Publications and communications of Jean-François Liégeois

Vitello, R.* , Taouba, H.* , Derand, M., & Liégeois, J.-F. (2024). The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels. ACS Medicinal Chemistry Letters. doi:10.1021/acsmedchemlett.3c00452

Robaye, L., Engel, D., Liégeois, J.-F., Kerff, F., Quertemont, E., & Seutin, V. (24 November 2023). Organotypic slice cultures from the P1 mouse dorsal raphe: Methodological development and first results [Poster presentation]. National committee of physiology and pharmacology, Autumn Meeting, Brussels, Belgium.

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (07 September 2023). Towards a high-throughput mass spectrometry methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Poster presentation]. 39ème Journées Françaises de Spectrométrie de Masse, Marseille, France.

Vitello, R., Taouba, H., Pereira Barbon, D., Tumanov, N., Wouters, J., Seutin, V., & Liégeois, J.-F. (10 May 2023). Tetrahydroisoquinoline derivatives as blockers of SK channels: A new pharmacophore identified [Poster presentation]. Cambridge Ion Channels Forum 2023, Cambridge, United Kingdom.

Taouba, H., Vitello, R., Frederich, M., Wouters Johan, & Liégeois, J.-F. (28 April 2023). SMALL-CONDUCTANCE Ca2+-ACTIVATED K+ CHANNELS, A NOVEL TARGET FOR THE ALKALOIDS CEPHARANTHINE AND BERBAMINE [Paper presentation]. 21st FORUM OF PHARMACEUTICAL SCIENCES, Blankenberge, Belgium.

Vitello, R., Taouba, H., Pereira Barbon, D., Tumanov, N., Wouters, J., Seutin, V., & Liégeois, J.-F. (28 April 2023). A Not-So-Simple Simplifictaion [Poster presentation]. PhysPhar Spring meeting 2023, Bruxelles, Belgium.

Falinski, S. P., Taouba, H., Vitello, R., & Liégeois, J.-F. (01 February 2023). The prospect of using a thallium flux assay to study native and mutated hSK2 & hSK3 channels in transiently transfected HEK293 cells [Poster presentation]. CIRM Day 2023, Liège, Belgium.

Taouba, H., Vitello, R., & Liégeois, J.-F. (01 February 2023). CEPHARANTHINE AND BERBAMINE HAVE A SIGNIFICANT AFFINITY FOR THE SMALL CONDUCTANCE Ca 2+ - ACTIVATED K+ CHANNELS [Paper presentation]. C.I.R.M. day 2023, Liège, Belgium.

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (18 October 2022). Towards a high-throughput MS methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Paper presentation]. Congrès International de Toxinologie - IST, Abu-Dhabi, United Arab Emirates.

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (07 October 2022). Towards a high-throughput mass spectrometry methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Poster presentation]. BSMS 2022, Braine l'Alleud, Belgium.

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (01 September 2022). HIGH-THROUGHPUT MASS SPECTROMETRY METHODOLOGY TO FISH PEPTIDE TOXINS FROM CRUDE VENOMS BY AFFINITY CAPTURE ON CELL MEMBRANE RECEPTORS [Paper presentation]. 2022 International Mass Spectrometry Conference, Maastricht, Netherlands.

Taouba, H., Vitello, R., Lumb, J.-P., Seutin, V., Frederich, M., & Liégeois, J.-F. (19 November 2021). A NEW APPROACH FOR THE TREATMENT OF MALARIA THROUGH SK CHANNEL MODULATION ? [Poster presentation]. MedChem 2021, Liège, Belgium.

Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, S., Engel, D., Liégeois, J.-F., Lakaye, B., Roeper, J., & Seutin, V. (01 October 2021). The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. Neuropharmacology, 197, 1-15. doi:10.1016/j.neuropharm.2021.108722

Vitello, R., Seutin, V., Badarau, E., & Liégeois, J.-F. (28 May 2021). Benzhydrol analogues of bis-isoquinoliniums : chiral entities with potential to interact with SK channels [Paper presentation]. 2nd FNRS Med Chem Symposium, Belgium.

Taouba, H., Vitello, R., Lumb, J.-P., Seutin, V., Frederich, M., & Liégeois, J.-F. (26 May 2021). Could Bis-THIQ compounds inhibit plasmodial growth through SK channel interaction ? [Poster presentation]. CIRM-day, LIEGE, Belgium.

Wanko Nembot, A. M., Hayen, J.-L., Vitello, R., Damblon, C., & Liégeois, J.-F. (26 May 2021). Quantification of 2-disulfide bonded isomers of apamin, a peptidic toxin, leads to the observation of a structural rearrangement [Poster presentation]. CIRM-Day.

Andrade, Y., Ropke, J., Viana, T., Fanelli, C., Minaldi, E., Batista, L., Issy, A., Del Bel, E., Rodrigues, L., Liégeois, J.-F., & Moreira, F. (2021). Effects of JL13, a pyridobenzoxazepine compound, in dopaminergic and glutamatergic models of antipsychotic activity. Behavioural Pharmacology, 32, 2-8. doi:10.1097/FBP.0000000000000595

Vitello, R., Kerff, F., & Liégeois, J.-F. (2021). Deciphering the molecular mechanism of SK2 channel activation by intracellular calcium to develop new therapeutic agents. Acta physiologica, 231, 13574. doi:10.1111/apha.13574

Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Lakaye, B., Liégeois, J.-F., Roeper, J., & Seutin, V. (22 May 2020). On the path to understanding pacemaking of dopaminergic neurons [Poster presentation]. Virtual Dopamine Meeting.

Vitello, R., & Liégeois, J.-F. (23 February 2017). Chiral tools to explore SK channel functions [Paper presentation]. CIRM seminar.

Dilly, S., & Liégeois, J.-F. (2016). Structural insights into 5-HT1A/D4 selectivity of WAY-100635 analogues: molecular modeling, synthesis and in vitro binding. Journal of Chemical Information and Modeling, 56, 1324-1331. doi:10.1021/acs.jcim.5b00753

Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J., & Liégeois, J.-F. (05 June 2014). A PREFERENTIAL FOLDED CONFORMATION OF SOME BIS-(8-ISOPROPYL-ISOQUINOLINIUM) DERIVATIVES EXPLAINS STEREOSELECTIVE REDUCTION BY SODIUM BOROHYDRIDE [Poster presentation]. 28èmes Journées Franco-Belges de Pharmacochimie, Metz, France.

Dilly, S., Badarau, E., Dufour, F., Nistor, I., Hubert, P., Seutin, V., Wouters, J., & Liégeois, J.-F. (2014). Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride. Journal of Molecular Structure. doi:10.1016/j.molstruc.2014.06.042

Badarau, E.* , Dilly, S.* , Wouters, J., Seutin, V., & Liégeois, J.-F. (2014). Chemical modifications of the N-methyl laudanosine scaffold point to new directions for SK channels exploration. Bioorganic and Medicinal Chemistry Letters, 24, 5616-5620. doi:10.1016/j.bmcl.2014.10.083

Liégeois, J.-F., Lespagnard, M., Meneses Salas, E., Mangin, F., Scuvée-Moreau, J., & Dilly, S. (2014). Enhancing a CH-pi interaction to increase the affinity for 5-HT1A receptors. ACS Medicinal Chemistry Letters, 5, 358-362. doi:10.1021/ml4004843

Liégeois, J.-F., Wouters, J., Seutin, V., & Dilly, S. (2014). Bis-(1,2,3,4-tetrahydroisoquinolinium): a chiral scaffold for developing high affinity ligands for SK channels. ChemMedChem, 9, 737-740. doi:10.1002/cmdc.201400028

Liégeois, J.-F., Seutin, V., & Dilly, S. (09 November 2013). Increased affinity of N-Methyl-AG525 stereoisomers for SK2 and SK3 channels [Poster presentation]. 43th Annual Meeting Neuroscience, San Diego, United States.

Liégeois, J.-F., Lespagnard, M., Meneses-Salas, E., Mangin, F., & Dilly, S. (July 2013). CHANGING THE ELECTRONIC DENSITY OF THE DISTAL PHENYL RING OF 4-ARYL-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES TO INFLUENCE THE AFFINITY FOR 5-HT1A RECEPTORS [Poster presentation]. Rencontres Internationales de Chimie Thérapeutique (RICT) 2013, Nice, France.

Dilly, S., & Liégeois, J.-F. (June 2013). A HYDROGEN BOND INFLUENCES THE 5-HT1A/D4 SELECTIVITY OF WAY-100635 ANALOGUES: AN IN SILICO APPROACH [Poster presentation]. 27èmes Journées franco-belges de Pharmacochimie et 21èmes Conférences européennes du GP2A, Lille, France.

Dilly, S., Philippart, F., Lamy, C., Poncin, S., Snyders, D., Seutin, V., & Liégeois, J.-F. (2013). The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels. Biochemical Pharmacology, 85, 560-569. doi:10.1016/j.bcp.2012.12.015

Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Oprean, R., Badarau, E., Dufour, F., Dossou, K. S. S., Fillet, M., Liégeois, J.-F., Hubert, P., & Rozet, E. (2013). Implementation of a Design Space Approach for Enantiomeric Separations in Polar Organic Solvent Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 74, 273-283. doi:10.1016/j.jpba.2012.10.015

Dilly, S., Mangin, F., Joly, B., Scuvée-Moreau, J., Evans, J., Setola, V., Roth, B., & Liégeois, J.-F. (24 May 2012). PHARMACOMODULATIONS DU WAY-100635 : DE NOUVELLES PISTES DANS LA CONCEPTION D’ANTAGONISTES SÉLECTIFS DES RÉCEPTEURS 5-HT1A [Poster presentation]. 26èmes Journées Franco-Belges de Pharmacochimie 2012, Orléans, France.

Dilly, S., Poncin, S., Lamy, C., Liégeois, J.-F., & Seutin, V. (April 2012). Physiologie, pharmacologie et modélisation de canaux potassiques : zoom sur les canaux SK. MS. Medecine Sciences, 28, 395-402. doi:10.1051/medsci/2012284017

Dilly, S., Lamy, C., Poncin, S., Seutin, V., Snyders, D., & Liégeois, J.-F. (16 March 2012). Interactions of apamin with pore mutated SK3 channels [Poster presentation]. Belgian Society for Fundamental and Clinical Physiology and Pharmacology, Spring Meeting 2010, Brussels, Belgium.

Liégeois, J.-F., DEVILLE, M., Dilly, S., Lamy, C., Mangin, F., Résimont, M., & Tarazi, F. (2012). New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation. Journal of Medicinal Chemistry, 55 (1572), 1582. doi:10.1021/jm2013419

Mangin, F., Dilly, S., Joly, B., Scuvée-Moreau, J., Evans, J., Setola, V., Roth, B., & Liégeois, J.-F. (2012). Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors. Bioorganic and Medicinal Chemistry Letters. doi:10.1016/j.bmcl.2012.05.119

Badarau, E., Dilly, S., Dufour, F., Poncin, S., Seutin, V., & Liégeois, J.-F. (15 November 2011). Synthesis and radioligand binding studies of bis-(8-isopropylisoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels. Bioorganic and Medicinal Chemistry Letters, 21 (22), 6756-6759. doi:10.1016/j.bmcl.2011.09.043

Dilly, S., Lamy, C., Marrion, N., Liégeois, J.-F., & Seutin, V. (16 August 2011). Ion channel modulators: more diversity than previously thought. Chembiochem: A European Journal of Chemical Biology, 12 (12), 1808-1812. doi:10.1002/cbic.201100236

Vignisse, J., Liégeois, J.-F., Wins, P., & Bettendorff, L. (July 2011). Thiamin derivatives in the brain of a mouse model of Alzheimer's disease and in cultured Neuroblastoma cells treated with benfotiamine [Poster presentation]. FENS/IBRO Summer School 2011: Metabolic Aspects of Chronic Brain Diseases, Gunzburg, Germany.

Dilly, S., & Liégeois, J.-F. (2011). Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study. Journal of Computer-Aided Molecular Design, 25 (2), 163-169. doi:10.1007/s10822-010-9407-8

Dilly, S., Scuvée-Moreau, J., Wouters, J., & Liégeois, J.-F. (2011). The 5-HT1A agonism potential of substituted-piperazine-ethyl-amide derivatives is conserved in the hexyl homologues: molecular modeling and pharmacological evaluation. Journal of Chemical Information and Modeling, 51 (11), 2961-2966. doi:10.1021/ci200313r

Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Rozet, E., Oprean, R., Badarau, E., Dufour, F., Liégeois, J.-F., & Hubert, P. (2011). Implementation of a design space approach for enatiomeric separations in polar organic solvent chromatography [Poster presentation]. 36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Budapest, Hungary.

Weatherall, K., Seutin, V., Liégeois, J.-F., & Marrion, N. (2011). Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channel. Proceedings of the National Academy of Sciences of the United States of America, 108 (45), 18488-18493. doi:10.1073/pnas.1110724108

Liégeois, J.-F., & Dilly, S. (16 November 2010). Binding properties of clozapine and related compounds on native D2 dopamine receptors in normal and oxidative medium [Poster presentation]. 40th Annual Meeting Neuroscience, San Diego, United States.

Dilly, S., Lamy, C., Snyders, D., Liégeois, J.-F., & Seutin, V. (16 October 2010). Block of SK channels by the sigma agonist 1,3-di-o-tolyl-guanidine: evidence for a novel site of action for SK blockers [Poster presentation]. Belgian Society for Fundamental and Clinical Physiology and Pharmacology, Autumn Meeting 2010, Brussels, Belgium.

Dilly, S., Lamy, C., Seutin, V., & Liégeois, J.-F. (20 May 2010). Etude du mode de liaison des canaux potassiques de type SK et l’apamine par modélisation moléculaire [Poster presentation]. 24èmes JOURNEES FRANCO-BELGES DE PHARMACOCHIMIE, Bruxelles, Belgium.

Dilly, S., Graulich, A., & Liégeois, J.-F. (January 2010). Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: A new step towards the design of high-affinity 5-HT1A ligands. Bioorganic and Medicinal Chemistry Letters, 20 (2), 1118-1123. doi:10.1016/j.bmcl.2009.12.027

Dilly, S., Lamy, C., Liégeois, J.-F., & Seutin, V. (2010). Combined experimental and computational approaches to study the action of blockers of small conductance calcium-activated potassium (SK) channels. Acta Physiologica Scandinavica, 199 (supplement 678), 10.

Drion, G., Bonjean, M., Waroux, O., Scuvée-Moreau, J., Liégeois, J.-F., Sejnowski, T., Sepulchre, R., & Seutin, V. (2010). M-type channels selectively control bursting in rat dopaminergic neurons. European Journal of Neuroscience, 31, 827-835. doi:10.1111/j.1460-9568.2010.07107.x

Graulich, A., Léonard, M., Résimont, M., Huang, X.-P., Roth, B. L., & Liégeois, J.-F. (2010). Chemical Modifications on 4-Arylpiperazine-Ethyl Carboxamide Derivatives Differentially Modulate Affinity for 5-HT1A, D4.2, and alpha(2A) Receptors: Synthesis and In Vitro Radioligand Binding Studies. Australian Journal of Chemistry, 63, 56-67. doi:10.1071/CH09353

Lamy, C.* , Goodchild, S. J.* , Weatherall, K. L., Jane, D. E., Liégeois, J.-F., Seutin, V.* , & Marrion, N. V.*. (2010). Allosteric block of KCa2 channels by apamin. Journal of Biological Chemistry, 287, 27067-77. doi:10.1074/jbc.M110.110072

Lamy, C., Scuvée-Moreau, J., Dilly, S., Liégeois, J.-F., & Seutin, V. (2010). The sigma agonist 1,3-di-o-tolylguanidine directly blocks SK channels in dopaminergic neurons and in cell lines. European Journal of Pharmacology, 641, 23-28. doi:10.1016/j.ejphar.2010.05.008

Résimont, M., & Liégeois, J.-F. (2010). Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: Impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, alpha(2A), D4.2, D3 and D2L receptors. Bioorganic and Medicinal Chemistry Letters, 20, 5199-5202. doi:10.1016/j.bmcl.2010.07.002

Wouters, J., Elasaad, K., Norberg, B., Graulich, A., & Liégeois, J.-F. (2010). Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline). European Journal of Medicinal Chemistry, 45, 3240-3244. doi:10.1016/j.ejmech.2010.03.020

Dilly, S., Graulich, A., & Liégeois, J.-F. (14 May 2009). Conformational analysis of new 5-HT1A ligands by molecular modeling [Paper presentation]. 14th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Lamy, C., Scuvée-Moreau, J., Dilly, S., Goodchild, S., Marrion, N., Liégeois, J.-F., & Seutin, V. (17 November 2008). Direct block of SK2 and SK3 current by the sigma agonist 1,3-di-(2-tolyl)guanidine [Poster presentation]. 38th Annual Meeting Neuroscience, Washington, United States.

Rouchet, N., Waroux, O., Lamy, C., Massotte, L., Scuvée-Moreau, J., Liégeois, J.-F., & Seutin, V. (28 September 2008). SK Channel blockade promotes burst firing in dorsal raphe serotonergic neurons. European Journal of Neuroscience, 28 (6), 1108-15. doi:10.1111/j.1460-9568.2008.06430.x

Dilly, S., Graulich, A., Chavatte, P., Seutin, V., & Liégeois, J.-F. (30 May 2008). Molecular modelling study of bis-isoquinolinium derivatives as small conductance Ca2+ - activated K+ channel blockers [Poster presentation]. 22èmes journées franco-belges de pharmacochimie, Caen, France.

Rouchet, N., Waroux, O., Alix, P., Scuvée-Moreau, J., Liégeois, J.-F., & Seutin, V. (17 May 2008). SK Channel blockade promotes bursting in vivo in dorsal raphe serotonergic neurons. Acta Physiologica, 194 (supll. 666), 01.

Graulich, A., Lamy, C., Alleva, L., Dilly, S., Chavatte, P., Wouters, J., Seutin, V., & Liégeois, J.-F. (2008). Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers. Bioorganic and Medicinal Chemistry Letters, 18 (11), 3440-3445. doi:10.1016/j.bmcl.2008.03.069

Neny, M., Lemmer, Y., Graulich, A., Alleva, L., Piazza, P. V., Seutin, V., Spampinato, U., & Liégeois, J.-F. (2008). The SK channel blocker AG525E1 increases locomotor activity and in vivo dopamine release in the rat nucleus accumbens. In P. E. M. Phillips, S. G. Sandberg, S. Ahn, ... A. G. Phillips (Eds.), Monitoring Molecules in Neuroscience - Proceedings of the 12th International Conference on In Vivo Methods (pp. 267-270). Vancouver, Canada: University of Bristish Columbia.

Rouchet, N., Waroux, O., Scuvée-Moreau, J., Lamy, C., Graulich, A., Liégeois, J.-F., & Seutin, V. (04 November 2007). Direct induction of burst firing by SK channel blockade in serotonergic neurons in vivo [Paper presentation]. Neuroscience 2007, San Diego, United States - California.

Graulich, A., Dilly, S., Farce, A., Scuvée-Moreau, J., Waroux, O., Lamy, C., Chavatte, P., Seutin, V., & Liégeois, J.-F. (18 October 2007). Synthesis and Radioligand Binding Studies of Bis-Isoquinolinium Derivatives as Small Conductance Ca(2+)-Activated K(+) Channel Blockers. Journal of Medicinal Chemistry, 50 (21), 5070-5075. doi:10.1021/jm070412j

Graulich, A., Norberg, B., Liégeois, J.-F., & Wouters, J. (July 2007). (+/-)-2-Benzoyl-8-ethyl-1,2-dihydro-isoquinoline-1-carbonitrile: an original Reissert compound. Acta Crystallographica. Section E, Structure Reports Online, 63 (Part 7), 3161-U3073. doi:10.1107/S1600536807027729

Seutin, V., & Liégeois, J.-F. (July 2007). SK channels are on the move. British Journal of Pharmacology, 151 (5), 568-570. doi:10.1038/sj.bjp.0707282

Ris, L., Capron, B., Sclavons, C., Liégeois, J.-F., Seutin, V., & Godaux, E. (June 2007). Metaplastic effect of apamin on LTP and paired-pulse facilitation. Learning and Memory, 14 (6), 390-399. doi:10.1101/lm.571007

Carato, P., Graulich, A., Jensen, N., Roth, B. L., & Liégeois, J.-F. (15 March 2007). Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D-2L, D-4.2, and 5-HT2A receptors. Bioorganic and Medicinal Chemistry Letters, 17 (6), 1570-1574. doi:10.1016/j.bmcl.2006.12.106

Carato, P., Graulich, A., Jensen, N., Roth, B. L., & Liégeois, J.-F. (15 March 2007). Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D-2L, D-4.2, and 5-HT2A receptors. Bioorganic and Medicinal Chemistry Letters, 17 (6), 1565-1569. doi:10.1016/j.bmcl.2006.12.096

Tarazi, F. I., Moran-Gates, T., Gardner, M. P., Graulich, A., Lamy, C., & Liégeois, J.-F. (2007). Long-term effects of JL 13, a potential atypical antipsychotic, on Ionotropic glutamate receptors. Journal of Molecular Neuroscience, 32 (3), 192-198. doi:10.1007/s12031-007-0034-3

Graulich, A., Scuvée-Moreau, J., Alleva, L., Lamy, C., Waroux, O., Seutin, V., & Liégeois, J.-F. (30 November 2006). Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+- activated K+ channels. Journal of Medicinal Chemistry, 49 (24), 7208-7214. doi:10.1021/jm0607395

Alleva, L., Rouchet, N., Waroux, O., Lamy, C., Scuvée-Moreau, J., Graulich, A., Liégeois, J.-F., & Seutin, V. (17 October 2006). Effect of SK channel blockade on the firing of dorsal raphe neurons in anaesthetized rats [Poster presentation]. 2006 Neuroscience Meeting Planner, Atlanta, United States.

Moran-Gates, T., Massari, C., Graulich, A., Liégeois, J.-F., & Tarazi, F. I. (15 August 2006). Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes. Journal of Neuroscience Research, 84 (3), 675-682. doi:10.1002/jnr.20972

Dilly, S., Graulich, A., Farce, A., Seutin, V., Liégeois, J.-F., & Chavatte, P. (December 2005). Identification of a pharmacophore of SKCa channel blockers. Journal of Enzyme Inhibition and Medicinal Chemistry, 20 (6), 517-523. doi:10.1080/14756360500210989

Waroux, O., Massotte, L., Alleva, L., Graulich, A., Thomas, E., Liégeois, J.-F., Scuvée-Moreau, J., & Seutin, V. (December 2005). SK channels control the firing pattern of midbrain dopaminergic neurons in vivo. European Journal of Neuroscience, 22 (12), 3111-3121. doi:10.1111/j.1460-9568.2005.04484.x

de Ruyck, J., de Hassonville, S. H., Liégeois, J.-F., & Wouters, J. (November 2005). Cyproterone and a comparison with its acetate ester. Acta Crystallographica. Section E, Structure Reports Online, 61 (Part 11), 3576-O3578. doi:10.1107/S1600536805031673

Graulich, A., Scuvée-Moreau, J., Seutin, V., & Liégeois, J.-F. (28 July 2005). Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine. Journal of Medicinal Chemistry, 48 (15), 4972-4982. doi:10.1021/jm049025p

Dilly, S., Graulich, A., Farce, A., Seutin, V., Liégeois, J.-F., & Chavatte, P. (28 January 2005). Recherche d’un pharmacophore de ligands de canaux SK par Modélisation Moléculaire [Paper presentation]. 12ème Journée Jeunes Chercheurs, Institut Curie, Paris, France.

Graulich, A., Mercier, F., Scuvée-Moreau, J., Seutin, V., & Liégeois, J.-F. (2005). Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers. Bioorganic and Medicinal Chemistry, 13 (4), 1201-9. doi:10.1016/j.bmc.2004.11.025

Scuvée-Moreau, J., Boland, A., Graulich, A., Van Overmeire, L., D'hoedt, D., Graulich-Lorge, F., Thomas, E., Abras, A., Stocker, M., Liégeois, J.-F., & Seutin, V. (November 2004). Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices. British Journal of Pharmacology, 143 (6), 753-764. doi:10.1038/sj.bjp.0705979

Henry de Hassonville, S., Chiap, P., Liégeois, J.-F., Evrard, B., Delattre, L., Crommen, J., Piel, G., & Hubert, P. (21 September 2004). Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin. Journal of Pharmaceutical and Biomedical Analysis, 36 (1), 133-143. doi:10.1016/j.jpba.2004.05.023

Graulich, A., & Liégeois, J.-F. (2004). A rapid synthesis of thieno[2,3-c]pyridine and 2-substituted thieno[2,3-c]pyridines. Synthesis, (12), 1935-1937. doi:10.1055/s-2004-829134

Dupont, L., & Liégeois, J.-F. (2004). Crystal structure of bis(8-chloro-5-(4-methylpiperazinium-1-yl)pyrido[2,3-b][1,5]benzoxazepine) fumarate-fumaric acid solvate (1 : 1), (C17H18ClN4O)(2)(C4H2O4)center dot C4H4O4. Zeitschrift für Kristallographie. New Crystal Structures, 219 (2), 147-149.

Dupont, L., & Liégeois, J.-F. (December 2003). 8-Chloro-5-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,5]benzoxazepine. Acta Crystallographica. Section E, Structure Reports Online, 59 (Part 12), 1962-O1963. doi:10.1107/S1600536803025844

Spirlet, M.-R., Graulich, A., & Liégeois, J.-F. (December 2003). 8-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine. Acta Crystallographica. Section E, Structure Reports Online, 59 (Part 12), 1990-O1991. doi:10.1107/S1600536803026448

Ellenbroek, B. A., & Liégeois, J.-F. (2003). JL 13, an atypical antipsychotic: A preclinical review [letter to the editor]. CNS Drug Reviews, 9 (1, Spring), 41-56. doi:10.1111/j.1527-3458.2003.tb00243.x

Liégeois, J.-F., Mercier, F., Graulich, A., Graulich-Lorge, F., Scuvée-Moreau, J., & Seutin, V. (2003). Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry. Current Medicinal Chemistry, 10 (8), 625-47. doi:10.2174/0929867033457908

Liégeois, J.-F., Eyrolles, L., Ellenbroek, B. A., Lejeune, C., Carato, P., Bruhwyler, J., Geczy, J., Damas, J., & Delarge, J. (07 November 2002). New pyridobenzodiazepine derivatives: Modifications of the basic side chain differentially modulate binding to dopamine (D-4.2, D-2L) and serotonin (5-HT2A) receptors. Journal of Medicinal Chemistry, 45 (23), 5136-5149. doi:10.1021/jm0104825

Scuvée-Moreau, J., Liégeois, J.-F., Massotte, L., & Seutin, V. (September 2002). Methyl-laudanosine: A new pharmacological tool to investigate the function of small-conductance Ca2+-activated K+ channels. Journal of Pharmacology and Experimental Therapeutics, 302 (3), 1176-1183. doi:10.1124/jpet.302.3.1176

Liégeois, J.-F., Ichikawa, J., & Meltzer, H. Y. (30 August 2002). 5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner. Brain Research, 947 (2), 157-165. doi:10.1016/S0006-8993(02)02620-3

Liégeois, J.-F., Bruhwyler, J., Hendrick, J. C., Delarge, J., Legros, J.-J., & Damas, J. (February 2002). Minimal effects of JL 13, a pyridobenzoxazepine derivative with an antipsychotic potential, on circulating prolactin levels in male rats. Neuroscience Letters, 319 (1), 49-52. doi:10.1016/S0304-3940(01)02539-3

Dupont, L., Eyrolles, L., Evrard, G., Delarge, J., & Liégeois, J.-F. (January 2002). 8-Chloro-6-(3-dimethylaminopropylamino)-11H-pyrido[2,3-b][1,4]benzodiazepine. Acta Crystallographica. Section E, Structure Reports Online, 58 (Part 1), 69-O71. doi:10.1107/S1600536801021286

Liégeois, J.-F. (2002). La clozapine, source d'inspiration pour les pharmacochimistes, les pharmacologues et les psychopharmacologues [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/79585

Damas, J., Garbacki, N., Liégeois, J.-F., & Juchmes, J. (December 2001). Le controle du reseau vasculaire cutane. Revue Médicale de Liège, 56 (12), 846-9.

Mouithys-Mickalad, A., Kauffmann, J. M., Petit, C., Bruhwyler, J., Liao, Y., Wikstrom, H., Damas, J., Delarge, J., Deby-Dupont, G., Geczy, J., & Liégeois, J.-F. (01 March 2001). Electrooxidation Potential as a Tool in the Early Screening for New Safer Clozapine-Like Analogues. Journal of Medicinal Chemistry, 44 (5), 769-76. doi:10.1021/jm000221f

Alvarez, C., Van Hees, T., Piel, G., Liégeois, J.-F., Delattre, L., & Evrard, B. (2001). Preparation of mebendazole HP-beta-cyclodextrin complexes using water-soluble polymers and organic acids. STP Pharma Sciences, 11 (6), 439-442.

Alvarez, C, Van Hees, T., Piel, G., Liégeois, J.-F., Evrard, B., Torrado, J.J, & Delattre, L. (2001). Préparation de complexes mebendazole-HPβCD à l'aide de polymères solubles dans l'eau et d'acides organiques. Annales Pharmaceutiques Françaises, 59, 380.

Casey, D., Bruhwyler, J., Delarge, J., Géczy, J., & Liégeois, J.-F. (2001). The behavioral effects of acute and chronic JL 13, a putative antipsychotic, in Cebus non-human primates. Psychopharmacology, 157, 228-235. doi:10.1007/s002130100808

Damas, J., Garbacki, N., Delarge, J., & Liégeois, J.-F. (2001). Inhibition by JL3 of some effects of histamine and of the anaphylactoid reactions induced by dextran in rats [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Gent, Belgium.

Damas, J., & Liégeois, J.-F. (2001). About the relationship between the kallikrein-kinin system and insulin. Current Topics in Peptide and Protein Research, 4, 89-96.

Ellenbroek, B., Liégeois, J.-F., Bruhwyler, J., & Cools, A. (2001). The effects of JL 13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia. Journal of Pharmacology and Experimental Therapeutics, 298, 386-391.

Liégeois, J.-F., Ichikawa, J., & Meltzer, H. Y. (2001). Scopolamine reduces clozapine-induced dopamine release in rat striatum. In W. T. O'Connor, J. P. Lowry, O'Connor, ... R. D. O'Neill (Eds.), Monitoring Molecules in Neuroscience - Proceedings of the 9th International Conference on In Vivo Methods (pp. 267-269). Dublin, Ireland: University College Dublin.

Rogister, F., Laeckmann, D., Plasman, P.-O., Van Eylen, F., Ghyoot, M., Maggetto, C., Liégeois, J.-F., Géczy, J., Herchuelz, A., Delarge, J., & Masereel, B. (2001). Novel inhibitors of the sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives. European Journal of Medicinal Chemistry, 36, 597-614. doi:10.1016/S0223-5234(01)01247-8

Alvarez, C., Van Hees, T., Piel, G., Liégeois, J.-F., Evrard, B., Torrado, J., & Delattre, L. (December 2000). Préparation de complexes mébendazole-HPbCD à l'aide de polymères solubles dans l'eau et d'acides organiques [Paper presentation]. 4ème Journée du Club français des Cyclodextrines, Grenoble, France.

Alvarez, C., Van Hees, T., Piel, G., Liégeois, J.-F., Evrard, B., Torrado, J., & Delattre, L. (April 2000). Preparation of mebendazole HP-b-cyclodextrin complexes using water soluble polymers and organic acids [Paper presentation]. IXth Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Liégeois, J.-F., Zahid, N., Bruhwyler, J., & Uetrecht, J. (March 2000). Hypochlorous Acid, a Major Oxidant Produced by Activated Neutrophils, Has Low Effect on Two Pyridobenzazepine Derivatives, Jl 3 and Jl 13. Archiv der Pharmazie, 333 (2-3), 63-7. doi:10.1002/(SICI)1521-4184(200002)333:2/3<63::AID-ARDP63>3.0.CO;2-C

Géczy, J., Bruhwyler, J., Scuvée-Moreau, J., Seutin, V., Masset, H., Heugen, Dresse, A., Lejeune, C., Decamp, E., Szente, L., Szejtli, J., & Liégeois, J.-F. (2000). The inclusion of fluoxetine into gamma-cyclodextrine increases its bioavailability: behavioural, electrophysiological and pharmacokinetics studies. Psychopharmacology, 151, 328-334.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l'Alleud, Belgium.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M. H., Kempen, I., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (26 November 1999). Enantiomeric resolution of pirlindole at the preparative scale: derivatization and chromatographic methods [Poster presentation]. Chirality: Impact in Drug Design and Development, Braine l’Alleud, Belgium.

Liégeois, J.-F., Bruhwyler, J., Petit, C., Damas, J., Delarge, J., Geczy, J., Kauffmann, J. M., Lamy, M., Meltzer, H., & Mouithys-Mickalad, A. (01 October 1999). Oxidation Sensitivity May Be a Useful Tool for the Detection of the Hematotoxic Potential of Newly Developed Molecules: Application to Antipsychotic Drugs. Archives of Biochemistry and Biophysics, 370 (1), 126-37. doi:10.1006/abbi.1999.1380

Damas, J., & Liégeois, J.-F. (March 1999). The Inflammatory Reaction Induced by Formalin in the Rat Paw. Naunyn-Schmiedeberg's Archives of Pharmacology, 359 (3), 220-7. doi:10.1007/PL00005345

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1999). Effective resolution of racemic pirlindole at the preparative scale. Chirality, 11, 261-266. doi:10.1002/(SICI)1520-636X(1999)11:4<261::AID-CHIR1>3.0.CO;2-S

Liégeois, J.-F., Seutin, V., Scuvée-Moreau, J., Dresse, A., Bruhwyler, J., Geczy, J., Delarge, J., & Damas, J. (1999). Influence of JL3, a potential antidepressant, on rat noradrenergic and serotonergic systems. European Journal of Pharmacology, 386, 211-216. doi:10.1016/S0014-2999(99)00777-3

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (December 1998). Enantiomeric Separation of Pirlindole by Liquid Chromatography Using Different Types of Chiral Stationary Phases. Journal of Pharmaceutical and Biomedical Analysis, 18 (4-5), 605-14. doi:10.1016/S0731-7085(98)00213-1

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (01 September 1998). Simultaneous Determination of Pirlindole Enantiomers and Dehydropirlindole by Chiral Liquid Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 17 (6-7), 1071-9. doi:10.1016/S0731-7085(98)00073-9

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration [Poster presentation]. Fourth European Congress of Pharmaceutical Sciences, Milan, Italy.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (September 1998). Effective resolution of racemic pirlindole at the preparative scale: derivatization method and absolute configuration [Poster presentation]. XVth EFMC International Symposium on Medicinal Chemistry.

De Tullio, P., Ceccato, A., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (16 January 1998). Séparation énantiomérique du pirlindole à l’échelle préparative [Poster presentation]. Journées Jeunes Chercheurs, Paris, France.

Bruhwyler, J., Liégeois, J.-F., & Geczy, J. (1998). Facilitatory effects of chronically administered citicoline on learning and memory processes in the dog. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 22 (1), 115-28. doi:10.1016/S0278-5846(97)00183-8

Bruhwyler, J., Liégeois, J.-F., Gerardy, J., Damas, J., Chleide, E., Lejeune, C., Decamp, E., De Tullio, P., Delarge, J., Dresse, A., & Geczy, J. (1998). Comparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques. Behavioural Pharmacology, 9 (8), 731-7. doi:10.1097/00008877-199812000-00008

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Felikidis, A., Geczy, J., & Crommen, J. (1998). Liquid chromatographic separation of pirlindole enantiomers using different types of chiral stationary phases. Journal de Pharmacie de Belgique, 53, 168.

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Stachow, M., Geczy, J., & Crommen, J. (1998). Determination of the enantiomeric purity of pirlindole by liquid chromatography using a cellulose based chiral stationary phase. Journal de Pharmacie de Belgique, 53, 169.

De Tullio, P., Ceccato, A., Liégeois, J.-F., Pirotte, B., Felekidis, A., Stachow, M., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Preparative resolution of racemic pirlindole: chromatographic methods and determination of the absolute configuration. European Journal of Pharmaceutical Sciences, suppl.1, 37.

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindole. Journal de Pharmacie de Belgique, 53, 55.

De Tullio, P., Felekidis, A., Pirotte, B., Liégeois, J.-F., Stachow, M., Delarge, J., Ceccato, A., Hubert, P., Crommen, J., & Geczy, J. (1998). First preparative enantiomer resolution of pirlindole, a potent antidepressant drug. Helvetica Chimica Acta, 81, 539-547. doi:10.1002/hlca.19980810307

De Tullio, P., Felikidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Résolution préparative du pirlindol, journées franco-belges de pharmacochimie. Journal de Pharmacie de Belgique, 53, 55.

Liégeois, J.-F., Eyrolles, L., Bruhwyler, J., & Delarge, J. (1998). Dopamine D4 receptors, a new opportunity for research on schizophrenia. Current Medicinal Chemistry, 5, 77-100.

Petit, C., Quilinc, A., Quilinc, E., Ortiz Borondo, G., Liégeois, J.-F., & Kauffmann, J.-M. (1998). Horseradish peroxidase electrode for phenothiazine analysis. Electroanalysis, 10, 1241-1248. doi:10.1002/(SICI)1521-4109(199812)10:18<1241::AID-ELAN1241>3.0.CO;2-Q

Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole. Journal de Pharmacie de Belgique, 53, 60.

Pirotte, B., De Tullio, P., Stachow, M., Felikidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (1998). Tentatives de synthèse énantiosélective des isomères R et S du pirlindol. Journal de Pharmacie de Belgique, 53, 60.

Liégeois, J.-F., Mouithys-Mickalad, A., Bruhwyler, J., Delarge, J., Petit, C., Kauffmann, J. M., & Lamy, M. (08 September 1997). Jl 13, a Potential Successor to Clozapine, Is Less Sensitive to Oxidative Phenomena. Biochemical and Biophysical Research Communications, 238 (1), 252-5. doi:10.1006/bbrc.1997.7270

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (September 1997). Simultaneous determination of pirlindole enantiomers and dehydropirlindole by liquid chromatography using a cellulose based chiral stationary phase [Poster presentation]. 7th Meeting on Recent Developments in Pharmaceutical Analysis, Ile d'Elbe, Italy.

Damas, J., Liégeois, J.-F., & Bourdon, V. (May 1997). Involvement of 5-Hydroxytryptamine and Bradykinin in the Hyperalgesia Induced in Rats by Collagenase from Clostridium Histolyticum. Naunyn-Schmiedeberg's Archives of Pharmacology, 355 (5), 566-70. doi:10.1007/PL00004984

De Tullio, P., Felekidis, A., Liégeois, J.-F., Pirotte, B., Stachow, M., Ceccato, A., Hubert, P., Crommen, J., Cegzy, J., & Delarge, J. (May 1997). Résolution préparative du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Pirotte, B., De Tullio, P., Stachow, M., Felekidis, A., Liégeois, J.-F., Ceccato, A., Hubert, P., Crommen, J., Geczy, J., & Delarge, J. (May 1997). Tentatives de synthèse énantiosélective des isomères R et S du pirlindole [Poster presentation]. Onzièmes Journées Franco-Belges de Pharmacochimie, Bruxelles, Belgium.

Damas, J., & Liégeois, J.-F. (March 1997). La famille des peptides natriurétiques. Revue Médicale de Liège, 52 (3), 169-73.

Bruhwyler, J., Liégeois, J.-F., Bergman, J., Carey, G., Goudie, A., Taylor, A., Meltzer, H. Y., Delarge, J., & Géczy, J. (1997). JL 13, a pyridobenzoxazepine compound with potential atypical antipsychotic activity: a review of its behavioral properties. Pharmacological Research, 36, 255-264. doi:10.1006/phrs.1997.0231

Bruhwyler, J., Liégeois, J.-F., & Geczy, J. (1997). Pirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties. Pharmacological Research, 36 (1), 23-33. doi:10.1006/phrs.1997.0196

Ceccato, A., Hubert, P., De Tullio, P., Liégeois, J.-F., Pirotte, B., Stachow, M., Delarge, J., Geczy, J., & Crommen, J. (1997). Enantiomeric separation of pirlindole enantiomers and dehydroprilindole by chrial liquid chromatography [Poster presentation]. VIIth meeting on recent developments in pharmaceutical analysis.

Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., Bregadze, V. I., Dolgushin, F. M., Yanovsky, A. I., & Struchkov, Y. T. (1997). Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes. Molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-Rh C2B9H11]. Journal of Organometallic Chemistry, 536-537, 405-412. doi:10.1016/S0022-328X(96)06743-5

Liégeois, J.-F., & Bruhwyler, J. (1997). Dopamine D4 selective ligands as potential antipsychotics. In F. Awouters (Ed.), Proceedings of the XIVth International Symposium on Medicinal Chemistry (pp. 271-290).

Damas, J., Bourdon, V., Liégeois, J.-F., & Simmons, W. H. (November 1996). Influence of Several Peptidase Inhibitors on the Pro-Inflammatory Effects of Substance P, Capsaicin and Collagenase. Naunyn-Schmiedeberg's Archives of Pharmacology, 354 (5), 662-9. doi:10.1007/BF00170843

Damas, J., Liégeois, J.-F., & Simmons, W. H. (November 1996). Potentiation of the Pro-Inflammatory Effects of Bradykinin by Inhibition of Angiotensin-Converting Enzyme and Aminopeptidase P in Rat Paws. Naunyn-Schmiedeberg's Archives of Pharmacology, 354 (5), 670-6. doi:10.1007/BF00170844

Dupont, L., Liégeois, J.-F., Rogister, F., & Delarge, J. (1996). 8-Chloro-5-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,5]benzodiazepine. Acta Crystallographica. Section C, Crystal Structure Communications, C52, 391-393. doi:10.1107/S0108270195011942

Liégeois, J.-F., Scuvée-Moreau, J., Giesbers, I., Damas, J., Bruhwyler, J., Geczy, J., Delarge, J., & Dresse, A. (1996). Dibenzoazepine analogues : the electrophysiological properties of JL3, a potential atypical antidepressant. European Journal of Pharmacology, 310, 9-12. doi:10.1016/0014-2999(96)00361-5

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (1996). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas. Journal de Pharmacie de Belgique, 51, 17.

Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (June 1995). Synthesis and diuretic properties of pyrid-3-ylsulfonylcyanoguanidines [Poster presentation]. 31èmes Rencontres Internationales de Chimie Thérapeutique, Lyon, France.

Masereel, B., Lambert, D., Bia, F., Diouf, O., Liégeois, J.-F., De Tullio, P., Pirotte, B., Pochet, L., Khelili, S., & Delarge, J. (June 1995). Anticonvulsant properties of 4-cycloalkylamino-pyrid-3-yl sulfonylureas and -thioureas [Poster presentation]. Neuvièmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Liégeois, J.-F., Rogister, F., Delarge, J., & Pincemail, J. (February 1995). Peroxidase-Catalysed Oxidation of Different Dibenzazepine Derivatives. Archiv der Pharmazie, 328 (2), 109-12. doi:10.1002/ardp.19953280203

Bruhwyler, J., Liégeois, J.-F., Lejeune, C., Rogister, F., Delarge, J., & Geczy, J. (1995). New dibenzazepine derivatives with disinhibitory and/or antidepressant potential: neurochemical and behavioural study in the open-field and forced swimming tests. Behavioural Pharmacology, 6 (8), 830-838.

Dupont, L., Liégeois, J.-F., Rogister, F., & Delarge, J. (1995). 3-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine. Acta Crystallographica. Section C, Crystal Structure Communications, C51, 1889-1891. doi:10.1107/S0108270195003337

Dupont, L., Liégeois, J.-F., Rogister, F., & Delarge, J. (1995). 11-(4-methylpiperazin-1-yl)-5H-pyrido[4,3-b][1,5]benzodiazepine. Acta Crystallographica. Section C, Crystal Structure Communications, C51, 1379-1381. doi:10.1107/S0108270194014459

Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., & Bregadze, V. I. (1995). Influence de la nature des ligands sur l'hydrogenation de la méthacycline en doxycycline et en épi-doxycycline par des complexes du Rhodium. Journal de Pharmacie de Belgique, 50, 232.

Liégeois, J.-F., Bonaventure, P., Delarge, J., & Damas, J. (1995). Antipsychotics and Neuropeptides: The Atypical Profile of Ci-943 and Its Relationship to Neurotensin. Neuroscience and Biobehavioral Reviews, 19 (4, Winter), 519-31. doi:10.1016/0149-7634(95)00016-X

Liégeois, J.-F., Bruhwyler, J., Damas, J., Rogister, F., Masereel, B., Geczy, J., & Delarge, J. (1995). Modulation of the Clozapine Structure Increases Its Selectivity for the Dopamine D4 Receptor. European Journal of Pharmacology, 273 (3), 1-3. doi:10.1016/0014-2999(94)00782-3

Liégeois, J.-F., Bruhwyler, J., Rogister, F., & Delarge, J. (1995). Diarylazepine derivatives as potent atypical neuroleptic drugs: Recent advances. Current Medicinal Chemistry, 1, 471-501.

Masereel, B., Dupont, L., Laeckmann, D., Liégeois, J.-F., Pirotte, B., De Tullio, P., & Delarge, J. (1995). Synthesis and pharmacology of pyrid-3-ylsulfonylcyanoguanidines as diuretics. European Journal of Medicinal Chemistry, 30, 343-351. doi:10.1016/0223-5234(96)88244-4

Felekidis, A., Goblet-Stachow, M., Liégeois, J.-F., Pirotte, B., Delarge, J., Demonceau, A., Fontaine, M., Noels, A. F., Chizhevsky, I. T., Zinevich, T. V., & Bregadze, V. I. (May 1994). Influence de la nature des ligands sur l'hydrogénation de la méthacycline en doxycycline et en épi-doxycycline par des complexes du Rhodium [Poster presentation]. Huitièmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Liégeois, J.-F., Rogister, F. A., Bruhwyler, J., Damas, J., Nguyen, T. P., Inarejos, M. O., Chleide, E. M., Mercier, M. G., & Delarge, J. E. (10 February 1994). Pyridobenzoxazepine and Pyridobenzothiazepine Derivatives as Potential Central Nervous System Agents: Synthesis and Neurochemical Study. Journal of Medicinal Chemistry, 37 (4), 519-25. doi:10.1021/jm00030a011

Liégeois, J.-F., Bruhwyler, J., Damas, J., Nguyen, T. P., Chleide, E. M., Mercier, M. G., Rogister, F. A., & Delarge, J. E. (23 July 1993). New Pyridobenzodiazepine Derivatives as Potential Antipsychotics: Synthesis and Neurochemical Study. Journal of Medicinal Chemistry, 36 (15), 2107-14. doi:10.1021/jm00067a009

Liégeois, J.-F., & Damas, J. (01 July 1993). Un messager intercellulaire original, le NO (monoxyde d'azote). Revue Médicale de Liège, 48 (7), 406-13.

Bruhwyler, J., Chleide, E., Liégeois, J.-F., & Carreer, F. (1993). Nitric oxide: a new messenger in the brain. Neuroscience and Biobehavioral Reviews, 17 (4), 373-84. doi:10.1016/S0149-7634(05)80114-9

Bruhwyler, J., Liégeois, J.-F., Chleide, E., Rogister, F., Damas, J., Delarge, J., & Mercier, M. (1992). Comparative study of typical neuroleptics, clozapine and newly synthesized clozapine-analogues: correlations between neurochemistry and behaviour. Behavioural Pharmacology, 3 (6), 567-579.

Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1992). Structure du 8-chloro-11-(méthylpipérazin-1-yl)dibenzo[b,f]-1,4-thiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C48, 1851-1853. doi:10.1107/S0108270192001021

Dupont, L., Englebert, S., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1992). Structure du 6-(4-méthylpipérazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazépine 1,5-hydrate. Acta Crystallographica. Section C, Crystal Structure Communications, C48, 1322-1324. doi:10.1107/S0108270191013744

Liégeois, J.-F. (1992). Etudes pharmacochimiques et pharmacologiques dans la série des azaarylazépines [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/79584

Liégeois, J.-F., Dupont, L., & Delarge, J. (1992). Application de l'analyse CoMFA (Comparative Molecular Field Analysis) à une série de dérivés tricycliques apparentés à la clozapine. Journal de Pharmacie de Belgique, 47, 100-108.

Bruhwyler, J., Chleide, E., Liégeois, J.-F., Delarge, J., & Mercier, M. (1991). Effects of specific dopaminergic agonists and antagonists in the open-field test. Pharmacology, Biochemistry and Behavior, 39 (2), 367-71. doi:10.1016/0091-3057(91)90193-6

Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1991). Structure du méthyl-4 pipérazinyl-1)-10 pyrido[4,3-b][1,4]benzothiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C47, 1740-1742. doi:10.1107/S0108270191001191

Dupont, L., Englebert, S., Dideberg, O., Liégeois, J.-F., & delarge, J. (1991). Structures du 11-formyl-5-(4-méthylpipérazin-1-yl)-11H-pyrido[2,3b][1,5]benzodiazépine et du 6-(4-méthylpipérazin-1-yl)-11-méthyl-11H-pyrido[2,3-b][1,4]benzodiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C47, 2690-2693.

Liégeois, J.-F., Dive, G., Dupont, L., & Delarge, J. (1991). New alkoxypyridine Sulfonamides: Synthesis, Biological Evaluation and Physicochemical Properties. Helvetica Chimica Acta, 74 (8), 1764-1772. doi:10.1002/hlca.19910740819

Bruhwyler, J., Chleide, E., Liégeois, J.-F., Delarge, J., & Mercier, M. (1990). Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test. Pharmacology, Biochemistry and Behavior, 36 (1), 57-61. doi:10.1016/0091-3057(90)90125-2

Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1990). Structure du N-diméthylaminoéthyl Méthoxy-4 Pyridinesulfonamide-3 et du N-[(éthyl-1pyrrolidinyl-2) méthyl] Pyridinesulfonamide-3. Acta Crystallographica. Section C, Crystal Structure Communications, C46, 1863-1866.

Liégeois, J.-F. (1990). Contribution à l'étude des relations structure-activité parmi les antipsychotiques atypiques : synthèse et évaluation pharmacologique de pyridobenzoazépines bioisostères de la clozapine [Specialised master, ULille - Université de Lille]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/79583

Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1988). Structure du N-diéthylaminoéthyl méthoxy-4 pyridine sulfonamide-3. Acta Crystallographica. Section C, Crystal Structure Communications, C44, 907-909. doi:10.1107/S010827018800099X

Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1988). Structure du (Méthyl-1-pipérazinyl-4)-5 Pyrido[2,3-b][1,5]benzothiazépine. Acta Crystallographica. Section C, Crystal Structure Communications, C44, 319-321. doi:10.1107/S0108270187010151

Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1987). Structure du maléate de (pyrido[2,3-b]benzo-1,5-oxazépinyl-11)-4-méthyl-1H+-pipérazinium, C17H19N4OH + C4H3O4. Acta Crystallographica. Section C, Crystal Structure Communications, C43, 716-718.

Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1987). Structure de la clothiapine. Acta Crystallographica. Section C, Crystal Structure Communications, C43, 720-722. doi:10.1107/S010827018709437X

Sbit, M., Dupont, L., Dideberg, O., Liégeois, J.-F., & Delarge, J. (1987). Structure de l'acide diphénylamino-2 carboxylique. Acta Crystallographica. Section C, Crystal Structure Communications, C43, 926-928.

Wittner, M., Di Stefano, A., Wangemann, P., Delarge, J., Liégeois, J.-F., & Greger, R. (1987). Analogues of torasemide--structure function relationships--experiments in the thick ascending limb of the loop of Henle of rabbit nephron. Pflügers Archiv: European Journal of Physiology, 408 (1), 54-62. doi:10.1007/BF00581840