Publications and communications of Pascal De Tullio

Cirillo, A., Vandermeulen, M., ERPICUM, P., Pinto Coelho, T., MEURISSE, N., Detry, O., Jouret, F., & De Tullio, P. (09 March 2024). Untargeted NMR-based metabolomics analysis of kidney allograft perfusates identifies a signature of delayed graft function. Metabolomics, 20 (2), 39. doi:10.1007/s11306-024-02106-1

Schoumacher, M., Massonnet, P., Kaux, J.-F., De Tullio, P., Cavalier, E., & Le Goff, C. (March 2024). NMR-based Metabolomics and athletes monitoring: fitness and internal overload prevention. British Journal of Sports Medicine, 58 (Suppl 2), 113-A114. doi:10.1136/bjsports-2024-IOC.201

Lefebvre, T.* , Campas, M.* , Matta, K., Ouzia, S., Guitton, Y., Duval, G., Ploteau, S., Marchand, P., Le Bizec, B., Freour, T., Antignac, J.-P., De Tullio, P.* , & Cano-Sancho, G.*. (03 February 2024). A comprehensive multiplatform metabolomic analysis reveals alterations of 2-hydroxybutyric acid among women with deep endometriosis related to the pesticide trans-nonachlor. Science of the Total Environment, 918, 170678. doi:10.1016/j.scitotenv.2024.170678

Coelho Cristino Mamede, L. C., Fall, F., Schoumacher, M., Ledoux, A., Bugli, C., De Tullio, P., Quetin-Leclercq, J., Govaerts, B., & Frederich, M. (February 2024). Comparison of extraction methods in vitro Plasmodium falciparum: A 1 H NMR and LC-MS joined approach. Biochemical and Biophysical Research Communications, 703, 149684. doi:10.1016/j.bbrc.2024.149684

Cirillo, A., Résimont, G., Jouret, F., Vidal-Petiot, E., Flamant, M., Delanaye, P., & De Tullio, P. (31 January 2024). How can metabolomics help the follow-up management of kidney transplantation recipients? An untargeted based-metabolomics multiplatform study [Paper presentation]. Metabolomics in Life Science, Umea, Sweden.

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (09 December 2023). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036

Iovino, M., Colonval, M., Wilkin, C., L'Homme, L., Lassence, C., Campas, M., Peulen, O., De Tullio, P., Piette, J., & Legrand, S. (2023). Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid. Frontiers in Immunology. doi:10.3389/fimmu.2023.1204126

Coelho Cristino Mamede, L. C., Rangel, G. W., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Frederich, M., & Llinás, M. (17 July 2023). Profiling plants with antimalarial blood stage activity using metabolomics: an added dimension to drug discovery [Paper presentation]. 6e Symposium International de l’AFERP.

Cirillo, A., Vandermeulen, M., Erpicum, P., Pinto Coelho, T., MEURISSE, N., Detry, O., Jouret, F., & De Tullio, P. (18 June 2023). Untargeted 1H NMR-based analysis of kidney allograft perfusates identifies a metabolomics signature of delayed graft function [Poster presentation]. Metabolomics Society, Niagara Falls, Canada.

Coelho Cristino Mamede, L. C., W. Rangel, G., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Llinás, M., & Frederich, M. (25 April 2023). Profiling plant extracts with antimalarial bloodstage activity using metabolomics [Poster presentation]. WORLD MALARIA DAY SYMPOSIUM: Blood Stage Malaria | Staving Off the Firestorm, Baltimore, United States.

Goffin, E., Fraikin, P., Abboud, D., De Tullio, P., Beaufour, C., Botez, I., Hanson, J., Danober, L., Francotte, P., & Pirotte, B. (15 March 2023). New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European Journal of Medicinal Chemistry, 250, 115221. doi:10.1016/j.ejmech.2023.115221

Cirillo, A., Leenders, J., Squatrito, M., Celine Bugli, Bernadette Govaerts, Michèle Nisolle, Munaut, C., & De Tullio, P. (February 2023). Metabiose project: an endometriosis predictive signature through metabolomics [Paper presentation]. CIRM day.

Arslan, D., Schoumacher, M., Dilly, S., Elmoualij, B., Zorzi, D., Quatresooz, P., Lambert, V., Noël, A., Pirotte, B., & De Tullio, P. (2023). Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors. Medicinal Chemistry, 19 (3), 276-296. doi:10.2174/1573406418666220819102627

Wouters, C., Toquet, M.-P., Fortier-Guillaume, J., Marcillaud-Pitel, C., De Tullio, P., Votion, D.* , & Richard, É. A.*. (2022). Identification de métabolites sanguins discriminant les survivants et non-survivants de la myopathie atypique des équidés. In Proceeding Journée AVEF (Association des Vétérinaires Equins Français). France: Mespoulhès-Rivière, Céline.

Coelho Cristino Mamede, L. C., Fall, F., Schoumacher, M., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., & Frederich, M. (2022). Recent metabolomic developments for antimalarial drug discovery. Parasitology Research. doi:10.1007/s00436-022-07673-7

De Tullio, P. (05 September 2022). From case-control study to longitudinal patient’s follow-up using NMR-based metabolomics: back to the “real-life” of clinics. The case of neovascular Age-related Macular Degeneration (nAMD) [Paper presentation]. Analytics 2022, Nantes, France.

Khbouz, B., LALLEMAND, F., Cirillo, A., Rowart, P., Legouis, D., Sounni, N. E., Noël, A., De Tullio, P., de Seigneux, S., & JOURET, F. (2022). Kidney-targeted irradiation triggers renal ischaemic preconditioning in mice. American Journal of Physiology. Renal Physiology. doi:10.1152/ajprenal.00005.2022

Rademaker, G.* , Boumahd, Y.* , Peiffer, R., Anania, S., Wissocq, T., Liégeois, M., Luis, G., Sounni, N. E., Agirman, F., Maloujahmoum, N., De Tullio, P., Thiry, M., Bellahcene, A., Castronovo, V., & Peulen, O. (July 2022). Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biology, 53, 102324. doi:10.1016/j.redox.2022.102324

Iovino, M., Wilkin, C., Colonval, M., L'Homme, L., Campas, M., Schoumacher, M., De Tullio, P., Piette, J., & Legrand, S. (27 June 2022). IRE1 endoribonuclease plays a key role in activation of both HIF-1alpha and glucose metabolism in saturated fatty acid-treated human macrophages [Poster presentation]. Cell Symposium: Translational Immunometabolism, Bâle, Switzerland.

Campas, M., Lefebvre Tiphaine, Guitton, Y., Ploteau, S., Le Bizec, B., Antignac, J.-P., Cano Sancho, G., & De Tullio, P. (21 June 2022). Application of NMR-based metabolomics to the study of endometriosis and infertility in French women [Poster presentation]. 18th Annual Conference for the Metabolomics Society, Valence, Spain.

Cirillo, A., Résimont, G., Delanaye, P., Emmanuelle Vidal-Petiot, Martin Flamant, Jouret, F., & De Tullio, P. (19 June 2022). Application of metabolomics to the evaluation of kidney function and kidney transplantation [Poster presentation]. Metabolomics Society.

Fall, F., Coelho Cristino Mamede, L. C., Schioppa, L., Ledoux, A., De Tullio, P., Michels, P., Frederich, M., & Quetin-Leclercq, J. (19 March 2022). Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery. Metabolomics, 18 (4), 20. doi:10.1007/s11306-022-01880-0

Coelho Cristino Mamede, L. C., Schoumacher, M., Cirillo, A., Fall, F., Bugli, C., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Govaerts, B., & Frederich, M. (02 February 2022). Exploration of untargeted metabolomic extraction methods of in vitro malaria samples by 1H NMR analysis - follow up [Poster presentation]. CIRM Day, Liège, Belgium.

Cirillo, A.* , Schoumacher, M.* , De Tullio, P.* , Campas, M. (Other coll.), & Gauthy, C. (Other coll.). (2022). Dried blood spot sampling: a new tool for NMR-based metabolomics approach [Poster presentation]. Analystics.

Schoumacher, M., Lambert, V., Govaerts Bernadette, Rakic, J.-M., Noël, A., & De Tullio, P. (2022). From cohort study to the “real life” in patient’s follow-up and personalized medicine using NMR- based clinical metabolomics; results, issues, problems and prospects: the case of neovascular Age-related Macular Degeneration (nAMD) [Poster presentation]. Metabolomics 2022 Valence, valence, Spain.

Coelho Cristino Mamede, L. C., Schoumacher, M., Cirillo, A., Fall, F., Bugli, C., Ledoux, A., De Tullio, P., Quetin-Leclercq, J., Govaerts, B., & Frederich, M. (November 2021). Exploration of untargeted metabolomic extraction methods for in vitro malaria samples by 1H NMR analysis [Poster presentation]. 14èmes Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique, Aussois, France.

De Tullio, P. (01 October 2021). NMR in clinical metabolomics: an outdated tool? [Paper presentation]. Webinar du Réseau Francophone de Métabolomique et de Fluxomique.

Cirillo, A., Huart, J., Taminiau, B., Descy, J., Saint-Remy, A., Daube, G., KRZESINSKI, J.-M., MELIN, P., JOURET, F., & De Tullio, P. (26 May 2021). Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study [Poster presentation]. CIRM day.

HUART, J.* , Cirillo, A.* , Taminiau, B., DESCY, J., SAINT-REMY, A., Daube, G., KRZESINSKI, J.-M., MELIN, P., De Tullio, P.* , & JOURET, F.*. (29 April 2021). Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study. Metabolites, 11 (5), 282. doi:10.3390/metabo11050282

HUART, J.* , Cirillo, A.* , SAINT-REMY, A., KRZESINSKI, J.-M., De Tullio, P.* , & Jouret, F.*. (2021). The faecal abundance of short chain fatty acids is increased in men with a non-dipping blood pressure profile. Acta Cardiologica. doi:10.1080/00015385.2021.1901020

Letertre, M. P. M., Giraudeau, P., & De Tullio, P. (2021). Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives. Frontiers in Molecular Biosciences, 8. doi:10.3389/fmolb.2021.698337

Peirsman, A., Blondeel, E., Ahmed, T., Anckaert, J., Audenaert, D., Boterberg, T., Buzas, K., Carragher, N., Castellani, G., Castro, F., Dangles-Marie, V., Dawson, J., De Tullio, P., De Vlieghere, E., Dedeyne, S., Depypere, H., Diosdi, A., Dmitriev, R. I., Dolznig, H., ... De Wever, O. (2021). MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity. Nature Methods, 18 (11), 1294-1303. doi:10.1038/s41592-021-01291-4

Wouters, C., Toquet, M.-P., Renaud, B., François, A.-C., Fortier-Guillaume, J., Marcillaud-Pitel, C., BOEMER, F., De Tullio, P., Richard, E., & Votion, D. (2021). Metabolomic Signatures Discriminate Horses with Clinical Signs of Atypical Myopathy from Healthy Co-grazing Horses. Journal of Proteome Research. doi:10.1021/acs.jproteome.1c00225

LAMBERT, V.* , hansen, S.* , Schoumacher, M.* , Lecomte, J., Leenders, J., Hubert, P., Herfs, M., Blacher, S., Carnet, O., Yip, C., BLAISE, P., DUCHATEAU, E., LOCHT, B., THYS, M., CAVALIER, E., GOTHOT, A., Govaerts, B., RAKIC, J.-M., Noël, A.* , & De Tullio, P.*. (2020). Pyruvate dehydrogenase kinase/lactate axis: a therapeutic target for neovascular age-related macular degeneration identified by metabolomics. Journal of Molecular Medicine. doi:10.1007/s00109-020-01994-9

Ledoux, A., Coelho Cristino Mamede, L. C., Palazzo, C., Furst, T., Jansen, O., De Tullio, P., Kagisha, V., Pendeville-Samain, H., Fillet, M., Piel, G., & Frederich, M. (18 May 2020). Heparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B. Planta Medica International Open, 7 (e), 73–80. doi:10.1055/a-1158-0569

Féraud, B., Martineau, E., Leenders, J., Govaerts, B., De Tullio, P., & Giraudeau, P. (01 April 2020). Combining rapid 2D NMR experiments with novel pre-processing workflows and MIC quality measures for metabolomics. Metabolomics, 16, 42. doi:10.1007/s11306-020-01662-6

Stiti, M. Z., Belghobsi, M., Habila, T., Goffin, E., De Tullio, P., Pirotte, B., Faury, G., & Khelili, S. (March 2020). Synthesis and vasodilator activity of new 1,4-dihyropyridines bearing sulfonylurea, urea and thiourea moieties. Chemical Papers, 74 (3), 915 - 928. doi:10.1007/s11696-019-00925-4

Bayiha, J. C., Evrard, B., Cataldo, D., De Tullio, P., & Mingeot-Leclercq, M.-P. (2020). The Budesonide-Hydroxypropyl-β-Cyclodextrin Complex Attenuates ROS Generation, IL-8 Release and Cell Death Induced by Oxidant and Inflammatory Stress. Study on A549 and A-THP-1 Cells. Molecules, 25, 4882. doi:10.3390/molecules25214882

Mouithys-Mickalad, A., Ceusters, J., Charif, M., Elmoualij, B., Schoumacher, M., Plyte, S., Franck, T., Bettendorff, L., Pirotte, B., Serteyn, D., & De Tullio, P. (2020). Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chemico-Biological Interactions, 331, 109272. doi:10.1016/j.cbi.2020.109272

Arslan, D., LAMBERT, V., Noël, A., Pirotte, B., De Tullio, P., Zorzi, D. (Other coll.), & Hansen, S. (Other coll.). (11 December 2019). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase (PDK) Inhibitors [Poster presentation]. 2nd CIRM-day.

Cirillo, A., Schoumacher, M. (Other coll.), & De Tullio, P. (Other coll.). (11 December 2019). Study of dried blood spots sampling for NMR based metabolomics [Poster presentation]. CIRM day.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Rakic, J.-M., Noël, A., & De Tullio, P. (11 December 2019). New Insight into exudative Age-related Macular Degeneration (AMD): A Metabolomics Approach [Paper presentation]. nd CIRM Day, Liège, Belgium.

Leenders, J., vega de Ceninga, M., Chakfé, N., KOLH, P., & De Tullio, P. (2019). Metabolomics toward a personalized approach of vascular diseases. In European Symposium on Vascular biomaterials 2019.

Huart, J.* , Leenders, J.* , Taminiau, B., Descy, J., Saint-Remy, A., Daube, G., KRZESINSKI, J.-M., MELIN, P., De Tullio, P.* , & Jouret, F.*. (2019). Gut Microbiota and Fecal Levels of Short-Chain Fatty Acids Differ Upon 24-Hour Blood Pressure Levels in Men. Hypertension. doi:10.1161/HYPERTENSIONAHA.118.12588

Schoumacher, M., LAMBERT, V., Hansen, S., leenders, J., govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (23 June 2019). New insight in Metabolomics based study of Age Related Macular Degeneration (AMD): Lipoprotein profile and patients follow-up [Poster presentation]. Metabolomics 2019, The Hague, Netherlands.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Rakic, J.-M., Noël, A., & De Tullio, P. (23 May 2019). New insight in Metabolomics based study of Age Related Macular Degeneration (AMD): Lipoprotein profile and patients follow-up [Paper presentation]. 12èmes journées RFMF, Clermont-Ferrand, France.

DEVILLE, M., DUBOIS, N., Cieckiewicz, E., De Tullio, P., LEMAIRE, E., & CHARLIER, C. (25 March 2019). Death following consumption of MDAI and 5-EAPB. Forensic Science International, 299, 89-94. doi:10.1016/j.forsciint.2019.03.023

Costanza, B., Rademaker, G., Tiamiou, A., De Tullio, P., Leenders, J., Blomme, A., Bellier, J., Bianchi, E., Turtoi, A., Delvenne, P., Bellahcene, A., Peulen, O.* , & Castronovo, V.*. (2019). TGFBI, an ECM interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration. International Journal of Cancer. doi:10.1002/ijc.32247

De Tullio, P., Leenders, J., Vega de Ceniga, M., Chakfé, N., & Kolh, P. (March 2019). Metabolomics as an Innovative Tool for a Personalised Approach to Vascular Disease. European Journal of Vascular and Endovascular Surgery, 57 (3), 329. doi:10.1016/j.ejvs.2019.01.003

Depetter, Y., Geurs, S., De Vreese, R., Goethals, S., Vandoorn, E., Steenbrugge, J., Meyer, E., De Tullio, P., Bracke, M., D'Hooghe, M., & De Wever, O. (2019). Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models. International Journal of Cancer. doi:10.1002/ijc.32169

Feraud, B., Leenders, J., Martineau, E., Giraudeau, P., Govaerts, B., & De Tullio, P. (2019). Two data pre‑processing workflows to facilitate the discovery of biomarkers by 2D NMR metabolomics. Metabolomics, 15 (63). doi:10.1007/s11306-019-1524-3

Habila, T., Belghobsi, M., Stiti, M.-Z., Goffin, E., De Tullio, P., Faury, G., Pirotte, B., & Khelili, S. (2019). Synthesis and vasodilator activity of 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties. Canadian Journal of Chemistry, 97 (1), 20 - 28. doi:10.1139/cjc-2018-0239

Arslan, D., LAMBERT, V., Noël, A., Pirotte, B., De Tullio, P., Schoumacher, M. (Other coll.), Hansen, S. (Other coll.), & Elmoualij, B. (Other coll.). (19 December 2018). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase (PDK) Inhibitors [Paper presentation]. 1st CIRM DAY.

Coelho Cristino Mamede, L. C., Ledoux, A., Desdemoustier, P., Jansen, O., Piel, G., Fillet, M., De Tullio, P., & Frederich, M. (19 December 2018). Quantitative analysis of a natural compound and heparin by HPLC-DAD and 1H NMR for the characterization of a liposomal formulation [Poster presentation]. The first CIRM scientific Day, Liège, Belgium.

Kok, M., Nix, C., Nys, G., De Tullio, P., Lecomte, J., LAMBERT, V., & Fillet, M. (19 December 2018). Fluxomics of AMD using mass spectrometry from 10 µL of mice whole blood; investigation of DCA treatment [Poster presentation]. First CIRM Day.

Arslan, D., LAMBERT, V., Elmoualij, B., Noël, A., Pirotte, B., De Tullio, P., Schoumacher, M. (Other coll.), & Hansen, S. (Other coll.). (23 November 2018). From Metabolomics Study of Age Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. MedChem 2018 New Avenues in Kinase Drug Discovery: a Bright Future ?.

De Tullio, P. (14 November 2018). Nuclear magnetic Resonance (NMR) spectroscopy: a powerful tool for the qualitative and the quantitative analysis of complex biological media [Paper presentation]. Farah Seminar.

LAMBERT, V., Schoumacher, M., Lecomte, J., Arslan, D., Leenders, J., Govaerts, B., RAKIC, J.-M., Noël, A., & De Tullio, P. (19 September 2018). Metabolomics for the discovery of new therapeutic approach and personalized medicine: the case of exudative Age-related Macular Degeneration [Paper presentation]. Benelux metabolomics Days, Netherlands.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Rakic, J.-M., Noël, A., & De Tullio, P. (19 September 2018). NMR-based metabolomics study of Age-related Macular Degeneration (AMD): patient follow-up and new target discovery [Poster presentation]. Benelux metabolomics Days, Netherlands.

Martin, M., Legat, B., Leenders, J., Vanwinsberghe, J., Rousseau, R., Boulanger, B., Eilers H.C., P., De Tullio, P., & Govaerts, B. (August 2018). PepsNMR for 1H NMR metabolomic data pre-processing. Analytica Chimica Acta, 1019. doi:10.1016/j.aca.2018.02.067

Schoumacher, M., LAMBERT, V., Leenders, J., Roblain, Q., govaerts, B., Rakic, J.-M., Noël, A., & De Tullio, P. (05 July 2018). NMR-based Metabolomics for New Target Discovery and Personalized Medicine: Application to Age-Related Macular Degeneration (AMD) [Paper presentation]. EUROMAR (European Magnetic Resonance Meeting), Nantes, France.

De Tullio, P. (01 July 2018). NMR-based metabolomics for new target discovery and personalized medicine : application to Age-related Macular Degeneration (AMD) [Paper presentation]. Euromar, Nantes, France.

Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Guesquière, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., RORIVE, A., JERUSALEM, G., Leucci, E., ... Close, P. (28 June 2018). Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature, 558, 605-609. doi:10.1038/s41586-018-0243-7

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (24 June 2018). NMR-Based metabolomics study of Age-related Macular Degeneration (AMD): from pre-clinic model to new target discovery [Poster presentation]. Metabolomics 2017, Seattle, United States.

Cataldo, D., Evrard, B., Dufour, G., De Tullio, P., & Maes, P. (12 June 2018). Cyclodextrin and Budesonide derivative compositions and methods.

Leenders, J., Martin, M., NISOLLE, M., Munaut, C., & De Tullio, P. (June 2018). Endometriosis: a deep insight into the pathology through metabolomics [Poster presentation]. 14th International Conference of the Metabolomics Society, Seattle, United States.

Cauchie, E., Leenders, J., Baré, G., Tahiri, A., Delhalle, L., Korsak Koulagenko, N., De Tullio, P., & Daube, G. (24 May 2018). A NMR-based metabolomics study of minced pork meat inoculated with Brochothrix thermosphacta, Leuconostoc gelidum and Pseudomonas fragi [Paper presentation]. 11ème JS du RFMF, Liège, Belgium.

Cauchie, E., Leenders, J., Baré, G., Tahiri, A., Delhalle, L., Korsak Koulagenko, N., De Tullio, P., & Daube, G. (24 May 2018). A NMR-based metabolomics study of minced pork meat inoculated with Brochothrix thermosphacta, Leuconostoc gelidum and Pseudomonas fragi [Poster presentation]. 11ème JS du RFMF 2018, Liège, Belgium.

Schoumacher, M., LAMBERT, V., Govaerts, B., Rakic, J.-M., Noël, A., & De Tullio, P. (23 May 2018). New insight in Metabolomics based study of Age Related Macular Degeneration (AMD): Lipoprotein profile and subclass analysis [Poster presentation]. 11e JS du RFMF, Liege, Belgium.

HUART, J., Leenders, J., Taminiau, B., DESCY, J., SAINT-REMY, A., Daube, G., KRZESINSKI, J.-M., MELIN, P., De Tullio, P., & JOURET, F. (18 May 2018). GUT MICROBIOTA AND FAECAL LEVELS OF SHORT CHAIN FATTY ACIDS DIFFER UPON BLOOD PRESSURE LEVELS IN MAN. Nephrology Dialysis Transplantation, 33 (Issue suppl_1), 368–i369. doi:10.1093/ndt/gfy104.SP069

Leenders, J., Martin, M., NISOLLE, M., Munaut, C., Govaerts, B., & De Tullio, P. (May 2018). Endometriosis: deep insight into the pathology through metabolomics [Poster presentation]. 11 Journées scientifiques du RFMF (Réseau Francophone de Métabolomique et Fluxomique), Liège, Belgium.

Salvé, M., Avohou, T. H., Monbaliu, J.-C., Lebrun, P., Lemaire, C., Damblon, C., De Tullio, P., Hubert, P., Hustinx, R., & Luxen, A. (12 February 2018). NOTA‐PRGD2 and NODAGA‐PRGD2: Bioconjugation, characterization, radiolabelling, and design space. Journal of Labelled Compounds and Radiopharmaceuticals, 61, 487-500. doi:10.1002/jlcr.3613

Cauchie, E., Korsak Koulagenko, N., Leenders, J., Baré, G., Tahiri, A., Delhalle, L., De Tullio, P., & Daube, G. (2018). A NMR-based metabolomics approach for reducing food losses: the example of minced pork meat. In Proceedings of the First international Conference on "Innovative Food Ingredients and Food safety" (pp. 89-99). Bangkok, Thailand: Asian Institute of Technology.

Goffin, E.* , Drapier, T.* , Probst Larsen, A., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., De Tullio, P., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Sandholm Kastrup, J., & Francotte, P. (2018). 7‐Phenoxy-Substituted 3,4-Dihydro‐2H‐1,2,4-benzothiadiazine 1,1- Dioxides as Positive Allosteric Modulators of α‐Amino-3-hydroxy-5- methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. Journal of Medicinal Chemistry, 61, 251-264. doi:10.1021/acs.jmedchem.7b01323

Tommelein, J., De Vlieghere, E., Verset, L., Melsens, E., Leenders, J., Descamps, B., Debucquoy, A., Vanhove, C., Pauwels, P., Gespach, C. P., Vral, A., De Boeck, A., Haustermans, K., De Tullio, P., Ceelen, W., Demetter, P., Boterberg, T., Bracke, M., & De Wever, O. (2018). Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF-1R activation. Cancer Research. doi:10.1158/0008-5472.CAN-17-0524

Yakulov, T. A., Todkar, A. P., Slanchev, K., Wiegel, J., Bona, A., Gross, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T. B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., De Tullio, P., Jouret, F., Kramer-Zucker, A., & Walz, G. (2018). CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nature Communications, 9 (1), 3660. doi:10.1038/s41467-018-06094-4

CHIAP, P., Van Heugen, J.-C., Dubrowski, T., DEVILLE, M., DUBOIS, N., & De Tullio, P. (19 October 2017). Utilisation de la Résonance Magnétique Nucléaire (RMN) pour la caractérisation de métabolites et de produits de dégradation de médicaments [Paper presentation]. 6èmes Journées Internationales de Toxicologie, Liège, Belgium.

Cauchie, E., Leenders, J., Baré, G., Tahiri, A., Delhalle, L., Korsak Koulagenko, N., De Tullio, P., & Daube, G. (13 October 2017). A NMR-based metabolomics study of minced pork meat inoculated with Brochothrix thermosphacta, Leuconostoc gelidum and Pseudomonas fragi [Poster presentation]. FARAH Day 2017, Liège, Belgium.

Leenders, J., Buemi, A., Mourad, M., Buemi, A., JOURET, F., & De Tullio, P. (04 October 2017). Development of an analytical pre-treatment protocol for NMR metabolomic analysis of frozen kidney samples in OCT (Optimal Cutting Temperature Compound) [Paper presentation]. Spectrométrie de Masse, Métabolomique et Analyse Protéomique 2017 (SMMAP 2017).

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (02 October 2017). New translational metabolomics exploration of age-related macular degeneration: from patients to functional implication of lactate [Paper presentation]. SMMAP 2017, Paris, France.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (02 October 2017). New Translational Metabolomics Exploration of Age-Related Macular Degeneration: From Patients to Functional Implication of Lactate [Poster presentation]. SMMAP 2017, Paris, France.

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (14 September 2017). From Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. 31éme ournée Franco-Belge de Pharmacochimie, SPA, Belgium.

Schoumacher, M., Lambert, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., RAKIC, J.-M., Noël, A., & De Tullio, P. (14 September 2017). Drug Target Discovery for Age-Related Macular Degeneration (AMD) Through a Metabolomics Approach [Poster presentation]. Journées Franco-Belges de Pharmacochimie, SPA, Belgium.

Leenders, J., Munaut, C., NISOLLE, M., Govaerts, B., & De Tullio, P. (12 September 2017). Metabolomics approaches of endometriosis [Paper presentation]. PhD day of the 2017 EDT pharmaceutical sciences 2017.

Habyarimana, J. B. A., Baise, E., Douny, C., Weber, M., BOEMER, F., De Tullio, P., Franck, T., Marcillaud-Pitel, C., Frederich, M., Mouithys-Mickalad, A., Richard, E., Scippo, M.-L., Votion, D., & Gustin, P. (2017). Development of an HPTLC method for determination of hypoglycin A in aqueous extracts of seedlings and samaras of Acer species. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/212226. doi:10.1101/148262

Schnekenburger, M., Goffin, E., Lee, J.-Y., Jang, J. Y., Mazumder, A., Ji, S., Rogister, B., Bouider, N., Lefranc, F., Miklos, W., Mathieu, V., De Tullio, P., Kim, K.-W., Dicato, M., Berger, W., Han, B., Kiss, R., Pirotte, B., & Diederich, M. (08 June 2017). Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. Journal of Medicinal Chemistry, 60 (11), 4714-4733. doi:10.1021/acs.jmedchem.7b00533

Bigazzi, W., Dufour, G., De Tullio, P., Piel, G., Cataldo, D., & Evrard, B. (June 2017). Interest of cylodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide [Poster presentation]. EuroDrying’2017 – 6th European Drying Conference, Liège, Belgium.

Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103

Feraud, B., Rousseau, R., De Tullio, P., Verleysen, M., & Govaerts, B. (2017). Independent Component Analysis and Statistical Modelling for the Identification of Metabolomics Biomarkers in 1H-NMR Spectroscopy. Journal of Biometrics and Biostatistics, 8 (4), 1-8. doi:10.4172/2155-6180.1000367

Leenders, J., Buemi, A., Mourad, M., De Tullio, P.* , & Jouret, F.*. (2017). Nuclear magnetic resonance-based metabolomics of OCT-embedded frozen kidney samples in mouse and man following standardized pre-analytics. Metabolomics, 13 (8). doi:10.1007/s11306-017-1232-9

Blomme, A., Costanza, B., De Tullio, P., Thiry, M., Van Simaeys, G., Boutry, S., Doumont, G., Di Valentin, E., Hirano, T., Yokobori, T., GOFFLOT, S., Peulen, O., Bellahcene, A., Sherer, F., Le Goff, C., Cavalier, E., Mouithys-Mickalad, A., Jouret, F., CUSUMANO, G., ... Turtoi, A. (2016). Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer. Oncogene. doi:10.1038/onc.2016.369

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Scheijen, J., Schalkwijk, C., Leenders, J., De Tullio, P., BIANCHI, E., Thiry, M., Uchida, K., Spiegel, D., Cochrane, J., ... Bellahcene, A. (2016). Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP- mediated tumor growth and metastasis. eLife. doi:10.7554/eLife.19375

Jouret, F., Leenders, J., Defraigne, J.-O., Krzesinski, J.-M., & De Tullio, P. (22 September 2016). Nuclear Magnetic Resonance Metabolomic Profiling of Mouse Kidney, Urine and Serum Following Renal Ischemia/Reperfusion Injury. PLoS ONE, 11 (9), 1-14. doi:10.1371/journal.pone.0163021

Baré, G., Cauchie, E., Leenders, J., Tahiri, A., Delhalle, L., Korsak Koulagenko, N., De Tullio, P., & Daube, G. (July 2016). Challenge testing with Brochothrix thermosphacta on minced pork meat shows interest to couple metagenetics to metabolomics to study food spoilage [Poster presentation]. 17th European Congress on Biotechnology, Cracovie, Poland.

Schoumacher, M., LAMBERT, V., Hansen, S., Leenders, J., Govaerts, B., Pirotte, B., Rakic, J.-M., Noël, A., & De Tullio, P. (27 June 2016). New Insight into exudative Age-related Macular Degeneration (AMD): A Metabolomics Approach [Poster presentation]. Metabolomics 2016, Dublin, Ireland.

Leenders, J., JOURET, F., De Tullio, P., POMA, L. (Other coll.), Defraigne, J.-O. (Other coll.), & KRZESINSKI, J.-M. (Other coll.). (June 2016). Nuclear magnetic resonance profiling of mouse kidney, urine and serum following renal ischemia/reperfusion injury [Poster presentation]. 12th Annual Conference of the Metabolomics Society, Dublin, Ireland.

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (May 2016). From Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK) [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie, Amboise, France.

Leenders, J., De Tullio, P., Munaut, C., Govaerts, B., Nisolle, M. (Other coll.), & Martin, M. (Other coll.). (May 2016). Endometriosis : clinical study of human serum and urine using metabolomics [Poster presentation]. 30èmes Journées Franco-Belges de Pharmacochimie, Amboise, France.

Leenders, J., De Tullio, P., Munaut, C., Nisolle, M. (Other coll.), Martin, M. (Other coll.), & Govaerts, B. (Other coll.). (May 2016). Endometriosis : clinical study of human serum and urine using metabolomics [Poster presentation]. 10èmes Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique, Montpellier, France.

Schoumacher, M., De Tullio, P., LAMBERT, V. (Other coll.), Hansen, S. (Other coll.), Leenders, J. (Other coll.), Govaerts, B. (Other coll.), Pirotte, B. (Other coll.), RAKIC, J.-M. (Other coll.), & Noël, A. (Other coll.). (May 2016). From Metabolomics to Identification of a new therapeutic approach for Age-Related Macular Degeneration (AMD) [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie, Amboise, France.

Leenders, J., De Tullio, P., KRZESINSKI, J.-M., & JOURET, F. (21 April 2016). Study of ischemia-reperfusion injury by metabolomics [Paper presentation]. Séminaires CIRM.

Leroi, N., BLACHER, S., Lallemand, F., Leenders, J., De Tullio, P., COUCKE, P., Noël, A., & MARTINIVE, P. (30 January 2016). Metabolomic analyzes of the tumor microenvironment after neoadjuvant radiotherapy implicated in surgery-related metastatic spreading [Paper presentation]. BACR, Bruxelles, Belgium.

Frederich, M., Pirotte, B., Fillet, M., & De Tullio, P. (2016). Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine. Journal of Medicinal Chemistry, 59 (19), 8649–8666. doi:10.1021/acs.jmedchem.5b01335

Harrouche, K., Renard, J., Bouider, N., De Tullio, P., Goffin, E., Lebrun, P., Faury, G., Pirotte, B., & Khelili, S. (2016). Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process. European Journal of Medicinal Chemistry, 115, 352-360. doi:10.1016/j.ejmech.2016.03.028

Pirotte, B., Florence, X., Goffin, E., Medeiros, M., De Tullio, P., & Lebrun, P. (2016). 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion. European Journal of Medicinal Chemistry, 121, 338-351. doi:10.1016/j.ejmech.2016.05.042

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Eppe, G., Castronovo, V., & Mottet, D. (03 December 2015). Compensatory Metabolism Promotes Cancer Cell Adaptation to HDAC5 Silencing [Poster presentation]. Séminaires des chercheurs Télévie 2016, Gembloux, Belgium.

Habyalimana, V., Mbinze Kindenge, J., Kalenda Tshilombo, N., Dispas, A., Yemoa Loconon, A., Sacre, P.-Y., Widart, J., De Tullio, P., Counerotte, S., Kadima Ntokamunda, J.-L., Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R. (02 December 2015). Analytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines. American Journal of Analytical Chemistry, 6, 977-994. doi:10.4236/ajac.2015.613093

Arslan, D., Schoumacher, M., Pirotte, B., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (12 November 2015). FROM METABOLOMICS STUDY OF AGE RELATED MACULAR DEGENERATION (AMD) TO THE DEVELOPMENT OF NEW PDK INHIBITORS [Poster presentation]. International Gazi Pharma Symposium Series, Antalya, Turkey.

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Leenders, J., De Tullio, P., BIANCHI, E., Thiry, M., Uchida, K., Spiegel, D., Cochrane, J., Hutton, C., De Pauw, E., ... Bellahcene, A. (29 September 2015). Methylglyoxal, a glycolysis side-product, induces Hsp90 post-translational glycation and YAP-mediated breast tumor growth and metastasis [Poster presentation]. Cancer and Metabolism Conference, Cambridge, United Kingdom.

Jouret, F., Leenders, J., POMA, L., Defraigne, J.-O., Krzesinski, J.-M., & De Tullio, P. (13 September 2015). METABOLOMIC STUDY OF MOUSE KIDNEY AND URINE FOLLOWING RENAL ISCHEMIA/REPERFUSION [Poster presentation]. 17th Congress of the European Society for Organ Transplantation, Brussels, Belgium.

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Smargiasso, N., De Tullio, P., BIANCHI, E., Baiwir, D., Thiry, M., Turtoi, A., De Pauw, E., DELVENNE, P., Castronovo, V., & Bellahcene, A. (09 September 2015). Methylglyoxal, a glycolysis side-product, induces Hsp90 post-translational glycation and YAP-mediated breast tumor growth and metastasis [Poster presentation]. Metabolism in Cancer and Stromal Cells, Leuven, Belgium.

Feraud, B., Govaerts, B., Verleysen, M., & De Tullio, P. (23 July 2015). Statistical treatment of 2D NMR COSY spectra in metabolomics: data preparation, clustering-based evaluation of the Metabolomic Informative Content and comparison with 1H-NMR. Metabolomics, 11 (6), 1756-1768. doi:10.1007/s11306-015-0830-7

Ledoux, A., Martin, B., De Tullio, P., Tits, M., Wauters, J.-N., Choi, Y. H., Bodson, M., & Frederich, M. (16 July 2015). Metabolomics analysis of Galium odoratum (L.) Scop.: impact of the plant population origin and growth conditions [Poster presentation]. 2ème Symposium international AFERP – STOLON, Lyon, France.

Leenders, J., De Tullio, P., Jouret, F., POMA, L. (Other coll.), KRZESINSKI, J.-M. (Other coll.), & DEFRAIGNE, J. (Other coll.). (09 June 2015). Metabolomic study of mouse kidney and urine in ischemia-reperfusion injury [Paper presentation]. 9èmes Journées Scientifiques du Reseau Francophone de Métabolomique et Fluxomique, France.

Leenders, J., JOURET, F., De Tullio, P., POMA, L. (Other coll.), Defraigne, J.-O. (Other coll.), & KRZESINSKI, J.-M. (Other coll.). (June 2015). Study of ischemia-reperfusion injury in mouse kidney and urine by metabolomics [Poster presentation]. 29ème Journées Franco-belge de Pharmachimie.

Martin, B., Frederich, M., De Tullio, P., Tits, M., Wauters, J.-N., Choi, & Bodson, M. (June 2015). Metabolomics analysis of Galium odoratum (L.) Scop.: impact of the plant population origin and growth conditions. Current Metabolomics, 3.

Schoumacher, M., Arslan, D., De Tullio, P., Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), Noël, A. (Other coll.), & Pirotte, B. (Other coll.). (June 2015). From Metabolic Study of Age-Related Macular Degeneration (AMD) to Development of New PDH Kinase Inhibitors [Poster presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Habyalimana, V., Dispas, A., Sacre, P.-Y., Widart, J., De Tullio, P., Counerotte, S., Kadima, N. J., Ziemons, E., Hubert, P., & Marini Djang'Eing'A, R. (28 May 2015). USE OF SIMPLE AND COMPLEX ANALYTICAL TOOLS TO DETECT POOR QUALITY MEDICINES: CASE OF RWANDA [Paper presentation]. 18th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Leenders, J., De Tullio, P., Jouret, F., POMA, L. (Other coll.), Defraigne, J.-O. (Other coll.), & KRZESINSKI, J.-M. (Other coll.). (30 April 2015). Metabolomic study of mouse kidney and urine in ischemia/reperfusion injury [Paper presentation]. Belgian Society of Nephrology, Annual Meeting, Brussels, Belgium.

Bentaib, A., De Tullio, P., Chneiweiss, H., Hermans, E., Junier, M.-P., & Leprince, P. (March 2015). Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study. Data in Brief, 2 (0), 1-5. doi:10.1016/j.dib.2014.09.004

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (11 February 2015). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. Seminaires des chercheurs Télévie 2015, Bruxelles, Belgium.

Blomme, A., Costanza, B., Thiry, M., De Tullio, P., Perez-Palacios, A., Mouithys-Mickalad, A., LIFRANGE, E., Delvenne, P., Castronovo, V., & Turtoi, A. (31 January 2015). Myoferlin Regulates Endosomal Trafficking and Tunes Cancer Cell Metabolism [Poster presentation]. ASSOCIATION BELGE POUR L'ETUDE DU CANCER "A.B.E.C» ANNUAL MEETING 2015: TUMOR METABOLISM AND MITOCHONDRIA, Louvain, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (31 January 2015). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. ABEC TUmor Metabolism and Mitochondria, Bruxelles, Belgium.

WEEKERS, L., De Tullio, P., BOVY, C., Poma, L., Marée, R., BONVOISIN, C., Defraigne, J.-O., Krzesinski, J.-M., & Jouret, F. (30 January 2015). Activation of the calcium-sensing receptor before renal ischemia/reperfusion exacerbates kidney injury. American Journal of Translational Research, 7 (1), 128-138.

Blomme, A., Costanza, B., Thiry, M., De Tullio, P., Perez Palacios, A., LIFRANGE, E., DELVENNE, P., Castronovo, V., & Turtoi, A. (27 January 2015). Myoferlin regulates endosomal trafficking and tunes cancer cell metabolism [Poster presentation]. GIGA-DAY 2015: Current advances in medical genetics and genomics, Liège, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (27 January 2015). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. Giga Cancer Day 2015 Current Advances in Medical Genetics and Genomics, Liège, Belgium.

Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Smargiasso, N., Baiwir, D., De Pauw, E., De Tullio, P., Thiry, M., Peulen, O., Turtoi, A., Castronovo, V., & Bellahcene, A. (27 January 2015). Accumulation of methylglyoxal, a glycolysis by-product modulates YAP1 transcription co-factor localization and activity in human breast cancer cells through HSP90 modification [Poster presentation]. GIGA-DAY: Current advances in medical genetics and genomics, Liège, Belgium.

Bentaib, A., De Tullio, P., Chneiweiss, H., Hermans, E., Junier, M.-P., & Leprince, P. (January 2015). Metabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study. Journal of Proteomics, 113, 292-314. doi:10.1016/j.jprot.2014.09.019

Cieckiewicz, E., Mathieu, V., Angenot, L., Gras, T., Dejaegher, B., De Tullio, P., Pirotte, B., & Frederich, M. (2015). Semisynthesis and in Vitro Photodynamic Activity Evaluations of Halogenated and Glycosylated Derivatives of Pheophorbide a. European Journal of Organic Chemistry, 2015 (27), 6061-6074. doi:10.1002/ejoc.201500387

Dufour, G., Bigazzi, W., Wong, N., Boschini, F., De Tullio, P., Piel, G., CATALDO, D., & Evrard, B. (2015). Interest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide. International Journal of Pharmaceutics, 495 (2), 869-878. doi:10.1016/j.ijpharm.2015.09.052

Dufour, G., Evrard, B., & De Tullio, P. (2015). Rapid quantification of 2-hydroxypropyl-β-cyclodextrin in liquid pharmaceutical formulations by 1H nuclear magnetic resonance spectroscopy. European Journal of Pharmaceutical Sciences. doi:10.1016/j.ejps.2015.03.005

Dufour, G.* , Evrard, B.* , & De Tullio, P.*. (2015). 2D-COSY NMR spectroscopy as a quantitative tool in biological matrix: Application to cyclodextrins. AAPS Journal. doi:10.1208/s12248-015-9806-9

Habyarimana, J. B. A., BOEMER, F., Amory, H., Baise, E., Carlier, J., De Tullio, P., Douny, C., Gault, G., Gustin, P., Fanck, T., Frederich, M., Marcillaud-Pitel, C., Richard, E., Patarin, F., Weber, M., & Votion, D. (2015). Les nouveaux outils de diagnostic et de pronostic de la myopathie atypique. In Proceeding de la 41ème Journée de la Recherche équine.

Leenders, J., Frederich, M., & De Tullio, P. (2015). Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process. Drug Discovery Today. Technologies, 13, 39-46. doi:10.1016/j.ddtec.2015.06.005

Munaut, C., Leenders, J., LABIED, S., Martin, M., Govaerts, B., De Tullio, P., & NISOLLE, M. (2015). Use of an endometriosis model in rats to reveal new non invasive biomarkers [Paper presentation]. 31ème meeting annuel de l’European Society of Human Reproduction & Embryology (ESHRE).

Francotte, P.* , Nørholm, A.-B.* , Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., De Tullio, P., Challal, S., Thomas, J.-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S., & Pirotte, B. (06 November 2014). Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. Journal of Medicinal Chemistry, 57 (22), 9539-9553. doi:10.1021/jm501268r

JOURET, F., Leenders, J., De Tullio, P., POMA, L. (Other coll.), Defraigne, J.-O. (Other coll.), & KRZESINSKI, J.-M. (Other coll.). (November 2014). Metabolomics study of mouse kidney and urine in ischemia/reperfusion injury [Poster presentation]. American Society of Nephrology - Kidney Week, Philadelphia, United States.

Cimino, J., Sounni, N. E., Blacher, S., Primac, I., Truong, A., Mazzucchelli, G., PAYE, A., Debois, D., De Tullio, P., De Pauw, E., & Fassotte-Noël, A. (30 September 2014). Blocking lipid synthesis overcomes tumor re-growth and metastasis after anti-angiogenic therapy withdrawal [Paper presentation]. EDT CANCER 2014.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (30 September 2014). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Paper presentation]. Annual Mini symposium 2014, Liège, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (25 September 2014). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. Metabolism and Cancer Nice, Nice, France.

Arslan, D., Pirotte, B., De Tullio, P., Charif, M. (Other coll.), Dilly, S. (Other coll.), Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (09 September 2014). AGE-RELATED MACULAR DEGENERATION (AMD): FROM METABOLOMICS APPROACH TO THE INHIBITION OF PDK AS A NEW THERAPEUTIC TARGET [Poster presentation]. XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC 2014), Lisbonne, Portugal.

Ponthier, J., De Tullio, P., Parrilla Hernandez, S., Blommaert, D., GASPARD, O., & Deleuze, S. (September 2014). Glucose use and lactate production by equine fresh semen in human and equine extender. Reproduction in Domestic Animals, 49 (suppl 3), 13.

LAMBERT, V., Dufour, G., Chiap, P., Evrard, B., Noël, A., Pirotte, B., & De Tullio, P. (23 June 2014). NMR in the Pharmaceutical and Biomedical areas for identification and quantification of drugs and metabolomics applications [Paper presentation]. Drug Analysis 2014, Liège, Belgium.

Arslan, D., Pirotte, B., De Tullio, P., Charif, M. (Other coll.), Dilly, S. (Other coll.), Hansen, S. (Other coll.), LAMBERT, V. (Other coll.), Elmoualij, B. (Other coll.), & Noël, A. (Other coll.). (June 2014). Inhibition of PDH Kinase as a new therapeutic target for Age-related Macular Degeneration (AMD) [Poster presentation]. 28e Journées franco-belges de Pharmacochimie, Communauté de Metz Métropole, France.

Dufour, G., Evrard, B., & De Tullio, P. (June 2014). Quantification of 2-hydroxypropyl-β-cyclodextrin in liquid pharmaceutical formulations by using 1H Nuclear Magnetic Resonance spectroscopy [Poster presentation]. 10th International Symposium on Drug Analysis; 25th International Symposium on Pharmaceutical and Biomedical Analysis.

Cimino, J., Sounni, N. E., Debois, D., Truong, A., Quoirin, G., Blacher, S., De Tullio, P., De Pauw, E., & Fassotte-Noël, A. (19 May 2014). Tumor shift their metabolism to evade anti-angiogenic therapy. Poster presentation [Poster presentation]. GIGA-CANCER DAY.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (19 May 2014). Glucose-dependent metabolic reprogramming in HDAC5-depleted cancer cells [Poster presentation]. Giga Cancer Day 2014 THE LYMPHATIC SYSTEM : THE BED AND BENCH POINT OF VIEWS, Liège, Belgium.

JOURET, F., Poma, L., Defraigne, J.-O., Krzesinski, J.-M., & De Tullio, P. (May 2014). Metabolomics analysis of urine and kidney samples after renal ischemia/reperfusion injury in mouse. Transplant International, 27, 1.

Cimino, J., Sounni, N. E., Blacher, S., Primac, I., Truong, A., Mazzucchelli, G., PAYE, A., Debois, D., De Tullio, P., De Pauw, E., & Fassotte-Noël, A. (25 April 2014). Mechanisms of Tumor Adaptation to anti-angiogenic Receptor Tyrosine Kinase Inhibitors (RTKIs) [Poster presentation]. GIGA CANCER DAY 2014.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (25 April 2014). Glucose-dependent metabolic reprogramming in HDAC5-depleted cancer cells [Poster presentation]. Reactive Oxygen Species in Cell Metabolism 11th Meeting of the FRS-FNRS contact group on oxidative stress and anti-oxidants 210th Meeting of the Belgian Society of Biochemistry and Molecular Biology, Belgium.

Dufour, G., Evrard, B., & De Tullio, P. (April 2014). Detection and quantification of 2-hydroxypropyl-β-cyclodextrin in solution by 1H NMR spectroscopy as a tool for quality control [Poster presentation]. 9TH WORLD MEETING on Pharmaceutics, Biopharmaceuticsand Pharmaceutical Technology.

Cataldo, D., Evrard, B., Dufour, G., De Tullio, P., & Maes, P. (28 March 2014). Compositions of Cyclodextrin with Budesonide Derivatives and Methods.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Castronovo, V., & Mottet, D. (01 February 2014). Complex I Mitochondrial Dysfunction in HDAC5-depleted Cancer Cells Induces Glucose-dependent Metabolic Reprogramming [Poster presentation]. Association Belge pour l'étude du cancer A.B.E.C 2014, Anvers, Belgium.

Cimino, J., Sounni, N. E., Debois, D., Truong, A., Blacher, S., De Tullio, P., De Pauw, E., & Fassotte-Noël, A. (29 January 2014). Cancer metabolism adaptation to Receptor Tyrosine Kinase (RTK) inhibition [Poster presentation]. GIGA DAY 2014.

Hendrick, E., Peixoto, P., Matheus, N., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (27 January 2014). Complex I Mitochondrial Dysfunction in HDAC5-depleted Cancer Cells Induces Glucose-dependent Metabolic Reprogramming [Poster presentation]. Giga Day 2014, Liège, Belgium.

Cataldo, D., Evrard, B., Dufour, G., De Tullio, P., & Maes, P. (2014). Composition of Cyclodextrin with Budesonide Derivatives for treatment and Prevention of Pulmonary Inflammatory Disease.

Florence, X., Desvaux, V., Goffin, E., De Tullio, P., Pirotte, B., & Lebrun, P. (2014). Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers? European Journal of Medicinal Chemistry, 80, 36-46. doi:10.1016/j.ejmech.2014.04.024

Jouret, F., De Tullio, P., Poma, L., Marée, R., BOVY, C., & DEFRAIGNE, J. (2014). ACTIVATION OF THE CALCIUM-SENSING RECEPTOR BEFORE RENAL ISCHEMIA/REPERFUSION EXACERBATES KIDNEY INJURY IN MOUSE. Transplant International, 27 suppl 1, 15-20.

Matheus, N., Hansen, S., Rozet, E., Peixoto, P., Maquoi, E., LAMBERT, V., Noël, A., Frederich, M., Mottet, D., & De Tullio, P. (January 2014). An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics. Phytochemical Analysis, 25, 342-349. doi:10.1002/pca.2498

Ponthier, J., De Tullio, P., Blommaert, D., Parrilla Hernandez, S., & Deleuze, S. (January 2014). Sperm Motility and Lactate production at different sperm concentrations. Journal of Equine Veterinary Science, 34 (1), 75-76.

Sounni, N. E., Cimino, J., Blacher, S., Primac, I., Truong, A., Mazzucchelli, G., Paye, A., Calligaris, D., Debois, D., De Tullio, P., Mari, B., De Pauw, E., & Noël, A. (2014). Blocking lipid synthesis overcomes tumor re-growth and metastasis after anti-angiogenic therapy withdrawal. Cell Metabolism, 20 (2), 280-94. doi:10.1016/j.cmet.2014.05.022

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., Elmoualij, B., De Tullio, P., Castronovo, V., & Mottet, D. (05 December 2013). HDAC5 depletion Decreases NDUFB5 Subunit of Mitochondrial Complex- I leading to Glucose-dependent Metabolic Reprogrammation [Poster presentation]. Séminaire des chercheurs Télévie 2014, Bruxelles, Belgium.

LAMBERT, V., De Tullio, P., & Hansen, S. (04 October 2013). Age-related Macular Degeneration Study: A Metabolomics Approach [Paper presentation]. GIGA Cancer Seminar.

Francotte, P., Goffin, E., Fraikin, P., Graindorge, E., Lestage, P., Danober, L., Challal, S., Rogez, N., Nosjean, O., Caignard, D.-H., Pirotte, B., & De Tullio, P. (03 October 2013). Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors. Journal of Medicinal Chemistry, 56 (20), 7838-7850. doi:10.1021/jm400676g

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Castronovo, V., & Mottet, D. (13 September 2013). Complexe I mitochondrial dysfunction in HDAC5 depleted cancer cells induces glucose-dependent metabolic reprogrammation [Poster presentation]. Annual Mini symposium 2013, Bruxelles, Belgium.

Morin, A. N., Detrembleur, C., Jérôme, C., De Tullio, P., Poli, R., & Debuigne, A. (11 June 2013). Effect of head-to-head addition in vinyl acetate controlled radical polymerization: why is Co(acac)2-mediated polymerization so much better? Macromolecules, 46 (11), 4303-4312. doi:10.1021/ma400651a

Arslan, D., Dilly, S., LAMBERT, V., Hansen, S., RAKIC, J.-M., Noël, A., Govaerts, B., Pirotte, B., & De Tullio, P. (06 June 2013). Age-related Macular Degeneration (AMD): from Metabolomics approach to the inhibition of PDH Kinase as a new therapeutic target [Poster presentation]. 27e Journées franco-belges de Pharmacochimie, Lille, France.

Votion, D., Van Galen, G., Sweetan, BOEMER, F., De Tullio, P., Dopagne, C., Lefere, L., Mouithys-Mickalad, A., Patarin, F., Rouxhet, S., van Loon, G., Serteyn, D., Sponseller, B., & Valber, S. (2013). Identification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy. Equine Veterinary Journal. doi:10.1111/evj.12117

LAMBERT, V., Hansen, S., Rousseau, R., Govaerts, B., Pirotte, B., RAKIC, J.-M., Noël, A., & De Tullio, P. (23 May 2013). Age-related Macular Degeneration Study: A Metabolomics Approach [Paper presentation]. First Belgian-Netherlands Joint Symposium on Metabolomics: Transational approaches in Metabolomics, Spa, Belgium.

Cimino, J., Sounni, N. E., Debois, D., Blacher, S., De Tullio, P., De Pauw, E., & Fassotte-Noël, A. (17 May 2013). Mechanism of resistance to anti-angiogenic therapy [Poster presentation]. GIGA CANCER DAY 2013.

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Castronovo, V., & Mottet, D. (17 May 2013). Mitochondrial dysfunction in HDAC5-depleted cancer cells induces glucose-dependent metabolic adaptation [Poster presentation]. GIGA-Cancer Day 2013, Liège, Belgium.

Cimino, J., Sounni, N. E., Debois, D., Blacher, S., De Tullio, P., De Pauw, E., & Fassotte-Noël, A. (13 May 2013). New mechanism of resistance to anti-angiogenic therapy [Paper presentation]. Metabolomic seminar.

Rozet, E., De Tullio, P., Hubert, P., & Govaerts, B. (13 May 2013). MEASURING VARIABILITY SOURCES IN NMR METABOLOMIC STUDIES [Paper presentation]. First Belgian-Netherlands Joint symposium on Metabolomics, SPA, Belgium.

Denooz, R., VAN HEUGEN, J.-C., Frederich, M., De Tullio, P.* , & Charlier, C.*. (March 2013). Identification and structure elucidation of four cannabimimetic compounds in seized products. Journal of Analytical Toxicology, 37 (2), 56-63. doi:10.1093/jat/bks095

Constant-Urban, C., Charif, M., Goffin, E., VAN HEUGEN, J.-C., Elmoualij, B., CHIAP, P., Mouithys-Mickalad, A., Serteyn, D., Lebrun, P., Pirotte, B., & De Tullio, P. (2013). Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic and Medicinal Chemistry Letters, 23, 5878-5881. doi:10.1016/j.bmcl.2013.08.091

Denooz, R., Frederich, M., Charlier, C., & De Tullio, P. (2013). Application de la résonance magnétique nucléaire (RMN) en toxicologie judiciaire. Acta Clinica Belgica, 68 (6), 470.

LAMBERT, V., Lecomte, J., Hansen, S., Blacher, S., Alvarez Gonzalez, M.-L., Struman, I., Sounni, N. E., Rozet, E., De Tullio, P., Foidart, J.-M., Rakic, J.-M., & Noël, A. (2013). Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice. Nature Protocols, 8 (11), 2197-2211. doi:10.1038/nprot.2013.135

Mouithys-Mickalad, A., Ceusters, J., Charef, M., Pirotte, B., Ballarini, M., Franck, T., Elmoualij, B., Plyte, S., Fancelli, D., Deby-Dupont, G., De Tullio, P., & Serteyn, D. (2013). Effects of diazoxide, benzothiadiazine and benzopyrane derivatives on mitochondrial proton and electron leaks of cardiomyocytes (H9C2 cell line) [Poster presentation]. 4th World Congress on Targeting Mitochondria 2013 - Berlin, Germany, Berlin, Germany.

Pirotte, B., De Tullio, P., Florence, X., Goffin, E., Somers, F., Boverie, S., & Lebrun, P. (2013). 1,4,2-Benzo/pyridodithiazine 1,1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1,2,4-Benzo/pyridothiadiazine 1,1-Dioxides Exert a Myorelaxant Activity Linked to a Distinct Mechanism of Action. Journal of Medicinal Chemistry, 56, 3247-3256. doi:10.1021/jm301743b

Pirotte, B., Francotte, P., Goffin, E., & De Tullio, P. (2013). AMPA receptor positive allosteric modulators: a patent review. Expert Opinion on Therapeutic Patents, 23, 615-628. doi:10.1517/13543776.2013.770840

Cimino, J., Sounni, N. E., Calligaris, D., Debois, D., Truong, A., Blacher, S., De Tullio, P., De Pauw, E., & Noël, A. (10 December 2012). Séminaire des chercheurs Télévie 2013 [Poster presentation]. Séminaire des chercheurs Télévie 2013.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., Botez, I., Pirotte, B., & De Tullio, P. (September 2012). Design, Synthesis and Biological Evaluation of 4-Cycloalkyl-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides Acting as AMPA Potentiators [Poster presentation]. ISMC2012, Berlin, Germany.

De Tullio, P. (25 May 2012). Métabolomique et Chimie Médicinale, vers la découverte de nouvelles cibles thérapeutiques : application à la dégénérescence maculaire liée à l'âge (DMLA) [Paper presentation]. 26èmes Journées Franco-Belges de Pharmacochimie, Orléans, France.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., De Tullio, P., & Pirotte, B. (24 May 2012). Développement d’agents cognitifs agissant par potentialisation des récepteurs AMPA : Design de nouvelles thiénothiadiazine 1,1-dioxydes [Poster presentation]. 26es Journées Franco-Belges de Pharmacochimie, Orléans, France.

De Tullio, P. (08 May 2012). Biomedical application of NMR metabolomics: study of Age-related Macular Degeneration (AMD) [Paper presentation]. Netherlands Metabolomics Days Spring 2012, Breukelen, Netherlands.

De Tullio, P. (21 March 2012). Modulation des récepteurs glutamatergiques de sous-type AMPA : Pharmacochimie autour du noyau arylthiadiazine 1,1-dioxyde [Paper presentation]. Séminaire de l'ICAO, Orléans, France.

Timmermans, C., De Tullio, P., Lambert, V., Frederich, M., Rousseau, R., & von Sachs, R. (2012). Advantages of the Bagidis methodology for metabonomics analyses: application to a spectroscopic study of Age-related Macular Degeneration. In Proceedings of the 12th European Symposium on Statistical Methods for the Food Industry.

Goffin, E., Lamoral-Theys, D., Tajeddine, N., De Tullio, P., Mondin, L., Lefranc, F., Gailly, P., ROGISTER, B., Kiss, R., & Pirotte, B. (2012). N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis. European Journal of Medicinal Chemistry, 54, 834-44. doi:10.1016/j.ejmech.2012.06.050

Khelili, S., Kihal, N., Yekhlef, M., De Tullio, P., Lebrun, P., & Pirotte, B. (2012). Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells. European Journal of Medicinal Chemistry, 54, 873-878. doi:10.1016/j.ejmech.2012.05.011

Francotte, P., De Tullio, P., Pirotte, B., Botez, I., Danober, L., & Lestage, P. (14 July 2011). Preparation of cyclopropyl thiochroman derivatives and their use as AMPA receptor modulators.

Ceusters, J., Mouithys-Mickalad, A., De Tullio, P., Elmoualij, B., Plyte, S., Ballarini, M., Fancelli, D., Deby-Dupont, G., Pirotte, B., & Serteyn, D. (2011). MODULATING EFFECT OF THE RESPIRATORY RATE OF CARDIOMYOCYTES (H9C2 CELLS) AND MITOCHONDRIAL SWELLING BY DIAZOXIDE ANALOGUES: STRUCTURE–FUNCTION RELATIONSHIPS [Poster presentation]. 2nd world Congress on Targeting Mitochondria, Berlin, Germany.

De Tullio, P., Servais, A.-C., Fillet, M., Gillotin, F., Somers, F., CHIAP, P., Lebrun, P., & Pirotte, B. (2011). Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-Isopropylamino-4H-1,2,4- benzothiadiazine 1,1-dioxides: Toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability. Journal of Medicinal Chemistry, 54, 8353-8361. doi:10.1021/jm200786z

Dintilhac, G., Arslan, D., Dilly, S., Danober, L., Botez, I., Lestage, P., Pirotte, B., & De Tullio, P. (2011). New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4- benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. MedChemComm, 2, 509. doi:10.1039/c1md00069a

Florence, X., Dilly, S., De Tullio, P., Pirotte, B., & Lebrun, P. (2011). Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process. Bioorganic and Medicinal Chemistry. doi:10.1016/j.bmc.2011.05.040

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2011). Development of cognitive enhancers: design of novel thienothiadiazine 1,1-dioxides acting as AMPA potentiators [Paper presentation]. Giga-day, Liège, Belgium.

Frederich, M., Wauters, J.-N., Tits, M., Jason, C., De Tullio, P., Van der Heyden, Y., Fan, G., & Angenot, L. (2011). Quality Assessment of Polygonum cuspidatum and Polygonum multiflorum by 1H NMR Metabolite Fingerprinting and Profiling Analysis. Planta Medica, 77, 81-86. doi:10.1055/s-0030-1250132

Pirotte, B., De Tullio, P., Boverie, S., Michaux, C., & Lebrun, P. (2011). Impact of the Nature of the Substituent at the 3-Position of 4H-1,2,4-Benzothiadiazine 1,1-Dioxides on Their Opening Activity toward ATP-Sensitive Potassium Channels. Journal of Medicinal Chemistry, 54, 3188-3199. doi:10.1021/jm200100c

De Tullio, P. (25 October 2010). Metabolomics : a new insight into cells and organisms diseases [Paper presentation]. Conférence au SKC-CEN.

De Tullio, P. (08 October 2010). Metabolomics : Toward a better understanding of cells and organisms diseases [Paper presentation]. GiGa-Cancer seminars.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D.-H., De Tullio, P., & Pirotte, B. (08 September 2010). Development of cognitive enhancers acting through AMPA potentiation: design of novel thienothiadiazine 1,1-dioxides [Poster presentation]. ISMC2010, Bruxelles, Belgium.

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D. H. (15 January 2010). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t

Frederich, M., Jansen, C., De Tullio, P., Tits, M., Demoulin, V., & Angenot, L. (2010). Metabolomic analysis of Echinacea spp. by (1)H nuclear magnetic resonance spectrometry and multivariate data analysis technique. Phytochemical Analysis, 21 (1), 61-65. doi:10.1002/pca.1156

Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928

Hemmer, M., Kempen, I., De Tullio, P., Frankenne, F., Lambert, V., Blacher, S., Bueb, J.-L., Foidart, J.-M., Noël, A., Tschirhart, E., & Pirotte, B. (2010). New Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent. Drug Development Research, 71, 1-10. doi:10.1002/ddr.20364

Pirotte, B., De Tullio, P., Nguyen, Q.-A., Somers, F., Fraikin, P., Florence, X., Wahl, P., Hansen, J. B., & Lebrun, P. (2010). Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity. Journal of Medicinal Chemistry, 53, 147-154. doi:10.1021/jm9010093

Pirotte, B., Francotte, P., Goffin, E., fraikin, P., Danober, L., Lesur, B., Botez, I., Caignard, D. H., Lestage, P., & De Tullio, P. (2010). Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators. Current Medicinal Chemistry, 17, 3575-3582. doi:10.2174/092986710792927859

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D.-H. (07 July 2009). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Florence, X., De Tullio, P., Pirotte, B., & Lebrun, P. (June 2009). Original cromakalim analogues as KATP channel openers [Paper presentation]. 2nd International Brussels Pancreatic Islet Symposium, Bruxelles, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2009). Les canaux potassiques ATP-dépendants: nouvelles cibles potentielles pour le traitement de divers troubles métaboliques [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Francotte, P., Fraikin, P., Goffin, E., Danober, L., Lestage, P., Caignard, D. H., Lesur, B., Botez, I., Van Heugen, J.-C., Chiap, P., Pirotte, B., & De Tullio, P. (May 2009). Stabilisation métabolique par introduction d’atomes de fluor : application aux benzothiadiazine 1,1-dioxydes agissant en tant que potentialisateurs AMPA [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Hemmer, M., Bambi Nyanguile, S.-M., De Tullio, P., Konradowski, E., Frankenne, Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2009). Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu’agents anti-cancéreux potentiels [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Dintilhac, G., Florence, X., Guillotin, F., Chiap, P., Lebrun, P., Pirotte, B., & De Tullio, P. (28 April 2009). Synthèse, étude de la métabolisation et évaluation pharmacologique du 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxyde (BPDZ 73) et de ses métabolites [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (03 February 2009). Les canaux potassiques ATP-dépendants : nouvelles cibles potentielles pour le traitement de divers troubles métaboliques [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

Hemmer, M., De Tullio, P., Konradowski, E., Frankenne, F., Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (03 February 2009). Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu’agents anti-cancéreux potentiels [Paper presentation]. Forum des jeunes chercheurs du CIRM, Liège, Belgium.

De Tullio, P. (30 January 2009). Application of Metabolomic Approaches to the Age-related Macular Degeneration (AMD) [Paper presentation]. First Belgian Symposium on Metabolomics and Metabonomics.

Florence, X., De Tullio, P., Pirotte, B., & Lebrun, P. (2009). Original cromakalim analogues as KATP channel openers. Metabolic and Functional Research on Diabetes, 2, 19-44 (A16.

Florence, X., Sebille, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2009). New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as KATP channel openers: modulation of the 4-position. Bioorganic and Medicinal Chemistry, 17, 7723-7731. doi:10.1016/j.bmc.2009.09.041

Kempen, I., Hemmer, M., Counerotte, S., Pochet, L., De Tullio, P., Foidart, J.-M., Blacher, S., Noël, A., Frankenne, F., & Pirotte, B. (December 2008). 6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis. European Journal of Medicinal Chemistry, 43 (12), 2735-50. doi:10.1016/j.ejmech.2008.01.024

Lambert, V., Frederich, M., Rousseau, R., Detry, B., Peulen, O., Rakic, J.-M., Noël, A., Pirotte, B., Govaert, B., & De Tullio, P. (August 2008). 1H NMR metabolomic approach of the laser-induced choroidal neovascularization in mice [Poster presentation]. 20th International Symposium on Medicinal Chemistry, Vienne, Austria.

De Tullio, P. (08 June 2008). The arylthiadiazine 1,1-dioxides in medicinal chemistry [Paper presentation]. Conférence à L'Université de Sienne (Italie).

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (17 May 2008). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2008). 6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Francotte, P., De Tullio, P., Fraikin, P., Goffin, E., Dintilhac, G., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D. H., & Pirotte, B. (May 2008). Development of cognitive enhancers acting through AMPA potentiation: design of novel benzothiadiazine 1,1-dioxides with improved pharmacokinetic profile [Paper presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Hemmer, M., Kempen, I., De Tullio, P., Haan, , Lambert, V., Noël, A., Foidart, J.-M., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2008). New biological investigations on the anti-angiogenic agent 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate: in search of its original mechanism of action [Poster presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Francotte, P., De Tullio, P., Podona, T., Diouf, O., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2008). Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. Bioorganic and Medicinal Chemistry, 16 (23), 9948-56. doi:10.1016/j.bmc.2008.10.036

Frederich, M., Jansen, C., De Tullio, P., Demoulin, V., Tits, M., & Angenot, L. (2008). Metabolomic analysis of Echinacea sp. by H-1 Nuclear magnetic resonance spectrometry and multivariate analysis techniques. Planta Medica, 74 (9), 1089-1089.

Khelili, S., Florence, X., Bouhadja, M., Abdelaziz, S., Mechouch, N., Mohamed, Y., De Tullio, P., Lebrun, P., & Pirotte, B. (2008). Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators. Bioorganic and Medicinal Chemistry, 16, 6124-6130. doi:10.1016/j.bmc.2008.04.043

Lebrun, P., Becker, B., Morel, N., Ghisdal, P., Antoine, M.-H., De Tullio, P., & Pirotte, B. (2008). KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1 -dioxides. Biochemical Pharmacology, 75, 468-475. doi:10.1016/j.bcp.2007.08.032

Sebille, S., De Tullio, P., Florence, X., Becker, B., Antoine, M.-H., Michaux, C., Wouters, J., Pirotte, B., & Lebrun, P. (2008). new R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylainothiocarbonylamino)-2H-1-benzopyrans structually related to (+/-)-cromakalim as tissue-selective pancreatic beta-celle KATP channel openers. Bioorganic and Medicinal Chemistry, 16, 5704-5719.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (October 2007). Design, synthesis, and pharmacological evaluation of cromakalim analogues as pancreatic β-cell-selective KATP channel openers [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Francotte, P., Gillotin, F., Van Heuguen, J. C., Frederich, M., Lebrun, P., CHIAP, P., Pirotte, B., & De Tullio, P. (October 2007). Application of LC-SPE-NMR to the structural determination of metabolites of KATP channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Hemmer, M., De Tullio, P., Bernard, Y., Konradowski, E., Frankenne, F., Bueb, J. L., Tschirhart, E., & Pirotte, B. (October 2007). Design, synthesis and anticancer activity of novel hydroxylated coumarin derivatives [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (July 2007). Cromakalim analogues as pancreatic β-cell-selective KATP channel openers [Poster presentation]. 1st International Brussels Islet Symposium, Bruxelles, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2007). Synthèse et évaluation biologique de nouveaux activateurs des canaux potassiques ATP-dépendants en série benzopyrane [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Graindorge, E., Dintilhac, G., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Lesur, B., Caignard, D. H., & Pirotte, B. (May 2007). Design, synthèse et évaluation pharmacologique de 1,2,4-thiénothiadiazine 1,1-dioxydes en tant que nouveaux potentialisateurs AMPA [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Hemmer, M., De Tullio, P., Bernard, Y., Konradowski, E., Frankenne, F., Bueb, J. L., Tschirhart, E., & Pirotte, B. (May 2007). Conception, synthèse et évaluation biologique de composés coumariniques en tant qu’agents anti-cancéreux potentiels [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

De Tullio, P. (2007). Le noyau arylthiadiazine 1,1-dioxyde en chimie médicinale : développements originaux de composés à potentialités thérapeutiques [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/63196

Francotte, P., De Tullio, P., Goffin, E., Dintilhac, G., Graindorge, E., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2007). Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Journal of Medicinal Chemistry, 50 (13), 3153-3157. doi:10.1021/jm070120i

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Novel dipyrazoles acting as glutamate modulators. Expert Opinion on Therapeutic Patents, 17 (12), 1489-1493. doi:10.1517/13543776.17.12.1489

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Cholinergic Transmission and Acetylcholine release enhancers. In Protein Misfolding in neuro degenerative Diseases : Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 96-103). Routledge.

Francotte, P., De Tullio, P., & Pirotte, B. (2007). AChE Inhibitors and their Clinical Assessment. In Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 114-144).

Gillotin, F., De Tullio, P., VAN HEUGEN, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Pirotte, B., & CHIAP, P. (2007). Coupling of the LC-MS/MS and the LC-SPE-NMR for the structural identification of pancreatic KATP channel openers metabolites following in vitro biotransformation [Poster presentation]. HPLC 2007, Gent, Belgium.

Martin, G., Chiap, P., Paquet, P., Pierard, G., De Tullio, P., Martin, Y., Rozet, E., Hubert, P., Crommen, J., & Fillet, M. (2007). Development of a mass spectrometry method for the determination of a melanoma biomarker, 5-S-cysteinyldopa, in human plasma using solid phase extraction for sample clean-up. Journal of Chromatography. A, 1156 (1-2), 141-8. doi:10.1016/j.chroma.2006.12.088

Francotte, P., De Tullio, P., & Pirotte, B. (14 December 2006). Etude de la métabolisation in vitro d’activateurs des canaux potassiques appurtenant à la classe des 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes: utilisation conjuguée de la LC-MS et de la LC-SPE-NMR [Paper presentation]. Forum des jeunes chercheurs du CIRM.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (18 November 2006). In vitro metabolisation study of several 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : combined use of LC-Q-TOF MS/MS and LC-SPE-NMR [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (18 November 2006). New developments in benzopyran derivatives as pancreatic β-cell KATP channel openers [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Frederich, M., Chiap, P., Kremers, P., Francotte, P., Lebrun, P., & Pirotte, B. (17 November 2006). Application of LC-SPE-NMR to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxide derivatives [Paper presentation]. 5th YBMRS, Bruxelles, Belgium.

De Tullio, P., Gillotin, F., Francotte, P., Van Heugen, J.-C., Frederich, M., Lebrun, P., Chiap, P., & Pirotte, B. (August 2006). Combined use of LC-SPE-NMR and LC-MS for the metabolites characterization of ATP-sensitive potassium channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2006). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (June 2006). Application de la LC-SPE-RMN et de la LC-MS à la détermination structurale des métabolites d’activateurs des canaux KATP de la classe des 3-alkylamino-4H-arylthiadiazine 1,1-dioxydes [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Florence, X., De Tullio, P., Lebrun, P., & Pirotte, B. (June 2006). Nouveaux développements dans le domaine des activateurs des canaux potassiques ATP-dépendants en série benzopyrane [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Francotte, P., Fraikin, P., De Tullio, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (June 2006). Design, synthèse et évaluation pharmacologique de 1,2,4-pytridothiadiazine 1,1-dioxydes en tant que nouveaux potentiateurs AMPA [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Gillotin, F., De Tullio, P., Van Heugen, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Chiap, P., & Pirotte, B. (17 May 2006). Application of LC-SPE-NMR and LC-Q-TOF MS/MS to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. 10th Bioforum, Liège, Belgium.

De Tullio, P., Dupont, L., Francotte, P., Counerotte, S., Lebrun, P., & Pirotte, B. (2006). Three-Dimentional Quantitative Structure-Activity Relationships of ATP-Sensitive Potassium (KATP) Channel Openers Belonging to the 3-Alkylamino-4H-1,2,4-benzo- and 3-Alkylamino-4H-1,2,4-pyridothiadiazine 1,1-Dioxide Families. Journal of Medicinal Chemistry, 49, 6779-6788. doi:10.1021/jm060534w

De Tullio, P., Lebrun, P., Florence, X., Antoine, M. H., Francotte, P., & Pirotte, B. (2006). Selective pancreatic ATP-sensitive potassium channel openers for the treatement of glucose homeostasis disorders. Drugs of the Future, 31, 991-1001. doi:10.1358/dof.2006.031.11.1036837

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., & Pirotte, B. (2006). In Search of Novel Ampa Potentiators. Recent Patents on CNS Drug Discovery, 1 (3), 239-46. doi:10.2174/157488906778773661

Francotte, P., De Tullio, P., Fraikin, P., & Pirotte, B. (2006). New trends in the design of drugs against Alzheimer disease. Frontiers in Medicinal Chemistry, 3, 249-284.

Khelili, S., Lebrun, P., De Tullio, P., & Pirotte, B. (2006). Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2-H-1-benzopyran-4-yl)ureas structurally related to cromakalim. Bioorganic and Medicinal Chemistry, 14, 3530-3534. doi:10.1016/j.bmc.2006.01.009

Sebille, S., Gall, D., De Tullio, P., Florence, X., Lebrun, P., & Pirotte, B. (2006). Design, Synthesis and Pharmacological Evaluation of R/S-3,4-Dihydro-2,2-Dimethyl-6-Halo-4-(Phenylaminocarbonylamino)-2H-1-Benzopyrans: Towards Tissue-Selective Pancreatic Beta-Cells KATP Channel Openers Structually Related to (+/-)-Cromakalim. Journal of Medicinal Chemistry, 49, 4690-4697. doi:10.1021/jm060161z

Sebille, S., Pirotte, B., Boverie, S., De Tullio, P., Lebrun, P., & Antoine, M. H. (18 August 2005). Benzopyran derivatives, method of production and use thereof.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D.-H., & Renard, P. (27 July 2005). Preparation of fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D. H., & Renard, P. (27 July 2005). Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

De Tullio, P. (12 May 2005). Toward the discovery of pancreatic B-cells selective ATP-sensitive potassium channel openers [Paper presentation]. 15th Noordwijkerhout-Camerino Symposium.

Florence, X., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2005). Synthèse et évaluation biologique d’analogues 6,7-disubstitués du (R)-3-[2-(1-hydroxypropylamino)]-4H-1,2,4-benzothiadiazine 1,1-dioxyde en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP et leurs analogues biotinylés en tant qu’outils pharmacologiques [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (May 2005). Modulateurs allostériques positifs des récepteurs AMPA de la classe des 1,2,4-benzothiadiazine 1,1-dioxydes : conception, synthèse et évaluation pharmacologique [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Sebille, S., Florence, X., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (May 2005). Vers la découverte d’activateurs sélectifs du canal KATP pancréatique, analogues du cromakalim : synthèse et évaluation pharmacologique du R/S-4-(4-chlorophénylaminothiocarbonylamino)-3,4-dihydro-2,2-diméthyl-6-fluoro-2H-1-benzopyrane [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Boverie, S., Antoine, M.-H., Somers, F., Becker, B., Sebille, S., Ouedraogo, R., Counerotte, S., Pirotte, B., Lebrun, P., & De Tullio, P. (2005). Effect on KATP channel activation properties and tissue selctivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine. Journal of Medicinal Chemistry, 48, 3492-3503. doi:10.1021/jm0311339

De Tullio, P., Boverie, S., Becker, B., Antoine, M.-H., Nguyen, Q.-A., Francotte, P., Counerotte, S., Sebille, S., Pirotte, B., & Lebrun, P. (2005). 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : effect of 6,7-distribution on potency and tissue selectivity. Journal of Medicinal Chemistry, 48, 4990-5000. doi:10.1021/jm0580050

Dupont, L., Boverie, S., De Tullio, P., & Pirotte, B. (2005). Crystal structure of 7-chloro-3-isopropylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H11CIN2O2S2. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 467-468.

Dupont, L., Boverie, S., Pirotte, B., & De Tullio, P. (2005). Crystal structure of 7-chloro-3-isopropoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate, C10H13CIN2O4S H2O. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 565-566.

Dupont, L., Pirotte, B., & De Tullio, P. (2005). Crystal structure of 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide, C10H12CIN3O2S. Zeitschrift für Kristallographie. New Crystal Structures, NCS 220, 353-354.

Pirotte, B., De Tullio, P., Antoine, M.-H., Sebille, S., Florence, X., & Lebrun, P. (2005). New insights into the development pf ATP-sensitive potassium channel openers. Expert Opinion on Therapeutic Patents, 15, 497-504. doi:10.1517/13543776.15.5.497

Sebille, S., De Tullio, P., Becker, B., Antoine, M.-H., Boverie, S., Pirotte, B., & Lebrun, P. (2005). 4,6-Disubstitued 2,2-dimethylchromans structually related to the KATP channel opener cromakalim : design, synthesis, and effect on insulin release and vascular tone. Journal of Medicinal Chemistry, 48, 614-621.

De Tullio, P., Sebille, S., Florence, X., Lebrun, P., & Pirotte, B. (17 November 2004). Utilisation de la spectrométrie RMN dans l’identification de structure de dérivés biotinylés de modulateurs de canaux potassiques ATP-dépendants [Paper presentation]. CREMAN, Séminaire.

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., Pirotte, B., Lestage, P., Danober, L. P., Renard, P., & Caignard, D. H. (12 November 2004). Novel thiadiazine derivatives useful as AMPA receptor modulators, preparation method, and pharmaceutical compositions containing them.

De Tullio, P., Dupont, L., Boverie, S., Becker, B., Antoine, M. H., Sebille, S., Lebrun, P., & Pirotte, B. (August 2004). Improvement of the pharmacophoric model for an agonistic activity of arylthiadiazine dioxides on pancreatic KATP channels using the CoMSIA approach [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2004). Synthesis and biological evaluation of novel 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark.

Boverie, S., De Tullio, P., Sebille, S., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (July 2004). Relaxant effects on the rat uterine smooth muscle of putative K+ATP channel openers [Poster presentation]. EPHAR 2004, Porto, Portugal.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Pirotte, B., & Lebrun, P. (July 2004). New analogues of the potassium channel opener cromakalim : effects on rat pancreatic B-cells and rat aorta rings [Poster presentation]. EPHAR 2004, Porto, Portugal.

Boverie, S., Antoine, M. H., De Tullio, P., Sebille, S., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (June 2004). Synthèse de nouveaux analogues benzothiadiaziniques en tant qu’activateurs potentiels des canaux KATP et leur évaluation pharmacologique in vitro sur cellules B pancréatiques, aorte et utérus de rats [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (June 2004). Prodrogues de modulateurs allostériques positifs des récepteurs AMPA apparentés à l’IDRA-21 : design, synthèse, étude de la stabilité et évaluation pharmacologique [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (June 2004). Nouveaux activateurs des canaux KATP analogues du cromakalim : synthèse et évaluation pharmacologique in vitro sur cellules B pancréatiques et aortes de rats [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (May 2004). Prodrugs of AMPA potentiators structurally related to IDRA-21: design, preparation, hydrolysis study and pharmacological evaluation [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (May 2004). New analogues of the potassium channel opener cromakalim: effects on rat pancreatic B-cells and rat aorta rings [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2004). Produgs of AMPA potentiators structurally related to IDRA21 : design, preparation, hydrolysis study and pharmacological evaluation. Fundamental and Clinical Pharmacology, 595.

Francotte, P., Graindorge, E., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the design of drugs against Alzheimer's disease. Current Medicinal Chemistry, 11 (13), 1757-1778. doi:10.2174/0929867043364946

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the development of positive allosteric modulators of AMPA receptors. Current Medicinal Chemistry - Central Nervous System Agents, 4, 95-103.

Sebille, S., Boverie, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (2004). Effects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators. Fundamental and Clinical Pharmacology, 271.

Sebille, S., De Tullio, P., Antoine, M. H., Boverie, S., Lebrun, P., & Pirotte, B. (2004). New analogues of the KATP channel opener cromakalim : synthesis and pharmacological evaluation on rat pancreatic B-cells and rat aorta rings. Fundamental and Clinical Pharmacology, 599.

Sebille, S., De Tullio, P., Boverie, S., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2004). Recent developments in the chemistry of potassium channel activators : the cromakalim analogues. Current Medicinal Chemistry, 11, 1213-1222. doi:10.2174/0929867043365378

Sebille, S., Boverie, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (22 November 2003). Effects of cromakalim analogues on rat pancreatic B-cells, rat aorta rings and rat uterus. Study of their mechanism of action as potassium channel activators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Lebrun, P., Antoine, M. H., Dabrowski, M., Bondo-Hansen, J., Pirotte, B., & De Tullio, P. (July 2003). Towards tissue-selective KATP channel openers [Poster presentation]. 3rd F.E.P.S. - European Physiological Society, Nice, France.

Sebille, S., Becker, B., Boverie, S., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2003). 3,4-Dihydro-2,2-dimethylchromans structurally related to the KATP channel opener cromakalim: design, synthesis, effect on insulin release and vascular tone [Poster presentation]. 11th Forum of pharmaceutical sciences, Spa, Belgium.

Sebille, S., Becker, B., De Tullio, P., Boverie, S., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2003). Evaluation pharmacologique et étude du mécanisme d’action de molécules structurellement apparentées au cromakalim en tant qu’activateurs des canaux KATP [Poster presentation]. XVIIèmes Journées Franco-Belges de Pharmacochimie, Woluwe-Saint-Lambert, Belgium.

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Préparation et évaluation pharmacologique de modulateurs allostériques positifs des récepteurs AMPA : les 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes [Poster presentation]. 10ème Journée Jeunes Chercheurs, Paris, France.

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Nouveaux composés agissant en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA : les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes [Poster presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Boverie, S., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (31 January 2003). Nouveaux analogues du cromakalim en tant qu’agents pharmacologiques potentials de la classe des activateurs des canaux KATP [Paper presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

De Tullio, P., Becker, B., Boverie, S., Dabrowski, M., Wahl, P., Antoine, M.-H., Somers, F., Sebille, S., Ouedraogo, R., Hansen, J. B., Lebrun, P., & Pirotte, B. (2003). Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides. Journal of Medicinal Chemistry, 46, 3342-3353. doi:10.1021/jm021117w

Dupont, L., Somers, F., De Tullio, P., & Pirotte, B. (2003). 3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide. Acta Crystallographica, 1509-o1511. doi:10.1107/S1600536803020324

Evrard, B., Chiap, P., De Tullio, P., Ghalmi, F., Piel, G., Van Hees, T., Crommen, J., Losson, B., & Delattre, L. (13 December 2002). Oral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-beta-cyclodextrin. Journal of Controlled Release, 85 (1-3), 45-50. doi:10.1016/S0168-3659(02)00270-5

Sebille, S., Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Lebrun, P., & Pirotte, B. (15 November 2002). Synthesis and pharmacological evaluation of cromakalim analogues as potassium channel activators [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

Boverie, S., De Tullio, P., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (September 2002). Relaxant effects on the rat uterine smooth muscle of K+ATP channel openers compared to ritodrine, diltiazem and verapamil : development of new pharmacological in vitro models [Poster presentation]. XVIIth International Symposium on Medicinal Chemistry, Barcelone, Spain.

De Tullio, P., Boverie, S., Becker, B., Antoine, M. H., Sebille, S., Lebrun, P., & Pirotte, B. (September 2002). 6,7-Disubstituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potent ATP-sensitive potassium channel openers [Poster presentation]. XVIIth International Symposium on Medicinal Chemistry, Barcelone, Spain.

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Synthèse et évaluation biologique de 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Sebille, S., Becker, B., De Tullio, P., Boverie, S., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 2002). Synthèse et évaluation pharmacologique in vitro de nouveaux analogues du cromakalim en tant qu’activateurs potentiels des canaux KATP [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Lee, A. T., Cosgrove, K. E., Barnes, P. B., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (April 2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic β-cells [Poster presentation]. 21th Joint Meeting of the British Endocrine Societies, Harrogate, United Kingdom.

Boverie, S., Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., & De Tullio, P. (02 March 2002). Development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on different smooth muscle preparations [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Tullio, P., Boverie, S., Dewalque, D., Damas, J., Sebille, S., & Pirotte, B. (02 March 2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models [Paper presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (02 March 2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (02 March 2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic β-cells [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Lee, A. T., Cosgrove, K. E., Barnes, P. B., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (March 2002). BPDZ 154: a novel activator of KATP channels in β-cells [Poster presentation]. U.K.-German Joint Physiological Society Meeting, Tuebingen, Germany.

Boverie, S., Dewalque, D., Sebille, S., Damas, J., Pirotte, B., & De Tullio, P. (25 January 2002). Action myorelâchante sur la fibre musculaire lisse utérine de nouveaux dérivés de type 4H-1,2,4-benzothiadiazine 1,1-dioxyde diversement substitués en position 3 et 7 [Paper presentation]. Journée Jeunes Chercheurs, Paris, France.

Sebille, S., Becker, B., Antoine, M. H., De Tullio, P., Lebrun, P., & Pirotte, B. (25 January 2002). Synthèse et évaluation pharmacologique in vitro sur cellules B pancréatiques de rats, aortes de rats et utérus de rates de molécules apparentées au cromakalim en tant qu'activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., De Tullio, P., & Boverie, S. (2002). Development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on different smooth muscle preparations. Fundamental and Clinical Pharmacology, 246.

Boverie, S., Becker, B., Sebille, S., Antoine, M. H., Pirotte, B., Lebrun, P., & De Tullio, P. (2002). development of 4H-1,2,4-benzothiadiazine 1,1-dioxides as putative tocolytic agents: pharmacological evaluation on diferent smooth muscle preparations. Fundamental and Clinical Pharmacology, 246.

Boverie, S., Becker, B., Somers, F., Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Lebrun, P., Pirotte, B., & De Tullio, P. (2002). 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxides as potential K+ATP channel activators: influence of stereochemistry on biological activity and tissue selectivity. Fundamental and Clinical Pharmacology, 69.

Cosgrove, K. E., Antoine, M.-H., Lee, A. T., Barnes, P. D., De Tullio, P., Clayton, P., McCloy, R., De Lonlay, P., Nihoul-Fekete, C., Robert, J. J., Saudubray, J.-M., Rahier, J., Lindley, K. J., Hussain, K., Aynsley-Green, A., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 Activates Adenosine 5’-Triphosphate-Sensitive Potassium Channels; In Vitro Studies Using Rodent Insulin-Secreting Cells and Islets Isolated from Patients with Hyperinsulinism. Journal of Clinical Endocrinology and Metabolism, 87, 4860-4868. doi:10.1210/jc.2002-020439

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle; phrmacological in vitro models. Fundamental and Clinical Pharmacology, 245.

De Tullio, P., Boverie, S., Dewalque, D., Sebille, S., Damas, J., & Pirotte, B. (2002). Relaxant effect of K+ATP channel openers on the uterine smooth muscle: pharmacological in vitro models. Fundamental and Clinical Pharmacology, 245.

De Tullio, P., Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M. H., Pirotte, B., & Lebrun, P. (2002). 2-N-alkylation of 3-alkylamino-substituted 2H-benzo- and 2H-pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? Fundamental and Clinical Pharmacology, 68.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic Beta-cells. Endocrine Abstracts, 16.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells. Endocrine abstracts 2002, 16.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154: a novel activator of KATP channels in beta-cells. Pflügers Archiv: European Journal of Physiology, 338.

Lee, A. T., Cosgrove, K. E., Barnes, P. D., Lindley, K. J., Aynsley-Green, A., De Tullio, P., Pirotte, B., Lebrun, P., & Dunne, M. J. (2002). BPDZ 154: a novel activator of K ATP channels in Beta-cells. Pflugers Archiv für die Gesamte Physiologie des Menschen und der Tiere, 338.

Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M.-H., Pirotte, B., Lebrun, P., & De Tullio, P. (2002). 2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? Biological Chemistry, 383, 1759-1768. doi:10.1515/BC.2002.197

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic -cells. Fundamental and Clinical Pharmacology, 245.

Sebille, S., becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic Beta-cells. Fundamental and Clinical Pharmacology, 246.

Sebille, S., Becker, B., Antoine, M. H., Boverie, S., De Tullio, P., Lebrun, P., & Pirotte, B. (2002). Pharmacological evaluation of cromakalim analogues: towards the discovery of new inhibitors of insulin secretion from rat pancreatic Beta-cells. Fundamental and Clinical Pharmacology, 246.

De Tullio, P., Becker, B., Ouedraogo, R., Boverie, S., Somers, F., Pirotte, B., Lebrun, P., & Antoine, M. H. (08 December 2001). 2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: Ca++ channel blockers rather than K+ATP channel openers? [Poster presentation]. Workshop on the Endocrine Pancreas, Bruxelles, Belgium.

Boverie, S., Becker, B., Somers, F., Nguyen, Q. A., Ouedraogo, R., Antoine, M. H., Lebrun, P., Pirotte, B., & De Tullio, P. (17 November 2001). 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxides as potential K+ATP channel activators: influence of stereochemistry on biological activity and tissue selectivity [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Ouedraogo, R., Becker, B., Boverie, S., Somers, F., Antoine, M. H., Pirotte, B., & Lebrun, P. (17 November 2001). 2-N-alkylation of 3-alkylamino-substituted 2H-benzo- and 2H-pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers? [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Boverie, S., Kempen, I., & Lestage, P. (07 June 2001). Novel benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing them.

Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (01 June 2001). Propriétés biologiques des 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxydes diversement substitués en position 3: nouveaux analogues du diazoxide [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

De Tullio, P., Ouedraogo, R., Boverie, S., Antoine, M. H., Becker, B., Delarge, J., Lebrun, P., & Pirotte, B. (01 June 2001). Les 3-alkylamino-2-méthyl-2H-benzo- et pyridothiadiazine dioxydes en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. XVémes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Boverie, S., De Tullio, P., Becker, B., Antoine, M. H., Dewalque, D., Damas, J., Lebrun, P., & Pirotte, B. (May 2001). Preparation and biological properties of chemically diverse 3-substituted 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the potassium channel opener diazoxide [Paper presentation]. 10th Forum of Pharmaceutical Sciences, Montréal, Canada.

Somers, F., De Tullio, P., Boverie, S., Nguyen, Q. A., Becker, B., Antoine, M. H., Pirotte, B., & Lebrun, P. (26 January 2001). Les 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes diversement substitués par un atome de chlore en tant qu’activateurs des canaux KATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Boverie, S., Antoine, M.-H., De Tullio, P., Somers, F., Becker, B., Sebille, S., Lebrun, P., & Pirotte, B. (2001). Effect on insulin release of compounds structurally related to the potassium channel opener 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide (BPDZ 73): introduction of heteroatoms on the 3-alkylamino side chain of the benzothiadiazine 1,1-dioxide ring. Journal of Pharmacy and Pharmacology, 53, 973-980. doi:10.1211/0022357011776216

Dupont, L., De Tullio, P., Boverie, S., & Pirotte, B. (2001). 3-Amino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, E57, 602-o603. doi:10.1107/S1600536801009904

Dupont, L., De Tullio, P., Tinant, B., & Pirotte, B. (2001). (R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide mono-hydrate. Acta Crystallographica, E57, 1050-o1051.

Dupont, L., Khellili, S., Pirotte, B., Tinant, B., & De Tullio, P. (2001). Absolute configuration of N-[(R)-3-methyl-2-butyl]-(S)-2-(6-methoxy-2-naphthyl)-propionamide. Acta Crystallographica, E57, 650-o651. doi:10.1107/S1600536801010285

Dupont, L., Somers, F., Boverie, S., Pirotte, B., Tinant, B., & De Tullio, P. (2001). 7-Chloro-2-methyl-3-methylamino-2H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, E57, 652-o654.

Somers, F., Ouedraogo, R., Antoine, M.-H., De Tullio, P., Becker, B., Fontaine, J., Damas, J., Dupont, L., Rigo, B., Delarge, J., Lebrun, P., & Pirotte, B. (2001). Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP channel activity. Journal of Medicinal Chemistry, 44, 2575-2585. doi:10.1021/jm0004648

Boverie, S., Becker, B., Somers, F., De Tullio, P., Dewalque, D., Antoine, M. H., Arkhammar, Nielsen, F. E., Hansen, J. B., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (01 December 2000). New 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides related to BPDZ 73 as putative KATP channel openers: design, synthesis and pharmacological evaluation [Poster presentation]. One Day Symposium : Drug Discovery Strategies: Hit and Lead Finding, Mont-St-Guibert, Belgium.

De Tullio, P., Boverie, S., Somers, F., Ouedraogo, J., Antoine, M. H., Becker, B., Nielsen, F. E., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (01 December 2000). Preparation and biological evaluation of new 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides, analogues of the KATP channel opener BPDZ 73 [Poster presentation]. One Day Symposium : Drug Discovery Strategies: Hit and Lead Finding, Mont-St-Guibert, Belgium.

Boverie, S., Antoine, M. H., Becker, B., De Tullio, P., Somers, F., Sebille, S., Lebrun, P., & Pirotte, B. (September 2000). Effect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide [Poster presentation]. 68ème Congrès de la Société de Physiologie, Liège, Belgium.

Boverie, S., Becker, B., Somers, F., De Tullio, P., Dewalque, D., Antoine, M. H., Arkhammar, P., Nielsen, F. E., Hansen, J. B., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (September 2000). Synthesis and biological evaluation of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides as KATP channel openers structurally related to BPDZ 73 [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

De Tullio, P., Somers, F., Ouedraogo, J., Boverie, S., Antoine, M. H., Becker, B., Nielsen, F. E., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (September 2000). 7-Substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as potent KATP channel openers: synthesis and bioloigical in vitro evaluation [Poster presentation]. XVIth International Symposium on Medicinal Chemistry, Bologne, Italy.

Boverie, S., Antoine, M. H., De Tullio, P., Somers, F., Lebrun, P., & Pirotte, B. (May 2000). Synthèse et évaluation biologique de composés structuralement apparentés au 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxyde (BPDZ 73): introduction d’hétéroatomes au niveau de la chaîne latérale en position 3 du cycle benzothiadiazine 1,1-dioxyde [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Tullio, P., Boverie, S., Nguyen, Q. A., Ouedraogo, R., Somers, F., Sebille, S., Antoine, M. H., Becker, B., Nielsen, F., Arkhammar, P., Hansen, J. B., Delarge, J., Lebrun, P., & Pirotte, B. (May 2000). Les 3-R/S-(hydroxyalkylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux KATP: Influence de la stéréochimie sur l’activité pharmacologique et la sélectivité tissulaire [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Somers, F., Boverie, S., Nguyen, Q. A., Antoine, M. H., Dogne, J. M., Lebrun, P., Pirotte, B., & De Tullio, P. (May 2000). 3-Alkylamino-6,7-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxydes: synthèse et évaluation pharmacologique en tant qu’activateurs potentiels du canal potassique ATP-dépendant [Poster presentation]. 14èmes Journées Franco-Belges de Pharmacochimie, lille, France.

Boverie, S., Somers, F., Ouedraogo, R., Antoine, M. H., Dogne, J. M., De Leval, X., De Tullio, P., Pirotte, B., & Lebrun, P. (04 March 2000). 7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., & Lestage, P. (04 March 2000). New chemical and pharmacological developments in the field of positive allosteric modulators of AMPA receptors structurally related to cyclothiazide and diazoxide [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Chiap, P., Evrard, B., Bimazubute, M. A., De Tullio, P., Hubert, P., Delattre, L., & Crommen, J. (10 February 2000). Determination of Albendazole and Its Main Metabolites in Ovine Plasma by Liquid Chromatography with Dialysis as an Integrated Sample Preparation Technique. Journal of Chromatography. A, 870 (1-2), 121-34. doi:10.1016/S0021-9673(99)00938-3

Boverie, S., De Tullio, P., Ouedraogo, R., Nguyen, Q. A., Somers, F., Damas, J., Lebrun, P., & Pirotte, B. (28 January 2000). Les 3-alkylsulfanyl- et 3-alkoxy-4H-1,2,4-benzothiadiazine 1,1-dioxydes structuralement apparentés aux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Somers, F., Boverie, S., Ouedraogo, R., Antoine, M. H., Dogne, J. M., De Leval, X., Lebrun, P., Pirotte, B., & De Tullio, P. (28 January 2000). Nouveaux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes: synthèse et évaluation pharmacologique en tant qu’inhibiteurs potentiels du processus insulino-sécrétoire [Poster presentation]. Journée Jeunes Chercheurs, Paris, France.

Boverie, S., Antoine, M.-H., Becker, B., De Tullio, P., Somers, F., Sebille, S., Lebrun, P., & Pirotte, B. (2000). Effect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide. Pflügers Archiv: European Journal of Physiology, 439, 220-R221.

Boverie, S., Somers, F., Ouedraogo, R., Antoine, M.-H., Dogne, J.-M., De Leval, X., De Tullio, P., Pirotte, B., & Lebrun, P. (2000). 7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro. Fundamental and Clinical Pharmacology, 14, 299.

De Leval, X., Delarge, J., Somers, F., De Tullio, P., Henrotin, Y., Pirotte, B., & Dogne, J.-M. (2000). Recent advances in inducible cyclooxygenase (COX-2) inhibition. Current Medicinal Chemistry, 7 (10), 1041-1062. doi:10.2174/0929867003374417

De Tullio, P., Delarge, J., & Pirotte, B. (2000). Therapeutic and chemical developments of cholecystokinin receptor ligands. Expert Opinion on Investigational Drugs, 9, 129-146. doi:10.1517/13543784.9.1.129

Pirotte, B., Ouedraogo, R., De Tullio, P., Khelili, S., Somers, F., Boverie, S., Dupont, L., Fontaine, J., Damas, J., & Lebrun, P. (2000). 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis and pharmacological evaluation. Journal of Medicinal Chemistry, 43, 1456-1466. doi:10.1021/jm991069o

Somers, F., De Tullio, P., Boverie, S., Dogne, J.-M., de Leval, X., Antoine, M.-H., Lebrun, P., & Pirotte, B. (2000). Synthesis and biological effects of new 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides on insulin-secreting cells. Pharmacy and Pharmacology Communications, 6, 89-95. doi:10.1211/096089296765556980

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M.-H., Boverie, S., Fontaine, J., Damas, J., Pirotte, B., & Lebrun, P. (2000). Comparison between the effects of 3-aralkylamino-/3-cycloalkylalkylamino-substituted benzothiadiazine dioxides and their corresponding quinazolinone isosteres on different smooth muscle preparations. Fundamental and Clinical Pharmacology, 14, 171.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M. H., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l’Alleud, Belgium.

Somers, F., De Tullio, P., Ouedraogo, R., Antoine, M. H., Boverie, S., Fontaine, J., Damas, J., Lebrun, P., & Pirotte, B. (26 November 1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides and 2-alkylamino 3H-quinazolin-4-ones as putative KATP channel openers: influence of stereochemistry on biological activity [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

Boverie, S., De Tullio, P., Ouedraogo, R., Nguyen, Q. A., Somers, F., Damas, J., Lebrun, P., & Pirotte, B. (20 November 1999). 3-Alkylsulfanyl- and 3-alkoxy-substituted benzothiadiazines structurally related to 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M. H., Boverie, S., Fontaine, J., Damas, J., Pirotte, B., & Lebrun, P. (20 November 1999). Comparison between the effects of 3-aralkylamino-/3-cycloalkylalkylamino-substituted benzothiadiazine dioxides and their corresponding quinazolinone isosteres on different smooth muscle preparations [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Dupont, L., De Tullio, P., Khelili, S., Somers, F., Delarge, J., & Pirotte, B. (28 October 1999). Crystal structures of R- and S-7-chloro-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide (absolute configurations) [Poster presentation]. First Belgian Crystallography Symposium, Bruxelles, Belgium.

De Tullio, P., Boverie, S., Somers, F., Lebrun, P., Pirotte, B., Nielsen, F., & Hansen, J. B. (01 July 1999). Pyrido 1,2,4-thiadiazine derivatives, their preparation and use.

De Tullio, P., Nielsen, F. E., Hansen, J. B., Hansen, H. C., Pirotte, B., Boverie, S., Somers, F., Lebrun, P., & Mogensen, J. P. (01 July 1999). 1,2,4-Benzothiadiazine derivatives, their preparation and use.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Morain, P., Lestage, P., & Lebrun, P. (July 1999). Pyrido- and benzothiadiazine dioxides related to diazoxide: structural requirements leading to a KATP channel activator or to an allosteric modulator of the AMPA receptors [Poster presentation]. Second European Congress of Pharmacology, Budapest, Budapest, Hungary.

Boverie, S., Nguyen, Q. A., De Tullio, P., Somers, F., Pirotte, B., & Lebrun, P. (12 June 1999). Pharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Somers, F., De Tullio, P., Boverie, S., Dogne, J. M., Antoine, M. H., Lebrun, P., & Pirotte, B. (12 June 1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Boverie, S., De Tullio, P., Somers, F., Lebrun, P., & Pirotte, B. (May 1999). Les 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxydes structuralement apparentés au diazoxide en tant qu’activateurs potentiels des canaux potassiques sensibles à l’ATP [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

De Leval, X., Dogne, J. M., Neven, P., Labasse, A., Masreel, B., Somers, F., Pirotte, B., De Tullio, P., Delarge, J., Reginster, J.-Y., & Henrotin, Y. (May 1999). Evaluation de la sélectivité COX-1 vs COX-2 de drogues à potentialités anti-inflammatoires [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Dogne, J. M., Neven, P., Rolin, S., De Leval, X., Somers, F., David, J. L., Delarge, J., De Tullio, P., Pirotte, B., & Masereel, B. (May 1999). Impact d’antagonistes du thromboxane A2 dérivés du torasémide sur la fonction plaquettaire [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Somers, F., De Tullio, P., Boverie, S., Dogne, J. M., Antoine, M. H., Lebrun, P. H., & Pirotte, B. (May 1999). Conception, synthèse et évaluation pharmacologique de nouveaux 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant qu’activateurs potentiels des canaux potassiques ATP-dépendants [Poster presentation]. Treizièmes Journées Franco-Belges de Pharmacochimie, Liège, Liège, Belgium.

Dorwald, F. Z., Hansen, J. B., Mogensen, J. P., Tagmose, T. M., Pirotte, B., Lebrun, P., De Tullio, P., Boverie, S., & Delarge, J. (08 February 1999). Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use.

Boverie, S., Nguyen, Q.-A., De Tullio, P., Somers, F., Pirotte, B., & Lebrun, P. (1999). Pharmacological evaluation of 3-alkylsulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to the KATP channel opener diazoxide. Fundamental and Clinical Pharmacology, 13, 605.

Chiap, P., Evrard, B., Bimazubute, M., De Tullio, P., Hubert, P., Delattre, L., & Crommen, J. (1999). On-line combinaison of dialysis with liquid chromatography for the automated determination of albendazole and its main metabolites in ovine plasma [Paper presentation]. VIIIème Forum des Sciences Pharmaceutiques, Spa, Belgium.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1999). Effective resolution of racemic pirlindole at the preparative scale. Chirality, 11, 261-266. doi:10.1002/(SICI)1520-636X(1999)11:4<261::AID-CHIR1>3.0.CO;2-S

De Tullio, P., Delarge, J., & Pirotte, B. (1999). Recent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists). Current Medicinal Chemistry, 6, 433-455.

De Tullio, P., Khelili, S., Ouedraogo, R., Somers, F., Boverie, S., Dupont, L., Fontaine, J., Antoine, M.-H., Delarge, J., Lebrun, P., & Pirotte, B. (1999). 3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potent KATP-channel activators: structural study and influence of stereochemistry. Pharmacy and Pharmacology Communications, 5, 195-198.

De Tullio, P., Ouedraogo, R., Dupont, L., Somers, F., Boverie, S., Dogne, J.-M., Delarge, J., & Pirotte, B. (1999). Synthesis and structural studies of 3-alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides: a new class of heterocyclic compounds with therapeutical promises. Tetrahedron, 55, 5419-5432. doi:10.1016/S0040-4020(99)00231-8

Dupont, L., De Tullio, P., Khelili, S., Somers, F., Delarge, J., & Pirotte, B. (1999). 7-Chloro-(R)-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide and 7-chloro-(S)-3-[1-(cyclohexyl)ethylamino]-4H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, C55, 1945-1947. doi:10.1107/S0108270199010069

Dupont, L., Pirotte, B., & De Tullio, P. (1999). 7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide. Acta Crystallographica, C55, 1152-1154. doi:10.1107/S0108270199000669

Dupont, L., Pirotte, B., Podona, T., Diouf, O., Delarge, J., & De Tullio, P. (1999). 4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C55, 461-464. doi:10.1107/S0108270198013894

Evrard, B., De Tullio, P., Chiap, P., Van Hees, T., Piel, G., Crommen, J., Losson, B., & Delattre, L. (1999). The effect of hydroxypropyl-b-cyclodextrins on the pharamacokinetics of albendazole in sheep. In Proceedings of 26th International Symposium on Controlled Release of Bioactive Materials.

Khelili, S., De Tullio, P., Lebrun, P., Fillet, M., Antoine, M.-H., Ouedraogo, R., Dupont, L., Fontaine, J., Felekidis, A., Leclerc, G., Delarge, J., & Pirotte, B. (1999). Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers. Bioorganic and Medicinal Chemistry, 7 (8), 1513-1520. doi:10.1016/S0968-0896(99)00082-6

Ouedraogo, R., Nguyen, Q.-A., Antoine, M.-H., Fontaine, J., Somers, F., De Tullio, P., Pirotte, B., & Lebrun, P. (1999). Pharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides. Fundamental and Clinical Pharmacology, 13, 245.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Morain, P., Lestage, P., & Lebrun, P. (1999). Pyrido- and benzothiadiazine dioxides related to diazoxide: structural requirements leading to a KATP channel activator or to an allosteric modulator of the AMPA receptors. Fundamental and Clinical Pharmacology, 13, Suppl. 1, 134.

Somers, F., De Tullio, P., Boverie, S., Dogne, J.-M., Antoine, M.-H., Lebrun, P., & Pirotte, B. (1999). New 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation. Fundamental and Clinical Pharmacology, 13, 607.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (December 1998). Enantiomeric Separation of Pirlindole by Liquid Chromatography Using Different Types of Chiral Stationary Phases. Journal of Pharmaceutical and Biomedical Analysis, 18 (4-5), 605-14. doi:10.1016/S0731-7085(98)00213-1

Dogne, J. M., De Leval, X., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Neven, P., Delarge, J., & Masereel, B. (27 November 1998). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoïd thromboxane A2 receptor antagonists [Paper presentation]. Annual Meeting of the Belgian Society on Thrombosis and Haemostasis, Zemst, Belgium.

Dogne, J. M., De Leval, X., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Neven, P., Delarge, J., & Masereel, B. (27 November 1998). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane A2 receptor antagonists [Poster presentation]. Annual meeting of the Belgian Society on thrombosis and haemostasis, Zemst, Belgium.

Ouedraogo, R., Nguyen, Q. A., Antoine, M. H., Fontaine, J., Somers, F., De Tullio, P., Pirotte, B., & Lebrun, P. (21 November 1998). Pharmacological study of original 3-alkylamino-2-methyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Anvers, Belgium.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (01 September 1998). Simultaneous Determination of Pirlindole Enantiomers and Dehydropirlindole by Chiral Liquid Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 17 (6-7), 1071-9. doi:10.1016/S0731-7085(98)00073-9

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration [Poster presentation]. Fourth European Congress of Pharmaceutical Sciences, Milan, Italy.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Effective resolution of racemic pirlindole at the preparative scale: derivatization method and absolute configuration [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Somers, F., Boverie, S., Delarge, J., Lebrun, P., & Pirotte, B. (September 1998). Synthesis and biological evaluation of the 3-alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potential KATP channels openers [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Somers, F., Boverie, S., Delarge, J., Lebrun, P., & Pirotte, B. (September 1998). 3-Alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides as new potent KATP channels activators [Poster presentation]. Fourth European Congress of Pharmaceutical Sciences, Milan, Italy.

Pirotte, B., Diouf, O., Podona, T., De Tullio, P., Delarge, J., Morain, P., & Lestage, P. (September 1998). 2,3-Dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

Boverie, S., Pirotte, B., Somers, F., Lacan, F., Dogne, J. M., Delarge, J., & De Tullio, P. (May 1998). Utilisation du 1,1’-thiocarbonyldiimidazole comme agent de cyclisation des aminoarylsulfonamides en vue de l’obtention d’intermédiaires utilisables dans la synthèse de nouveaux activateurs de canaux KATP [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

De Tullio, P., Khelili, S., Fillet, M., Ouedraogo, R., Dupont, L., Antoine, M. H., Lebrun, P., Fontaine, J., Delarge, J., & Pirotte, B. (May 1998). Résolutions énantiomériques et évaluations biologiques des isomères du BPDZ 42 et du BPDZ 44 [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

De Tullio, P., Somers, F., Boverie, S., Dupont, L., Khelili, S., Ouedraogo, R., Fontaine, J., Antoine, M. H., Delarge, J., & Pirotte, B. (May 1998). Les 3-alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant quactivateurs de canaux KATP: étude structurale et influence de la stéréochimie [Paper presentation]. Journées Franco-Belges de Pharmacochimie, Caen, France.

De Tullio, P., Somers, F., Boverie, S., Dupont, L., Ouedraogo, R., Lebrun, P., Fontaine, J., & Pirotte, B. (May 1998). Les 3-alkylamino[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant qu’activateurs des canaux KATP: détermination de la position de la liaison double du cycle thiadiazine [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Ouedraogo, R., Nguyen, Q. A., Fontaine, J., Somers, F., De Tullio, P., Antoine, M. H., Lebrun, P., & Pirotte, B. (May 1998). Les arylthiadiazinedioxydes en tant qu’activateurs des canaux potassiques: etude pharmacologique des 3-alkylamino-2-méthyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Pirotte, B., Ouedraogo, R., De Tullio, P., Antoine, M. H., Somers, F., Fontaine, J., Delarge, J., & Lebrun, P. (May 1998). Les 3-alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxydes structuralement apparentés au diazoxide et au pinacidil: conception, synthèse et évaluation biologique [Poster presentation]. Douzièmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M. H., Fontaine, J., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (14 February 1998). New quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers [Paper presentation]. Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Ceccato, A., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (16 January 1998). Séparation énantiomérique du pirlindole à l’échelle préparative [Poster presentation]. Journées Jeunes Chercheurs, Paris, France.

Somers, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M. H., Damas, J., Dogne, J. M., Delarge, J., & Pirotte, B. (16 January 1998). Nouvelles 2-alkylamino-quinazoline-4-ones, synthèse et évaluation pharmacologique en tant qu’isostères potentiels de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Paper presentation]. Journées Jeunes Chercheurs, Paris, France.

Bruhwyler, J., Liégeois, J.-F., Gerardy, J., Damas, J., Chleide, E., Lejeune, C., Decamp, E., De Tullio, P., Delarge, J., Dresse, A., & Geczy, J. (1998). Comparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques. Behavioural Pharmacology, 9 (8), 731-7. doi:10.1097/00008877-199812000-00008

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (1998). Liquid chromatographic separation of pirlindole enantiomers using different types of chiral stationary phases. Journal de Pharmacie de Belgique, 53, 168.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (1998). Determination of the enantiomeric purity of pirlindole by liquid chromatography using a cellulose based chiral stationary phase. Journal de Pharmacie de Belgique, 53, 169.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration. European Journal of Pharmaceutical Sciences, suppl.1, 37.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindole. Journal de Pharmacie de Belgique, 53, 55.

De Tullio, P., Felekidis, A., Pirotte, B., Liégeois, J.-F., Stachow, M., Delarge, J., Ceccato, A., Hubert, P., Crommen, J., & Geczy, J. (1998). First preparative enantiomer resolution of pirlindole, a potent antidepressant drug. Helvetica Chimica Acta, 81, 539-547. doi:10.1002/hlca.19980810307

De Tullio, P., Felikidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindol, journées franco-belges de pharmacochimie. Journal de Pharmacie de Belgique, 53, 55.

De Tullio, P., Pirotte, B., Somers, F., Boverie, S., Lacan, F., & Delarge, J. (1998). Study of the ring closure reaction of o-aminoarylsulfonamides with 1,1’-thiocarbonyldiimidazole. Tetrahedron, 54, 4935-4942. doi:10.1016/S0040-4020(98)00195-1

De Tullio, P., Somers, F., Boverie, S., Delarge, J., Lebrun, P., & Pirotte, B. (1998). 3-Alkylamino-7-halogeno-4H-1,2,4-benzothiadiazine 1,1-dioxides as new potent KATP channels activators. European Journal of Pharmaceutical Sciences, suppl.1, 34.

Masereel, B., De Tullio, P., Dogne, J.-M., Lacan, F., Pirotte, B., Pochet, L., Somers, F., & Delarge, J. (1998). Design of new potential hypoglycemic drugs. Journal de Pharmacie de Belgique, 53, 58.

Masereel, B., Ouedraogo, R., Dogne, J.-M., Antoine, M.-H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Lebrun, P. (1998). Design, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas. Journal de Pharmacie de Belgique, 53, 57-58.

Ouedraogo, R., Somers, F., Pirotte, B., De Tullio, P., Antoine, M.-H., Lebrun, P., & Fontaine, J. (1998). Etude pharmacologique comparative de quelques 3-alkylamino-4H-1,2,4-benzo- et pyridothiadiazine 1,1-dioxydes, activateurs de canaux potassiques ATP-dépendants. Journal de Pharmacie de Belgique, 53, 61.

Pirotte, B., De Tullio, P., Podona, T., Diouf, O., Dewalque, D., Neven, P., Masereel, B., Caignard, D.-H., Renard, P., & Delarge, J. (1998). Pyridothiadiazinedioxides structurally related to quinazolinones cholecystokinin/gastrin receptor ligands: synthesis and biological evaluation. European Journal of Pharmaceutical Sciences, 7, 29-40. doi:10.1016/S0928-0987(98)00003-7

Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole. Journal de Pharmacie de Belgique, 53, 60.

Pirotte, B., De Tullio, P., Stachow, M., Felikidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindol. Journal de Pharmacie de Belgique, 53, 60.

Pirotte, B., Podona, T., Diouf, O., De Tullio, P., Lebrun, P., Dupont, L., Somers, F., Delarge, J., Morain, P., Lestage, P., Lepagnol, J., & Spedding, M. (1998). 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology and structure-activity relationships. Journal of Medicinal Chemistry, 41, 2946-2959. doi:10.1021/jm970694v

Somers, F., Ouedraogo, R., De Tullio, P., Antoine, M.-H., Fontaine, J., Damas, J., Delarge, J., Lebrun, P., & Pirotte, B. (1998). New quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers. Fundamental and Clinical Pharmacology, 12, 306.

Somers, F., Rogister, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M.-H., Pochet, L., Dogne, J.-M., Masereel, B., Delarge, J., & Pirotte, B. (1998). Design, synthèse et évaluation pharmacologique de nouvelles 2-alkylamino-quinazoline-4-ones en tant du’isostères de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes. Journal de Pharmacie de Belgique, 53, 56.

Pirotte, B., Lebrun, P., De Tullio, P., Somers, F., Delarge, J., Hansen, J. B., Nielsen, F. E., Hansen, H. C., Mogensen, J. P., & Tagmose, T. M. (31 December 1997). 1,2,4-Benzothiadiazine derivatives, their preparation and use.

Somers, F., Ouedraogo, R., De Tullio, P., Lebrun, P., Antoine, M. H., Fontaine, J., Damas, J., Delarge, J., & Pirotte, B. (13 December 1997). Design and synthesis of novel quinazolinones structurally related to pyridothiadiazine-type potassium channel openers acting on pancreatic B-cells [Paper presentation]. Contact Group “Pancreas Endocrine”, Bruxelles, Belgium.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (September 1997). Simultaneous determination of pirlindole enantiomers and dehydropirlindole by liquid chromatography using a cellulose based chiral stationary phase [Poster presentation]. 7th Meeting on Recent Developments in Pharmaceutical Analysis, Ile d'Elbe, Italy.

Pirotte, B., Lebrun, P., De Tullio, P., Somers, F., Delarge, J., Hansen, H. C., Nielsen, F. E., & Hansen, J. B. (24 July 1997). Pyrido 1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, their preparation and use.

Pirotte, B., De Tullio, P., Ouedraogo, R., Somers, F., Antoine, M. H., Fontaie, J., Delarge, J., & Lebrun, P. (July 1997). 1,2,4-Pyridothiadiazine 1,1-dioxides as a new class of potassium channel openers: structural requirements leading to tissue selectivity [Poster presentation]. XXXIII International Congress of Physiological Sciences IUPS 1997.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Cegzy, J., & Delarge, J. (May 1997). Résolution préparative du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Masereel, B., De Tullio, P., Dogne, J. M., Lacan, F., Pirotte, B., Pochet, L., Somers, F., & Delarge, J. (May 1997). Design of new potential hypoglycemic drugs [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Masereel, B., Ouedraogo, R., Dogne, J. M., Antoine, M. H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Lebrun, P. (May 1997). Design, synthesis and pharmacology of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Ouedraogo, R., Somers, F., Pirotte, B., De Tullio, P., Antoine, M. H., Lebrun, P., & Fontaine, J. (May 1997). Etude pharmacologique comparative de quelques 3-alkylamino-4H-1,2,4-benzo- et pyridothiadiazine 1,1-dioxydes, activateurs de canaux potassiques ATP-dépendants [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (May 1997). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Somers, F., Rogister, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M. H., Pochet, L., Dogne, J. M., Masereel, B., Delarge, J., & Pirotte, B. (May 1997). Design, synthèse et évaluation pharmacologique de nouvelles 2-alkylamino-quinazoline-4-ones en tant du’isostères de 3-alkylamino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Dogne, J. M., Varache-Lembege, M., Damas, J., Nuhrich, A., Fontaine, J., De Tullio, P., Somers, F., Pirotte, B., Pochet, L., Neven, P., Delarge, J., & Masereel, B. (April 1997). Design, synthesis and biological evaluation of sulfonylureas as original non-prostanoid thromboxane receptor antagonists [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Masereel, B., Dogne, J. M., Damas, J., Nuhrich, A., Varache-Lembege, M., Fontaine, J., Pochet, L., Somers, F., De Tullio, P., Pirotte, B., & Delarge, J. (April 1997). Pharmacomodulation of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Ouedraogo, R., Somers, F., De Tullio, P., Antoine, M. H., Lebrun, P., Pirotte, B., & Fontaine, J. (April 1997). Pharmacological analysis of ATP-dependent potassium channels openers on vascular smooth muscle [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Somers, F., Rogister, F., Ouedraogo, R., Lebrun, P., De Tullio, P., Fontaine, J., Antoine, M. H., Pochet, L., Dogne, J. M., Masereel, B., Delarge, J., & Pirotte, B. (April 1997). 2-Alkylamino-3H-quinazolin-4-ones structurally related to the arylthiadiazine class of potassium channel openers: design, synthesis and pharmacological evaluation [Paper presentation]. 7th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Dogne, J. M., Varache-Lembeche, M., Damas, J., Nuhrich, A., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Masereel, B. (12 January 1997). Synthèse et évaluation biologique de sulfonylurées en tant qu’antagonistes du thromboxane A2 [Paper presentation]. 4ème Journée Jeunes Chercheurs de la Société de Chimie Thérapeutique, Paris, France.

Pochet, L., Doucet, C., Pirotte, B., Thierry, N., Boggetto, N., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (10 January 1997). Nouvelles perspectives de développement d’aryl- et de cycloalkylesters de l’acide 6-chlorométhyl-2-oxo-2H-1-benzopyrane-3-carboxylique en tant qu’inhibiteurs de l’élastase leucocytaire et de l’-chymotrypsine [Poster presentation]. 4ème Journée Jeunes Chercheurs, Paris, France.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (1997). Enantiomeric separation of pirlindole enantiomers and dehydroprilindole by chrial liquid chromatography [Poster presentation]. VIIth meeting on recent developments in pharmaceutical analysis.

De Tullio, P., Pirotte, B., Neven, P., Masereel, B., Dewalque, D., Diouf, O., Podona, T., Caignard, D., Renard, P., & Delarge, J. (1997). Synthesis and biological evaluation of new 3-aralkylamino-2-aryl-2H-1,2,4-pyridothiadiazine 1,1-dioxides as potential CCK receptor ligands. Journal of Pharmacy and Pharmacology, 49, 463-471. doi:10.1111/j.2042-7158.1997.tb06825.x

Lebrun, P., Antoine, M.-H., Ouedraogo, R., Herchuelz, A., De Tullio, P., Delarge, J., & Pirotte, B. (1997). Pyridothiadiazines as potent inhibitors of glucose-induced insulin release. In Physiology and Pathophysiology of the Islets of Langerhans (pp. 145-148). New York, United States - New York: Soria, Plenum Press.

Masereel, B., Dogne, J.-M., Damas, J., Nuhrich, A., Varache-Lembege, M., Fontaine, J., Pochet, L., Somers, F., De Tullio, P., Pirotte, B., & Delarge, J. (1997). Pharmacomodulation of torasemide led to original diuretic, neuroprotective, anticonvulsant and antithrombotic drugs. Journal de Pharmacie de Belgique, 52, 157-158.

Masereel, B., Ouedraogo, R., Dogne, J.-M., Antoine, M.-H., De Tullio, P., Pirotte, B., Pochet, L., Delarge, J., & Lebrun, P. (1997). Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas. European Journal of Medicinal Chemistry, 32, 453-456. doi:10.1016/S0223-5234(97)81682-0

Pirotte, B., De Tullio, P., Neven, P., Dewalque, D., & Delarge, J. (1997). The chemistry of 3-phthalimidomethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides and their use in the synthesis of potential cholecystokinin/gastrin receptor ligands. Bulletin des Sociétés Chimiques Belges, 106, 781-790.

Scuvée-Moreau, J., Seutin, V., Vrijens, B., Pirotte, B., De Tullio, P., Massotte, L., Albert, A., Delarge, J., & Dresse, A. (1997). Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro. Archives of Physiology and Biochemistry, 105 (5), 421-8. doi:10.1076/apab.105.5.421.3285

Pirotte, B., De Tullio, P., Ouedraogo, R., Dupont, L., Fang, Z. Y., Fontaine, J., Antoine, M. H., Masereel, B., Pochet, L., Delarge, J., & Lebrun, P. (September 1996). Myorelaxant effects of 2-alkyl-substituted 2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides [Poster presentation]. XIVth International Symposium on Medicinal Chemistry, Maastricht, Netherlands.

De Tullio, P., Pirotte, B., Ouedraogo, R., Dupont, L., Lebrun, P., Fang, Z. Y., Masereel, B., Fontaine, J., Antoine, M. H., Neven, P., Pochet, L., & Delarge, J. (May 1996). 2-, 3- and 4-substituted pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Masereel, B., Lambert, D., Dogne, J. M., De Tullio, P., Pirotte, B., Pochet, L., & Delarge, J. (May 1996). BM 34, an anticonvulsant sulfonylthiourea with a phenitoin-like profile [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Pirotte, B., Khelili, S., De Tullio, P., Fang, Z. Y., Ouedraogo, R., Antoine, M. H., Fontaine, J., Masereel, B., Dewalque, D., Damas, J., Pochet, L., Delarge, J., & Lebrun, P. (May 1996). 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J. M., & Reboud-Ravaux, M. (May 1996). Design and synthesis of aromatic esters and amides of 6-chloromethyl-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin [Paper presentation]. 6ème Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Khelili, S., Pirotte, B., De Tullio, P., Lebrun, P., Ouedraogo, R., Antoine, M. H., Fang, Z. Y., Fontaine, J., Masereel, B., & Delarge, J. (12 January 1996). Pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides: novel class of vasorelaxant drugs [Poster presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

Masereel, B., Varache-Lembege, M., Damas, J., Nuhrich, A., De Tullio, P., Khelili, S., Pirotte, B., Pochet, L., & Delarge, J. (12 January 1996). Synthèse et évaluation biologique d’antagonistes non-carboxyliques du récepteur au thromboxane A2 [Poster presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

Pirotte, B., Ouedraogo, R., Fang, Z. Y., De Tullio, P., Khelili, S., Fontaine, J., Lebrun, P., Pochet, L., Masereel, B., Dupont, L., & Delarge, J. (12 January 1996). Les 3-alkylamino-2-méthyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant que nouveaux agents myorelâchants [Poster presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., & Reboud-Ravaux, M. (12 January 1996). Conception et synthèse de dérivés de l’acide 6-(chloro)méthyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu’inhibiteurs de l’élastase leucocytaire et de l’α-chymotripsine [Paper presentation]. 3ème Journée Jeunes Chercheurs, Paris, France.

De Tullio, P., Pirotte, B., Lebrun, P., Fontaine, J., Dupont, L., Antoine, M.-H., Ouedraogo, R., Maggetto, C., Masereel, B., Khelili, S., Diouf, O., Podona, T., & Delarge, J. (1996). 3- and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation and structure-activity relationships. Journal of Medicinal Chemistry, 39, 937-948. doi:10.1021/jm9500582

De Tullio, P., Pirotte, B., Ouedraogo, R., Dupont, L., Lebrun, L., Fang, Z. Y., Masereel, B., Fontaine, J., Antoine, M.-H., Neven, P., Pochet, L., & Delarge, J. (1996). 2-, 3- and 4-substituted pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers. Journal de Pharmacie de Belgique, 51, 108.

Diouf, O., Pirotte, B., Podona, T., De Tullio, P., Masereel, B., Delarge, J., Morain, P., & Lepagnol, J. (1996). Synthèse de nouvelles pyridothiadiazines et leur évaluation en tant que modulateurs des récepteurs glutamatergiques à l'acide a-amino-3-hydroxy-5-méthyl-4-isoxazolepropionique. Journal de Pharmacie de Belgique, 51, 20.

Doucet, C., Pochet, L., Schynts, M., Pirotte, B., Thierry, N., Boggetto, N., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (1996). Nouveaux dérivés de l'acide 6-chlorométhyl-2-oxo-2H-1-benzopyran-3-carboxylique en tant qu'inhibiteurs de protéases à sérine: étude des relations structure-activité expliquant leur sélectivité d'action. Journal de Pharmacie de Belgique, 51, 18.

Dupont, L., Pirotte, B., De Tullio, P., & Delarge, J. (1996). Absolute configuration of (R)-1-phenylethyl ammonium (S)-2-(6-methoxy-2-naphthyl)-propionate. Acta Crystallographica, C52, 393-395.

Dupont, L., Pirotte, B., De Tullio, P., & Delarge, J. (1996). 3-Isopropylamino-4-methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide. Acta Crystallographica, C52, 1741-1743. doi:10.1107/S0108270196001941

Khelili, S., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1996). Nouvelles stratégies de synthèse vers des pyridothiadiazinedioxydes structuralement apparentés au diazoxide. Journal de Pharmacie de Belgique, 51, 19.

Lebrun, P., Antoine, M.-H., Ouedraogo, R., Dunne, M., Kane, C., Hermann, M., Herchuelz, A., Masereel, B., Delarge, J., De Tullio, P., & Pirotte, B. (1996). Activation of ATP-dependant K+ channels and inhibition of insulin release: effect of BPDZ 62. Journal of Pharmacology and Experimental Therapeutics, 277, 156-162.

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (1996). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas. Journal de Pharmacie de Belgique, 51, 17.

Masereel, B., Lambert, D., Dogne, J.-M., De Tullio, P., Pirotte, B., Pochet, L., & Delarge, J. (1996). BM 34, an anticonvulsant sulfonylthiourea with a phenitoin-like profile. Journal de Pharmacie de Belgique, 51, 115.

Masereel, B., Lebrun, P., Dogne, J.-M., De Tullio, P., Pirotte, B., Pochet, L., Diouf, O., & Delarge, J. (1996). First synthesis of 4-substituted benzenesulfonylcyanoguanidines. Tetrahedron Letters, 37, 7253-7254. doi:10.1016/0040-4039(96)01663-2

Ouedraogo, R., Pirotte, B., Antoine, M. H., De Tullio, P., Masereel, B., Dunne, M., Kane, C., & Lebrun, P. (1996). Les canaux potassiques ATP-dépendants et la sécrétion d'insuline: effets du BPDZ 62. Journal de Pharmacie de Belgique, 51, 41.

Ouedraogo, R., Pirotte, B., Antoine, M.-H., De Tullio, P., Masereel, B., Dunne, M., Kane, C., & Lebrun, P. (1996). Les canaux potassiques ATP-dépendants et la sécrétion d'insuline: effet du BPDZ 62. Journal de Pharmacie de Belgique, 51, 41.

Pirotte, B., De Tullio, P., & Lebrun, P. (1996). Recent advances in drugs acting as tissue selective potassium channel openers. Potassium Channel Modulators; ID Research Alert, 1, 4.

Pirotte, B., Khelili, S., De Tullio, P., Fang, Z. Y., Ouedraogo, R., Antoine, M.-H., Fontaine, J., Masereel, B., Dewalque, D., Damas, J., Pochet, L., Delarge, J., & Lebrun, P. (1996). 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to both diazoxide and pinacidil: a new class of potassium channel openers. Journal de Pharmacie de Belgique, 51, 117.

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Jiang, K. Y., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (1996). Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of a-chymotrypsin: significance of the ‘aromatic’ nature of the novel ester-type coumarin for strong inhibitory activity. Journal of Medicinal Chemistry, 39, 2579-2585. doi:10.1021/jm960090b

Pochet, L., Doucet, C., Schynts, M., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (1996). Design and synthesis of aromatic esters and amides of 6-chloromethyl-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin. Journal de Pharmacie de Belgique, 51, 117.

Lebrun, P., Antoine, M. H., Ouedraogo, R., Herchuelz, A., Dunne, M., Kane, C., De Tullio, P., Delarge, J., & Pirotte, B. (September 1995). ATP-sensitive K+ channels and insulin release: effect of BPDZ 62 [Poster presentation]. 31st Annual Meeting of the European Association for the Study of Diabetes, Stockholm, Sweden.

Scuvée-Moreau, J., Seutin, V., Pirotte, B., De Tullio, P., Massotte, L., Delarge, J., & Dresse, A. (08 June 1995). Comparative effect of various potassium channel openers on the firing rate of hippocampal and dopaminergic neurons in vitro [Paper presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Diouf, O., Pirotte, B., Podona, T., De Tullio, P., Masereel, B., Delarge, J., Morain, P., & Lepagnol, P. (June 1995). Synthèse de nouvelles pyridothiadiazines et leur évaluation en tant que modulateurs des récepteurs glutamatergiques à l'acide a-amino-3-hydroxy-5-méthyl-4-isoxazolepropionique [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Khelili, S., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (June 1995). Nouvelles stratégies de synthèse vers des pyridothiadiazinedioxydes structuralement apparentés au diazoxide [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (June 1995). Synthesis and diuretic properties of pyrid-3-ylsulfonylcyanoguanidines [Poster presentation]. 31èmes Rencontres Internationales de Chimie Thérapeutique, Lyon, France.

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (June 1995). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Ouedraogo, R., Pirotte, B., Antoine, M. H., De Tullio, P., Masereel, B., Dunne, M., Kane, C., & Lebrun, P. (June 1995). Les canaux potassiques ATP-dépendants et la sécrétion d'insuline: effets du BPDZ 62 [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Tullio, P., Pirotte, B., Antoine, M. H., Lebrun, P., Maggetto, C., Fontaine, J., Masereel, B., & Delarge, J. (18 February 1995). Pyrido- and benzothiadiazinedioxides structurally related to diazoxide: new activators of the pancreatic and vascular KATP channels [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

Ouedraogo, R., Antoine, M. H., De Tullio, P., Dunne, M., Kane, C., Pirotte, B., & Lebrun, P. (18 February 1995). ATP-sensitive K+ channels and insulin release: effect of BPDZ 62 [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gand, Belgium.

De Tullio, P., Pirotte, B., Fontaine, J., Antoine, M. H., Masereel, B., Diouf, O., Podona, T., Delarge, J., & Lebrun, P. (12 January 1995). Nouveaux 1,2,4-pyrido- et benzothiadiazine 1,1-dioxydes, analogues du diazoxide et puissants activateurs du canal potassique ATP-dépendant: synthèse, evaluation biologique et sélectivité tissulaire [Poster presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

De Tullio, P., Pirotte, B., Fontaine, J., Antoine, M. H., Masereel, B., Diouf, O., Podona, T., Delarge, J., & Lebrun, P. (12 January 1995). Nouveaux 1,2,4-pyrido- et benzothiadiazine 1,1-dioxydes, analogues du diazoxide et puissants activateurs du canal potassique ATP-dépendant: synthèse, evaluation biologique et sélectivité tissulaire [Paper presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

Masereel, B., Laeckmann, D., Dupont, L., Pirotte, B., De Tullio, P., Diouf, O., & Delarge, J. (12 January 1995). Synthesis and diuretic properties of novel pyrid-3-ylsulfonylcyanoguanidines [Poster presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

Pochet, Doucet, C., Schynts, M., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (12 January 1995). Synthèse et évaluation enzymatique de nouveaux dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine [Poster presentation]. 2ème Journée Jeunes Chercheurs, Paris, France.

De Tullio, P. (1995). Synthèse de dérivés originaux de la classe des 1,2,4-pyridothiadiazine 1,1-dioxydes : Potentialités pharmacologiques et thérapeutiquess [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/93523

De Tullio, P., Pirotte, B., Antoine, M.-H., Lebrun, P., Maggetto, C., Fontaine, J., Masereel, B., & Delarge, J. (1995). Pyrido- and benzothiadiazinedioxides structurally related to diazoxide: new activators of the pancreatic and vascular KATP channels. Pflügers Archiv: European Journal of Physiology, 430, 8.

De Tullio, P., Pirotte, B., Dupont, L., Masereel, B., Laeckmann, D., Podona, T., Diouf, O., Lebrun, P., & Delarge, J. (1995). Synthesis ans structural studies of a new class of heterocyclic compounds: 1,2,4-pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides. Tetrahedron, 51, 3221-3234.

De Tullio, P., Pirotte, B., Masereel, B., Diouf, O., Caignard, D.-H., Renard, P., & Delarge, J. (1995). Synthèse de dérivés 3-aminoaralkyl-2-aryl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes et leur évaluation en tant qu'antagonistes de la cholécystokinine. Journal de Pharmacie de Belgique, 50, 244.

Dupont, L., De Tullio, P., Pirotte, B., Masereel, B., & Delarge, J. (1995). 7-Methyl-3-methylthio-4H-pyrido[4,3-e]-1,2,4-thiadiazin-7-ium-4-ide 1,1-dioxide zwitterion. Acta Crystallographica, C51, 2416-2417. doi:10.1107/S0108270195008031

Dupont, L., De Tullio, P., Pirotte, B., Masereel, B., & Delarge, J. (1995). 3-Methyl-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate. Acta Crystallographica, C51, 946-948. doi:10.1107/S0108270194013235

Dupont, L., De Tullio, P., Pirotte, B., Masereel, B., & Delarge, J. (1995). 3-Benzamido-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 1903-1905.

Dupont, L., Masereel, B., De Tullio, P., Pirotte, B., & Delarge, J. (1995). N2-cyano-N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulfonyl]guanidine. Acta Crystallographica, C51, 505-507.

Dupont, L., Pirotte, B., De Tullio, P., Diouf, O., Masereel, B., & Delarge, J. (1995). 2,4,7-Trimethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazinium 1,1-dioxide iodide. Acta Crystallographica, C51, 2412-2414. doi:10.1107/S0108270195008006

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). Les activateurs de canaux potassiques: étude structurale comparative du pinacidil, du diazoxide et du cromakalim. Annales Pharmaceutiques Françaises, 53 (5), 201-208.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3-Methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 944-946.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3-Methyl-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 2064-2066.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3-amino-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate and 3-tert-butyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide. Acta Crystallographica, C51, 1385-1388. doi:10.1107/S0108270195000278

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., & Delarge, J. (1995). 3,7-Dimethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide zwitterion. Acta Crystallographica, C51, 2414-2416. doi:10.1107/S010827019500802X

Lebrun, P., Antoine, M.-H., Ouedraogo, R., Herchuelz, A., Dunne, M., Kane, C., De Tullio, P., Delarge, J., & Pirotte, B. (1995). ATP-sensitive K+ channels and insulin release: effect of BPDZ 62. Diabetologia, 38, 195.

Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (1995). Synthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics. European Journal of Medicinal Chemistry, 30, 343-351. doi:10.1016/0223-5234(96)88244-4

Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (1995). Synthesis and pharmacology of N"-(4-arylaminopyrid-3-yl)sulfonyl-N-cyano-N'-isopropyl-guanidines. Journal de Pharmacie de Belgique, 50, 250.

Pirotte, B., De Tullio, P., Podona, T., Masereel, B., Caignard, D.-H., Renard, P., & Delarge, J. (1995). 3-Arylcarboxamidométhyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant qu'antagonistes non peptidiques de la cholécystokinine: synthèse et évaluation pharmacologique. Journal de Pharmacie de Belgique, 50, 253.

Scuvée-Moreau, J., Seutin, V., Pirotte, B., De Tullio, P., Massotte, L., Delarge, J., & Dresse, A. (1995). Comparative effect of various potassium channel openers on the firing rate of hippocampal and dopaminergic neurons in vitro. Pflügers Archiv: European Journal of Physiology, 430, 182.

Lebrun, P., Antoine, M. H., Ouedraogo, R., Herchuelz, A., De Tullio, P., Masereel, B., Delarge, J., & Pirotte, B. (10 December 1994). Pyridothiadiazines inhibit glucose-induced insulin release by activating ATP-sensitive K+ channels [Paper presentation]. Contact group FNRS "Endocrine Pancreas", Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Antoine, M. H., Masereel, B., Delarge, J., & Lebrun, P. (10 December 1994). Selection of a new and potent activator of the pancreatic KATP channel based on structure-activity relationships in the pyridothiadiazinedioxide chemical class [Paper presentation]. Contact group FNRS "Endocrine Pancreas", Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Masereel, B., Delarge, J.-L., Lepagnol, J., & Renard, P. (05 October 1994). Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them.

De Tullio, P., Pirotte, B., Fontaine, J., Antoine, M. H., Masereel, B., Delarge, J., & Lebrun, P. (October 1994). Different tissue selectivity of pyrido- and benzothiadiazinedioxides, potassium channel openers related to diazoxide [Poster presentation]. 6th International Symposium: Pharmacological control of calcium and potassium homeostasis, Florence, Italy.

Lebrun, P., De Tullio, P., Antoine, M. H., Herchuelz, A., Delarge, J., & Pirotte, B. (October 1994). Pyridothiadiazines as potent activators of KATP channels and inhibitors of insulin secretion [Poster presentation]. 6th International Symposium: Pharmacological control of calcium and potassium homeostasis, Florence, Italy.

Pirotte, B., De Tullio, P., Antoine, M. H., Masereel, B., Delarge, J., & Lebrun, P. (October 1994). Structure-activity relationships of pyridothiadiazines that activate the pancreatic KATP channel: a proposed pharmacophore for optimal binding site interaction [Poster presentation]. 6th International Symposium: Pharmacological control of calcium and potassium homeostasis, Florence, Italy.

Masereel, B., Renard, P., Pirotte, B., De Tullio, P., & Delarge, J. (September 1994). A novel pyrid-3-yl sulfonylurea, BM 27, effective in brain edema and stroke treatment [Paper presentation]. XIIIth International Symposium of Medicinal Chemistry, Paris, France.

Pirotte, B., De Tullio, P., Masereel, B., Diouf, O., Caignard, D. H., Renard, P., & Delarge, J. (September 1994). Benzo- and pyridothiadiazinedioxides as nonpeptidal cholecystokinin antagonists related to quinazolinones cholecystokinin/gastrin receptor ligands [Poster presentation]. XIIIth International Symposium of Medicinal Chemistry, Paris, France.

Reboud-Ravaux, M., Thierry, N., Schynts, M., Jiang, K. Y., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., & Delarge, J. (September 1994). Synthesis and enzymatic evaluation of novel coumarinic derivatives as inhibitors of serine proteases [Poster presentation]. XIIIth International Symposium of Medicinal Chemistry, Paris, France.

Scuvée-Moreau, J., Pirotte, B., Seutin, V., Massote, L., De Tullio, P., Delarge, J., & Dresse, A. (June 1994). Effect of potassium channel openers on the firing rate of hippocampal pyramidal neurons in vitro [Poster presentation]. GESA XXIV, Nîmes, France.

De Tullio, P., Pirotte, B., Masereel, B., Diouf, O., Caignard, D. H., Renard, P., & Delarge, J. (May 1994). Synthèse de dérivés 3-aminoaralkyl-2-aryl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes et leur evaluation en tant qu'antagonistes de la cholécystokinine [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Masereel, M. B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (May 1994). Synthesis and pharmacology of N"-(4-arylaminopyrid-3-yl)sulfonyl-N-cyano-N'-isopropylguanidines [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Pirotte, B., De Tullio, P., Podona, T., Masereel, Caignard, D. H., Renard, P., & Delarge, J. (May 1994). 3-Arylcarboxamidomethyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxydes en tant qu'antagonistes non peptidiques de la cholécystokinine: synthèse et évaluation pharmacologique [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Schynts, M., Boggetto, N., Jiang, K. Y., Thierry, N., Masereel, B., Pirotte, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (May 1994). Développement d'une nouvelle serie d'inactivateurs de protéases à sérine [Poster presentation]. RECOB 5, Aussois, France.

De Tullio, P., Pirotte, B., Dupont, L., Lebrun, P., Antoine, M. H., Fontaine, J., Masereel, B., Schynts, M., & Delarge, J. M. (March 1994). Synthesis of a series of 4H-1,2,4-pyridothiadiazine 1,1-dioxides and their evaluation as new potassium channel openers [Paper presentation]. Cinquième Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. M. (March 1994). Pharmacology of a new sulfonylurea (BM 27) effective in brain edema [Paper presentation]. Cinquième Forum des Sciences Pharmaceutiques, Blankenberge, Belgium.

De Tullio, P., Pirotte, B., Lebrun, P., Antoine, M. H., Fontaine, J., Masereel, B., Schynts, M., Dupont, L., & Delarge, J. (19 January 1994). 4H-1,2,4-pyridothiadiazine 1,1-dioxydes en tant que nouveaux activateurs du canal potassique ATP-dépendant [Poster presentation]. Journées Jeunes Chercheurs, Paris, France.

Schynts, M., Jiang, K. Y., Thierry, N., Boggetto, N., Pirotte, B., Masereel, B., De Tullio, P., Delarge, J., & Reboud-Ravaux, M. (19 January 1994). Design, synthèse et évaluation biologique de nouveaux dérivés coumariniques inhibiteurs de protéases à sérine [Poster presentation]. Journées Jeunes Chercheurs, Paris, France.

Antoine, M.-H., Pirotte, B., Hermann, M., De Tullio, P., Herchuelz, A., Delarge, J., & Lebrun, P. (1994). Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets. Experientia, 50, 830-832. doi:10.1007/BF01956464

De Tullio, P., Pirotte, B., Dupont, L., Lebrun, P., Antoine, M.-H., Fontaine, J., Masereel, B., Schynts, M., & Delarge, J. (1994). Synthesis of a series of 4H-1,2,4-pyridothiadiazine 1,1-dioxides and their evaluation as new potassium channel openers. Journal de Pharmacie de Belgique, 49, 85.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (1994). Etude structurale comparative du pinacidil, du diazoxide et du cromakalim, ouvreurs de canaux potassiques appartenant à trois classes chimiques distinctes. Journal de Pharmacie de Belgique, 49, 282.

Masereel, B., Renard, P., Pirotte, B., De Tullio, P., & Delarge, J. (1994). Synthesis and pharmacology of pyrid-3-yl sulfonylureas and thioureas as astrocytic Na+ 2Cl- K+ cotransporter inhibitors. European Journal of Medicinal Chemistry, 29, 527-535. doi:10.1016/0223-5234(94)90145-7

Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (1994). Pharmacology of a new sulfonylurea (BM 27) effective in brain edema. Journal de Pharmacie de Belgique, 49, 88.

Pirotte, B., Antoine, M.-H., De Tullio, P., Hermann, M., Herchuelz, A., Delarge, J., & Lebrun, P. (1994). A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+-channels. Biochemical Pharmacology, 47, 1381-1386. doi:10.1016/0006-2952(94)90337-9

Antoine, M. H., Pirotte, B., De Tullio, P., Delarge, J., Herchuelz, A., & Lebrun, P. (20 November 1993). A new and potent activator of ATP-sensitive K+ channels [Poster presentation]. Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Lebrun, P., Antoine, M.-H., Masereel, B., Schynts, M., Fontaine, J., Dupont, L., Herchuelz, A., & Delarge, J. (15 October 1993). 3-(Alkylamino)-4h-Pyrido[4,3-E]-1,2,4-Thiadiazine 1,1-Dioxides as Powerful Inhibitors of Insulin Release from Rat Pancreatic B-Cells: A New Class of Potassium Channel Openers? Journal of Medicinal Chemistry, 36 (21), 3211-3213. doi:10.1021/jm00073a025

Lebrun, P., Pirotte, B., Antoine, M. H., De Tullio, P., Delarge, J., & Herchuelz, A. (September 1993). BPDZ 44 : a new and potent activator of ATP-sensitive K+ channels [Poster presentation]. EASD 29th annual meeting, Istanbul, Turkey.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (August 1993). Comparative structural and stereoelectronical study of pinacidil, diazoxide and cromakalim, potassium channel openers belonging to three different chemical classes [Poster presentation]. IUCr XVI, Beijing, China.

Dupont, L., Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (May 1993). Etude structurale comparative du pinacidil, du diazoxide et du cromakalim, ouvreurs de canaux potassiques appartenant à trois classes chimiques distinctes [Poster presentation]. 7èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Lebrun, P., Pirotte, B., Antoine, M.-H., De Tullio, P., Delarge, J., & Herchuelz, A. (1993). BPDZ 44: a new and potent activator of ATP-sensitive K+ channels. Diabetologia, 36, 406.

Pirotte, B., De Tullio, P., Lebrun, P., Antoine, M.-H., Masereel, B., Schynts, M., & Delarge, J. (1993). Improved pancreatic K-ATP channel openers belonging to the pyridothiadiazine chemical class. Journal de Pharmacie de Belgique, 48, 143.

Pirotte, B., De Tullio, P., Masereel, B., Schynts, M., Delarge, J., DUPONT, L., & THUNUS, L. (1993). 4-Acylamino-4H-1,2,4-triazoles and related structures: new investigations of their chemical and physicochemical properties associated to their particular exocyclic amide function. Canadian Journal of Chemistry, 71, 1857-1866. doi:10.1139/v93-233

Pirotte, B., Dupont, L., De Tullio, P., Masereel, B., Schynts, M., & Delarge, J. (1993). Structural study of pinacidil, a potassium channel opener belonging to the chemical class of N-alkyl-N"-cyano-N'-pyridylguanidines. Helvetica Chimica Acta, 76, 1311-1318. doi:10.1002/hlca.19930760318

Masereel, B., Schynts, M., Pirotte, B., De Tullio, P., & Delarge, J. (July 1992). synthesis of sulfonylthioureas related to torasemide as new "high ceiling diuretics [Poster presentation]. XXXVIIIèmes Rencontres Internationales de Chimie Thérapeutique, Toulouse, France.

Pirotte, B., De Tullio, P., Parmentier, M., Masereel, B., Schynts, M., & Delarge, J. (1992). 3-Oxo-2H,4H-pyrido[2,3-e][1,2,4]-thiadiazine 1,1-dioxide, a sweetening agent of the sulfonamide family structurally related to saccharin and acesulfame. Pharmaceutisch Weekblad, 14, 10.

Pirotte, B., De Tullio, P., Parmentier, M., Masereel, B., Schynts, M., & Delarge, J. (18 October 1991). 3-oxo-2H,4H-pyrido [2,3-e][1,2,4]-thiadiazine 1,1-dioxide, a sweetening agent of the sulfonamide family structurally related to saccharin and acesulfame [Poster presentation]. Receptors signal transduction and drug design, Anvers, Belgium.