Article (Scientific journals)
Vitamin D, cardiovascular disease and mortality
Pilz, Stefan; Tomaschitz, Andreas; März, Winfried et al.
2011In Clinical Endocrinology, 75 (5), p. 575-84
Peer Reviewed verified by ORBi
 

Files


Full Text
VTD_Cardiovascular_Clin Endo_Pilz.pdf
Author postprint (633.23 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
vitamin D; atherosclerosis; recommandations; prospective; intervention
Abstract :
[en] A poor vitamin D status, i.e. low serum levels of 25-hydroxyvitamin D (25[OH]D), is common in the general population. This finding is of concern not only because of the classic vitamin D effects on musculoskeletal outcomes, but also because expression of the vitamin D receptor (VDR) and vitamin D metabolizing enzymes in the heart and blood vessels suggests a role of vitamin D in the cardiovascular system. VDR-knockout mice suffer from cardiovascular disease (CVD) and various experimental studies suggest cardiovascular-protection by vitamin D, including anti-atherosclerotic, anti-inflammatory and direct cardio-protective actions, beneficial effects on classic cardiovascular risk factors as well as suppression of parathyroid hormone (PTH) levels. In epidemiological studies, low levels of 25(OH)D are associated with increased risk of CVD and mortality. Data from randomized controlled trials (RCTs) are sparse and have partially, but not consistently, shown some beneficial effects of vitamin D supplementation on cardiovascular risk factors (e.g. arterial hypertension). We have insufficient data on vitamin D effects on cardiovascular events, but meta-analyses of RCTs indicate that vitamin D may modestly reduce all-cause mortality. Despite accumulating data suggesting that a sufficient vitamin D status may protect against CVD, we still must wait for results of large-scale RCTs before raising general recommendations for vitamin D in the prevention and treatment of CVD. In current clinical practice the overall risks and costs of vitamin D supplementation should be weighed against the potential adverse consequences of untreated vitamin D deficiency
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Pilz, Stefan
Tomaschitz, Andreas
März, Winfried
Drechsler, Christiane
Ritz, Eberhard
Zittermann, Armin
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Pieber, Thomas
Lappe, Joan
Grant, William
Holick, Michael
Dekker, Jacquelin
Language :
English
Title :
Vitamin D, cardiovascular disease and mortality
Publication date :
November 2011
Journal title :
Clinical Endocrinology
ISSN :
0300-0664
eISSN :
1365-2265
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
75
Issue :
5
Pages :
575-84
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 June 2011

Statistics


Number of views
406 (2 by ULiège)
Number of downloads
630 (2 by ULiège)

Scopus citations®
 
207
Scopus citations®
without self-citations
175
OpenCitations
 
151

Bibliography


Similar publications



Contact ORBi