References of "Cavalier, Etienne"
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See detailImpact of the type of dialysis membranes on the circulating concentration of markers of vitamin D metabolism.
Cavalier, Etienne ULiege; Torres, Pablo U.; Dubois, Bernard E. et al

in International Journal of Artificial Organs (2017)

INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to ... [more ▼]

INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to-patient inconsistency can be observed in response to the treatment. In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage. MATERIAL AND METHODS: Alb (Cobas), VDBP (R&D) and 25(OH)D (liquid chromatography-tandem mass spectrometry) were measured in 75 patients before and after a 4-hour dialysis session. Ten dialysis membranes were used: FX10, FX80, FX800, BK-2.1F, BG-2.1U, Rexeed 15 A, Rexeed 21 A, TS 1.8 SL and TS 2.1 SL manque la ELISIO 21H. Accordingly, 13 patients were dialyzed with membranes possessing high adsorption and high cut-off properties (BK), 17 with membranes possessing high adsorption but usual cut-off properties (BG) and all the remaining 45 patients with polysufone (PS) membranes with usual adsorptive and cut-off properties. Among these 45 patients treated with PS, we compared those treated by classical dialysis (HD) (n = 14) and hemodiafiltration (HDF) (n = 31). Results were corrected for total extracellular volume to take into consideration the hemoconcentration after dialysis. RESULTS: The 3 analytes showed a decreased concentration after the dialysis session. The decrease of ALB, VDBP and 25(OH)D was similar with the adsorptive (BG) and PS membranes. However, patients treated with adsorptive and high cut-off membrane (BK) presented a significantly higher decrease values of Alb (-9.6%[-15.1; -7.5]), of VDBP (-20.6%[-36.6; -17.2] and 25(OH)D (-17%[-27.3; -12.3]) compared to other membranes (BG and PS).When we limited our study to PS membranes, we did not observe any significant difference between the HD or HDF modalities in the decrease for any of the studied parameters. CONCLUSIONS: A significant loss of Alb, VDBP and 25(OH)D occurs after a dialysis session. This loss is significantly more important when patients are dialyzed with high adsorption and high cut-off dialysis membranes. [less ▲]

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See detailIntérêt de nouveaux marqueurs biologiques dans l’évaluation de la sarcopénie en dialyse.
DELANAYE, Pierre ULiege; QUINONEZ, Kevin ULiege; Buckinx, Fanny ULiege et al

in Néphrologie & Thérapeutique (2017), 13(5), 269

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See detailAssociation entre les taux circulants de matrix-gla protein et rigidité artérielle en transplantation rénale.
Dinic, M; Maillard, N; DELANAYE, Pierre ULiege et al

in Néphrologie & Thérapeutique (2017), 13(5), 309

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See detailMeasuring Plasma Clearance for Exact Assessment of GFR: Multi versus Single Sampling
Ebert, Natalie; Schaeffner, Elke; Pottel, Hans et al

Poster (2017)

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See detailVitamin D and osteosarcopenia: an update from epidemiological studies.
Bruyère, Olivier ULiege; CAVALIER, Etienne ULiege; Reginster, Jean-Yves ULiege

in Current Opinion in Clinical Nutrition & Metabolic Care (2017), 20(6),

PURPOSE OF REVIEW: The review summarizes recent epidemiological studies that examined the relationship between osteoporosis and sarcopenia to assess the impact of vitamin D status or supplementation on ... [more ▼]

PURPOSE OF REVIEW: The review summarizes recent epidemiological studies that examined the relationship between osteoporosis and sarcopenia to assess the impact of vitamin D status or supplementation on health outcomes related to these two medical conditions. [less ▲]

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See detailLes pentes d’évolution des CTX, de la phosphatase alkaline osseuse et du P1NP sont associées à celles de la PTH en hémodialyse chronique.
Maillard, Nicolas; Warling, Xavier; Moonen, Martial et al

Poster (2017)

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See detailDFG en population saine africaine : comparaison des performances de 11 équations d’estimation à marquer unique ou combinés, avec et sans facteur ethnique
yayo, Eric; Yao-Papo, E; Gnionsahé, A et al

in Néphrologie & Thérapeutique (2017), 13(5), 277

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See detailVariations of parathyroid hormone and bone biomarkers are concordant only after a long term follow-up in hemodialyzed patients
DELANAYE, Pierre ULiege; Warling, Xavier; Moonen, Martial et al

in Scientific Reports (2017), 7(1), 12623

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See detailOccurrence of Clinical Bone Fracture Following a Prolonged Stay in Intensive Care Unit: A Retrospective Controlled Study
ROUSSEAU, Anne-Françoise ULiege; CAVALIER, Etienne ULiege; Reginster, Jean-Yves ULiege et al

in Calcified Tissue International (2017), (Online),

Clinical consequences of critical illness and critical care (CC) on bone health remain largely unexplored. This retrospective study aimed to assess the number of new bone fractures (BF) following a ... [more ▼]

Clinical consequences of critical illness and critical care (CC) on bone health remain largely unexplored. This retrospective study aimed to assess the number of new bone fractures (BF) following a prolonged length of stay (LOS) in intensive care unit (ICU). Adults admitted in our tertiary ICU during 2013 with a stay [7 days were included (CC group). Patients who died in ICU or lost to follow-up were excluded. For each CC patient still alive after 2 years of follow-up, 2 control patients, scheduled for surgery during 2013, were recruited and matched for gender and age. Basal fracture risk before admission was calculated using FRAX tool. General practitioners were phoned to check out new bone fracture (BF) during 2 years after admission. Of the 457 enrolled CC patients, 207 did not meet inclusion criteria and 72 died during FU (median age 72 [65–77] years). New BF occurred in 9 of the 178 patients still alive at the end of FU (5%). Median age of these patients was 64 [53–73] years. Fractured patients did not differ from non-fractured ones based on demographic and clinical characteristics, excepting for FRAX risks that were higher in fractured patients. In the control group, 327 patients were analyzed. Their rate of BF was 3.4% without statistical significance compared to the CC group. FRAX risks were similar in both groups. The risk of new BF in CC group, expressed as an odds ratio, was 50% higher than in the control group without achieving statistical significance (odds ratio 1.53; 95% confidence interval 0.62–3.77; p = 0.35). When comparing ICU survivors to patients who underwent uncomplicated surgery in the present preliminary study included limited cohorts, the fracture risk in the 2 years following prolonged ICU stay was not statistically higher. However, CC fractured patients had higher FRAX risks than non-fractured patients. Such screening could help to target prevention and appropriate treatment strategies. [less ▲]

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See detailMulticenter Evaluation of Cystatin C Measurement after Assay Standardization.
Bargnoux, Anne-Sophie; Pieroni, Laurence; Cristol, Jean-Paul et al

in Clinical Chemistry (2017), 63(4), 833-841

BACKGROUND: Since 2010, a certified reference material ERM-DA471/IFCC has been available for cystatin C (CysC). This study aimed to assess the sources of uncertainty in results for clinical samples ... [more ▼]

BACKGROUND: Since 2010, a certified reference material ERM-DA471/IFCC has been available for cystatin C (CysC). This study aimed to assess the sources of uncertainty in results for clinical samples measured using standardized assays. METHODS: This evaluation was performed in 2015 and involved 7 clinical laboratories located in France and Belgium. CysC was measured in a panel of 4 serum pools using 8 automated assays and a candidate isotope dilution mass spectrometry reference measurement procedure. Sources of uncertainty (imprecision and bias) were evaluated to calculate the relative expanded combined uncertainty for each CysC assay. Uncertainty was judged against the performance specifications derived from the biological variation model. RESULTS: Only Siemens reagents on the Siemens systems and, to a lesser extent, DiaSys reagents on the Cobas system, provided results that met the minimum performance criterion calculated according to the intraindividual and interindividual biological variations. Although the imprecision was acceptable for almost all assays, an increase in the bias with concentration was observed for Gentian reagents, and unacceptably high biases were observed for Abbott and Roche reagents on their own systems. CONCLUSIONS: This comprehensive picture of the market situation since the release of ERM-DA471/IFCC shows that bias remains the major component of the combined uncertainty because of possible problems associated with the implementation of traceability. Although some manufacturers have clearly improved their calibration protocols relative to ERM-DA471, most of them failed to meet the criteria for acceptable CysC measurements. [less ▲]

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See detailSerum Creatinine: Not So Simple!
DELANAYE, Pierre ULiege; Cavalier, Etienne ULiege; Pottel, Hans

in Nephron (2017), 136(4), 302-308

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological ... [more ▼]

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDMS traceability), analytical interferences, analytical coefficient of variation (CV), biological CV and critical difference. Because the relationship between serum creatinine and glomerular filtration rate is hyperbolic, all these CVs will impact not only the precision of serum creatinine but still more the precision of different creatinine-based equations, especially in low or normal-low creatinine levels (or high or normal-high glomerular filtration rate range). [less ▲]

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See detailBiomarkers Predicting Bone Turnover in the Setting of CKD.
Evenepoel, Pieter; Cavalier, Etienne ULiege; D'Haese, Patrick C.

in Current Osteoporosis Reports (2017)

PURPOSE OF THE REVIEW: Impaired bone quality contributes to the increased fracture risk in chronic kidney disease patients. Both low and high turnover bone disease may compromise bone quality. The ... [more ▼]

PURPOSE OF THE REVIEW: Impaired bone quality contributes to the increased fracture risk in chronic kidney disease patients. Both low and high turnover bone disease may compromise bone quality. The question arises whether bone biomarkers may be additive or replace bone histormorphometry for diagnosing the extremes of bone turnover. RECENT FINDINGS: Studies exploring the performance of established and emerging bone biomarkers against histomorphometric assessment of bone turnover are limited and overall yield inconclusive results as to their diagnostic utility. Bone biomarkers, although promising, currently fail to meet the needed diagnostic accuracy to replace bone histomorphometry and thus are not yet ready for clinical use. Bone biomarkers have not only several advantages, but also important limitations such as high biological variability, retention with kidney disease, preanalytical issues, and interassay variability. These important issues must be considered when developing and evaluating bone biomarkers. There is an urgent need for harmonization and standardization of available assays and additional bone biopsy studies. [less ▲]

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See detailVitamin K plasma levels determination in human health
Fusaro, M; Gallieni, M; Rizzo, MA et al

in Clinical Chemistry & Laboratory Medicine (2017), 55(6), 789-799

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See detailWhen obtaining a blood sample from the right arm was not the right thing to do: a case of elevated parathyroid hormone levels 27 years after thyroidectomy.
Wolff, Fleur; Gervy, Christine; Cavalier, Etienne ULiege et al

in Clinical Chemistry & Laboratory Medicine (2016)

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See detailAssociation entre taux circulants de matrix-gla protéine et rigidité artérielle en transplantation rénale.
Dinic, Miriana; Maillard, Nicolas; DELANAYE, Pierre ULiege et al

Conference (2016, December)

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See detailPrevalence of the hypovitaminosis D among Moroccan woman consulting in ambulatory medicine
Nejjar, Basma ULiege; Bour, Abdellatif; Beaudart, Charlotte ULiege et al

in Journal of Innovative Research and Applied Sciences (2016), 3(2), 476-483

Actuellement, la vitamine D est considérée comme une hormone aux effets pleïotropes et ne peut plus être limitée uniquement qu’à la prévention du rachitisme et de l’ostéomalacie. Une déficience en ... [more ▼]

Actuellement, la vitamine D est considérée comme une hormone aux effets pleïotropes et ne peut plus être limitée uniquement qu’à la prévention du rachitisme et de l’ostéomalacie. Une déficience en vitamine D dans l’organisme est corollaire à une panoplie de pathologies osseuses et extra osseuses chroniques. Objectif : La présente étude s'intéressait à la prévalence de l'hypovitaminose D chez les femmes en médecine ambulatoire dans la région de Meknès au Maroc. Matériel et méthodes : Un échantillonnage de convenance de 1247 femmes pour lesquelles un clinicien avait prescrit le dosage de la 25 Hydroxyvitamine D(25OHD) était sélectionné entre Janvier 2013 et Décembre 2015 auprès de deux laboratoires. La concentration de la 25OHD, la saison de son dosage et l'âge ont été recensés. La calcémie n’était évaluée que pour 759 femmes de l'échantillon. Résultats : La prévalence de l'hypovitaminose D, pour un seuil inférieur à 20 ng/ml, était de 70,1%, et variait significativement en fonction de la saison et de l'âge. Les prescriptions du dosage de la 25OHD émanaient à 52.8% de médecins généralistes et de rhumatologues et 32,8% des dosages étaient enregistrés en hiver. La calcémie était de 2,28 mg/l (ET 0,22) chez les 759 (60,8%) femmes, 188 (37,8%) parmi elles, présentaient une hypocalcémie et une hypovitaminose D. La régression logistique indiquait que la saison (Exp (B)=0,23, p<0.01) était un facteur associé à la variation de l'hypovitaminose D. Conclusion : L’hypovitaminose D représente Mots un problème de santé publique et les médecines doivent être sensibilisés à ce sujet. [less ▲]

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