PMID- 25126385
OWN - NLM
STAT- PubMed-not-MEDLINE
DA  - 20140815
DCOM- 20140815
LR  - 20140818
IS  - 1948-0210 (Electronic)
IS  - 1948-0210 (Linking)
VI  - 6
IP  - 3
DP  - 2014 Jul 26
TI  - Umbilical cord fibroblasts: Could they be considered as mesenchymal stem cells?
PG  - 367-70
LID - 10.4252/wjsc.v6.i3.367 [doi]
AB  - In cell therapy protocols, many tissues were proposed as a source of mesenchymal 
      stem cells (MSC) isolation. So far, bone marrow (BM) has been presented as the
      main source of MSC despite the invasive isolation procedure related to this
      source. During the last years, the umbilical cord (UC) matrix was cited in
      different studies as a reliable source from which long term ex vivo proliferating
      fibroblasts were isolated but with contradictory data about their
      immunophenotype, gene expression profile, and differentiation potential. Hence,
      an interesting question emerged: Are cells isolated from cord matrix (UC-MSC)
      different from other MSCs? In this review, we will summarize different studies
      that isolated and characterized UC-MSC. Considering BM-MSC as gold standard, we
      will discuss if UC-MSC fulfill different criteria that define MSC, and what
      remain to be done in this issue.
FAU - Zeddou, Mustapha
AU  - Zeddou M
AD  - Mustapha Zeddou, Biserka Relic, Michel G Malaise, Laboratory of Rheumatology,
      GIGA-I3, GIGA Research Centre, University and CHU of Liege, 4000 Liege, Belgium.
FAU - Relic, Biserka
AU  - Relic B
AD  - Mustapha Zeddou, Biserka Relic, Michel G Malaise, Laboratory of Rheumatology,
      GIGA-I3, GIGA Research Centre, University and CHU of Liege, 4000 Liege, Belgium.
FAU - Malaise, Michel G
AU  - Malaise MG
AD  - Mustapha Zeddou, Biserka Relic, Michel G Malaise, Laboratory of Rheumatology,
      GIGA-I3, GIGA Research Centre, University and CHU of Liege, 4000 Liege, Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Stem Cells
JT  - World journal of stem cells
JID - 101535826
PMC - PMC4131277
OID - NLM: PMC4131277
OTO - NOTNLM
OT  - Bone marrow
OT  - Cord matrix
OT  - Differentiation
OT  - Immunophenotype
OT  - Mesenchymal stem cells
EDAT- 2014/08/16 06:00
MHDA- 2014/08/16 06:01
CRDT- 2014/08/16 06:00
PHST- 2014/01/10 [received]
PHST- 2014/03/11 [revised]
PHST- 2014/05/16 [accepted]
AID - 10.4252/wjsc.v6.i3.367 [doi]
PST - ppublish
SO  - World J Stem Cells. 2014 Jul 26;6(3):367-70. doi: 10.4252/wjsc.v6.i3.367.