References of "CHARLIER, Corinne"
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See detailPollution chimique de l'environnement et risque toxique pour l'homme. Le rôle particulier des dérivés pesticides organochlorés
Charlier, Corinne ULiege; Plomteux, Guy ULiege

in Annales de Biologie Clinique (2002), 60(1, Jan-Feb), 37-46

There is an increasing concern about environmental exposure to multiple chemicals and adverse changes in reproductive development, function, or behaviour in wildlife. The major group of environmental ... [more ▼]

There is an increasing concern about environmental exposure to multiple chemicals and adverse changes in reproductive development, function, or behaviour in wildlife. The major group of environmental chemicals, such as organochlorine pesticides, polychlorinated biphenyls (PCBs) and other xenoestrogens are currently known to have estrogenic effects in vertebrates or fishes. Recent studies suggest that past exposure to such estrogenic compounds may affects the risk of developing breast cancer, precocious puberty, or impaired fertility in man. [less ▲]

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See detailActualités sur les porphyries
Charlier, Corinne ULiege

Conference (2002)

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See detailLes interactions médicamenteuses
Charlier, Corinne ULiege

Conference (2002)

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See detailLes interactions médicamenteuses
Charlier, Corinne ULiege

Conference (2002)

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See detailLes effets disrupteurs hormonaux des pesticides organochlorés
Charlier, Corinne ULiege

Conference (2002)

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See detailEntre aliénations et libertés: les toxicomanies
Charlier, Corinne ULiege

Conference (2002)

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See detailSexual Precocity after Immigration from Developing Countries to Belgium: Evidence of Previous Exposure to Organochlorine Pesticides
Krstevska-Konstantinova, M.; Charlier, Corinne ULiege; Craen, M. et al

in Human Reproduction (2001), 16(5), 1020-6

In a retrospective auxological study of 145 patients seen in Belgium during a 9-year period for treatment of precocious puberty, 28% appeared to be foreign children (39 girls, one boy) who immigrated 4 to ... [more ▼]

In a retrospective auxological study of 145 patients seen in Belgium during a 9-year period for treatment of precocious puberty, 28% appeared to be foreign children (39 girls, one boy) who immigrated 4 to 5 years earlier from 22 developing countries, without any link to a particular ethnic or country background. The patients were either adopted (n = 28) or non-adopted (n = 12), the latter having normal weight and height at immigration and starting early puberty without evidence of earlier deprivation. This led to the hypothesis that the mechanism of precocious puberty might involve previous exposure to oestrogenic endocrine disrupters. A toxicological plasma screening for eight pesticides detected p,p'-DDE, which is derived from the organochlorine pesticide DDT. Median p,p'-DDE concentrations were respectively 1.20 and 1.04 ng/ml in foreign adopted (n = 15) and non-adopted (n = 11) girls with precocious puberty, while 13 out of 15 Belgian native girls with idiopathic or organic precocious puberty showed undetectable concentrations (<0.1 ng/ml). A possible relationship between transient exposure to endocrine disrupters and sexual precocity is suggested, and deserves further studies in immigrant children with non-advanced puberty. [less ▲]

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See detailMethadone Maintenance Treatment: Is It Possible to Adapt the Daily Doses to the Metabolic Activity of the Patient?
Charlier, Corinne ULiege; Dessalles, M. C.; Plomteux, Guy ULiege

in Therapeutic Drug Monitoring (2001), 23(1), 1-3

Controversy still exists concerning the proper daily dose of methadone to be used in opiate dependency treatment. Because it is admitted that serum methadone concentration may be significantly correlated ... [more ▼]

Controversy still exists concerning the proper daily dose of methadone to be used in opiate dependency treatment. Because it is admitted that serum methadone concentration may be significantly correlated with the amount of drug available at the receptor level, it could be interesting to predict the methadone daily doses necessary to reach such a serum concentration. The authors have attempted to correlate the serum methadone level with the daily intake, considering the metabolic activity of the patients. A poor correlation was found between methadone doses and methadone serum concentrations (r2 = 0.0409, p = 0.048). The test used to determine the metabolic activity of patients is the 6-OH cortisol/17-OH corticosteroids ratio in urine. This urinary 6-OH cortisol/17-OH corticosteroids ratio was tested because cortisol is metabolized through the same P450 cytochromes as methadone, namely cytochrome P450 3A4. This determination could be of interest because it could be tested before methadone administration to predict optimal doses. But when the authors tried to correlate the methadone serum concentration with the steroid ratio, they failed to find a significant correlation (r2 = 0.0046, N.S.), even when they took into account the daily doses (r2 = 0.0015, N.S.), most probably because of some limitations of the cortisol ratio. [less ▲]

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See detailLes pesticides organochlorés: leur rôle de "disrupteurs hormonaux"
Charlier, Corinne ULiege

Conference (2001)

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See detailEffets disrupteurs hormonaux des pesticides organochlorés
Charlier, Corinne ULiege

Conference (2001)

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See detailEffets perturbateurs endocriniens des pesticides organochlorés
Charlier, Corinne ULiege

in Acta Clinica Belgica (2001)

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See detailRelationship between Clinical Effects, Serum Drug Concentration, and Concurrent Drug Interactions in Depressed Patients Treated with Citalopram, Fluoxetine, Clomipramine, Paroxetine or Venlafaxine
Charlier, Corinne ULiege; Pinto, Emmanuel ULiege; Ansseau, Marc ULiege et al

in Human Psychopharmacology (2000), 15(6), 453-459

The relationship between clinical effects and plasma concentrations of citalopram, fluoxetine, clomipramine, paroxetine and venlafaxine was studied in 119 cases of major depression. Clinical effects were ... [more ▼]

The relationship between clinical effects and plasma concentrations of citalopram, fluoxetine, clomipramine, paroxetine and venlafaxine was studied in 119 cases of major depression. Clinical effects were evaluated using the Clinical Global Impression (CGI) improvement scale. Antidepressants were quantified by a separative chromatographic methodology. Plasma concentrations in responder patients were compared with the plasma concentrations proposed in literature as effective values. We found that the usual therapeutic window is convenient for citalopram and clomipramine, but could be reduced for fluoxetine and increased for venlafaxine and paroxetine. Concurrent drug interactions were also evaluated and clomipramine or citalopram plasma levels were found to be influenced by the presence of associated drugs. A larger study is needed, taking into account not only plasma concentrations and clinical effects, but also some pharmacokinetic data, especially the metabolic activity characterising the patient, and the presence or not of associated drugs. Copyright 2000 John Wiley [less ▲]

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See detailEvaluation of EMIT tox benzodiazepine and barbiturate assays on the Vitalab Viva analyser and FPIA on the Abbott ADx analyser
Charlier, Corinne ULiege; Plomteux, Guy ULiege

in Clinical Chemistry & Laboratory Medicine (2000), 38(7), 615-618

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in ... [more ▼]

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in preliminary therapeutic drug monitoring or acute drug intoxication detection. Performance, as indicated by CVs, of the Emit® tox benzodiazepine and barbiturate assays and FPIA showed that both immunochemical techniques are precise and have good reproducibility. For within-run studies, results from benzodiazepine determinations showed maximum CV values of 1.91% for the Emit® method and 2.65% for FPIA; results from barbiturate determinations showed maximum CV values of 2.01% for the Emit® method and 1.89% for FPIA. For between-run studies, results from benzodiazepine determinations showed maximum CV values of 1.79% for the Emit® method and 1.12% for FPIA; results from barbiturate determinations showed maximum CV values of 2.09% for the Emit® method and 2.02% for FPIA. [less ▲]

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See detailSurveillance thérapeutique des traitements anticancéreux
Gougnard, Th; Charlier, Corinne ULiege; Plomteux, Guy ULiege

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2000), 15(4), 258-261

Drug monitoring of anticancer chemotherapies.Drug doses used in anticancer treatments are mostly calculated by the use of clinical criteria, sometimes by using nomograms providing a posology based on the ... [more ▼]

Drug monitoring of anticancer chemotherapies.Drug doses used in anticancer treatments are mostly calculated by the use of clinical criteria, sometimes by using nomograms providing a posology based on the body surface area (BSA) but rarely by taking into account classical pharmacokinetic parameters, as usually for optimizing the treatment with other pharmaceutical classes of drugs (antibiotics, antiepileptics,…). Because the narrow therapeutic index and important intra- and interindividual variations of the pharmacokinetic parameters, anticancer drugs could constitute a pharmacological class for which the posology could be defined by a classical therapeutic drug monitoring. Of course, the determination of the plasmatic level of anticancer drug does not always permit to predict their pharmacological efficacy and toxicity. To reach it, it is necessary to calculate the area under the curve obtained on base of several blood concentrations. [less ▲]

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See detailCyanures et thiocyanates en toxicologie hospitalière
Charlier, Corinne ULiege; Gougnard, Th; Lamiable, D. et al

in Annales de Toxicologie Analytique (2000), XII(2), 131-136

Cyanide is a highly toxic poison, able to very rapidly induce the death. Thiocyanate anion (SCN-) is a metabolic product of cyanide and cyano-containing organic substances, produced by two major enzymes ... [more ▼]

Cyanide is a highly toxic poison, able to very rapidly induce the death. Thiocyanate anion (SCN-) is a metabolic product of cyanide and cyano-containing organic substances, produced by two major enzymes : thiosulfate sulfure transferase and β mercaptopyruvate transsulfurase. Determinations of blood cyanide is important to confirm the diagnostic of intoxication. A survey of methods for the quantitative determination of cyanide and thiocyanate in biological matrices is presented. Particular attention is paid to the rapidity and to the sensitivity of the method. [less ▲]

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See detailInfluence des stupéfiants sur la conduite automobile
Charlier, Corinne ULiege

Conference (2000)

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See detailPesticides organochlorés et cancer du sein
Charlier, Corinne ULiege

in Annales de Toxicologie Analytique (2000)

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See detailEndocrine disruptors and breast cancer risk
Meurisse, M.; Plomteux, Guy ULiege; Charlier, Corinne ULiege et al

Poster (2000)

Detailed reference viewed: 7 (0 ULiège)
See detailInfluence des médicaments sur les capacités de conduite
Grenez, O.; Charlier, Corinne ULiege; Maes, V. et al

in I.B.S.R (1999)

Detailed reference viewed: 53 (6 ULiège)