Publications and communications of Paola Mercuri

Cawez, F., Mercuri, P., Piccirilli, A., Perilli, M., Morales Yánez, F. J., Dumoulin, M., & Galleni, M. (02 June 2023). Selection and characterization of anti-NDM-1 nanobodies [Poster presentation]. 14 th Beta-Lactam and beta-lactamase meeting, L'Aquila, Italy.

Cawez, F., Mercuri, P., Morales Yánez, F. J., Maalouf, R., Vandevenne, M., Kerff, F., Guérin, V., Mainil, J., Thiry, D., Saulmont, M., Vanderplasschen, A., Lafaye, P., Aymé, G., Bogaerts, P., Dumoulin, M., & Galleni, M. (2023). Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C b-Lactamases. Antimicrobial Agents and Chemotherapy. doi:10.1128/aac.01499-22

Zouaoui, E., Mercuri, P., Radaoui, A., Ben Salah, N., Galleni, M., Ben-Mahrez, K., & Réjiba, S. (2023). High Prevalence of blaNDM Among Carbapenem Non‑Susceptible Klebsiella pneumoniae in a Tunisian Hospital First Report of blaNDM‑9, blaKPC‑20, and blaKPC‑26 Genes. Current Microbiology, 80 (152). doi:10.1007/s00284-023-03268-2

Guérin, V., Farchi, A., Cawez, F., Mercuri, P., Lucas, P., Blanchard, Y., Saulmont, M., Mainil, J., & Thiry, D. (07 September 2022). A three-year evolution and comparison of the bla CTX-M genes in pathogenic and non-pathogenic Escherichia coli isolated from young diarrheic and septicaemic calves in Belgium. Research in Veterinary Science, 152, 647-650. doi:10.1016/j.rvsc.2022.09.037

Gavara, L., Verdirosa, F., Sevaille, L., Legru, A., Corsica, G., Nauton, L., Mercuri, P., Sannio, F., De Luca, F., Hadjadj, M., Cerboni, G., Vo Hoang, Y., Licznar-Fajardo, P., Galleni, M., Docquier, J.-D., & Hernandez, J.-F. (11 August 2022). 1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors. Bioorganic and Medicinal Chemistry, 72, 116964. doi:10.1016/j.bmc.2022.116964

Verdirosa, F.* , Gavara, L.* , Sevaille, L., Tassone, G., Corsica, G., Legru, A., Feller, G., Chelini, G., Mercuri, P., Tanfoni, S., Sannio, F., Benvenuti, M., Cerboni, G., De Luca, F., Bouajila, E., Hoang, Y. V., Licznar-Fajardo, P., Galleni, M., Pozzi, C., ... Hernandez, J.-F.*. (20 January 2022). 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors. ChemMedChem, 17 (7), 202100699. doi:10.1002/cmdc.202100699

Guérin, V., Farchi, A., Thiry, D., Cawez, F., Mercuri, P., Galleni, M., Mainil, J., & Saulmont, M. (2022). Seven-Year Evolution of β-Lactam Resistance Phenotypes in Escherichia coli Isolated from Young Diarrheic and Septicaemic Calves in Belgium. Veterinary Sciences. doi:10.3390/vetsci9020045

Lupo, V., Mercuri, P., Frère, J.-M., Joris, B., Galleni, M., Baurain, D.* , & Kerff, F.*. (2022). An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains. Microbiology Spectrum, 10 (2), 0031522. doi:10.1128/spectrum.00315-22

de Barsy, M., Mercuri, P., Oueslati, S., Elisée, E., Huang, T.-D., Sacré, P., Iorga, B. I., Naas, T., Galleni, M., & Bogaerts, P. (18 October 2021). Detection and Characterization of VIM-52, a New Variant of VIM-1 from a Klebsiella pneumoniae Clinical Isolate. Antimicrobial Agents and Chemotherapy, 65 (Issue 11), 02660-20. doi:10.1128/AAC.02660-20

Piccirilli, A., Mercuri, P., Segatore, B., Galleni, M., Brisdelli, F., Kerff, F., Amicosante, G., & Perilli, M. (June 2021). Laboratory Variants GESG170L, GESG170K, and GESG170H Increase Carbapenem Hydrolysis and Confer Resistance to Clavulanic Acid. Antimicrobial Agents and Chemotherapy, 65 (6), 01931-20. doi:10.1128/AAC.01931-20

Gavara, L., Legru, A., Verdirosa, F., Sevaille, L., Nauton, L., Corsica, G., Mercuri, P., Sannio, F., Feller, G., Coulon, R., De Luca, F., Cerboni, G., Tanfoni, S., Chelini, G., Galleni, M., Docquier, J.-D., & Hernandez, J.-F. (2021). 4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors. Bioorganic Chemistry, 113. doi:10.1016/j.bioorg.2021.105024

Guérin, V., Thiry, D., Lucas, P., Blanchard, Y., Cawez, F., Mercuri, P., Galleni, M., Saulmont, M., & Mainil, J. (2021). Identification of b-Lactamase-Encoding (bla) Genes in Phenotypically b-Lactam-Resistant Escherichia coli Isolated from Young Calves in Belgium. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease. doi:10.1089/mdr.2020.0472

Piccirilli, A., Criscuolo, E., Brisdelli, F., Mercuri, P., Cherubini, S., De Scicio, M. L., Maccarrone, M., Galleni, M., Amicosante, G., & Perilli, M. (2021). Exploring the Role of L10 Loop in New Delhi Metallo- beta-lactamase (NDM-1): Kinetic and Dynamic Studies. Molecules, 26, 5489. doi:10.3390/molecules26185489

Guérin, V., Thiry, D., Duprez, J.-N., Cawez, F., Mercuri, P., Saulmont, M., & Mainil, J. (December 2020). Triplex PCR to detect CTX M 1, CTX M 2 and CTX M 9 groups of extended spectrum β lactamase encoding genes in bovine Escherichia coli isolates [Poster presentation]. 40ème Réunion interdisciplinaire de chimiothérapie anti-infectieuse, Paris, France.

Guérin, V., Thiry, D., Duprez, J.-N., Cawez, F., Mercuri, P., Saulmont, M., & Mainil, J. (20 November 2020). Triplex PCR to detect CTX-M-1, CTX-M-2 and CTX-M-9 groups of extended-spectrum-β-lactamase encoding genes in bovine Escherichia coli isolates [Poster presentation]. 7th FARAH DAY, Liège, Belgium.

Mercuri, P., Esposito, R., Blétard, S., Di Costanzo, S., Perilli, M., Kerff, F., & Galleni, M. (2020). Mutational Effects on Carbapenem Hydrolysis of YEM-1, a New Subclass B2 Metallo-β-Lactamase from Yersinia mollaretii. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00105-20

Gavara, L., Sevaille, L., De Luca, F., Mercuri, P., Bebrone, C., Feller, G., Legru, A., Cerboni, G., Tanfoni, S., Baud, D., Cutolo, G., Bestgen, B., Chelini, G., Verdirosa, F., Sannio, F., Pozzi, C., Benvenuti, M., Kwapien, K., Fischer, M., ... Hernandez, J.-F. (2020). 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. European Journal of Medicinal Chemistry, 208, 112720. doi:10.1016/j.ejmech.2020.112720

Gavara, L., Verdirosa, F., Legru, A., Mercuri, P., Nauton, L., Sevaille, L., Feller, G., Berthomieu, D., Sannio, F., Marcoccia, F., Tanfoni, S., De Luca, F., Gresh, N., Galleni, M., Docquier, J.-D., & Hernandez, J.-F. (2020). 4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-Beta-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition. Biomolecules, 10 (8), 1094. doi:10.3390/biom10081094

Guérin, V., Thiry, D., Cawez, F., Mercuri, P., Saulmont, M., & Mainil, J. (December 2019). Escherichia coli bovines β-lactames résistantes : gènes identifiés par microarrays [Poster presentation]. 39ème Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse (RICAI), Paris, France.

Guérin, V., Thiry, D., Cawez, F., Mercuri, P., Mainil, J., & Saulmont, M. (July 2019). A two-year comparison of β-lactam resistance phenotypes at the disk diffusion assay of Escherichia coli from young calves in Wallonia, Belgium [Poster presentation]. 8th Symposium on Antimicrobial Resistance in Animals and the Environment (ARAE), Tours, France.

Guérin, V., Thiry, D., Cawez, F., Mercuri, P., Saulmont, M., & Mainil, J. (July 2019). bla gene identification by microarrays in phenotypically resistant Escherichia coli from young calves in Wallonia, Belgium [Poster presentation]. 8th Symposium on Antimicrobial Resistance in Animals and the Environment (ARAE), Tours, France.

Mercuri, P., Esposito, R., Blétard, S., Di Costanzo, S., Perilli, M., Kerff, F., & Galleni, M. (22 June 2019). Mutational Effects in Carbapenem Hydrolysis of YEM-1, a New Sub-Class B2 Metallo-beta-Lactamase from Yersinia mollaretii [Poster presentation]. asm microbe, San Francisco Ca, United States.

Guérin, V., Thiry, D., Cawez, F., Mercuri, P., Mainil, J., & Saulmont, M. (19 June 2019). Comparaison des phénotypes de résistance aux β-lactamines observés sur deux ans à l’antibiogramme d’Escherichia coli isolées de veaux en Wallonie [Poster presentation]. Un an de plus dans la lutte contre la résistance aux antibiotiques chez les animaux. Derniers résultats relatifs à l’utilisation des antibiotiques et à l’antibiorésistance dans une large perspective, Bruxelles, Belgium.

Guérin, V., Thiry, D., Cawez, F., Mercuri, P., Saulmont, M., & Mainil, J. (19 June 2019). Escherichia coli bovines beta-lactames résistantes : gènes identifiés par microarrays [Poster presentation]. Un an de plus dans la lutte contre la résistance aux antibiotiques chez les animaux. Derniers résultats relatifs à l’utilisation des antibiotiques et à l’antibiorésistance dans une large perspective, Bruxelles, Belgium.

Marcoccia, F., Mercuri, P., Galleni, M., Celenza, G., Amicosante, G., & Perilli, M. (2018). A Kinetic Study of the Replacement by Site Saturation Mutagenesis of Residue 119 in NDM-1 Metallo- beta-Lactamase. Antimicrobial Agents and Chemotherapy, 62 (8). doi:10.1128/AAC.02541-17

Piccirilli, A., Mercuri, P., Galleni, M., Aschi, M., Matagne, A., Amicosante, G., & Perilli, M. (2018). P174E Substitution in GES-1 and GES-5 beta-Lactamases Improves Catalytic Efficiency toward Carbapenems. Antimicrobial Agents and Chemotherapy, 62 (5). doi:10.1128/AAC.01851-17

Amisano, F., Silvestri, M., Mercuri, P., Gagliardi, A., Bini, L., Frère, J.-M., & Galleni, M. (17 June 2017). Study of the outer membrane permeability of Pseudomonas aeruginosa to ß-lactam antibiotics [Poster presentation]. 13th Beta lactamase meeting, Santo Stefano di Sessanio, Italy.

Marcoccia, F., Melchiorre, C., Robert, C., Mercuri, P., Galleni, M., Celenza, G., Amicosante, G., & Perilli, M. (June 2017). NDM-1 could still evolve: analysis of a random mutagenesis in position 123 [Poster presentation]. 13th β-lactamase Meeting", Santo Stefano di Sessanio, l'Aquila, Italy.

Mercuri, P., Blétard, S., Kerff, F., & Galleni, M. (June 2017). Characterisation of the sub-class B2 metallo-β-lactamase of Yersinia mollaretii Wauters [Poster presentation]. 13th β-lactamase Meeting", Santo Stefano di Sessanio, l'Aquila, Italy.

Piccirilli, A., Perilli, M., Mercuri, P., Aschi, M., Segatore, B., Galleni, M., Celenza, G., & Amicosante, G. (June 2017). Replacement of proline 174 with glutamic acid in GES-1 enzyme improve the flexibility of Ω-loop leading to an increase of catalytic efficiency towards carbapenems [Poster presentation]. 13th β-lactamase Meeting", Santo Stefano di Sessanio, l'Aquila, Italy.

Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Tanfoni, S., Borgianni, L., Guyon, C., Lonjon, P., Turan-Zitouni, G., Dzieciolowski, J., Becker, K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J.-M., ... Hernandez, J.-F. (2017). 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 12, 972-985. doi:10.1002/cmdc.201700186

Abboud, M., Damblon, C., Brem, J., Smargiasso, N., Mercuri, P., Gilbert, B., Rydzik, A., Claridge, T., Schofield, C., & Frère, J.-M. (September 2016). Interaction of Avibactam with Class B Metallo-β-Lactamases. Antimicrobial Agents and Chemotherapy, 60, 5655-6. doi:10.1128/AAC.00897-16

Bottoni, C., Perilli, M., Marcoccia, F., Piccirilli, A., Pellegrini, C., Colapietro, M., Sabatini, A., Celenza, G., Kerff, F., Amicosante, G., Galleni, M., & Mercuri, P. (2016). Kinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems. Antimicrobial Agents and Chemotherapy, 60 (5), 3123-6. doi:10.1128/AAC.01703-15

Marcoccia, F., Bottoni, C., Sabatini, A., Colapietro, M., Mercuri, P., Galleni, M., Kerff, F., Matagne, A., Celenza, G., Amicosante, G., & Perilli, M. (2016). Kinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35. Antimicrobial Agents and Chemotherapy, 60 (4), 2366-72. doi:10.1128/AAC.00531-15

Achour, N. B., Belhadj, O., Galleni, M., Moussa, M. B., & Mercuri, P. (2014). Study of a Natural Mutant SHV-Type beta-Lactamase, SHV-104, from Klebsiella pneumoniae. International Journal of Microbiology, 2014. doi:10.1155/2014/548656

Perilli, M., Celenza, G., Mercuri, P., Galleni, M., Pellegrini, C., Segatore, B., & Amicosante, G. (2013). R164H and V240H replacements by site-directed mutagenesis of TEM-149 extended-spectrum beta-lactamase: kinetic analysis of TEM-149H240 and TEM-149H164-H240 laboratory mutants. Antimicrobial Agents and Chemotherapy, 57 (2), 1047-9. doi:10.1128/AAC.01268-12

Van Oudenhove, L., De Vriendt, K., Van Beeumen, J., Mercuri, P., & Devreese, B. (August 2012). Differential proteomic analysis of the response of Stenotrophomonas maltophilia to imipenem. Applied Microbiology and Biotechnology, 95, 717-33. doi:10.1007/s00253-012-4167-0

Ben Achour, N., Power, P., Mercuri, P., Ben Moussa, M., Galleni, M., & Belhadj, O. (2012). First detection of a transferable blaCTX-M-14b gene in a Klebsiella pneumoniae clinical isolate from Tunisia and analysis of its genetic context. Annals of Microbiology, 62, 1737-1742.

Ben Aissa, M., Herteg Fernea, A., Bouraoui, H., Ben Aissa, R., Mercuri, P., & Manai, M. (2012). Molecular characterization of plasmid-encoded ACC-1a4 β-lactamase produced by Salmonella strains isolated from water in a Tunisian hospital. Annals of Microbiology, 62, 31-36.

Power, P., Mercuri, P., Herman, R., Kerff, F., Gutkind, G., Dive, G., Galleni, M., Charlier, P., & Sauvage, E. (2012). Novel fragments of clavulanate observed in the structure of the class A b-lactamase from Bacillus licheniformis BS3. Journal of Antimicrobial Chemotherapy, 67 (10), 2379-2387. doi:10.1093/jac/dks231

Réjiba, S., Mercuri, P., Power, P., & Kechrid, A. (June 2011). Emergence and dominance of CTX-M-15 extended spectrum beta-lactamase among Escherichia coli isolates from children. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 17, 135-40. doi:10.1089/mdr.2010.0098

Lassaux, P., Hamel, M., Gulea, M., Delbrück, H., Mercuri, P., Horsfall, L., Dehareng, D., Kupper, M., Frère, J.-M., Hoffmann, K., Galleni, M., & Bebrone, C. (2010). Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases. Journal of Medicinal Chemistry, 53, 4862–4876. doi:10.1021/jm100213c

Ben Achour, N., Mercuri, P., Ben Moussa, M., Galleni, M., & Belhadj, O. (2009). Characterization of a novel extended-spectrum TEM-type beta-lactamase, TEM-164, in a clinical strain of Klebsiella pneumoniae in Tunisia. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 15 (3), 195-9. doi:10.1089/mdr.2009.0900

Ben Achour, N., Mercuri, P., Power, P., Belhadj, C., Ben Moussa, M., Galleni, M., & Belhadj, O. (2009). First detection of CTX-M-28 in a Tunisian hospital from a cefotaxime-resistant Klebsiella pneumoniae strain. Pathologie Biologie, 57 (5), 343-8. doi:10.1016/j.patbio.2008.07.016

Pellegrini, C., Mercuri, P., Celenza, G., Galleni, M., Segatore, B., Sacchetti, E., Volpe, R., Amicosante, G., & Perilli, M. (2009). Identification of bla(IMP-22) in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location. Journal of Antimicrobial Chemotherapy, 63 (5), 901-8. doi:10.1093/jac/dkp061

Ben Achour, N., Mercuri, P., Belhadj, C., Ben Moussa, M., Galleni, M., & Belhadj, O. (2008). Cefotaxime and ceftriaxon resistant Klebsiella pneumoniae associated with SHV-11 hyperproduction. Annals of Microbiology, 5 (4), 727-730. doi:10.1007/BF03175582

Zervosen, A., Saegerman, C., Antoniotti, I., Robert, B., Ruth, N., Collard, A., Schynts, F., Galleni, M., & Mercuri, P. (2008). Characterization of the cattle serum antibody responses against TEM beta-lactamase and the nonimmunogenic Escherichia coli heat-stable enterotoxin (STaI). FEMS Immunology and Medical Microbiology, 54 (3), 319-329. doi:10.1111/j.1574-695X.2008.00482.x

Lassaux, P., Hamel, M., Gulea, M., Mercuri, P., Horsfall, L., Bebrone, C., Gaumont, A.-C., Frère, J.-M., & Galleni, M. (2007). Mercapto-phosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. International Journal of Antimicrobial Agents, 29 (Supplément 2), 95.

Ignatova, M., Voccia, S., Gilbert, B., Markova, N., Mercuri, P., Galleni, M., Sciannamea, V., Lenoir, S., Cossement, D., Gouttebaron, R., Jérôme, R., & Jérôme, C. (23 November 2004). Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization. Langmuir, 20 (24), 10718-10726. doi:10.1021/la048347t

Mercuri, P., Garcia-Saez, I., De Vriendt, K., Thamm, I., Devreese, B., Van Beeumen, J., Dideberg, O., Rossolini, G. M., Frère, J.-M., & Galleni, M. (06 August 2004). Probing the specificity of the subclass B3 FEZ-1 metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 279 (32), 33630-33638. doi:10.1074/jbc.M403671200

Garau, G., Garcia-Saez, I., Bebrone, C., Anne, C., Mercuri, P., Galleni, M., Frère, J.-M., & Dideberg, O. (July 2004). Update of the standard numbering scheme for class B beta-lactamases. Antimicrobial Agents and Chemotherapy, 48 (7), 2347-2349. doi:10.1128/AAC.48.7.2347-2349.2004

Garcia-Saez, I., Mercuri, P., Papamicael, C., Kahn, R., Frère, J.-M., Galleni, M., Rossolini, G. M., & Dideberg, O. (24 January 2003). Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. Journal of Molecular Biology, 325 (4), 651-660. doi:10.1016/S0022-2836(02)01271-8

Mercuri, P., Ishii, Y., Ma, L., Rossolini, G. M., Luzzaro, F., Amicosante, G., Franceschini, N., Frère, J.-M., & Galleni, M. (2002). Clonal diversity and metallo-beta-lactamase production in clinical isolates of Stenotrophomonas maltophilia. Microbial Drug Resistance: Mechanism, Epidemiology, and Disease, 8 (3), 193-200. doi:10.1089/107662902760326904

Zervosen, A., Valladares, M. H., Devreese, B., Prosperi, C., Adolph, H.-W., Mercuri, P., Vanhove, M., Amicosante, G., van Beeumen, J., Frère, J.-M., & Galleni, M. (July 2001). Inactivation of Aeromonas Hydrophila Metallo-Beta-Lactamase by Cephamycins and Moxalactam. European Journal of Biochemistry, 268 (13), 3840-50. doi:10.1046/j.1432-1327.2001.02298.x

Mercuri, P., Bouillenne, F., Boschi, L., Lamotte-Brasseur, J., Amicosante, G., Devreese, B., van Beeumen, J., Frère, J.-M., Rossolini, G. M., & Galleni, M. (April 2001). Biochemical Characterization of the Fez-1 Metallo-Beta-Lactamase of Legionella Gormanii Atcc 33297t Produced in Escherichia Coli. Antimicrobial Agents and Chemotherapy, 45 (4), 1254-62. doi:10.1128/AAC.45.4.1254-1262.2001

Boschi, L., Mercuri, P., Riccio, M. L., Amicosante, G., Galleni, M., Frère, J.-M., & Rossolini, G. M. (2000). The Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases. Antimicrobial Agents and Chemotherapy, 44 (6), 1538-43. doi:10.1128/AAC.44.6.1538-1543.2000

Rossolini, G. M., Franceschini, N., Riccio, M. L., Mercuri, P., Perilli, M., Galleni, M., Frère, J.-M., & Amicosante, G. (1998). Characterization and sequence of the Chryseobacterium (Flavobacterium) meningosepticum carbapenemase: a new molecular class B beta-lactamase showing a broad substrate profile. Biochemical Journal, 332 ( Pt 1), 145-52. doi:10.1042/bj3320145

Barrett, J. W., Lauzon, H. A. M., Mercuri, P., Krell, P. J., Sohi, S. S., & Arif, B. M. (1996). The Putative LEF-1 Proteins From Two Distinct Choristoneura fumiferana Multiple Nucleopolyhedroviruses Share Domain Homology to Eukaryotic Primases. Virus Genes, 13 (3), 229-237. doi:10.1007/BF00366983