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\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\pard\plain \ltrpar\ql \li0\ri0\sb100\sa270\sbauto1\sl240\slmult0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid7294592 \cbpat8 \rtlch\fcs1 
\af31507\afs22\alang1025 \ltrch\fcs0 \f31506\fs22\lang1036\langfe1033\cgrid\langnp1036\langfenp1033 {\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 \i\f1\fs18\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 Acta Physiologica 2008}{
\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 ; Volume 194, Supplement 666\line }{\field\fldedit{\*\fldinst {\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 
\f1\fs18\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592  HYPERLINK "http://www.blackwellpublishing.com/aphmeeting/meetingindex1.asp?MeetingID=747" }{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 
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\b\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 Belgian Society for Fundamental and Clinical Physiology and Pharmacology, Spring Meeting 2008}}}\sectd \ltrsect
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University of Li\'e8ge, Li\'e8ge, Belgium
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\f31506\fs22\lang1036\langfe1033\cgrid\langnp1036\langfenp1033 {\rtlch\fcs1 \ab\af1\afs18 \ltrch\fcs0 \b\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 
SK CHANNEL BLOCKADE PROMOTES BURSTING IN VIVO IN DORSAL RAPHE SEROTONERGIC NEURONS\line Abstract number: P-01
\par }{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 Rouchet}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\super\langfenp1036\insrsid7294592\charrsid7294592 1}{
\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 \~N., Waroux}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\super\langfenp1036\insrsid7294592\charrsid7294592 1}{
\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 \~O., Alix}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\super\langfenp1036\insrsid7294592\charrsid7294592 1}{
\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 \~Ph., Scuvee-Moreau}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\super\langfenp1036\insrsid7294592\charrsid7294592 1}{
\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 \~J., Liegeois}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\super\langfenp1036\insrsid7294592\charrsid7294592 2}{
\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 \~J-F., Seutin}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\super\langfenp1036\insrsid7294592\charrsid7294592 1}{
\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 \~V.
\par }{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 \i\f1\fs18\cf1\lang1033\langfe1036\super\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 1}{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 
\i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 Laboratory of Pharmacology, Center for Cellular and Molecular Neurobiology, \line }{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 
\i\f1\fs18\cf1\lang1033\langfe1036\super\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 2}{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 \i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 
Laboratory of Medicinal Chemistry, Natural and Synthetic Drugs Research Center., Univ. Lige, B-4000 Sart Tilman/ Lige 1, Belgium }{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 

\par SK channels are small conductance calcium-activa
ted potassium channels which trigger an outward current generating a medium-duration afterhyperpolarization (mAHP). This AHP follows a single or a train of action potentials, and therefore is important in the regulation of the firing frequency and/or patt
ern of many types of neurons. Serotonergic (5-HT) neurons from the raphe nuclei express SK3 channels and exhibit a significant AHP which can be blocked }{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 
\i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 in vitro}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 
 by apamin and N-methyl laudanosine (NML) (Scuv\'e9e-Moreau et al, 2004). In order to further charac
terize SK currents in 5-HT neurons, patch-clamp recordings were carried out in brain slices. In parallel, we wanted to determine the physiological role of these channels }{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 
\i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 in vivo}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 
, by using single unit extracellular recordings combined with iontophoresis of the specific non-peptidic SK channel blocker, UCL1684 (200 }{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f3\fs18\cf1\lang1036\langfe1036\langfenp1036\insrsid7294592\charrsid7294592 
\'6d}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 M), in anesthetized rats. }{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 
\i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 In vivo, }{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 
we observed a significant increase in the production of doublets in 17 out of 25 neurons, with no effect on their mean firing rate as compared to the control con
dition. The 8 other neurons were completely unaffected. As 5-HT neurons have an important GABAergic input, we applied a GABA}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\sub\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 A}
{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 
 antagonist, SR95531, prior to UCL1684, in order to rule out an indirect effect of the latter. In these conditions, UCL1684 still produced a marked increase of bursting in a subset of 5-HT neurons (11 out of 20).
\par In voltage-clamp recordings in slices, the 
mAHP current (peak at ~70 ms) was generated by a depolarizing step from -60 to 100 mV during 20 ms. Application of bicuculline methchloride (BMC), a reversible medium affinity SK channel blocker, or apamin, completely abolished the current. In addition, b
lockade of the SK current revealed the existence of an inward current which will have to be identified in later experiments.
\par In conclusion, }{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 \i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 in vivo,}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 
\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592  SK channels seem to play a role in controlling the firing pattern of a subgroup of 5-HT neurons. }{\rtlch\fcs1 \ai\af1\afs18 \ltrch\fcs0 
\i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 In vitro}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 \f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 , t
he SK current opposes an inward current which could have a role in the bursting behaviour.
\par }{\rtlch\fcs1 \ab\af1\afs18 \ltrch\fcs0 \b\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 To cite this abstract, please use the following information:}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 
\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 \line }{\rtlch\fcs1 \ab\ai\af1\afs18 \ltrch\fcs0 \b\i\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 Acta Physiologica 2008}{
\rtlch\fcs1 \ab\af1\afs18 \ltrch\fcs0 \b\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 ; Volume 194, Supplement 666 :P-01}{\rtlch\fcs1 \af1\afs18 \ltrch\fcs0 
\f1\fs18\cf1\lang1033\langfe1036\langnp1033\langfenp1036\insrsid7294592\charrsid7294592 
\par }\pard \ltrpar\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af31507 \ltrch\fcs0 \lang1033\langfe1033\langnp1033\insrsid6565770\charrsid7294592 
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