![]() Rostomyan, Liliya ![]() ![]() ![]() in Endocrine Abstracts (2015, May) Detailed reference viewed: 48 (8 ULiège)![]() Potorac, Iulia ![]() ![]() ![]() in Endocrine Abstracts (2015, May) Detailed reference viewed: 28 (1 ULiège)![]() ; ; Daly, Adrian ![]() in Endocrine Abstracts (2015, May) Detailed reference viewed: 17 (0 ULiège)![]() ; Daly, Adrian ![]() ![]() in Endocrine Abstracts (2015, May) Detailed reference viewed: 26 (1 ULiège)![]() ; Daly, Adrian ![]() in Endocrine Abstracts (2015, May) Detailed reference viewed: 34 (0 ULiège)![]() Daly, Adrian ![]() ![]() in Endocrine Abstracts (2015, May) Detailed reference viewed: 41 (3 ULiège)![]() Daly, Adrian ![]() in New England Journal of Medicine (2015), 372(13), 1265 Detailed reference viewed: 75 (6 ULiège)![]() ; Daly, Adrian ![]() in Abstract book - ENDO 2015 (2015, March) Detailed reference viewed: 49 (13 ULiège)![]() Daly, Adrian ![]() in Abstract book - ENDO 2015 (2015, March) Detailed reference viewed: 40 (12 ULiège)![]() ; ; Rostomyan, Liliya ![]() in Abstract book - 14th International Pituitary Congress (2015, March) Detailed reference viewed: 46 (5 ULiège)![]() ; Daly, Adrian ![]() in Abstract book - 43ème Congrès Annuel de la Société Belge de Pédiatrie (2015, March) Detailed reference viewed: 44 (0 ULiège)![]() ; ; et al in Abstract book - ENDO 2015 (2015, March) Detailed reference viewed: 11 (2 ULiège)![]() ; ; Daly, Adrian ![]() in Abstract book - ENDO 2015 (2015, March) Detailed reference viewed: 37 (8 ULiège)![]() Potorac, Iulia ![]() ![]() ![]() in Abstract book - ENDO 2015 (2015, March) Detailed reference viewed: 41 (6 ULiège)![]() Potorac, Iulia ![]() ![]() ![]() in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07) Detailed reference viewed: 54 (4 ULiège)![]() Potorac, Iulia ![]() ![]() in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07) Detailed reference viewed: 20 (3 ULiège)![]() Potorac, Iulia ![]() ![]() ![]() in Abstract book - 4th ENEA Workshop (2015) Detailed reference viewed: 43 (6 ULiège)![]() Beckers, Albert ![]() in Endocrine-Related Cancer (2015), 22 Detailed reference viewed: 61 (20 ULiège)![]() Rostomyan, Liliya ![]() ![]() ![]() in Endocrine-Related Cancer (2015) Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large ... [more ▼] Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients (163 males; 78.4%) with growth hormone excess and current/previous abnormal growth velocity for age or final height >2SD above country normal means. The median onset of rapid growth was 13.0 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs. 21.5 years, respectively). Adenomas were >/=10 mm (i.e. macroadenomas) in 84%, of which extrasellar extension occurred in 77% and invasion in 54%. GH/IGF-1 control was achieved in 39% during long-term follow-up. Final height was greater in those with younger age of onset, with larger tumors and higher GH levels. Later disease control was associated with a greater difference from mid-parental height (r=0.23, P=0.02). AIP mutations occurred in 29%; microduplication at Xq26.3 -X-linked acro-gigantism (X-LAG)- occurred in two familial isolated pituitary adenoma (FIPA) kindreds and in ten sporadic patients. Tumor size was not different in X-LAG, AIP mutated and genetically-negative patient groups. AIP-mutated and X-LAG patients had significantly younger age at onset and diagnosis, but disease control was worse in genetically-negative cases. Pituitary gigantism patients are characterized by male predominance and large tumors that are difficult to control. Treatment delay increases final height and symptom burden. AIP mutations and X-LAG explain many cases, but no genetic etiology is seen in >50% of cases. [less ▲] Detailed reference viewed: 71 (19 ULiège)![]() Daly, Adrian ![]() ![]() in Archives of Iranian Medicine (2015), 18(12), 871 Detailed reference viewed: 17 (5 ULiège) |
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