References of "Schoenen, Jean"
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See detailSphenopalatine ganglion stimulation in neurovascular headaches
SCHOENEN, Jean ULiege

in Progress in Neurological Surgery (2015), 29

Abstract The interest for the sphenopalatine ganglion (SPG) in neurovascular headaches dates back to 1908 when Sluder presented his work on the role of the sphenopalatine ganglion in «nasal headaches» ... [more ▼]

Abstract The interest for the sphenopalatine ganglion (SPG) in neurovascular headaches dates back to 1908 when Sluder presented his work on the role of the sphenopalatine ganglion in «nasal headaches» that are now part of the trigeminal autonomic cephalalgias and cluster headache (ICHD-III beta). Since then various interventions with blocking or lesional properties have targeted the SPG (transnasal injection of lidocaine and other agents, alcohol or steroid injections, radiofrequency lesions or even ganglionectomy); sucess rates varied, but benefit was usually transient. Here we briefly review some anatomo-physiological characteristics of the SPG and hypotheses about its pathophysiological role in neurovascular headaches before describing recent therapeutic results obtained with electrical stimulation of the SPG. Based on results of a prospective randomized controlled study, SPG stimulation appears to be an effective treatment option for patients with chronic cluster headaches; efficacy data indicate that acute electrical stimulation of the SPG provided significant attack pain relief and in many cases pain freedom compared to sham stimulation. Moreover, in some patients SPG stimulation was associated with a significant and clinically meaningful reduction in cluster headache attack frequency; this preventive effect of SPG stimulation warrants further investigation. For migraine attacks, the outcome of the proof-of-concept study using a temporary electrode implanted in the pterygopalatine fossa was less encouraging – but an ongoing multi-center trial evaluates the efficacy of long-term SPG stimulation against sham stimulation for acute and preventive treatment in patients with frequent migraine. [less ▲]

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See detailCerebral FDG uptake changes with supraorbital transcutaneous electrical stimulation for episodic migraine prevention
D'Ostilio, Kevin ULiege; Thibaut, Aurore ULiege; Laureys, Steven ULiege et al

Conference (2015, May)

Background: A recent multicentre RCT has shown that supraorbital transcutaneous stimulation (STS) targeting branches of the ophtalmic nerve with the Cefaly® device is effective as a preventive therapy for ... [more ▼]

Background: A recent multicentre RCT has shown that supraorbital transcutaneous stimulation (STS) targeting branches of the ophtalmic nerve with the Cefaly® device is effective as a preventive therapy for migraine (Schoenen et al., Neurology 2013). However, the mechanisms of action in the central nervous system remain unknown. Here, we conducted voxel-based analyses of [18]FDG-PET to evaluate metabolic changes immediately after the first STS session and after 3 months of treatment in patients with migraine. Methods: Twenty-eight subjects participated in the experiment: 14 patients with episodic migraine (ICHD3 beta criteria) and 14 age-matched controls. Healthy volunteers underwent only one [18]FDG-PET scan whereas patients were scanned at baseline, directly after a first session of STS and after 3 months of daily treatment. Results: Compliant patients showed a significant decrease in the number of attacks (p = 0.03). When compared to controls, patients (n = 14) at baseline were hypometabolic in the fronto-temporal regions (p < 0.001), especially in the orbitofrontal (OFC) and perigenual anterior cingulate cortex. OFC hypometabolism was not correlated with medication intake. In compliant patients, daily STS for 3 months was followed by a normalization of the fronto-temporal hypometabolism (p< 0.001; OFC: pFWE<0.01). Conclusion: Our study suggests that the OFC is hypoactive in episodic migraine. STS with the Cefaly° device is able to normalize this hypoactivity. This indicates that STS exerts its beneficial effect via slow neuromodulatory mechanisms, as also previously shown for percutaneous occipital nerve stimulation in refractory cluster headache (Magis et al., BMC Neurology 2011). [less ▲]

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See detailOne-year Prevalence of Migraine Using a Validated Extended French Version of the ID MigraineTM: a Belgian Population-Based Study
Schoenen, Jean ULiege; Streel, Sylvie ULiege; Donneau, Anne-Françoise ULiege et al

in Cephalalgia : An International Journal of Headache (2015, May), 35(6), 155-156

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See detailCerebral responses and role of the prefrontal cortex in conditioned pain modulation: an fMRI study in healthy subjects
Bogdanov, Volodymyr; Vigano, Alessandro; Noirhomme, Quentin ULiege et al

in Behavioural Brain Research (2015)

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See detailTargeting pericranial nerve branches to treat migraine: Current approaches and perspectives.
Ambrosini, Armin; D'Alessio, Costantino; MAGIS, Delphine ULiege et al

in Cephalalgia : An International Journal of Headache (2015)

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See detailDiagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society.
Paemeleire, K; Louis, P; MAGIS, Delphine ULiege et al

in Acta Neurologica Belgica (2015), 35(5), 437-442

This is a review of the pathophysiology of chronic migraine and of available therapies with a proposal for an algorithm of management.

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See detailCortical spreading depression decreases Fos expression in rat periaqueductal gray matter.
Bogdanov, Volodomir; Bogdanova, Olena; Lombard, Arnaud et al

in Neuroscience Letters (2015), 585

The migraine headache involves activation and central sensitization of the trigeminovascular pain path- way. The migraine aura is likely due to cortical spreading depression (CSD), a propagating wave of ... [more ▼]

The migraine headache involves activation and central sensitization of the trigeminovascular pain path- way. The migraine aura is likely due to cortical spreading depression (CSD), a propagating wave of brief neuronal depolarization followed by prolonged inhibition. The precise link between CSD and headache remains controversial. Our objectives were to study the effect of CSD on neuronal activation in the peri- aqueductal grey matter (PAG), an area known to control pain and autonomic functions, and to be involved in migraine pathogenesis. Fos-immunoreactive nuclei were counted in rostral PAG and Edinger–Westphal nuclei (PAG–EWn bregma −6.5 mm), and caudal PAG (bregma −8 mm) of 17 adult male Sprague–Dawley rats after KCl-induced CSD under chloral hydrate anesthesia. Being part of a pharmacological study, six animals had received, for the preceding 4 weeks daily, intraperitoneal injections of lamotrigine (15 mg/kg), six others had been treated with saline, while five sham-operated animals served as controls. We found that the number of Fos-immunoreactive nuclei in the PAG decreased after CSD provocation. There was no difference between lamotrigine- and saline-treated animals. The number of CSDs correlated negatively with Fos-immunoreactive counts. CSD-linked inhibition of neuronal activity in the PAG might play a role in central sensitization during migraine attacks and contribute to a better understanding of the link between the aura and the headache. [less ▲]

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See detailMigraine prevention with a supraorbital transcutaneous stimulator: A randomized controlled trial
Schoenen, Jean ULiege

in Neurology (2015), 86(2), 201-202

[No abstract available]

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See detailValidation of an extended French version of ID MigraineTM as a migraine-screening tool
Streel, Sylvie ULiege; Donneau, Anne-Françoise ULiege; Dardenne, Nadia ULiege et al

in Cephalalgia : An International Journal of Headache (2015), 35(5), 437-442

Introduction: Migraine has a considerable social, economic, physical and emotional burden but remains underdiagnosed and undertreated. A specific migraine screening tool could help remove barriers to ... [more ▼]

Introduction: Migraine has a considerable social, economic, physical and emotional burden but remains underdiagnosed and undertreated. A specific migraine screening tool could help remove barriers to health care and be an attractive instrument for epidemiological studies. The objective of this work was to assess the validity of an extended French version of ID MigraineTM as a migraine-screening tool. Methods: Sixty-seven subjects from the NESCaV study (2010–2012) completed the migraine screen and were diagnosed by a neurologist specializing in headache medicine using the International Classification of Headache Disorders, 2nd edition criteria (gold standard). Agreement between the two diagnoses was evaluated by Cohen kappa coefficient (k). Sensitivity, specificity and predictive values of the migraine screen were calculated. Results: Migraine was diagnosed in 21 (31.3%) of the 67 subjects according to the screening tool and in 24 (35.8%) by the neurologist (k¼0.90). The prevalence of migraine was unrelated to age, gender, education and perception of financial resources. Sensitivity and specificity of the screen were 87.5% and 100%, respectively. The screen prevalence of migraine with aura was 10.4% (sensitivity and specificity: 83.3% and 96.7%, respectively). Conclusion: The extended French version of ID MigraineTM (ef-ID Migraine) is a validated tool to screen migraine in French-speaking countries. [less ▲]

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See detailHeadache during cryoballoon ablation for atrial Fibrillation
Pison, L; Peeters, P; Blaauw, Y et al

in Europace (2015), 17(6), 898-901

Objective Headache has been reported to occur during cryoballoon ablation for atrial fibrillation (AF). No study has systematically analyzed this phenomenon. Methods Twenty consecutive patients with ... [more ▼]

Objective Headache has been reported to occur during cryoballoon ablation for atrial fibrillation (AF). No study has systematically analyzed this phenomenon. Methods Twenty consecutive patients with symptomatic AF, underwent cryoballoon ablation without sedation. Headache was evaluated before, during and after the first cryoapplication in every pulmonary vein (PV) using a visual representation of a head for location of the headache, a numerical rating scale (NRS) for measuring pain intensity and the short-form McGill pain questionnaire (MPQ) for qualitative analysis of pain. The order in which the PVs were ablated, was randomized. Results Sixteen (80%) patients perceived mainly frontal headache during cryoablation. The overall NRS scores were significantly higher during (5.1±1.7), compared to before (2.7±1.4), and after (3.5±2.2) a cryoapplication (p<0.05). The NRS score was significantly higher during ablation of the first PV. The intensity of the perceived headache was not related to the temperature reached 150 s after initiation of a cryoapplication (p = 0,81). Of the MPQ, 3 sensory adjectives and 1 affective adjective averaged between score 1 and 2, representing mild to moderate severity of pain. Conclusions The majority of patients treated by balloon cryoablation, experienced headache during a cryoapplication. There was no correlation between the temperature reached during a cryoballoon freeze and the intensity of the headache. Cryoballoon ablation of the first PV, was significantly more painfull than the remaining PV [less ▲]

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See detailCortical spreading depression decreases Fos expression in rat periaqueductal gray matter.
Borysovich Bogdanov, Volodymir; LOMBARD, Arnaud ULiege; Multon, Sylvie ULiege et al

in Neuroscience Letters (2015)

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See detailAnalysis and clinical correlates of 20 Hz photic driving on routine EEG in migraine.
Fogang, Y; Gérard, P; De Pasqua, V et al

in Acta Neurologica Belgica (2015), 115(1), 1-17

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See detailVisual evoked potentials in subgroups of migraine with aura patients
Coppola, G.; Bracaglia, M.; Di Lenola, D. et al

in Journal of Headache and Pain (2015), 16(1),

Background: Patients suffering from migraine with aura can have either pure visual auras or complex auras with sensory disturbances and dysphasia, or both. Few studies have searched for possible ... [more ▼]

Background: Patients suffering from migraine with aura can have either pure visual auras or complex auras with sensory disturbances and dysphasia, or both. Few studies have searched for possible pathophysiological differences between these two subgroups of patients. Methods: Methods - Forty-seven migraine with aura patients were subdivided in a subgroup with exclusively visual auras (MA, N = 27) and another with complex neurological auras (MA+, N = 20). We recorded pattern-reversal visual evoked potentials (VEP: 15 min of arc cheques, 3.1 reversal per second, 600 sweeps) and measured amplitude and habituation (slope of the linear regression line of amplitude changes from the 1st to 6th block of 100 sweeps) for the N1-P1 and P1-N2 components in patients and, for comparison, in 30 healthy volunteers (HV) of similar age and gender distribution. Results: VEP N1-P1 habituation, i.e. amplitude decrement between 1st and 6th block, which was obvious in most HV (mean slope −0.50), was deficient in both MA (slope +0.01, p = 0.0001) and MA+ (−0.0049, p = 0.001) patients. However, VEP N1-P1 amplitudes across blocks were normal in MA patients, while they were significantly greater in MA+ patients than in HVs. Conclusions: Our findings suggest that in migraine with aura patients different aura phenotypes may be underpinned by different pathophysiological mechanisms. Pre-activation cortical excitability could be higher in patients with complex neurological auras than in those having pure visual auras or in healthy volunteers. © 2015, Coppola et al. [less ▲]

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See detailCortical spreading depression decreases Fos expression in rat periaqueductal gray matter
Borysovych Bogdanov, V.; Bogdanova, O. V.; LOMBARD, Arnaud ULiege et al

in Neuroscience Letters (2015), 585

The migraine headache involves activation and central sensitization of the trigeminovascular pain pathway. The migraine aura is likely due to cortical spreading depression (CSD), a propagating wave of ... [more ▼]

The migraine headache involves activation and central sensitization of the trigeminovascular pain pathway. The migraine aura is likely due to cortical spreading depression (CSD), a propagating wave of brief neuronal depolarization followed by prolonged inhibition. The precise link between CSD and headache remains controversial. Our objectives were to study the effect of CSD on neuronal activation in the periaqueductal grey matter (PAG), an area known to control pain and autonomic functions, and to be involved in migraine pathogenesis. Fos-immunoreactive nuclei were counted in rostral PAG and Edinger-Westphal nuclei (PAG-EWn bregma -6.5. mm), and caudal PAG (bregma -8. mm) of 17 adult male Sprague-Dawley rats after KCl-induced CSD under chloral hydrate anesthesia. Being part of a pharmacological study, six animals had received, for the preceding 4 weeks daily, intraperitoneal injections of lamotrigine (15. mg/kg), six others had been treated with saline, while five sham-operated animals served as controls. We found that the number of Fos-immunoreactive nuclei in the PAG decreased after CSD provocation. There was no difference between lamotrigine- and saline-treated animals. The number of CSDs correlated negatively with Fos-immunoreactive counts. CSD-linked inhibition of neuronal activity in the PAG might play a role in central sensitization during migraine attacks and contribute to a better understanding of the link between the aura and the headache. © 2014 Published by Elsevier Ireland Ltd. [less ▲]

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See detailBrain functional connectivity and morphology changes in medication-overuse headache: Clue for dependence-related processes?
SCHOENEN, Jean ULiege; Chanraud, S; Di Scala, G et al

in Cephalalgia : An International Journal of Headache (2014), 34(8), 605-615

This study shows that in medication overuse headache patients, connectivity of the precuneus is decreased with areas of the default mode network, but increased with the hippocampus. There were no gross ... [more ▼]

This study shows that in medication overuse headache patients, connectivity of the precuneus is decreased with areas of the default mode network, but increased with the hippocampus. There were no gross morphological changes. [less ▲]

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See detailStimulation of the sphenopalatine ganglion in intractable cluster headache: Expert consensus on patient selection and standards of care.
Jürgens, T; SCHOENEN, Jean ULiege; Rostgaard, Jean et al

in Cephalalgia : An International Journal of Headache (2014), 34(13), 1100-1110

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See detailPrevalence of right-to-left shunts on transcranial Doppler in chronic migraine and medication-overuse headache.
Guo, Song; SCHOENEN, Jean ULiege

in Cephalalgia : An International Journal of Headache (2014), 34(1), 37-41

The prevalence of right-to-left shunts on transcranial Doppler is not increased in chronic migraine.

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