References of "Pierard, Luc"
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See detail2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N.; Humbert, M.; Vachiery, J.-L. et al

in European Heart Journal (2016), 37(1), 67-119

[No abstract available]

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See detailGuía ESC/ERS 2015 sobre diagnóstico y tratamiento de la hipertensión pulmonar
Galiè, N.; Humbert, M.; Vachiery, J.-L. et al

in Revista Espanola de Cardiologia (2016), 69(2), 1771-17762

[No abstract available]

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See detailActualités thérapeutiques dans l'endocardite infectieuse http://www.revmed.ch/contentrevmed/download/180856/1775148
MARCHETTA, Stella ULiege; Iovino, A.; Lancellotti, Patrizio ULiege et al

in Revue Médicale Suisse (2016), 12(527), 1358-1361

The European recommendations for the management of infective endocarditis have been updated in 2015. The therapeutic modalities depend on both a better prevention in high-risk population, a faster ... [more ▼]

The European recommendations for the management of infective endocarditis have been updated in 2015. The therapeutic modalities depend on both a better prevention in high-risk population, a faster diagnosis through new approaches in medical imaging, and interdisciplinary collaboration by an " endocarditis team. " Treatment involves antimicrobial therapy which can be complex, initially empirical and then targeted, depending on local infectious epidemiology, and whether the infringement affects a native or a prosthetic valve. The surgical indications are identified in the individual patient, based on the response to medical therapy, on complications (heart failure, uncontrolled infection and prevention of embolic events) the germ, the type of valve involved, and of course an integration with the patient's comorbidities. [less ▲]

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See detailActualites therapeutiques dans l'endocardite infectieuse.
MARCHETTA, Stella ULiege; Iovino, Alessandra; Lancellotti, Patrizio ULiege et al

in Revue Médicale Suisse (2016), 12(527), 1358-1361

The European recommendations for the management of infective endocarditis have been updated in 2015. The therapeutic modalities depend on both a better prevention in high-risk population, a faster ... [more ▼]

The European recommendations for the management of infective endocarditis have been updated in 2015. The therapeutic modalities depend on both a better prevention in high-risk population, a faster diagnosis through new approaches in medical imaging, and interdisciplinary collaboration by an << endocarditis team. >> Treatment involves antimicrobial therapy which can be complex, initially empirical and then targeted, depending on local infectious epidemiology, and whether the infringement affects a native or a prosthetic valve. The surgical indications are identified in the individual patient, based on the response to medical therapy, on complications (heart failure, uncontrolled infection and prevention of embolic events) the germ, the type of valve involved, and of course an integration with the patient's comorbidities. [less ▲]

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See detailRecommandations européennes sur la prise en charge de l’endocardite infectieuse (partim 1)
IOVINO, Alessandra ULiege; MARCHETTA, Stella ULiege; DULGHERU, Raluca Elena ULiege et al

in Revue Médicale de Liège (2016), 71(6), 281-286

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See detailHeart valve disease: (aorte valve disease): aortic regurgitation
TRIBOUILLOY, C; LANCELLOTTI, Patrizio ULiege; PETERS, F. et al

in THE EACVI TEXTBOOK OF ECHOCARDIOGRAPHY - SECOND EDITION (2016)

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See detailGraphene coating onto mechanical heart valve prosthesis and resistance to flow dynamics.
LANCELLOTTI, Patrizio ULiege; Oury, Cécile ULiege; Jérôme, Christine ULiege et al

in Acta Cardiologica (2016), 71(3), 253-5

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See detailLeft ventricular regional function and maximal exercise capacity in aortic stenosis.
DULGHERU, Raluca Elena ULiege; Magne, Julien; DAVIN, Laurent ULiege et al

in European Heart Journal - Cardiovascular Imaging (2016)

AIMS: The objective assessment of maximal exercise capacity (MEC) using peak oxygen consumption (VO2) measurement may be helpful in the management of asymptomatic aortic stenosis (AS) patients. However ... [more ▼]

AIMS: The objective assessment of maximal exercise capacity (MEC) using peak oxygen consumption (VO2) measurement may be helpful in the management of asymptomatic aortic stenosis (AS) patients. However, the relationship between left ventricular (LV) function and MEC has been relatively unexplored. We aimed to identify which echocardiographic parameters of LV systolic function can predict MEC in asymptomatic AS. METHODS AND RESULTS: Asymptomatic patients with moderate to severe AS (n = 44, aortic valve area <1.5 cm2, 66 +/- 13 years, 75% of men) and preserved LV ejection fraction (LVEF > 50%) were prospectively referred for resting echocardiography and cardiopulmonary exercise test. LV longitudinal strain (LS) of each myocardial segment was measured by speckle tracking echocardiography (STE) from the apical (aLS) 4-, 2-, and 3-chamber views. An average value of the LS of the analysable segments was provided for each myocardial region: basal (bLS), mid (mLS), and aLS. LV circumferential and radial strains were measured from short-axis views. Peak VO2 was 20.1 +/- 5.8 mL/kg/min (median 20.7 mL/kg/min; range 7.2-32.3 mL/kg/min). According to the median of peak VO2, patients with reduced MEC were significantly older (P < 0.001) and more frequently females (P = 0.05). There were significant correlations between peak VO2 and age (r = -0.44), LV end-diastolic volume (r = 0.35), LV stroke volume (r = 0.37), indexed stroke volume (r = 0.32), and E/e' ratio (r = -0.37, all P < 0.04). Parameters of AS severity and LVEF did not correlate with peak VO2 (P = NS for all). Among LV deformation parameters, bLS and mLS were significantly associated with peakVO2 (r = 0.43, P = 0.005, and r = 0.32, P = 0.04, respectively). With multivariable analysis, female gender (beta = 4.9; P = 0.008) and bLS (beta = 0.50; P = 0.03) were the only independent determinants (r2 = 0.423) of peak VO2. CONCLUSION: In asymptomatic AS, impaired LV myocardial longitudinal function determines reduced MEC. Basal LS was the only parameter of LV regional function independently associated with MEC. [less ▲]

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See detailApport du cathétérisme cardiaque dans le diagnostic et le traitement de la maladie coronarienne avant 40 ans
MEURICE, Caroline; LEGRAND, Victor ULiege; PIERARD, Luc ULiege

in Revue Médicale de Liège (2016), 71(3), 129-136

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See detailImpact of Serial B-Type Natriuretic Peptide Changes for Predicting Outcome in Asymptomatic Patients With Aortic Stenosis.
Henri, Christine; DULGHERU, Raluca Elena ULiege; Magne, Julien et al

in Canadian Journal of Cardiology (2016)

BACKGROUND: The aim of this study was to determine the impact on the outcome of serial B-type natriuretic peptide (BNP) changes during follow-up in asymptomatic patients with >/= moderate aortic stenosis ... [more ▼]

BACKGROUND: The aim of this study was to determine the impact on the outcome of serial B-type natriuretic peptide (BNP) changes during follow-up in asymptomatic patients with >/= moderate aortic stenosis (AS) and preserved left ventricular ejection fraction. METHODS: We prospectively screened 69 patients who underwent comprehensive transthoracic echocardiography, BNP level measurement at baseline and after every 6 or 12 months. Annualized BNP changes were calculated as the difference between the last and baseline BNP measurements divided by the duration of follow-up. The primary endpoint was the occurrence of symptoms, aortic valve replacement, or cardiovascular death. RESULTS: During a follow-up of 30 +/- 19 months, 43 patients experienced a cardiac event. These patients were significantly older (73 +/- 9 vs 65 +/- 16 years; P = 0.010), had more often dyslipidemia (79% vs 42%; P = 0.038), more severe AS (peak velocity: 3.9 +/- 0.6 vs 3.5 +/- 0.6 m/s; P = 0.002), larger indexed left atrial area (10.2 +/- 2.5 vs 8.7 +/- 1.9 cm2/m2; P = 0.006), and a higher increase in annualized BNP (+90 +/- 155 vs +7 +/- 49 pg/mL/y; P = 0.010). Patients with higher annualized BNP changes (> 20 pg/mL/y) had a significantly lower cardiac event-free survival (1 year: 63 +/- 8% vs 97 +/- 3%; 3 years: 31 +/- 8% vs 68 +/- 8%; P < 0.001). Using the multivariate Cox proportional hazards model, higher annualized BNP changes were significantly associated with increased risk of cardiac events (hazard ratio: 2.73, 95% confidence interval: 1.27-5.86; P = 0.010) after adjustment for age, dyslipidemia, and echocardiographic parameters. CONCLUSIONS: In asymptomatic patients with AS and preserved left ventricular ejection fraction, the use of serial BNP changes may help to anticipate development of class I indication for aortic valve replacement. [less ▲]

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See detailSTENOSE AORTIQUE SEVERE ASYMPTOMATIQUE A FRACTION D'EJECTION VENTRICULAIRE GAUCHE PRESERVEE. EVALUATION A L'EFFORT: QUELS RESULTATS ET QUELLES DECISIONS?
BENSAHI, I; ELFHAL, A; MAGNE, Julien et al

in Annales de Cardiologie et d'Angeiologie (2015), 64(2), 100-108

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See detailRAC avec discordance gradient/surface
HENRI, Christine; PIERARD, Luc ULiege

in Réalités Cardiologiques (2015), 307

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See detailExercice stress echocardiography in secondary mitral regurgitation : impact of pulmonary hypertension
MAGNE, Julien; PIERARD, Luc ULiege; LANCELLOTTI, Patrizio ULiege

in Archives of Cardiovascular Diseases (2015, January), 7

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See detailNew biomarkers for primary mitral regurgitation.
Deroyer, Céline ULiege; Magne, Julien; Moonen, Marie ULiege et al

in Clinical Proteomics (2015), 12

BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered ... [more ▼]

BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological deregulation. The purpose of this study was to highlight new biomarkers of mitral regurgitation in order to decipher the underlying pathological mechanism as well as to allow the diagnosis and the monitoring of the disease. RESULTS: Modulation of various blood proteins expression was examined in patients suffering from different grades of mitral regurgitation (mild, moderate and severe) compared to healthy controls. To this end, several routine clinical assays and the multi analyte profile technology targeting 184 proteins were used. High-density lipoprotein, apolipoprotein-A1, haptoglobin and haptoglobin-alpha2 chain levels significantly decreased proportionally to the degree of mitral regurgitation when compared to controls. High-density lipoprotein and apolipoprotein-A1 levels were associated with effective regurgitant orifice area and regurgitant volume. Apolipoprotein-A1 was an independent predictor of severe mitral regurgitation. Moreover, with ordinal logistic regression, apolipoprotein-A1 remained the only independent factor associated with mitral regurgitation. In addition, myxomatous mitral valves were studied by immunocytochemistry. We observed an increase of LC3, the marker of autophagy, in myxomatous mitral valves compared with healthy mitral valves. CONCLUSION: These potential biomarkers of mitral regurgitation highlighted different cellular processes that could be modified in myxomatous degenerescence: reverse cholesterol transport, antioxidant properties and autophagy. [less ▲]

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See detailDynamic stress evaluation of secondary mitral regurgitation
Lancellotti, Patrizio ULiege; DULGHERU, Raluca Elena ULiege; Pierard, Luc ULiege

in Secondary Mitral Valve Regurgitation (2015)

The emerging role of stress and particularly exercise echocardiography in secondary mitral regurgitation (SMR) has been recently emphasized. In fact, the evaluation of SMR only under resting conditions ... [more ▼]

The emerging role of stress and particularly exercise echocardiography in secondary mitral regurgitation (SMR) has been recently emphasized. In fact, the evaluation of SMR only under resting conditions might underestimate the full impact of the lesion and its clinical effects. Exercise echocardiography can identify what otherwise might be considered as a moderate valve disease. The severity of SMR at rest is not related to exercise induced changes in SMR severity. Worsening of SMR severity, marked increase in pulmonary arterial pressure, limited contractile reserve, impaired exercise capacity, together with the occurrence of symptoms during exercise echocardiography provide the clinician with diagnostic and prognostic information that can contribute importantly to identify a subset of patients at higher risk who may benefit from combined mitral valve surgery. © 2015 Springer-Verlag London. [less ▲]

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See detailWytyczne ESC/ERS dotyczace rozpoznawania i leczenia nadcisnienia plucnego w 2015 roku.
Galie, Nazzareno; Humbert, Marc; Vachiery, Jean-Luc et al

in Kardiologia Polska (2015), 73(12), 1127-206

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See detail2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N.; Humbert, M.; Vachiery, J.-L. et al

in European Respiratory Journal (2015), 46(4), 903-975

[No abstract available]

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See detailImpact of exercise pulmonary hypertension on postoperative outcome in primary mitral regurgitation
Magne, J.; Donal, E.; Mahjoub, H. et al

in Heart (2015), 101(5), 391-396

Aims The management of asymptomatic patients with mitral regurgitation (MR) remains controversial. Exerciseinduced pulmonary hypertension (ExPHT) was recently reported as a strong predictor of rapid onset ... [more ▼]

Aims The management of asymptomatic patients with mitral regurgitation (MR) remains controversial. Exerciseinduced pulmonary hypertension (ExPHT) was recently reported as a strong predictor of rapid onset of symptoms. We hypothesised that ExPHT is a predictor of postoperative cardiovascular events in patients with primary MR. Methods and results One hundred and two patients with primary MR, no or mild symptoms (New York heart association (NYHA) ≤2), and no LV dysfunction/ dilatation, were prospectively recruited in 3 centres and underwent exercise-stress echocardiography. The presence of ExPHT was defined as an exercise systolic pulmonary arterial pressure >60 mm Hg. All patients were closely followed up and operated on when indication for surgery was reached. Postoperative events were de fined as the occurrence of atrial fibrillation (AF), stroke, cardiac-related hospitalisation or death. Among the 102 patients included, 59 developed ExPHT (58%). These patients were significantly older than those without ExPHT (p=0.01). During a mean postoperative follow-up of 50±23 months, 28 patients (26%) experienced a predefined cardiovascular event. Patients with ExPHT had significantly higher rate of postoperative events (39% vs 12%, p=0.005); the rate of events was still higher in these patients (32% vs 9%, p=0.013), even when excluding early postoperative AF (ie, within 48 h). Event-free survival was significantly lower in the ExPHT group (all events: 5-year: 60±8% vs 88±5%, p=0.007, events without early AF: 5-year: 67±7% vs 90±4%, p=0.02). Using Cox multivariable analysis, ExPHT remained independently associated with higher risk of postoperative events in all models (all p≤0.04). Conclusions ExPHT is associated with increased risk of adverse cardiac events following mitral valve surgery in patients with primary MR. [less ▲]

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