References of "DELANAYE, Pierre"
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See detailNormal reference values for glomerular filtration rate: what do we really know?
DELANAYE, Pierre ULiege; Schaeffner, E; Ebert, N et al

in Nephrology Dialysis Transplantation (2012), 27(7), 2664-72

In nephrology, chronic kidney disease is defined by both proteinuria and measurement of glomerular filtration rate (GFR). This article focuses on GFR and different ways to define its normal reference ... [more ▼]

In nephrology, chronic kidney disease is defined by both proteinuria and measurement of glomerular filtration rate (GFR). This article focuses on GFR and different ways to define its normal reference values. In this context, we compare two perspectives: first the reference values defined by measuring GFR in normal individuals (the 'classical way') and secondly a fixed cut-off value at 60 mL/min/1.73 m(2) according to the associated mortality risk (the 'prognostic way'). Following the classical way, we can assert that normal GFR values are largely over 60 mL/min/1.73 m(2) in healthy subjects, at least before the age of 70 years. However, we know that GFR physiologically decreases with age, and in adults older than 70 years, values below 60 mL/min/1.73 m(2) could be considered normal. Following the 'prognostic way', the fixed cut-off of 60 mL/min/1.73 m(2) has been retained in the K-DIGO guidelines. However, we challenge this concept and the fact that the variable 'age' is poorly taken into account in these data. There is an obvious discrepancy between the reference values defined either by the 'classical way' or by the 'prognostic way' which we think could be largely reduced, if age was better taken into consideration in these definitions. [less ▲]

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See detailComparison of acid and enzymatic methods for insulin dosage: Analytical performances and impact on glomerular filtration rate evaluation
DELANAYE, Pierre ULiege; Thibaudin, L.; Souvignet, M. et al

in Clinica Chimica Acta (2012), 413(5-6), 556-560

Among issues susceptible to hamper a reliable measurement of inulin clearance, those regarding the dosage of inulin are largely neglected. We have compared the analytical performances of 2 commonly used ... [more ▼]

Among issues susceptible to hamper a reliable measurement of inulin clearance, those regarding the dosage of inulin are largely neglected. We have compared the analytical performances of 2 commonly used methods of inulin dosage (one “acid” and one “enzymatic” method) and studied their potential impact on the glomerular filtration rate (GFR) value given by inulin clearance. Repeatability, uncertainty and the beta-expectation limits were evaluated from pre-determined serum and urine pools of inulin. Agreement between the two methods was analyzed from 99 inulin clearances performed in renal transplant patients. Impact of the method of dosage on GFR evaluation was simulated according to the respective beta-expectations limits of each method. Overall, intra-assay coefficient of variability and relative bias were inferior to 5% and 10% for both methods. Contrary to the acid method, analytical performance of the enzymatic method was not influenced by the presence of glucose. The relative difference in GFR values obtained with the two methods in transplant patients was − 0.4 ± 10%. Simulations suggested that changes in inulin concentration attributable to analytical error could modify the value of GFR from − 12% to + 28%. In conclusion, while analytical performances are globally acceptable for both methods, they are not strictly equivalent. The impact on the determination of GFR, albeit limited, is not negligible and adds to other sources of inaccuracy. International standardization for the dosage of inulin is necessary. [less ▲]

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See detailDifference between total and intact assays for N-terminal propeptide of type I procollagen in renal impaired patients
CAVALIER, Etienne ULiege; CARLISI, Ignazia ULiege; ROUSSELLE, Olivier ULiege et al

in Osteoporosis International (2012, March), 23(Supplement 2), 339

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See detailOutcome of the living kidney donor
DELANAYE, Pierre ULiege; WEEKERS, Laurent ULiege; DUBOIS, Bernard ULiege et al

in Nephrology Dialysis Transplantation (2012), 27(1), 41-50

Renal transplantation from living kidney donors is still relatively marginal in most of the European countries. However, this source of kidney grafts may help to overcome in part the organ donor shortage ... [more ▼]

Renal transplantation from living kidney donors is still relatively marginal in most of the European countries. However, this source of kidney grafts may help to overcome in part the organ donor shortage of cadaveric donors. The living donor strategy implies correct and objective information about donation risks and completely free acceptance of the living candidate of the donation. In this paper, we reviewed the consequences of kidney donation on the living donor health, considering very short term (linked to the surgery), short term (effect of nephrectomy on glomerular filtration rate) and long term (risk of mortality, chronic kidney disease, proteinuria and hypertension) consequences of kidney donation. [less ▲]

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See detailCKD-EPI GFR estimating equations in kidney transplantation: which added value for the new cystatin C based equations?
Masson, I; Maillard, N; Kamar, K et al

Poster (2012)

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See detailCreatinine and/or cystatin C-based GFR estimation in HIV-infected patients
Gagneux-Brunon, A; DELANAYE, Pierre ULiege; Delavenne, X et al

Poster (2012)

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See detailTwo novel equations to estimate kidney function in persons aged 70 years or older
Schaeffner, ES; Ebert, N; DELANAYE, Pierre ULiege et al

Poster (2012)

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See detailCreatinine and/or cystatin C-based GFR estimation in HIV-infected patients.
Gagneux-Brunon, A; DELANAYE, Pierre ULiege; Fresard, A et al

Poster (2012)

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See detailPerformance, limitations and utility of cystatin C as an endogenous GFR marker in renal transplantation
Masson, I; Maillard, N; Tack, I et al

Poster (2012)

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See detailEstimating GFR in 2012: the creatinine-based equations
DELANAYE, Pierre ULiege

Conference (2012)

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See detailTwo novel equations to estimate kidney function in persons aged 70 years or older
Schaeffner, Elke; Ebert, Natalie; DELANAYE, Pierre ULiege et al

in Annals of Internal Medicine (2012), 157(7), 471-481

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See detailLe médicament du mois : Fébuxostat (Adenuric®)
DELANAYE, Pierre ULiege; BOUQUEGNEAU, Antoine ULiege; DUBOIS, Bernard ULiege et al

in Revue Médicale de Liège (2012), 67(4), 202-209

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