopathy
De Ridder, T; BOEMER, François ULiege; Baise, Etienne et al

Scientific conference (2015, October 16)

Detailed reference viewed: 14 (2 ULiège)
Full Text
See detailAtypical myopathy: a preliminary study to identify the site of hypoglycin A metabolism
Ernoult, O.; Baise, Etienne; BOEMER, François ULiege et al

Scientific conference (2015, October 16)

Detailed reference viewed: 13 (2 ULiège)
Full Text
See detailProceedings of the 2nd FARAH-Day / Faculty of Veterinary Medicine (University of Liege - Belgium)
Bayrou, Calixte ULiege; Cabaraux, Jean-François ULiege; Delguste, Catherine ULiege et al

Book published by Presses de la Faculté de Médecine vétérinaire de l’Université de Liège (2015)

Detailed reference viewed: 85 (37 ULiège)
Full Text
See detailLe syndrome coup de sang
Courouce-Malblanc, Anne; Daix, Charlène; Ferry, Bénédicte et al

E-print/Working paper (2015)

Le coup de sang est un terme utilisé pour nommer une myopathie brutale consécutive à un exercice qui se manifeste cliniquement par des crampes douloureuses et une urine de couleur anormalement foncée du ... [more ▼]

Le coup de sang est un terme utilisé pour nommer une myopathie brutale consécutive à un exercice qui se manifeste cliniquement par des crampes douloureuses et une urine de couleur anormalement foncée du fait de l’élimination de la myoglobine des cellules musculaires détruites (myoglobinurie). [less ▲]

Detailed reference viewed: 48 (9 ULiège)
Full Text
Peer Reviewed
See detailLes nouveaux outils de diagnostic et de pronostic de la myopathie atypique
Habyarimana, Jean Belt Adélite ULiege; BOEMER, François ULiege; Amory, Hélène ULiege et al

in Proceeding de la 41ème Journée de la Recherche équine (2015)

In equines, ingestion of hypoglycin A, a toxin produced in the seeds (samaras) of sycamore maple (Acer pseudoplatanus) tree alters the energetic metabolism of muscle cells and results in atypical myopathy ... [more ▼]

In equines, ingestion of hypoglycin A, a toxin produced in the seeds (samaras) of sycamore maple (Acer pseudoplatanus) tree alters the energetic metabolism of muscle cells and results in atypical myopathy (AM). This alterations leads to a characteristic biochemical profile of acylcarnitines (AC) that enables to confirm the diagnosis of AM. This study aims at validating a methodology for the dosage of hypoglycin A in vegetal extracts but also in blood. In addition, the biochemical profile in AC has been determined in AM cases (5 survivors and 13 deceased) and in 5 horses suffering from exercise-induced myopathy. The AC profiles of these horses have been compared to the one of healthy horses (n = 35). This study showed that hypoglycin A was present in seeds and spring seedlings of sycamore and also in blood of AM cases horses. In addition, the establishment of AC profile contributes to the diagnostic and helps to assess the prognosis of AM cases. [less ▲]

Detailed reference viewed: 294 (74 ULiège)
Full Text
Peer Reviewed
See detailThe cause of atypical myopathy has been discovered – what should we do now?
Votion, Dominique ULiege

in Pferdeheilkunde (2015), 31(6), 241-246

This review chronicles the events that led to the discovery of the cause of atypical myopathy (AM). This review answers the question, “How do horses get poisoned in the spring?” and raises the possible ... [more ▼]

This review chronicles the events that led to the discovery of the cause of atypical myopathy (AM). This review answers the question, “How do horses get poisoned in the spring?” and raises the possible role of humidity or other trees in the disease induction. Recent findings that might be of importance to prevent and/or cure AM are also summarised. The paper concludes with the necessity to continue the recording of cases to help horses’ owners prevent AM. [less ▲]

Detailed reference viewed: 89 (14 ULiège)
Full Text
See detailMyopathie atypique
Votion, Dominique ULiege

in Richard, Eric (Ed.) Maladies des chevaux: diagnostic, traitement, prévention. (2015)

Detailed reference viewed: 121 (72 ULiège)
Full Text
Peer Reviewed
See detailDetection of hypoglycin A in the seeds of sycamore (Acer pseudoplatanus) and box elder (A. negundo) in New Zealand; the toxin associated with cases of equine atypical myopathy.
McKenzie, R. K.; Hill, F. I.; Habyarimana, Jean Belt Adélite ULiege et al

in New Zealand Veterinary Journal (2015)

CASE HISTORY AND CLINICAL FINDINGS: During April and May 2014 four horses aged between 5 months and 9 years, located in the Canterbury, Marlborough and Southland regions, presented with a variety of ... [more ▼]

CASE HISTORY AND CLINICAL FINDINGS: During April and May 2014 four horses aged between 5 months and 9 years, located in the Canterbury, Marlborough and Southland regions, presented with a variety of clinical signs including recumbency, stiffness, lethargy, dehydration, depression, and myoglobinuria suggestive of acute muscle damage. Two horses were subjected to euthanasia and two recovered. In all cases seeds of sycamore maple (Acer pseudoplatanus) or box elder (A. negundo) were present in the area where the horse had been grazing. LABORATORY INVESTIGATION: The samaras (seeds) of some Acer spp. may contain hypoglycin A, that has been associated with cases of atypical myopathy in Europe and North America. To determine if hypoglycin A is present in the samaras of Acer spp. in New Zealand, samples were collected from trees throughout the country that were associated with historical and/or current cases of atypical myopathy, and analysed for hypoglycin A. Serum samples from the four cases and four unaffected horses were analysed for the presence of hypoglycin A, profiles of acylcarnitines (the definitive diagnosis for atypical myopathy) and activities of creatine kinase and aspartate aminotransferase. Markedly elevated serum activities of creatine kinase and aspartate aminotransferase, and increased concentrations of selected acylcarnitines were found in the case horses. Hypoglycin A was detected in the serum of those horses but not in the healthy controls. Hypoglycin A was detected in 10/15 samples of samaras from sycamore maple and box elder from throughout New Zealand. DIAGNOSIS: Cases of atypical myopathy were diagnosed on properties where samaras containing hypoglycin A were also found. CLINICAL RELEVANCE: Sycamore and box elder trees in New Zealand are a source of hypoglycin A associated with the development of atypical myopathy. If pastured horses present with clinical and biochemical signs of severe muscle damage then the environment should be checked for the presence of these trees. Horses should be prevented from grazing samaras from Acer spp. in the autumn. [less ▲]

Detailed reference viewed: 54 (13 ULiège)
Full Text
Peer Reviewed
See detailQuantification of hypoglycin A in serum using aTRAQ((R)) assay
BOEMER, François ULiege; DEBERG, Michelle ULiege; SCHOOS, Roland ULiege et al

in Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences (2015), 997

BACKGROUND: Hypoglycin A has been recently identified has the causal agent of atypical myopathy (AM) in horses. Its identification and quantification in equine's biological fluids is thus a major concern ... [more ▼]

BACKGROUND: Hypoglycin A has been recently identified has the causal agent of atypical myopathy (AM) in horses. Its identification and quantification in equine's biological fluids is thus a major concern to confirm maple poisoning and to provide insight into the poorly understood mechanism of hypoglycin A intoxication. METHODS: Quantification of hypoglycin A has been achieved with the aTRAQ kit for amino acid analysis of physiological fluids (AB Sciex). Acquisition method on mass spectrometer has been updated to record the hypoglycin A specific MRM transition. RESULTS: Outlined accuracy profiles demonstrated very reliable data. A good linearity was observed from 0.09 to 50mumol/L and precision was very good with coefficient of variation below 8%. Fifty-five samples collected from 25 confirmed AM horses revealed significant hypoglycin A concentrations, while toxin was not found in serum of 8 control animals. CONCLUSIONS: The described aTRAQ variant method has been analytically and clinically validated. The reliability of our approach is thus demonstrated into the workup of atypical myopathy. [less ▲]

Detailed reference viewed: 76 (24 ULiège)
Full Text
See detailValidation of HPTCL method for quantitative determination of Hypoglycin A in methanol extracts of Maple (Acer) samples
Habyarimana; Baise; Weber, Mireille ULiege et al

Scientific conference (2014, October 17)

Detailed reference viewed: 14 (1 ULiège)