References of "Evrard, Brigitte"
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See detailEvaluation of the correlation between "in vitro" and "in vivo" release of sulfamethazine from a long-acting ovine bolus
Evrard, Brigitte ULiege; Delattre, Luc ULiege

in Proceedingsof 1st World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (1995)

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See detailBiopharmaceutical aspects of the development of a sulfamethazine oral sustained release bolus for lambs
Evrard, Brigitte ULiege; Delahaut, P.; Hubert, Philippe ULiege et al

in Journal of Controlled Release (1995), 35

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the ... [more ▼]

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the rate constant for elimination (ke) for the intravenous solution was 0.18 h−1 compared to 0.10 h−1 for the oral aqueous solution. The absolute bioavailability of the oral solution was about 75%. A lipid matrix containing SMZ and a high density excipient is able to be retained in the reticulo-rumen and to produce a sustained release of the drug for at least 100 h provided that the mechanical strength of the bolus is sufficient. The pharmacokinetic data obtained with the lipid matrix show a release profile with two pulses due to both diffusion and erosion mechanisms. Plasma levels are maintained above the MIC of SMZ during 100 h with an absolute bioavailability of 51.7% [less ▲]

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See detailPharmacokinetic evaluation of a long-acting sulfamethazine bolus for lambs
Evrard, Brigitte ULiege; Delahaut, Philippe; Delattre, Luc ULiege

in Proceedings of 21th International Symposium on controlled release of Bioactive Materials (1994)

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See detailFully Automated Determination of Sulfamethazine in Ovine Plasma Using Solid-Phase Extraction on Disposable Cartridges and Liquid Chromatography
Hubert, Philippe ULiege; Chiap, Patrice ULiege; Evrard, Brigitte ULiege et al

in Journal of Chromatography. A (1993), 622(1), 53-60

An automatic sample preparation procedure followed by on-line injection of the sample extract into a HPLC system has been developed for the quantitative analysis of sulfamethazine and its N4-acetyl ... [more ▼]

An automatic sample preparation procedure followed by on-line injection of the sample extract into a HPLC system has been developed for the quantitative analysis of sulfamethazine and its N4-acetyl metabolite in ovine plasma. The sample clean-up was performed by solid-phase extraction (SPE) on C18 disposable extraction cartridges (DECs). All the sample handling operations were effected by a robotic auto-sampler. The DEC was first conditioned with methanol and phosphate buffer pH 7.4. After loading 1.0 ml of plasma sample onto the DEC, the latter was washed with the same buffer. The elution step was performed with methanol (0.25 ml) and the eluate was then diluted by adding 0.75 ml volume of phosphate buffer pH 6.4. A 20-microliters volume of the resultant solution was injected onto an octadecyl silica column preceded by a short guard column. The HPLC mobile phase was methanol-phosphate buffer pH 6.4 (25:75, v/v). Sulfamethazine and N4-acetylsulfamethazine were determined photometrically at 262 nm. Under these conditions, linear calibration curves ranging from 2 to 250 micrograms ml-1 have been obtained for both compounds. Drug recoveries were higher than 90% and typical relative standard deviation values were 0.7% (within-day) and 2.0% (between-day) at a plasma concentration of 50 micrograms ml-1. [less ▲]

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See detailEvaluations of an immunonephelometric assay for serum lipoprotein (a)
Evrard, Brigitte ULiege; Chapelle, Jean-Paul ULiege; Gielen, J.

Poster (1993, May)

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See detailEvaluation of a new laboratory high-shear mixer
Evrard, Brigitte ULiege; Peerboom, Claude; Delattre, Luc ULiege

Conference (1993)

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See detailAutomated determination of sulfadimidine in ovine plasma by solid phase extraction and HPLC
Hubert, Philippe ULiege; Evrard, Brigitte ULiege; Delattre, Luc ULiege et al

in Journal de Pharmacie de Belgique (1992), 47

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See detailDevelopment of a sustained release bolus for sheep : "in vitro" and "in vivo" results
Evrard, Brigitte ULiege; Dechesne, Jean-Paul; Fagetton, Xavier et al

in Proceedings of 19th International Symposium on controlled release of Bioactive Materials (1992)

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See detailDevelopment of a long acting sulfamethazine bolus for sheep
Evrard, Brigitte ULiege; Delattre, Luc ULiege

Conference (1992)

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See detailMelt-Granulation with a new laboratory high-shear mixer
Evrard, Brigitte ULiege; Delattre, Luc ULiege

in Proceedings of 6th International Conference of Pharmaceutical Technology (1992)

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See detailDevelopment of a long-acting sulfamethazine bolus for sheep
Evrard, Brigitte ULiege; Dechesne, Jean-Paul; Fagetton, Xavier et al

in Proceedings of 6th International Conference of Pharmaceutical Technology (1992)

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See detailDéveloppement galénique d'une forme matricielle à libération prolongée renfermant un actif hydrosoluble
Delneuville, Isabelle; Evrard, Brigitte ULiege; Kapusta, Dominique et al

in Proceedings of 6th International Conference of Pharmaceutical Technology (1992)

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See detailDevelopment of a sustained release bolus for lambs
Evrard, Brigitte ULiege; Dechesne, Jean-Paul; Fagetton, Xavier et al

Conference (1990, March)

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See detailStabilité des collyres à base de chlorhydrate de cystéine
Evrard, Brigitte ULiege; Delattre, Luc ULiege; Dechesne, J.-P.

in Pharmakon (1987), 69

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